The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Abeona Therapeutics Inc. COM 00289Y107 34,950 2,184,364 SH   SOLE   2,184,364 0 0
ACADIA Pharmaceuticals Inc. COM 004225108 415,777 27,228,338 SH   SOLE   27,228,338 0 0
Acceleron Pharma Inc. COM 00434H108 7,952 163,900 SH   SOLE   163,900 0 0
Achillion Pharmaceuticals, Inc. COM 00448Q201 5,500 1,943,620 SH   SOLE   1,943,620 0 0
Acorda Therapeutics, Inc. COM 00484M106 4,968 173,100 SH   SOLE   173,100 0 0
Adamas Pharmaceuticals, Inc. COM 00548A106 4,459 172,630 SH   SOLE   172,630 0 0
Adaptimmune Therapeutics plc SPONSORED ADR 00653A107 1,187 100,000 SH   SOLE   100,000 0 0
Aeglea BioTherapeutics, Inc. COM 00773J103 14,684 1,387,872 SH   SOLE   1,387,872 0 0
Aerie Pharmaceuticals, Inc. COM 00771V108 4,063 60,155 SH   SOLE   60,155 0 0
Aevi Genomic Medicine, Inc. COM 00835P105 4,501 4,055,142 SH   SOLE   4,055,142 0 0
Affimed N.V. COM N01045108 660 400,000 SH   SOLE   400,000 0 0
Aimmune Therapeutics, Inc. COM 00900T107 18,121 673,908 SH   SOLE   673,908 0 0
Akari Therapeutics, Plc SPONSORED ADR 00972G108 115 58,770 SH   SOLE   58,770 0 0
Albireo Pharma, Inc. COM 01345P106 8,875 250,000 SH   SOLE   250,000 0 0
Alexion Pharmaceuticals, Inc. COM 015351109 1,062,214 8,555,894 SH   SOLE   8,555,894 0 0
Alkermes plc SHS G01767105 4,126 100,251 SH   SOLE   100,251 0 0
Amarin Corporation plc SPONSORED ADR NEW 023111206 70,049 22,669,509 SH   SOLE   22,669,509 0 0
AnaptysBio, Inc. COM 032724106 5,192 73,086 SH   SOLE   73,086 0 0
Apellis Pharmaceuticals, Inc. COM 03753U106 4,314 196,078 SH   SOLE   196,078 0 0
Aquinox Pharmaceuticals, Inc. COM 03842B101 28,976 10,934,154 SH   SOLE   10,934,154 0 0
Arbutus Biopharma Corporation COM 03879J100 1,318 180,582 SH   SOLE   180,582 0 0
Arcus Biosciences, Inc. COM 03969F109 1,488 121,534 SH   SOLE   121,534 0 0
argenx SE SPONSORED ADR 04016X101 79,691 961,754 SH   SOLE   961,754 0 0
Array BioPharma Inc. COM 04269X105 94,911 5,656,196 SH   SOLE   5,656,196 0 0
Ascendis Pharma A/S SPONSORED ADR 04351P101 188,741 2,837,352 SH   SOLE   2,837,352 0 0
Assembly Biosciences, Inc. COM 045396108 5,826 148,587 SH   SOLE   148,587 0 0
Audentes Therapeutics, Inc. COM 05070R104 15,025 393,222 SH   SOLE   393,222 0 0
Autolus Therapeutics plc SPON ADS 05280R100 6,304 235,294 SH   SOLE   235,294 0 0
BeiGene, Ltd. SPONSORED ADR 07725L102 1,838,584 11,959,824 SH   SOLE   11,959,824 0 0
Bellicum Pharmaceuticals, Inc. COM 079481107 30,210 4,093,447 SH   SOLE   4,093,447 0 0
BioCryst Pharmaceuticals, Inc. COM 09058V103 80,290 14,012,172 SH   SOLE   14,012,172 0 0
BioDelivery Sciences International, Inc. COM 09060J106 620 210,021 SH   SOLE   210,021 0 0
BioMarin Pharmaceutical Inc. COM 09061G101 714,327 7,583,084 SH   SOLE   7,583,084 0 0
BioTime, Inc. *W EXP 10/1/201 09066L162 1 20,084 SH   SOLE   20,084 0 0
bluebird bio, Inc. COM 09609G100 31,390 200,000 SH   SOLE   200,000 0 0
Catalyst Pharmaceuticals, Inc. COM 14888U101 11,301 3,621,962 SH   SOLE   3,621,962 0 0
Cellectis S.A. SPONSORED ADS 15117K103 1,415 50,000 SH   SOLE   50,000 0 0
Cerus Corporation COM 157085101 71,702 10,749,937 SH   SOLE   10,749,937 0 0
ChemoCentryx, Inc. COM 16383L106 5,453 414,029 SH   SOLE   414,029 0 0
