The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AbbVie Inc. COM 00287Y109 904,636 14,343,358 SH   SOLE   14,343,358 0 0
Abeona Therapeutics Inc. COM 00289Y107 610 101,680 SH   SOLE   101,680 0 0
ACADIA Pharmaceuticals Inc. COM 004225108 821,327 25,819,768 SH   SOLE   25,819,768 0 0
Acceleron Pharma Inc. COM 00434H108 1,041 28,765 SH   SOLE   28,765 0 0
Achaogen, Inc. COM 004449104 479 100,000 SH   SOLE   100,000 0 0
Achillion Pharmaceuticals, Inc. COM 00448Q201 20,052 2,475,515 SH   SOLE   2,475,515 0 0
Acorda Therapeutics, Inc. COM 00484M106 76,443 3,661,082 SH   SOLE   3,661,082 0 0
Adamas Pharmaceuticals, Inc. COM 00548A106 2,833 172,630 SH   SOLE   172,630 0 0
Adaptimmune Therapeutics plc SPONSORED ADR 00653A107 705 100,000 SH   SOLE   600,000 0 0
Advanced Accelerator Applications S.A. SPONSORED ADR 00790T100 39,194 1,029,247 SH   SOLE   2,058,494 0 0
Aeglea BioTherapeutics, Inc. COM 00773J103 2,591 404,230 SH   SOLE   404,230 0 0
Aerie Pharmaceuticals, Inc. COM 00771V108 11,298 299,356 SH   SOLE   299,356 0 0
Affimed N.V. COM N01045108 1,112 400,000 SH   SOLE   400,000 0 0
Agios Pharmaceuticals, Inc. COM 00847X104 10,982 207,915 SH   SOLE   207,915 0 0
Aimmune Therapeutics, Inc. COM 00900T107 10,109 673,908 SH   SOLE   673,908 0 0
Akari Therapeutics plc SPONSORED ADR 00972G108 4,229 496,901 SH   SOLE   49,690,100 0 0
Alcobra Ltd. SHS M2239P109 5,771 2,336,359 SH   SOLE   2,336,359 0 0
Alder BioPharmaceuticals, Inc. COM 014339105 7,122 217,328 SH   SOLE   217,328 0 0
Aldeyra Therapeutics, Inc. COM 01438T106 1,110 142,000 SH   SOLE   142,000 0 0
Alexion Pharmaceuticals, Inc. COM 015351109 801,815 6,543,295 SH   SOLE   6,543,295 0 0
Alkermes plc SHS G01767105 11,769 250,251 SH   SOLE   250,251 0 0
Alnylam Pharmaceuticals, Inc. COM 02043Q107 769 11,340 SH   SOLE   11,340 0 0
Amarin Corporation plc SPONSORED ADR NEW 023111206 65,811 20,630,477 SH   SOLE   20,630,477 0 0
Aptose Biosciences Inc. COM NEW 03835T200 909 404,211 SH   SOLE   404,211 0 0
Aquinox Pharmaceuticals, Inc. COM 03842B101 140,762 10,536,092 SH   SOLE   10,536,092 0 0
Arbutus Biopharma Corporation COM 03879J100 621 180,582 SH   SOLE   180,582 0 0
Array BioPharma Inc. COM 04269X105 22,347 3,310,666 SH   SOLE   3,310,666 0 0
Arrowhead Pharmaceuticals, Inc. COM 04280A100 13,649 1,856,967 SH   SOLE   1,856,967 0 0
Ascendis Pharma A/S SPONSORED ADR 04351P101 14,985 745,521 SH   SOLE   745,521 0 0
Assembly Biosciences, Inc. COM 045396108 1,803 250,000 SH   SOLE   250,000 0 0
BeiGene, Ltd. SPONSORED ADR 07725L102 58,930 1,912,680 SH   SOLE   24,864,840 0 0
Bellicum Pharmaceuticals, Inc. COM 079481107 96,826 4,865,647 SH   SOLE   4,865,647 0 0
BioCryst Pharmaceuticals, Inc. COM 09058V103 48,351 10,963,944 SH   SOLE   10,963,944 0 0
