The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AbbVie Inc. COM 00287Y109 105,577 1,685,994 SH   SOLE   1,685,994 0 0
Abeona Therapeutics Inc. COM 00289Y107 8,169 1,684,364 SH   SOLE   1,684,364 0 0
ACADIA Pharmaceuticals Inc. COM 004225108 744,642 25,819,768 SH   SOLE   25,819,768 0 0
Acceleron Pharma Inc. COM 00434H108 734 28,765 SH   SOLE   28,765 0 0
Achaogen, Inc. COM 004449104 59,663 4,582,382 SH   SOLE   4,582,382 0 0
Achillion Pharmaceuticals, Inc. COM 00448Q201 7,668 1,856,637 SH   SOLE   1,856,637 0 0
Acorda Therapeutics, Inc. COM 00484M106 62,074 3,301,791 SH   SOLE   3,301,791 0 0
Adamas Pharmaceuticals, Inc. COM 00548A106 2,917 172,630 SH   SOLE   172,630 0 0
Adaptimmune Therapeutics plc SPONSORED ADR 00653A107 405 100,000 SH   SOLE   600,000 0 0
Advanced Accelerator Applications S.A. SPONSORED ADR 00790T100 57,993 2,167,137 SH   SOLE   4,334,274 0 0
Aeglea BioTherapeutics, Inc. COM 00773J103 1,758 404,230 SH   SOLE   404,230 0 0
Aerie Pharmaceuticals, Inc. COM 00771V108 11,331 299,356 SH   SOLE   299,356 0 0
Aevi Genomic Medicine, Inc. COM ADDED 00835P105 4,561 880,539 SH   SOLE   880,539 0 0
Affimed N.V. COM N01045108 720 400,000 SH   SOLE   400,000 0 0
Agios Pharmaceuticals, Inc. COM 00847X104 5,369 128,666 SH   SOLE   128,666 0 0
Aimmune Therapeutics, Inc. COM 00900T107 13,781 673,908 SH   SOLE   673,908 0 0
Akari Therapeutics plc SPONSORED ADR 00972G108 3,498 496,901 SH   SOLE   49,690,100 0 0
Alcobra Ltd. SHS M2239P109 4,906 2,336,359 SH   SOLE   2,336,359 0 0
Alder BioPharmaceuticals, Inc. COM 014339105 4,520 217,328 SH   SOLE   217,328 0 0
Aldeyra Therapeutics, Inc. COM 01438T106 760 142,000 SH   SOLE   142,000 0 0
Alexion Pharmaceuticals, Inc. COM 015351109 800,572 6,543,295 SH   SOLE   6,543,295 0 0
Alkermes plc SHS G01767105 8,351 150,251 SH   SOLE   150,251 0 0
Alnylam Pharmaceuticals, Inc. COM 02043Q107 425 11,340 SH   SOLE   11,340 0 0
Amarin Corporation plc SPONSORED ADR NEW 023111206 68,282 22,169,509 SH   SOLE   22,169,509 0 0
Aptose Biosciences Inc. COM NEW 03835T200 359 258,311 SH   SOLE   258,311 0 0
Aquinox Pharmaceuticals, Inc. COM 03842B101 173,951 10,536,092 SH   SOLE   10,536,092 0 0
Arbutus Biopharma Corporation COM 03879J100 442 180,582 SH   SOLE   180,582 0 0
Array BioPharma Inc. COM 04269X105 22,730 2,585,913 SH   SOLE   2,585,913 0 0
Ascendis Pharma A/S SPONSORED ADR 04351P101 20,711 1,023,266 SH   SOLE   1,023,266 0 0
Assembly Biosciences, Inc. COM 045396108 3,038 250,000 SH   SOLE   250,000 0 0
AveXis, Inc. COM 05366U100 15,049 315,300 SH   SOLE   315,300 0 0
BeiGene, Ltd. SPONSORED ADR 07725L102 111,518 3,673,175 SH   SOLE   47,751,275 0 0
Bellicum Pharmaceuticals, Inc. COM 079481107 66,270 4,865,647 SH   SOLE   4,865,647 0 0
