The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Abbott Laboratories Common 002824100 45,577 798,619 SH   SOLE   798,619 0 0
AbbVie Inc. Common 00287Y109 33,492 346,313 SH   SOLE   346,313 0 0
AC Immune SA Shares H00263105 2,199 171,813 SH   SOLE   171,813 0 0
Acadia Healthcare Company, Inc. Common 00404A109 8,888 272,400 SH   SOLE   272,400 0 0
ACADIA Pharmaceuticals Inc. Common 004225108 7,404 245,885 SH   SOLE   245,885 0 0
Acceleron Pharma Inc. Common 00434H108 12,027 283,383 SH   SOLE   283,383 0 0
Achillion Pharmaceuticals, Inc. Common 00448Q201 1,774 616,000 SH   SOLE   616,000 0 0
Adaptimmune Therapeutics plc Sponsored ADR 00653A107 6,248 935,368 SH   SOLE   935,368 0 0
Adverum Biotechnologies, Inc. Common 00773U108 2,604 743,974 SH   SOLE   743,974 0 0
Aegerion Pharmaceuticals, Inc. Note 2.00% 8/15/19 00767EAB8 10,335 13,000,000 PRN   SOLE   13,000,000 0 0
Aetna Inc. Common 00817Y108 8,580 47,566 SH   SOLE   47,566 0 0
Affimed N.V. Common N01045108 1,827 1,405,324 SH   SOLE   1,405,324 0 0
Alexion Pharmaceuticals, Inc. Common 015351109 78,884 659,618 SH   SOLE   659,618 0 0
Alkermes plc Shares G01767105 7,885 144,072 SH   SOLE   144,072 0 0
Allergan plc Shares G0177J108 34,054 208,180 SH   SOLE   208,180 0 0
Allergan plc 5.50% Convertible Preferred Series A G0177J116 2,931 5,000 SH   SOLE   5,000 0 0
Alliqua BioMedical, Inc. Common 019621309 302 165,000 SH   SOLE   165,000 0 0
Alnylam Pharmaceuticals, Inc. Common 02043Q107 14,606 114,966 SH   SOLE   114,966 0 0
Amarin Corporation plc Sponsored ADR 023111206 3,835 956,300 SH   SOLE   956,300 0 0
AmerisourceBergen Corporation Common 03073E105 15,362 167,307 SH   SOLE   167,307 0 0
Amgen Inc. Common 031162100 149,932 862,174 SH   SOLE   862,174 0 0
Amicus Therapeutics, Inc. Common 03152W109 8,705 604,920 SH   SOLE   604,920 0 0
Anthem, Inc. Common 036752103 10,107 44,918 SH   SOLE   44,918 0 0
ARCA biopharma, Inc. Common 00211Y407 1,115 811,227 SH   SOLE   811,227 0 0
Ardelyx, Inc. Common 039697107 4,220 639,370 SH   SOLE   639,370 0 0
argenx SE Sponsored ADR 04016X101 2,934 46,466 SH   SOLE   46,466 0 0
AstraZeneca PLC Sponsored ADR 046353108 15,358 442,600 SH   SOLE   442,600 0 0
Auris Medical Holding AG Common H03579101 457 774,504 SH   SOLE   774,504 0 0
Avadel Pharmaceuticals plc Sponsored ADR 05337M104 5,119 624,288 SH   SOLE   624,288 0 0
AveXis, Inc. Common 05366U100 7,785 70,347 SH   SOLE   70,347 0 0
BeiGene, Ltd. Sponsored ADR 07725L102 2,557 26,170 SH   SOLE   26,170 0 0
Bellicum Pharmaceuticals, Inc. Common 079481107 505 60,000 SH   SOLE   60,000 0 0
BioCryst Pharmaceuticals, Inc. Common 09058V103 2,206 449,255 SH   SOLE   449,255 0 0
Biogen Inc. Common 09062X103 141,957 445,607 SH   SOLE   445,607 0 0
BioMarin Pharmaceutical Inc. Common 09061G101 43,671 489,745 SH   SOLE   489,745 0 0
bluebird bio, Inc. Common 09609G100 8,387 47,093 SH   SOLE   47,093 0 0
Boston Scientific Corporation Common 101137107 6,559 264,600 SH   SOLE   264,600 0 0
Bristol-Myers Squibb Company Common 110122108 21,394 349,121 SH   SOLE   349,121 0 0
Cardinal Health, Inc. Common 14149Y108 386 6,300 SH   SOLE   6,300 0 0
Cascadian Therapeutics, Inc. Common 14740B606 2,741 740,769 SH   SOLE   740,769 0 0