BioDelivery Sciences International, Inc. COM 09060J106 567 210,021 SH   SOLE   210,021 0 0
BioMarin Pharmaceutical Inc. COM 09061G101 444,696 4,806,483 SH   SOLE   4,806,483 0 0
BioTime, Inc. *W EXP 10/1/201 09066L162 17 20,084 SH   SOLE   20,084 0 0
bluebird bio, Inc. COM 09609G100 19,923 293,943 SH   SOLE   293,943 0 0
Catalyst Pharmaceuticals, Inc. COM 14888U101 5,561 5,102,153 SH   SOLE   5,102,153 0 0
Cellectis S.A. SPONSORED ADS 15117K103 1,204 50,000 SH   SOLE   50,000 0 0
Cerus Corporation COM 157085101 81,061 13,053,275 SH   SOLE   13,053,275 0 0
ChemoCentryx, Inc. COM 16383L106 296 49,064 SH   SOLE   49,064 0 0
Chimerix, Inc. COM 16934W106 638 115,216 SH   SOLE   115,216 0 0
CoLucid Pharmaceuticals, Inc. COM 19716T101 1,156 30,310 SH   SOLE   30,310 0 0
Concert Pharmaceuticals, Inc. COM 206022105 3,205 316,976 SH   SOLE   316,976 0 0
ContraFect Corporation COM 212326102 10,034 4,045,876 SH   SOLE   4,045,876 0 0
Cyclacel Pharmaceuticals, Inc. PFD CONV EX 6% 23254L207 90 13,253 SH   SOLE   13,253 0 0
CytRx Corporation COM PAR $.001 232828509 388 659,995 SH   SOLE   659,995 0 0
DBV Technologies S.A. SPONSORED ADR 23306J101 200,162 5,509,560 SH   SOLE   2,754,780 0 0
Derma Sciences, Inc. COM PAR $.01 249827502 17,524 3,752,390 SH   SOLE   3,752,390 0 0
Dermira, Inc. COM 24983L104 11,040 326,428 SH   SOLE   326,428 0 0
Dimension Therapeutics, Inc. COM 25433V105 10,003 1,251,881 SH   SOLE   1,251,881 0 0
Dynavax Technologies Corporation COM NEW 268158201 787 75,000 SH   SOLE   75,000 0 0
Enanta Pharmaceuticals, Inc. COM 29251M106 2,005 75,357 SH   SOLE   75,357 0 0
Endocyte, Inc. COM 29269A102 2,685 868,983 SH   SOLE   868,983 0 0
Epizyme, Inc. COM 29428V104 2,288 232,481 SH   SOLE   232,481 0 0
Exelixis, Inc. COM 30161Q104 63,048 4,929,494 SH   SOLE   4,929,494 0 0
Five Prime Therapeutics, Inc. COM 33830X104 1,010 19,247 SH   SOLE   19,247 0 0
Foamix Pharmaceuticals Ltd. SHS M46135105 22,842 2,466,702 SH   SOLE   2,466,702 0 0
Foundation Medicine, Inc. COM 350465100 488 20,892 SH   SOLE   20,892 0 0
Fulgent Genetics, Inc. COM 359664109 1,153 125,000 SH   SOLE   125,000 0 0
Galapagos NV SPONSORED ADR 36315X101 16,805 259,894 SH   SOLE   259,894 0 0
Genomic Health, Inc. COM 37244C101 398,237 13,770,302 SH   SOLE   13,770,302 0 0
GlycoMimetics, Inc. COM 38000Q102 2,726 381,235 SH   SOLE   381,235 0 0
Halozyme Therapeutics, Inc. COM 40637H109 20,911 1,731,057 SH   SOLE   1,731,057 0 0
Heron Therapeutics, Inc. COM 427746102 49,230 2,857,250 SH   SOLE   2,857,250 0 0
Idera Pharmaceuticals, Inc. COM NEW 45168K306 17,956 7,014,015 SH   SOLE   7,014,015 0 0
Ignyta, Inc. COM 451731103 3,592 571,000 SH   SOLE   571,000 0 0
Immune Design Corp. COM 45252L103 1,129 148,937 SH   SOLE   148,937 0 0
ImmunoGen, Inc. COM 45253H101 8,081 3,015,353 SH   SOLE   3,015,353 0 0