BioCryst Pharmaceuticals, Inc. COM 09058V103 69,402 10,963,944 SH   SOLE   10,963,944 0 0
BioDelivery Sciences International, Inc. COM 09060J106 368 210,021 SH   SOLE   210,021 0 0
Biogen Inc. COM 09062X103 4,679 16,500 SH   SOLE   16,500 0 0
BioMarin Pharmaceutical Inc. COM 09061G101 398,169 4,806,483 SH   SOLE   4,806,483 0 0
BioTime, Inc. *W EXP 10/1/201 09066L162 14 20,084 SH   SOLE   20,084 0 0
bluebird bio, Inc. COM 09609G100 21,684 351,441 SH   SOLE   351,441 0 0
Catalyst Pharmaceuticals, Inc. COM 14888U101 5,357 5,102,153 SH   SOLE   5,102,153 0 0
Cellectis S.A. SPONSORED ADS 15117K103 848 50,000 SH   SOLE   50,000 0 0
Cerus Corporation COM 157085101 56,782 13,053,275 SH   SOLE   13,053,275 0 0
ChemoCentryx, Inc. COM 16383L106 363 49,064 SH   SOLE   49,064 0 0
Chimerix, Inc. COM 16934W106 530 115,216 SH   SOLE   115,216 0 0
Colucid Pharmaceuticals, Inc. COM 19716T101 1,103 30,310 SH   SOLE   30,310 0 0
Concert Pharmaceuticals, Inc. COM 206022105 1,574 152,964 SH   SOLE   152,964 0 0
ContraFect Corporation COM 212326102 7,080 4,045,876 SH   SOLE   4,045,876 0 0
Corbus Pharmaceuticals Holdings, Inc. COM 21833P103 2,198 260,129 SH   SOLE   260,129 0 0
Cyclacel Pharmaceuticals, Inc. PFD CONV EX 6% 23254L207 82 13,253 SH   SOLE   13,253 0 0
CymaBay Therapeutics, Inc. COM 23257D103 535 309,268 SH   SOLE   309,268 0 0
DBV Technologies S.A. SPONSORED ADR 23306J101 193,551 5,509,560 SH   SOLE   2,754,780 0 0
Derma Sciences, Inc. COM PAR $.01 249827502 19,512 3,752,390 SH   SOLE   3,752,390 0 0
Dermira, Inc. COM 24983L104 9,901 326,428 SH   SOLE   326,428 0 0
Dimension Therapeutics, Inc. COM 25433V105 5,446 1,251,881 SH   SOLE   1,251,881 0 0
Dynavax Technologies Corporation COM NEW 268158201 296 75,000 SH   SOLE   75,000 0 0
Enanta Pharmaceuticals, Inc. COM 29251M106 2,524 75,357 SH   SOLE   75,357 0 0
Epizyme, Inc. COM 29428V104 2,813 232,481 SH   SOLE   232,481 0 0
Exelixis, Inc. COM 30161Q104 44,783 3,003,569 SH   SOLE   3,003,569 0 0
Five Prime Therapeutics, Inc. COM 33830X104 964 19,247 SH   SOLE   19,247 0 0
Foamix Pharmaceuticals Ltd. SHS M46135105 27,380 2,466,702 SH   SOLE   2,466,702 0 0
Foundation Medicine, Inc. COM 350465100 370 20,892 SH   SOLE   20,892 0 0
Fulgent Genetics, Inc. COM 359664109 1,446 125,000 SH   SOLE   125,000 0 0
Galapagos NV SPONSORED ADR 36315X101 16,683 259,894 SH   SOLE   259,894 0 0
Genomic Health, Inc. COM 37244C101 404,709 13,770,302 SH   SOLE   13,770,302 0 0
GlycoMimetics, Inc. COM 38000Q102 2,326 381,235 SH   SOLE   381,235 0 0
Halozyme Therapeutics, Inc. COM 40637H109 13,748 1,391,507 SH   SOLE   1,391,507 0 0
Heron Therapeutics, Inc. COM 427746102 31,225 2,383,569 SH   SOLE   2,383,569 0 0
