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BAKER BROS. ADVISORS LP
> HRTX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 8,131,678 | 0 | 9,432,746,000 | -10,896,449,000 | $1,160.00 |
| 12/31/2022 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 8,131,678 | 0 | 20,329,195,000 | 20,294,879,000 | $2,500.00 |
| 09/30/2022 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 8,131,678 | 0 | 34,316,000 | 11,629,000 | $4.22 |
| 06/30/2022 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 8,131,678 | 0 | 22,687,000 | -23,826,000 | $2.79 |
| 03/31/2022 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 8,131,678 | 0 | 46,513,000 | -27,729,000 | $5.72 |
| 12/31/2021 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 8,131,678 | 0 | 74,242,220 | -12,685,780 | $9.13 |
| 09/30/2021 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 8,131,678 | 0 | 86,928,000 | -39,276,000 | $10.69 |
| 06/30/2021 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 8,131,678 | 2,136,974 | 126,204,000 | 29,030,000 | $15.52 |
| 03/31/2021 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 5,994,704 | 0 | 97,174,000 | -29,704,000 | $16.21 |
| 12/31/2020 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 8,064,832 | 2,070,128 | 170,692,169 | 81,850,169 | $21.17 |
| 09/30/2020 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 5,994,704 | -23,400 | 88,842,000 | 316,000 | $14.82 |
| 06/30/2020 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 6,018,104 | 0 | 88,526,000 | 17,873,000 | $14.71 |
| 03/31/2020 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 6,018,104 | 0 | 70,653,000 | -70,772,000 | $11.74 |
| 12/31/2019 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 7,979,853 | 1,961,749 | 187,526,546 | 76,191,546 | $23.50 |
| 09/30/2019 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 6,018,104 | 0 | 111,335,000 | -542,000 | $18.50 |
| 06/30/2019 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 6,018,104 | 1,000,000 | 111,877,000 | -10,765,000 | $18.59 |
| 03/31/2019 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 5,018,104 | 0 | 122,642,000 | -7,528,000 | $24.44 |
| 12/31/2018 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 6,908,244 | 1,882,946 | 179,199,849 | 20,148,849 | $25.94 |
| 09/30/2018 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 5,025,298 | 0 | 159,051,000 | -36,182,000 | $31.65 |
| 06/30/2018 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 5,025,298 | 1,964,657 | 195,233,000 | 139,835,000 | $38.85 |
| 12/31/2017 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 3,060,641 | 272,649 | 55,398,000 | 10,372,000 | $18.10 |
| 09/30/2017 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 2,787,992 | 4,423 | 45,026,000 | 6,474,000 | $16.15 |
| 06/30/2017 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 2,783,569 | 0 | 38,552,000 | -3,202,000 | $13.85 |
| 03/31/2017 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 2,783,569 | 400,000 | 41,754,000 | 10,529,000 | $15.00 |
| 12/31/2016 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 2,383,569 | -473,681 | 31,225,000 | -18,005,000 | $13.10 |
| 09/30/2016 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 2,857,250 | 0 | 49,230,000 | -2,343,000 | $17.23 |
| 06/30/2016 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 2,857,250 | -50,534 | 51,573,000 | -3,646,000 | $18.05 |
| 03/31/2016 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 2,907,784 | 0 | 55,219,000 | -22,419,000 | $18.99 |
| 12/31/2015 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 2,907,784 | 2,907,784 | 77,638,000 | 77,638,000 | $26.70 |
| 09/30/2015 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 2,907,784 | 2,907,784 | 70,950,000 | 70,950,000 | $24.40 |
| 06/30/2015 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 2,807,784 | 2,807,784 | 87,491,000 | 87,491,000 | $31.16 |
| 03/31/2015 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 2,607,784 | 2,607,784 | 37,943,000 | 37,943,000 | $14.55 |
| 12/31/2014 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 2,607,784 | 2,607,784 | 26,234,000 | 26,234,000 | $10.06 |
| 09/30/2014 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 2,607,784 | 2,607,784 | 21,723,000 | 21,723,000 | $8.33 |
| 06/30/2014 | HERON THERAPEUTICS, INC. /DE/ | HRTX | 2,607,784 | 2,607,784 | 32,128,000 | 32,128,000 | $12.32 |
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