Incyte Corporation COM 45337C102 2,215,711 23,498,898 SH   SOLE   23,498,898 0 0
Infinity Pharmaceuticals, Inc. COM 45665G303 905 580,400 SH   SOLE   580,400 0 0
Insmed Incorporated COM PAR $.01 457669307 5,808 400,000 SH   SOLE   400,000 0 0
Intellia Therapeutics, Inc. COM 45826J105 18,077 1,062,120 SH   SOLE   1,062,120 0 0
Intra-Cellular Therapies, Inc. COM 46116X101 9,284 609,166 SH   SOLE   609,166 0 0
Invitae Corporation COM 46185L103 57,422 6,554,967 SH   SOLE   6,554,967 0 0
InVivo Therapeutics Holdings Corp. COM NEW 46186M209 2,720 400,000 SH   SOLE   400,000 0 0
Ionis Pharmaceuticals, Inc. COM 462222100 2,094 57,140 SH   SOLE   57,140 0 0
Juno Therapeutics, Inc. COM 48205A109 2,401 80,000 SH   SOLE   80,000 0 0
Karyopharm Therapeutics Inc. COM 48576U106 2,111 216,990 SH   SOLE   216,990 0 0
La Jolla Pharmaceutical Company COM PAR $.0001 2 503459604 327 13,746 SH   SOLE   13,746 0 0
Ligand Pharmaceuticals Incorporated COM NEW 53220K504 7,490 73,386 SH   SOLE   73,386 0 0
Loxo Oncology, Inc. COM 548862101 3,606 137,735 SH   SOLE   137,735 0 0
MacroGenics, Inc. COM 556099109 10,878 363,676 SH   SOLE   363,676 0 0
Madrigal Pharmaceuticals, Inc. COM 558868105 732 57,762 SH   SOLE   57,762 0 0
Mast Therapeutics, Inc. COM 576314108 944 8,584,051 SH   SOLE   8,584,051 0 0
Medgenics, Inc. COM NEW 58436Q203 4,905 880,539 SH   SOLE   880,539 0 0
MediWound Ltd. ORD SHS M68830104 1,740 226,000 SH   SOLE   226,000 0 0
Merus N.V. COM N5749R100 19,430 1,160,014 SH   SOLE   1,160,014 0 0
Minerva Neurosciences, Inc. COM 603380106 3,653 258,805 SH   SOLE   258,805 0 0
Mirati Therapeutics, Inc. COM 60468T105 14,999 2,269,198 SH   SOLE   2,269,198 0 0
MyoKardia, Inc. COM 62857M105 1,634 100,000 SH   SOLE   100,000 0 0
Nabriva Therapeutics AG SPONSORED ADR 62957M104 2,468 350,000 SH   SOLE   35,000 0 0
Natera, Inc. COM 632307104 5,000 450,000 SH   SOLE   450,000 0 0
Neurocrine Biosciences, Inc. COM 64125C109 45,344 895,422 SH   SOLE   895,422 0 0
NeuroDerm Ltd. ORD SHS M74231107 5,639 305,000 SH   SOLE   305,000 0 0
Ophthotech Corporation COM 683745103 1,644 35,649 SH   SOLE   35,649 0 0
Osiris Therapeutics, Inc. COM 68827R108 2,476 499,193 SH   SOLE   499,193 0 0
Palatin Technologies, Inc. COM PAR $.01 696077403 1,289 2,050,000 SH   SOLE   2,050,000 0 0
Progenics Pharmaceuticals, Inc. COM 743187106 23,110 3,650,808 SH   SOLE   3,650,808 0 0
ProNAi Therapeutics, Inc. COM 74346L101 364 200,000 SH   SOLE   200,000 0 0
ProQR Therapeutics N.V. SHS EURO N71542109 5,739 860,464 SH   SOLE   860,464 0 0
Proteon Therapeutics, Inc. COM 74371L109 2,786 298,591 SH   SOLE   298,591 0 0
Ritter Pharmaceuticals, Inc. COM 767836109 672 400,000 SH   SOLE   400,000 0 0
Sage Therapeutics, Inc. COM 78667J108 9,594 208,328 SH   SOLE   208,328 0 0