Idera Pharmaceuticals, Inc. COM NEW 45168K306 15,408 10,272,314 SH   SOLE   10,272,314 0 0
Ignyta, Inc. COM 451731103 3,026 571,000 SH   SOLE   571,000 0 0
Immune Design Corp. COM 45252L103 819 148,937 SH   SOLE   148,937 0 0
ImmunoGen, Inc. COM 45253H101 6,151 3,015,353 SH   SOLE   3,015,353 0 0
Incyte Corporation COM 45337C102 2,356,253 23,499,087 SH   SOLE   23,499,087 0 0
Infinity Pharmaceuticals, Inc. COM 45665G303 784 580,400 SH   SOLE   580,400 0 0
Insmed Incorporated COM PAR $.01 457669307 5,292 400,000 SH   SOLE   400,000 0 0
Intellia Therapeutics, Inc. COM 45826J105 13,924 1,062,120 SH   SOLE   1,062,120 0 0
Intra-Cellular Therapies, Inc. COM 46116X101 9,192 609,166 SH   SOLE   609,166 0 0
Invitae Corporation COM 46185L103 57,869 7,288,300 SH   SOLE   7,288,300 0 0
InVivo Therapeutics Holdings Corp. COM NEW 46186M209 1,680 400,000 SH   SOLE   400,000 0 0
Ionis Pharmaceuticals, Inc. COM 462222100 2,733 57,140 SH   SOLE   57,140 0 0
Juno Therapeutics, Inc. COM 48205A109 1,508 80,000 SH   SOLE   80,000 0 0
Karyopharm Therapeutics Inc. COM 48576U106 2,040 216,990 SH   SOLE   216,990 0 0
La Jolla Pharmaceutical Company COM PAR $.0001 2 503459604 241 13,746 SH   SOLE   13,746 0 0
Ligand Pharmaceuticals Incorporated COM NEW 53220K504 7,457 73,386 SH   SOLE   73,386 0 0
Loxo Oncology, Inc. COM 548862101 4,423 137,735 SH   SOLE   137,735 0 0
MacroGenics, Inc. COM 556099109 7,434 363,676 SH   SOLE   363,676 0 0
Madrigal Pharmaceuticals, Inc. COM 558868105 861 57,762 SH   SOLE   57,762 0 0
MediWound Ltd. ORD SHS M68830104 1,035 226,000 SH   SOLE   226,000 0 0
Merus N.V. COM N5749R100 24,488 1,160,014 SH   SOLE   1,160,014 0 0
Minerva Neurosciences, Inc. COM 603380106 3,041 258,805 SH   SOLE   258,805 0 0
Mirati Therapeutics, Inc. COM 60468T105 10,779 2,269,198 SH   SOLE   2,269,198 0 0
MyoKardia, Inc. COM 62857M105 1,295 100,000 SH   SOLE   100,000 0 0
Nabriva Therapeutics AG SPONSORED ADR 62957M104 2,086 350,000 SH   SOLE   35,000 0 0
Natera, Inc. COM 632307104 2,919 249,269 SH   SOLE   249,269 0 0
Neurocrine Biosciences, Inc. COM 64125C109 34,653 895,422 SH   SOLE   895,422 0 0
NeuroDerm Ltd. ORD SHS M74231107 12,691 571,667 SH   SOLE   571,667 0 0
Osiris Therapeutics, Inc. COM 68827R108 2,451 499,193 SH   SOLE   499,193 0 0
Palatin Technologies, Inc. COM PAR $.01 696077403 1,035 2,050,000 SH   SOLE   2,050,000 0 0
Progenics Pharmaceuticals, Inc. COM 743187106 27,223 3,150,808 SH   SOLE   3,150,808 0 0
ProNAi Therapeutics, Inc. COM 74346L101 298 200,000 SH   SOLE   200,000 0 0
ProQR Therapeutics N.V. SHS EURO N71542109 1,042 212,698 SH   SOLE   212,698 0 0
Proteon Therapeutics, Inc. COM 74371L109 740 389,394 SH   SOLE   389,394 0 0