Celgene Corporation Common 151020104 157,991 1,513,904 SH   SOLE   1,513,904 0 0
Celldex Therapeutics, Inc. Common 15117B103 300 105,800 SH   SOLE   105,800 0 0
Cellectis S.A. Sponsored ADR 15117K103 9,044 310,250 SH   SOLE   310,250 0 0
Centene Corporation Common 15135B101 23,218 230,158 SH   SOLE   230,158 0 0
Charles River Laboratories International, Inc. Common 159864107 9,391 85,804 SH   SOLE   85,804 0 0
Cidara Therapeutics, Inc. Common 171757107 1,948 286,472 SH   SOLE   286,472 0 0
Cigna Corporation Common 125509109 20,309 100,002 SH   SOLE   100,002 0 0
Clovis Oncology, Inc. Common 189464100 5,127 75,400 SH   SOLE   75,400 0 0
Coherus BioSciences, Inc. Common 19249H103 792 90,000 SH   SOLE   90,000 0 0
Community Health Systems, Inc. Common 203668108 869 203,935 SH   SOLE   203,935 0 0
CVS Health Corporation Common 126650100 26,573 366,521 SH   SOLE   366,521 0 0
CymaBay Therapeutics, Inc. Common 23257D103 1,932 209,962 SH   SOLE   209,962 0 0
Cytokinetics, Inc. Common 23282W605 2,855 350,300 SH   SOLE   350,300 0 0
CytomX Therapeutics, Inc. Common 23284F105 5,595 265,045 SH   SOLE   265,045 0 0
Danaher Corporation Common 235851102 1,411 15,203 SH   SOLE   15,203 0 0
Dermira, Inc. Common 24983L104 7,467 268,500 SH   SOLE   268,500 0 0
DexCom, Inc. Common 252131107 3,096 53,950 SH   SOLE   53,950 0 0
Diplomat Pharmacy, Inc. Common 25456K101 12,855 640,492 SH   SOLE   640,492 0 0
Edwards Lifesciences Corporation Common 28176E108 7,337 65,100 SH   SOLE   65,100 0 0
Egalet Corporation Note 5.50% 4/1/20 28226BAB0 3,334 7,000,000 PRN   SOLE   7,000,000 0 0
Eli Lilly & Company Common 532457108 32,357 383,099 SH   SOLE   383,099 0 0
Endo International plc Shares G30401106 7,088 914,548 SH   SOLE   914,548 0 0
Epizyme, Inc. Common 29428V104 5,723 456,000 SH   SOLE   456,000 0 0
Evolent Health, Inc. Class A 30050B101 1,507 122,500 SH   SOLE   122,500 0 0
Exelixis, Inc. Common 30161Q104 11,820 388,822 SH   SOLE   388,822 0 0
Express Scripts Holding Company Common 30219G108 6,307 84,500 SH   SOLE   84,500 0 0
Foamix Pharmaceuticals Ltd. Shares M46135105 5,592 930,398 SH   SOLE   930,398 0 0
Galapagos NV Sponsored ADR 36315X101 4,988 53,200 SH   SOLE   53,200 0 0
Gilead Sciences, Inc. Common 375558103 180,553 2,520,281 SH   SOLE   2,520,281 0 0
Glaukos Corporation Common 377322102 1,413 55,079 SH   SOLE   55,079 0 0
GlaxoSmithKline plc Shares 37733W105 12,734 359,000 SH   SOLE   359,000 0 0
Global Blood Therapeutics, Inc. Common 37890U108 5,113 129,948 SH   SOLE   129,948 0 0
Global Medical REIT Inc. Common 37954A204 602 73,400 SH   SOLE   73,400 0 0
GW Pharmaceuticals plc ADS 36197T103 3,300 25,000 SH   SOLE   25,000 0 0
HCA Healthcare, Inc. Common 40412C101 5,572 63,432 SH   SOLE   63,432 0 0
HCP, Inc. Common 40414L109 1,187 45,500 SH   SOLE   45,500 0 0
Healthcare Realty Trust Incorporated Common 421946104 2,184 68,000 SH   SOLE   68,000 0 0
Healthcare Trust of America, Inc. Class A 42225P501 1,382 46,000 SH   SOLE   46,000 0 0
Henry Schein, Inc. Common 806407102 2,194 31,400 SH   SOLE   31,400 0 0
Horizon Pharma plc Shares G4617B105 2,378 162,900 SH   SOLE   162,900 0 0
