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Tekla Capital Management LLC
> CRL
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | CHARLES RIVER LABORATORIES INTERNATIONAL, INC. | CRL | 111,183 | -6,900 | 23,376,226,000 | -455,285,000 | $210,250.00 |
| 03/31/2023 | CHARLES RIVER LABORATORIES INTERNATIONAL, INC. | CRL | 118,083 | 45,408 | 23,831,511,000 | 23,817,209,000 | $201,820.00 |
| 09/30/2022 | CHARLES RIVER LABORATORIES INTERNATIONAL, INC. | CRL | 72,675 | 24,781 | 14,302,000 | 4,054,000 | $196.79 |
| 06/30/2022 | CHARLES RIVER LABORATORIES INTERNATIONAL, INC. | CRL | 47,894 | -14,096 | 10,248,000 | -7,355,000 | $213.97 |
| 03/31/2022 | CHARLES RIVER LABORATORIES INTERNATIONAL, INC. | CRL | 61,990 | 0 | 17,603,000 | -5,754,000 | $283.97 |
| 12/31/2021 | CHARLES RIVER LABORATORIES INTERNATIONAL, INC. | CRL | 61,990 | -16,494 | 23,357,000 | -9,031,000 | $376.79 |
| 09/30/2021 | CHARLES RIVER LABORATORIES INTERNATIONAL, INC. | CRL | 78,484 | 23,810 | 32,388,000 | 12,163,000 | $412.67 |
| 06/30/2021 | CHARLES RIVER LABORATORIES INTERNATIONAL, INC. | CRL | 54,674 | 11,600 | 20,225,000 | 7,741,000 | $369.92 |
| 03/31/2021 | CHARLES RIVER LABORATORIES INTERNATIONAL, INC. | CRL | 43,074 | 14,920 | 12,484,000 | 5,449,000 | $289.83 |
| 12/31/2020 | CHARLES RIVER LABORATORIES INTERNATIONAL, INC. | CRL | 28,154 | -2,600 | 7,035,000 | 71,000 | $249.88 |
| 09/30/2020 | CHARLES RIVER LABORATORIES INTERNATIONAL, INC. | CRL | 30,754 | 12,287 | 6,964,000 | 3,744,000 | $226.44 |
| 06/30/2020 | CHARLES RIVER LABORATORIES INTERNATIONAL, INC. | CRL | 18,467 | 0 | 3,220,000 | 889,000 | $174.37 |
| 03/31/2020 | CHARLES RIVER LABORATORIES INTERNATIONAL, INC. | CRL | 18,467 | -2,500 | 2,331,000 | -872,000 | $126.23 |
| 12/31/2019 | CHARLES RIVER LABORATORIES INTERNATIONAL, INC. | CRL | 20,967 | -4,100 | 3,203,000 | -115,000 | $152.76 |
| 09/30/2019 | CHARLES RIVER LABORATORIES INTERNATIONAL, INC. | CRL | 25,067 | 10,900 | 3,318,000 | 1,308,000 | $132.37 |
| 06/30/2019 | CHARLES RIVER LABORATORIES INTERNATIONAL, INC. | CRL | 14,167 | 3,527 | 2,010,000 | 465,000 | $141.88 |
| 03/31/2019 | CHARLES RIVER LABORATORIES INTERNATIONAL, INC. | CRL | 10,640 | -12,030 | 1,545,000 | -1,021,000 | $145.21 |
| 12/31/2018 | CHARLES RIVER LABORATORIES INTERNATIONAL, INC. | CRL | 22,670 | 0 | 2,566,000 | -484,000 | $113.19 |
| 09/30/2018 | CHARLES RIVER LABORATORIES INTERNATIONAL, INC. | CRL | 22,670 | 0 | 3,050,000 | 505,000 | $134.54 |
| 06/30/2018 | CHARLES RIVER LABORATORIES INTERNATIONAL, INC. | CRL | 22,670 | 0 | 2,545,000 | 125,000 | $112.26 |
| 03/31/2018 | CHARLES RIVER LABORATORIES INTERNATIONAL, INC. | CRL | 22,670 | -63,134 | 2,420,000 | -6,971,000 | $106.75 |
| 12/31/2017 | CHARLES RIVER LABORATORIES INTERNATIONAL, INC. | CRL | 85,804 | -41,296 | 9,391,000 | -4,338,000 | $109.45 |
| 09/30/2017 | CHARLES RIVER LABORATORIES INTERNATIONAL, INC. | CRL | 127,100 | 0 | 13,729,000 | 873,000 | $108.02 |
| 06/30/2017 | CHARLES RIVER LABORATORIES INTERNATIONAL, INC. | CRL | 127,100 | 0 | 12,856,000 | 1,423,000 | $101.15 |
| 03/31/2017 | CHARLES RIVER LABORATORIES INTERNATIONAL, INC. | CRL | 127,100 | -500 | 11,433,000 | 1,711,000 | $89.95 |
| 12/31/2016 | CHARLES RIVER LABORATORIES INTERNATIONAL, INC. | CRL | 127,600 | 12,600 | 9,722,000 | 138,000 | $76.19 |
| 09/30/2016 | CHARLES RIVER LABORATORIES INTERNATIONAL, INC. | CRL | 115,000 | 115,000 | 9,584,000 | 9,584,000 | $83.34 |
| 06/30/2011 | CHARLES RIVER LABORATORIES INTERNATIONAL, INC. | CRL | 0 | -193,170 | 0 | -7,414,000 | |
| 03/31/2011 | CHARLES RIVER LABORATORIES INTERNATIONAL, INC. | CRL | 193,170 | 18,537 | 7,414,000 | 1,208,000 | $38.38 |
| 12/31/2010 | CHARLES RIVER LABORATORIES INTERNATIONAL, INC. | CRL | 174,633 | 50,033 | 6,206,000 | 2,076,000 | $35.54 |
| 09/30/2010 | CHARLES RIVER LABORATORIES INTERNATIONAL, INC. | CRL | 124,600 | 8,154 | 4,130,000 | 146,000 | $33.15 |
| 06/30/2010 | CHARLES RIVER LABORATORIES INTERNATIONAL, INC. | CRL | 116,446 | 0 | 3,984,000 | -593,000 | $34.21 |
| 03/31/2010 | CHARLES RIVER LABORATORIES INTERNATIONAL, INC. | CRL | 116,446 | 0 | 4,577,000 | 654,000 | $39.31 |
| 12/31/2009 | CHARLES RIVER LABORATORIES INTERNATIONAL, INC. | CRL | 116,446 | 17,623 | 3,923,000 | 269,000 | $33.69 |
| 09/30/2009 | CHARLES RIVER LABORATORIES INTERNATIONAL, INC. | CRL | 98,823 | -43,277 | 3,654,000 | -2,854,000 | $36.98 |
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