Ra Pharmaceuticals, Inc. COM ADDED 74933V108 2,703 177,952 SH   SOLE   177,952 0 0
Rigel Pharmaceuticals, Inc. COM NEW 766559603 4,805 2,018,882 SH   SOLE   2,018,882 0 0
Ritter Pharmaceuticals, Inc. COM 767836109 1,084 400,000 SH   SOLE   400,000 0 0
Sage Therapeutics, Inc. COM 78667J108 10,637 208,328 SH   SOLE   208,328 0 0
Sangamo Therapeutics, Inc. COM 800677106 12,370 4,055,876 SH   SOLE   4,055,876 0 0
SCYNEXIS, Inc. COM 811292101 1,492 467,600 SH   SOLE   467,600 0 0
Seattle Genetics, Inc. COM 812578102 2,412,215 45,711,856 SH   SOLE   45,711,856 0 0
Selecta Biosciences, Inc. COM 816212104 3,013 175,712 SH   SOLE   175,712 0 0
Seres Therapeutics, Inc. COM 81750R102 1,238 125,000 SH   SOLE   125,000 0 0
Spark Therapeutics, Inc. COM 84652J103 65,785 1,318,341 SH   SOLE   1,318,341 0 0
Spring Bank Pharmaceuticals, Inc. COM 849431101 1,752 219,298 SH   SOLE   219,298 0 0
Stemline Therapeutics, Inc. COM 85858C107 3,568 333,497 SH   SOLE   333,497 0 0
Sunesis Pharmaceuticals, Inc. COM PAR 867328700 2,685 741,665 SH   SOLE   741,665 0 0
Syros Pharmaceuticals, Inc. COM 87184Q107 2,486 204,465 SH   SOLE   204,465 0 0
Tenax Therapeutics, Inc. COM 88032L100 819 420,000 SH   SOLE   420,000 0 0
Trevena, Inc. COM 89532E109 2,646 450,000 SH   SOLE   450,000 0 0
Trillium Therapeutics Inc. COM NEW 89620X506 2,337 413,697 SH   SOLE   413,697 0 0
Ultragenyx Pharmaceutical Inc. COM 90400D108 3,516 50,000 SH   SOLE   50,000 0 0
uniQure N.V. SHS N90064101 1,288 230,000 SH   SOLE   230,000 0 0
Versartis, Inc. COM 92529L102 28,621 1,920,845 SH   SOLE   1,920,845 0 0
Windtree Therapeutics, Inc. COM 97382D105 319 254,973 SH   SOLE   254,973 0 0
Xencor, Inc. COM 98401F105 22,953 872,072 SH   SOLE   872,072 0 0
Zogenix, Inc. COM NEW 98978L204 10,192 838,809 SH   SOLE   838,809 0 0
Acorda Therapeutics, Inc. NOTE 1.75% 6/15/2021 00484MAA4 26,570 35,083,000 PRN   SOLE   35,083,000 0 0
Aegerion Pharmaceuticals, Inc. NOTE 2.0% 8/15/2019 00767EAB8 19,103 26,517,000 PRN   SOLE   26,517,000 0 0
Array BioPharma Inc. NOTE 3.0% 6/1/2020 04269XAA3 4,195 3,000,000 PRN   SOLE   3,000,000 0 0
BioMarin Pharmaceutical Inc. NOTE 1.875% 4/23/2017 09061GAD3 90,531 22,379,000 PRN   SOLE   22,379,000 0 0
BioMarin Pharmaceutical Inc. NOTE 0.75% 10/15/2018 09061GAE1 13,733 12,228,000 PRN   SOLE   12,228,000 0 0
Incyte Corporation NOTE 0.375% 11/15/2018 45337CAK8 518,139 259,000,000 PRN   SOLE   259,000,000 0 0
Incyte Corporation NOTE 1.25% 11/15/2020 45337CAL6 558,650 274,500,000 PRN   SOLE   274,500,000 0 0
Inotek Pharmaceuticals Corporation NOTE 5.75% 8/1/2021 45780VAB8 5,167 5,000,000 PRN   SOLE   5,000,000 0 0
Protalix BioTherapeutics, Inc. NOTE 4.5% 9/15/2018 74365AAB7 2,293 3,423,000 PRN   SOLE   3,423,000 0 0