Humana Inc. Common 444859102 34,372 138,556 SH   SOLE   138,556 0 0
IDEXX Laboratories, Inc. Common 45168D104 20,697 132,352 SH   SOLE   132,352 0 0
Illumina, Inc. Common 452327109 62,442 285,791 SH   SOLE   285,791 0 0
Impax Laboratories, Inc. Common 45256B101 2,070 124,335 SH   SOLE   124,335 0 0
Incyte Corporation Common 45337C102 65,660 693,275 SH   SOLE   693,275 0 0
Innoviva, Inc. Common 45781M101 3,531 248,803 SH   SOLE   248,803 0 0
Intercept Pharmaceuticals, Inc. Note 3.250% 7/1/23 45845PAA6 5,486 6,900,000 PRN   SOLE   6,900,000 0 0
Intuitive Surgical, Inc. Common 46120E602 1,405 3,850 SH   SOLE   3,850 0 0
Ionis Pharmaceuticals, Inc. Common 462222100 6,485 128,930 SH   SOLE   128,930 0 0
Jazz Pharmaceuticals plc Shares G50871105 13,252 98,421 SH   SOLE   98,421 0 0
Johnson & Johnson Common 478160104 102,852 736,132 SH   SOLE   736,132 0 0
Karyopharm Therapeutics Inc. Common 48576U106 0 20 SH   SOLE   20 0 0
Koninklijke Philips N.V. NY Registry Shares 500472303 2,646 70,000 SH   SOLE   70,000 0 0
Lexicon Pharmaceuticals, Inc. Common 528872302 2,754 278,700 SH   SOLE   278,700 0 0
LTC Properties, Inc. Common 502175102 9,131 209,673 SH   SOLE   209,673 0 0
Mallinckrodt plc Shares G5785G107 1,396 61,900 SH   SOLE   61,900 0 0
McKesson Corporation Common 58155Q103 19,330 123,950 SH   SOLE   123,950 0 0
Medical Properties Trust, Inc. Common 58463J304 11,831 858,586 SH   SOLE   858,586 0 0
Medtronic plc Shares G5960L103 40,862 506,026 SH   SOLE   506,026 0 0
Merck & Co., Inc. Common 58933Y105 74,400 1,322,195 SH   SOLE   1,322,195 0 0
Merus B.V. Common N5749R100 9,276 479,150 SH   SOLE   479,150 0 0
Mylan N.V. Shares N59465109 67,828 1,603,112 SH   SOLE   1,603,112 0 0
Myovant Sciences Ltd. Common G637AM102 5,056 400,000 SH   SOLE   400,000 0 0
NanoString Technologies, Inc. Common 63009R109 555 74,250 SH   SOLE   74,250 0 0
Natera, Inc. Common 632307104 4,367 485,758 SH   SOLE   485,758 0 0
Neurocrine Biosciences, Inc. Common 64125C109 25,222 325,067 SH   SOLE   325,067 0 0
Nevro Corp. Common 64157F103 13,437 194,621 SH   SOLE   194,621 0 0
New Senior Investment Group Inc. Common 648691103 6,682 883,919 SH   SOLE   883,919 0 0
Novartis AG Sponsored ADR 66987V109 32,063 381,882 SH   SOLE   381,882 0 0
Novavax, Inc. Common 670002104 708 571,000 SH   SOLE   571,000 0 0
Novo Nordisk A/S Sponsored ADR 670100205 14,588 271,800 SH   SOLE   271,800 0 0
NuVasive, Inc. Common 670704105 6,869 117,437 SH   SOLE   117,437 0 0
Omega Healthcare Investors, Inc. Common 681936100 15,967 579,785 SH   SOLE   579,785 0 0
Ovid Therapeutics Inc. Common 690469101 5,289 535,824 SH   SOLE   535,824 0 0
Perrigo Company plc Shares G97822103 3,251 37,300 SH   SOLE   37,300 0 0
Pfizer Inc. Common 717081103 35,318 975,087 SH   SOLE   975,087 0 0
Physicians Realty Trust Common 71943U104 4,773 265,336 SH   SOLE   265,336 0 0
Pieris Pharmaceuticals, Inc. Common 720795103 14,816 1,962,380 SH   SOLE   1,962,380 0 0
PRA Health Sciences, Inc. Common 69354M108 5,912 64,920 SH   SOLE   64,920 0 0
Protagonist Therapeutics, Inc. Common 74366E102 1,723 82,822 SH   SOLE   82,822 0 0
Puma Biotechnology, Inc. Common 74587V107 4,784 48,392 SH   SOLE   48,392 0 0
