The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Abbott Laboratories Common 002824100 38,242 627,019 SH   SOLE   627,019 0 0
AbbVie Inc. Common 00287Y109 47,590 513,658 SH   SOLE   513,658 0 0
AC Immune SA Shares H00263105 1,598 171,813 SH   SOLE   171,813 0 0
Acadia Healthcare Company, Inc. Common 00404A109 11,144 272,400 SH   SOLE   272,400 0 0
ACADIA Pharmaceuticals Inc. Common 004225108 1,431 93,689 SH   SOLE   93,689 0 0
Acceleron Pharma Inc. Common 00434H108 8,286 170,766 SH   SOLE   170,766 0 0
Achillion Pharmaceuticals, Inc. Common 00448Q201 1,743 616,000 SH   SOLE   616,000 0 0
Adaptimmune Therapeutics plc Sponsored ADR 00653A107 10,154 855,468 SH   SOLE   855,468 0 0
Aegerion Pharmaceuticals, Inc. Note 2.00% 8/15/19 00767EAB8 8,436 13,000,000 PRN   SOLE   13,000,000 0 0
Aerpio Pharmaceuticals, Inc. Common 00810B105 3,175 765,000 SH   SOLE   765,000 0 0
Aetna Inc. Common 00817Y108 17,822 97,122 SH   SOLE   97,122 0 0
Affimed N.V. Common N01045108 2,681 1,624,792 SH   SOLE   1,624,792 0 0
Agios Pharmaceuticals, Inc. Common 00847X104 237 2,810 SH   SOLE   2,810 0 0
Akebia Therapeutics, Inc. Common 00972D105 2,661 266,612 SH   SOLE   266,612 0 0
Albireo Pharma, Inc. Common 01345P106 4,438 125,000 SH   SOLE   125,000 0 0
Alexion Pharmaceuticals, Inc. Common 015351109 54,429 438,416 SH   SOLE   438,416 0 0
Alkermes plc Shares G01767105 7,040 171,042 SH   SOLE   171,042 0 0
Allergan plc Shares G0177J108 41,486 248,836 SH   SOLE   248,836 0 0
Alliqua BioMedical, Inc. Common 019621309 338 165,000 SH   SOLE   165,000 0 0
Alnylam Pharmaceuticals, Inc. Common 02043Q107 12,841 130,376 SH   SOLE   130,376 0 0
Amarin Corporation plc Sponsored ADR 023111206 1,477 478,149 SH   SOLE   478,149 0 0
AmerisourceBergen Corporation Common 03073E105 7,905 92,707 SH   SOLE   92,707 0 0
Amgen Inc. Common 031162100 129,322 700,588 SH   SOLE   700,588 0 0
Amicus Therapeutics, Inc. Common 03152W109 13,672 875,304 SH   SOLE   875,304 0 0
Anthem, Inc. Common 036752103 26,334 110,633 SH   SOLE   110,633 0 0
ARCA biopharma, Inc. Common 00211Y407 451 811,227 SH   SOLE   811,227 0 0
Ardelyx, Inc. Common 039697107 2,366 639,370 SH   SOLE   639,370 0 0
Arena Pharmaceuticals, Inc. Common 040047607 4,088 93,767 SH   SOLE   93,767 0 0
argenx SE Sponsored ADR 04016X101 3,226 38,931 SH   SOLE   38,931 0 0
Array BioPharma Inc. Common 04269X105 4,297 256,056 SH   SOLE   256,056 0 0
Ascendis Pharma A/S Sponsored ADR 04351P101 2,921 43,914 SH   SOLE   43,914 0 0
AstraZeneca PLC Sponsored ADR 046353108 27,347 778,888 SH   SOLE   778,888 0 0
Avadel Pharmaceuticals plc Sponsored ADR 05337M104 4,993 814,588 SH   SOLE   814,588 0 0
Bausch Health Companies Inc. Common 91911K102 4,462 192,000 SH   SOLE   192,000 0 0
Baxter International Inc. Sponsored ADR 071813109 9,904 134,124 SH   SOLE   134,124 0 0
Becton, Dickinson and Company Common 075887109 12,691 52,978 SH   SOLE   52,978 0 0