Clementia Pharmaceuticals Inc. COM 185575107 15,695 1,192,595 SH   SOLE   1,192,595 0 0
ContraFect Corporation COM 212326102 15,808 7,153,076 SH   SOLE   7,153,076 0 0
Corbus Pharmaceuticals Holdings, Inc. COM 21833P103 1,250 247,450 SH   SOLE   247,450 0 0
Cyclacel Pharmaceuticals, Inc. PFD CONV EX 6% 23254L207 89 13,253 SH   SOLE   13,253 0 0
CymaBay Therapeutics, Inc. COM 23257D103 65,996 4,917,700 SH   SOLE   4,917,700 0 0
DBV Technologies S.A. SPONSORED ADR 23306J101 106,279 5,509,560 SH   SOLE   5,509,560 0 0
Dynavax Technologies Corporation COM NEW 268158201 1,144 75,000 SH   SOLE   75,000 0 0
Endocyte, Inc. COM 29269A102 31,434 2,277,799 SH   SOLE   2,277,799 0 0
ERYTECH Pharma S.A. SPONSORED ADR 29604W108 34,470 3,085,969 SH   SOLE   3,085,969 0 0
Exelixis, Inc. COM 30161Q104 11,049 513,410 SH   SOLE   513,410 0 0
Foamix Pharmaceuticals Ltd. SHS M46135105 7,466 1,490,201 SH   SOLE   1,490,201 0 0
Forty Seven, Inc. COM 34983P104 4,000 250,000 SH   SOLE   250,000 0 0
Fulgent Genetics, Inc. COM 359664109 518 125,000 SH   SOLE   125,000 0 0
G1 Therapeutics, Inc. COM 3621LQ109 7,366 169,492 SH   SOLE   169,492 0 0
Galapagos NV SPONSORED ADR 36315X101 23,957 259,894 SH   SOLE   259,894 0 0
Galmed Pharmaceuticals Ltd. SHS M47238106 7,570 636,140 SH   SOLE   636,140 0 0
Genomic Health, Inc. COM 37244C101 695,045 13,790,574 SH   SOLE   13,790,574 0 0
GlycoMimetics, Inc. COM 38000Q102 4,697 291,214 SH   SOLE   291,214 0 0
GW Pharmaceuticals plc ADS 36197T103 44,904 321,800 SH   SOLE   321,800 0 0
Halozyme Therapeutics, Inc. COM 40637H109 21,660 1,283,929 SH   SOLE   1,283,929 0 0
Heron Therapeutics, Inc. COM 427746102 195,233 5,025,298 SH   SOLE   5,025,298 0 0
Idera Pharmaceuticals, Inc. COM NEW 45168K405 51,024 38,654,811 SH   SOLE   38,654,811 0 0
Incyte Corporation COM 45337C102 2,294,819 34,251,034 SH   SOLE   34,251,034 0 0
Infinity Pharmaceuticals, Inc. COM 45665G303 1,109 580,400 SH   SOLE   580,400 0 0
InflaRx N.V. COM N44821101 8,347 258,824 SH   SOLE   258,824 0 0
Insmed Incorporated COM PAR $.01 457669307 16,555 700,000 SH   SOLE   700,000 0 0
Intellia Therapeutics, Inc. COM 45826J105 14,964 546,922 SH   SOLE   546,922 0 0
Invitae Corporation COM 46185L103 61,736 8,399,411 SH   SOLE   8,399,411 0 0
Jounce Therapeutics, Inc. COM 481116101 766 100,000 SH   SOLE   100,000 0 0
Kiniksa Pharmaceuticals, Ltd. COM CL A G5269C101 52,050 3,000,000 SH   SOLE   3,000,000 0 0
Krystal Biotech, Inc. COM 501147102 2,974 200,000 SH   SOLE   200,000 0 0
La Jolla Pharmaceutical Company COM PAR $.0001 2 503459604 4,512 154,675 SH   SOLE   154,675 0 0
MacroGenics, Inc. COM 556099109 4,495 217,695 SH   SOLE   217,695 0 0
Madrigal Pharmaceuticals, Inc. COM 558868105 327,035 1,169,278 SH   SOLE   1,169,278 0 0
MediWound Ltd. ORD SHS M68830104 1,559 226,000 SH   SOLE   226,000 0 0
Menlo Therapeutics Inc. COM 586858102 5,684 700,000 SH   SOLE   700,000 0 0
Merus N.V. COM N5749R100 26,402 1,160,014 SH   SOLE   1,160,014 0 0
Mirati Therapeutics, Inc. COM 60468T105 123,914 2,513,462 SH   SOLE   2,513,462 0 0
Molecular Templates, Inc. COM 608550109 379 72,412 SH   SOLE   72,412 0 0
Momenta Pharmaceuticals, Inc. COM 60877T100 6,309 308,500 SH   SOLE   308,500 0 0
MyoKardia, Inc. COM 62857M105 21,504 433,121 SH   SOLE   433,121 0 0