Sangamo BioSciences, Inc. COM 800677106 18,779 4,055,876 SH   SOLE   4,055,876 0 0
SCYNEXIS, Inc. COM 811292101 1,810 467,600 SH   SOLE   467,600 0 0
Seattle Genetics, Inc. COM 812578102 2,381,857 44,100,294 SH   SOLE   44,100,294 0 0
Selecta Biosciences, Inc. COM 816212104 2,550 178,950 SH   SOLE   178,950 0 0
Seres Therapeutics, Inc. COM 81750R102 1,536 125,000 SH   SOLE   125,000 0 0
Spark Therapeutics, Inc. COM 84652J103 79,180 1,318,341 SH   SOLE   1,318,341 0 0
Stemline Therapeutics, Inc. COM 85858C107 3,612 333,497 SH   SOLE   333,497 0 0
Sunesis Pharmaceuticals, Inc. COM PAR 867328700 3,241 741,665 SH   SOLE   741,665 0 0
Syros Pharmaceuticals, Inc. COM 87184Q107 2,836 204,465 SH   SOLE   204,465 0 0
Tenax Therapeutics, Inc. COM 88032L100 972 420,000 SH   SOLE   420,000 0 0
TG Therapeutics, Inc. COM 88322Q108 15,511 2,003,991 SH   SOLE   2,003,991 0 0
Trevena, Inc. COM 89532E109 3,038 450,000 SH   SOLE   450,000 0 0
Trillium Therapeutics Inc. COM NEW 89620X506 6,120 413,697 SH   SOLE   413,697 0 0
Ultragenyx Pharmaceutical Inc. COM 90400D108 7,094 100,000 SH   SOLE   100,000 0 0
uniQure N.V. SHS N90064101 1,760 230,000 SH   SOLE   230,000 0 0
Versartis, Inc. COM 92529L102 26,145 2,134,247 SH   SOLE   2,134,247 0 0
Vitae Pharmaceuticals, Inc. COM 92847N103 13,339 637,597 SH   SOLE   637,597 0 0
Windtree Therapeutics, Inc. COM 97382D105 653 254,973 SH   SOLE   254,973 0 0
Xencor, Inc. COM 98401F105 21,357 872,072 SH   SOLE   872,072 0 0
Zogenix, Inc. COM NEW 98978L204 11,430 1,000,000 SH   SOLE   1,000,000 0 0
Acorda Therapeutics, Inc. Notes 1.75% 6/15/2021 NOTE 1.75% 6/15/2021 00484MAA4 62,830 77,083,000 PRN   SOLE   77,083,000 0 0
Aegerion Pharmaceuticals, Inc. Notes 2.0% 8/15/2019 NOTE 2.0% 8/15/2019 00767EAB8 17,432 26,517,000 PRN   SOLE   26,517,000 0 0
Array BioPharma Inc. Notes 3.0% 6/1/2020 NOTE 3.0% 6/1/2020 04269XAA3 3,561 3,000,000 PRN   SOLE   3,000,000 0 0
BioMarin Pharmaceutical Inc. Notes 1.875% 4/23/2017 NOTE 1.875% 4/23/2017 09061GAD3 101,405 22,379,000 PRN   SOLE   22,379,000 0 0
BioMarin Pharmaceutical Inc. Notes 0.75% 10/15/2018 NOTE 0.75% 10/15/2018 09061GAE1 14,630 12,228,000 PRN   SOLE   12,228,000 0 0
Clovis Oncology, Inc. 2.5% 9/15/2021 NOTE 2.5% 9/15/2021 189464AB6 69,135 72,758,000 PRN   SOLE   72,758,000 0 0
Incyte Corporation Notes 0.375% 11/15/2018 144A NOTE 0.375% 11/15/2018 45337CAK8 491,344 259,000,000 PRN   SOLE   259,000,000 0 0
Incyte Corporation Notes 1.25% 11/15/2020 144A NOTE 1.25% 11/15/2020 45337CAL6 531,244 274,500,000 PRN   SOLE   274,500,000 0 0
Inotek Pharmaceuticals Corporation Notes 5.75% 8/1/2021 NOTE 5.75% 8/1/2021 45780VAB8 6,708 5,000,000 PRN   SOLE   5,000,000 0 0
Protalix BioTherapeutics, Inc. Notes 4.5% 9/15/18 NOTE 4.5% 9/15/2018 74365AAB7 2,294 3,423,000 PRN   SOLE   3,423,000 0 0