BeiGene, Ltd. Sponsored ADR 07725L102 8,422 54,785 SH   SOLE   54,785 0 0
Bellicum Pharmaceuticals, Inc. Common 079481107 443 60,000 SH   SOLE   60,000 0 0
Biogen Inc. Common 09062X103 117,244 403,955 SH   SOLE   403,955 0 0
BioMarin Pharmaceutical Inc. Common 09061G101 13,239 140,538 SH   SOLE   140,538 0 0
bluebird bio, Inc. Common 09609G100 11,331 72,198 SH   SOLE   72,198 0 0
Blueprint Medicines Corporation Common 09627Y109 9,268 146,001 SH   SOLE   146,001 0 0
Boston Scientific Corporation Common 101137107 14,963 457,585 SH   SOLE   457,585 0 0
Bristol-Myers Squibb Company Common 110122108 36,028 651,030 SH   SOLE   651,030 0 0
Cardinal Health, Inc. Common 14149Y108 308 6,300 SH   SOLE   6,300 0 0
Celgene Corporation Common 151020104 99,392 1,251,470 SH   SOLE   1,251,470 0 0
Celldex Therapeutics, Inc. Common 15117B103 53 105,800 SH   SOLE   105,800 0 0
Cellectis S.A. Sponsored ADR 15117K103 8,995 317,950 SH   SOLE   317,950 0 0
Centene Corporation Common 15135B101 22,772 184,819 SH   SOLE   184,819 0 0
Charles River Laboratories International, Inc. Common 159864107 2,545 22,670 SH   SOLE   22,670 0 0
Cidara Therapeutics, Inc. Common 171757107 826 158,784 SH   SOLE   158,784 0 0
Cigna Corporation Common 125509109 6,876 40,461 SH   SOLE   40,461 0 0
Clearside Biomedical, Inc. Common 185063104 884 82,665 SH   SOLE   82,665 0 0
Clovis Oncology, Inc. Common 189464100 3,428 75,400 SH   SOLE   75,400 0 0
Coherus Biosciences, Inc. Common 19249H103 3,372 240,843 SH   SOLE   240,843 0 0
Community Health Systems, Inc. Common 203668108 677 203,935 SH   SOLE   203,935 0 0
CRISPR Therapeutics AG Common H17182108 10,480 178,348 SH   SOLE   178,348 0 0
CVS Health Corporation Common 126650100 23,586 366,521 SH   SOLE   366,521 0 0
CymaBay Therapeutics, Inc. Common 23257D103 2,281 169,962 SH   SOLE   169,962 0 0
Danaher Corporation Common 235851102 19,033 192,871 SH   SOLE   192,871 0 0
Depomed, Inc. Common 249908104 420 62,973 SH   SOLE   62,973 0 0
Dermira, Inc. Common 24983L104 2,155 234,200 SH   SOLE   234,200 0 0
Diplomat Pharmacy, Inc. Common 25456K101 11,221 439,001 SH   SOLE   439,001 0 0
Editas Medicine, Inc. Common 28106W103 4,937 137,801 SH   SOLE   137,801 0 0
Edwards Lifesciences Corporation Common 28176E108 9,648 66,275 SH   SOLE   66,275 0 0
Egalet Corporation Note 5.50% 4/1/20 28226BAB0 2,445 7,000,000 PRN   SOLE   7,000,000 0 0
Eli Lilly and Company Common 532457108 33,288 390,108 SH   SOLE   390,108 0 0
Endo International plc Shares G30401106 10,169 1,078,414 SH   SOLE   1,078,414 0 0
Epizyme, Inc. Common 29428V104 6,576 485,325 SH   SOLE   485,325 0 0
Esperion Therapeutics, Inc. Common 29664W105 7,418 189,287 SH   SOLE   189,287 0 0
Evolent Health, Inc. Class A 30050B101 2,579 122,500 SH   SOLE   122,500 0 0
Exelixis, Inc. Common 30161Q104 9,211 428,022 SH   SOLE   428,022 0 0
Express Scripts Holding Company Common 30219G108 8,223 106,500 SH   SOLE   106,500 0 0
FibroGen, Inc. Common 31572Q808 11,156 178,207 SH   SOLE   178,207 0 0