Quorum Health Corporation Shares 74909E106 148 23,725 SH   SOLE   23,725 0 0
Quotient Limited Common G73268107 1,037 209,519 SH   SOLE   209,519 0 0
Ra Pharmaceuticals, Inc. Common 74933V108 3,028 356,237 SH   SOLE   356,237 0 0
Regeneron Pharmaceuticals, Inc. Common 75886F107 64,107 170,516 SH   SOLE   170,516 0 0
Revance Therapeutics, Inc. Common 761330109 1,152 32,225 SH   SOLE   32,225 0 0
The RMR Group Inc. Class A 74967R106 441 7,441 SH   SOLE   7,441 0 0
Sabra Health Care REIT, Inc. Common 78573L106 13,601 724,606 SH   SOLE   724,606 0 0
Sage Therapeutics, Inc. Common 78667J108 11,170 67,815 SH   SOLE   67,815 0 0
Sanofi Sponsored ADR 80105N105 7,736 179,900 SH   SOLE   179,900 0 0
Sarepta Therapeutics, Inc. Common 803607100 18,606 334,400 SH   SOLE   334,400 0 0
Seattle Genetics, Inc. Common 812578102 11,968 223,700 SH   SOLE   223,700 0 0
Senior Housing Properties Trust Shares 81721M109 12,382 646,554 SH   SOLE   646,554 0 0
Shire plc Sponsored ADR 82481R106 31,294 201,739 SH   SOLE   201,739 0 0
Smith & Nephew plc Sponsored ADR 83175M205 1,407 40,183 SH   SOLE   40,183 0 0
Spark Therapeutics, Inc. Common 84652J103 1,990 38,706 SH   SOLE   38,706 0 0
SPDR S&P Biotech ETF S&P Biotech ETF 78464A870 19,220 226,460 SH   SOLE   226,460 0 0
Stryker Corporation Common 863667101 4,877 31,500 SH   SOLE   31,500 0 0
Syndax Pharmaceuticals, Inc. Common 87164F105 1,752 200,000 SH   SOLE   200,000 0 0
Tenet Healthcare Corporation Common 88033G407 2,494 164,500 SH   SOLE   164,500 0 0
TESARO, Inc. Common 881569107 4,773 57,595 SH   SOLE   57,595 0 0
Tetraphase Pharmaceuticals, Inc. Common 88165N105 5,414 859,322 SH   SOLE   859,322 0 0
Teva Pharmaceutical Industries Ltd. Sponsored ADR 881624209 30,000 1,583,108 SH   SOLE   1,583,108 0 0
TherapeuticsMD, Inc. Common 88338N107 2,537 420,000 SH   SOLE   420,000 0 0
Thermo Fisher Scientific Inc. Common 883556102 26,197 137,968 SH   SOLE   137,968 0 0
Trillium Therapeutics Inc. Common 89620X506 3,285 450,000 SH   SOLE   450,000 0 0
Ultragenyx Pharmaceutical Inc. Shares 90400D108 6,890 148,558 SH   SOLE   148,558 0 0
uniQure N.V. Common N90064101 6,521 332,850 SH   SOLE   332,850 0 0
United Therapeutics Corporation Common 91307C102 2,400 16,220 SH   SOLE   16,220 0 0
UnitedHealth Group Inc. Class B 91324P102 67,436 305,886 SH   SOLE   305,886 0 0
Valeant Pharmaceuticals International, Inc. Common 91911K102 3,990 192,000 SH   SOLE   192,000 0 0
Ventas, Inc. Common 92276F100 5,281 87,996 SH   SOLE   87,996 0 0
Verona Pharma plc Sponsored ADR 925050106 3,278 275,000 SH   SOLE   275,000 0 0
Vertex Pharmaceuticals Incorporated Common 92532F100 96,474 643,762 SH   SOLE   643,762 0 0
Welltower Inc. 6.50% Preferred Perpetual 95040Q203 11,974 200,000 SH   SOLE   200,000 0 0
Welltower Inc. Common 95040Q104 1,365 21,400 SH   SOLE   21,400 0 0
Wright Medical Group N.V. Ordinary Shares N96617118 5,923 266,781 SH   SOLE   266,781 0 0
Xencor, Inc. Common 98401F105 438 20,000 SH   SOLE   20,000 0 0
Xenon Pharmaceuticals Inc. Common 98420N105 989 350,000 SH   SOLE   350,000 0 0
Zafgen, Inc. Common 98885E103 61 13,307 SH   SOLE   13,307 0 0
Zimmer Biomet Holdings, Inc. Common 98956P102 9,690 80,300 SH   SOLE   80,300 0 0