Nabriva Therapeutics plc SHS G63637105 3,265 938,235 SH   SOLE   938,235 0 0
Natera, Inc. COM 632307104 4,304 228,676 SH   SOLE   228,676 0 0
Neurocrine Biosciences, Inc. COM 64125C109 92,800 944,624 SH   SOLE   944,624 0 0
NewLink Genetics Corporation COM 651511107 2,415 507,273 SH   SOLE   507,273 0 0
Ovid Therapeutics Inc. COM 690469101 1,932 247,733 SH   SOLE   247,733 0 0
Progenics Pharmaceuticals, Inc. COM 743187106 7,871 979,016 SH   SOLE   979,016 0 0
Proteon Therapeutics, Inc. COM 74371L109 732 298,591 SH   SOLE   298,591 0 0
Ra Pharmaceuticals, Inc. COM 74933V108 1,771 177,952 SH   SOLE   177,952 0 0
Rhythm Pharmaceuticals, Inc. COM 76243J105 84,658 2,708,200 SH   SOLE   2,708,200 0 0
Rigel Pharmaceuticals, Inc. COM NEW 766559603 2,948 1,041,612 SH   SOLE   1,041,612 0 0
Ritter Pharmaceuticals, Inc. COM NEW 767836307 720 279,999 SH   SOLE   279,999 0 0
Sage Therapeutics, Inc. COM 78667J108 96,000 613,300 SH   SOLE   613,300 0 0
Sangamo Therapeutics, Inc. COM 800677106 18,232 1,283,923 SH   SOLE   1,283,923 0 0
Seattle Genetics, Inc. COM 812578102 3,388,948 51,046,060 SH   SOLE   51,046,060 0 0
Selecta Biosciences, Inc. COM 816212104 1,242 93,750 SH   SOLE   93,750 0 0
Sesen Bio, Inc. COM 817763105 5,118 2,624,412 SH   SOLE   2,624,412 0 0
Solid Biosciences Inc. COM 83422E105 20,946 587,884 SH   SOLE   587,884 0 0
Spark Therapeutics, Inc. COM 84652J103 114,551 1,384,130 SH   SOLE   1,384,130 0 0
Spring Bank Pharmaceuticals, Inc. COM 849431101 4,422 373,144 SH   SOLE   373,144 0 0
Stemline Therapeutics, Inc. COM 85858C107 715 44,524 SH   SOLE   44,524 0 0
Sunesis Pharmaceuticals, Inc. COM PAR 867328700 1,180 556,665 SH   SOLE   556,665 0 0
Syros Pharmaceuticals, Inc. COM 87184Q107 5,869 574,835 SH   SOLE   574,835 0 0
T2 Biosystems, Inc. COM 89853L104 774 100,000 SH   SOLE   100,000 0 0
Tetraphase Pharmaceuticals, Inc. COM 88165N105 3,338 935,000 SH   SOLE   935,000 0 0
Tonix Pharmaceuticals Holdings Corp. COM 890260409 3,113 699,500 SH   SOLE   699,500 0 0
Trevena, Inc. COM 89532E109 1,368 950,000 SH   SOLE   950,000 0 0
Tricida, Inc. COM 89610F101 47,840 1,600,000 SH   SOLE   1,600,000 0 0
Trillium Therapeutics Inc. COM NEW 89620X506 3,071 511,763 SH   SOLE   511,763 0 0
uniQure N.V. SHS N90064101 22,869 605,000 SH   SOLE   605,000 0 0
Vanda Pharmaceuticals Inc. COM 921659108 5,912 310,354 SH   SOLE   310,354 0 0
Versartis, Inc. COM 92529L102 4,913 2,426,310 SH   SOLE   2,426,310 0 0
Xencor, Inc. COM 98401F105 32,275 872,072 SH   SOLE   872,072 0 0
Zymeworks Inc. COM 98985W102 19,378 1,311,085 SH   SOLE   1,311,085 0 0
Aegerion Pharmaceuticals, Inc. NOTE 2% 8/15/2019 00767EAB8 6,027 9,517,000 PRN   SOLE   9,517,000 0 0
BioMarin Pharmaceutical Inc. NOTE 0.75% 10/15/2018 09061GAE1 13,000 12,228,000 PRN   SOLE   12,228,000 0 0
BioMarin Pharmaceutical Inc. NOTE 0.599% 8/1/2024 09061GAH4 15,198 15,000,000 PRN   SOLE   15,000,000 0 0
Corsicanto II Designated Activity Company NOTE 3.5% 1/5/2047 220485AB2 10,908 10,000,000 PRN   SOLE   10,000,000 0 0
Neurocrine Biosciences, Inc. NOTE 2.25% 5/15/2024 64125CAD1 14,466 10,000,000 PRN   SOLE   10,000,000 0 0
Novavax, Inc. NOTE 3.75% 2/1/23 670002AB0 42,667 73,500,000 PRN   SOLE   73,500,000 0 0