Foamix Pharmaceuticals Ltd. Shares M46135105 4,661 930,398 SH   SOLE   930,398 0 0
Galapagos NV Sponsored ADR 36315X101 8,003 86,815 SH   SOLE   86,815 0 0
Gilead Sciences, Inc. Common 375558103 146,192 2,063,699 SH   SOLE   2,063,699 0 0
GlaxoSmithKline plc Shares 37733W105 14,471 359,000 SH   SOLE   359,000 0 0
Global Blood Therapeutics, Inc. Common 37890U108 2,684 59,390 SH   SOLE   59,390 0 0
Global Medical REIT Inc. Common 37954A204 650 73,400 SH   SOLE   73,400 0 0
GW Pharmaceuticals plc ADS 36197T103 9,977 71,497 SH   SOLE   71,497 0 0
HCA Healthcare, Inc. Common 40412C101 7,704 75,090 SH   SOLE   75,090 0 0
HCP, Inc. Common 40414L109 1,175 45,500 SH   SOLE   45,500 0 0
Healthcare Realty Trust Incorporated Common 421946104 1,977 68,000 SH   SOLE   68,000 0 0
Healthcare Trust of America, Inc. Class A 42225P501 1,240 46,000 SH   SOLE   46,000 0 0
Henry Schein, Inc. Common 806407102 2,281 31,400 SH   SOLE   31,400 0 0
Hologic, Inc. Common 436440101 777 19,546 SH   SOLE   19,546 0 0
Horizon Pharma plc Shares G4617B105 2,698 162,900 SH   SOLE   162,900 0 0
Humana Inc. Common 444859102 31,267 105,053 SH   SOLE   105,053 0 0
IDEXX Laboratories, Inc. Common 45168D104 28,247 129,608 SH   SOLE   129,608 0 0
Illumina, Inc. Common 452327109 79,456 284,492 SH   SOLE   284,492 0 0
Incyte Corporation Common 45337C102 43,245 645,442 SH   SOLE   645,442 0 0
Innoviva, Inc. Common 45781M101 2,230 161,603 SH   SOLE   161,603 0 0
Intellia Therapeutics, Inc. Common 45826J105 4,580 167,381 SH   SOLE   167,381 0 0
Intuitive Surgical, Inc. Common 46120E602 11,234 23,479 SH   SOLE   23,479 0 0
Ionis Pharmaceuticals, Inc. Common 462222100 3,452 82,838 SH   SOLE   82,838 0 0
Iovance Biotherapeutics, Inc. Common 462260100 427 33,395 SH   SOLE   33,395 0 0
Jazz Pharmaceuticals plc Shares G50871105 19,031 110,452 SH   SOLE   110,452 0 0
Johnson & Johnson Common 478160104 108,367 893,082 SH   SOLE   893,082 0 0
Jounce Therapeutics, Inc. Common 481116101 78 10,127 SH   SOLE   10,127 0 0
LeMaitre Vascular, Inc. Common 525558201 909 27,150 SH   SOLE   27,150 0 0
LivaNova PLC Common G5509L101 628 6,287 SH   SOLE   6,287 0 0
Loxo Oncology, Inc. Common 548862101 1,798 10,365 SH   SOLE   10,365 0 0
LTC Properties, Inc. Common 502175102 8,961 209,673 SH   SOLE   209,673 0 0
Mallinckrodt plc Shares G5785G107 1,155 61,900 SH   SOLE   61,900 0 0
Masimo Corporation Common 574795100 4,689 48,020 SH   SOLE   48,020 0 0
McKesson Corporation Common 58155Q103 13,180 98,797 SH   SOLE   98,797 0 0
Medical Properties Trust, Inc. Common 58463J304 12,055 858,586 SH   SOLE   858,586 0 0
The Medicines Company Common 584688105 8,762 238,741 SH   SOLE   238,741 0 0
Medtronic plc Shares G5960L103 36,272 423,693 SH   SOLE   423,693 0 0
Merck & Co., Inc. Common 58933Y105 77,940 1,284,022 SH   SOLE   1,284,022 0 0
Merus N.V. Common N5749R100 9,425 414,115 SH   SOLE   414,115 0 0
Molecular Templates, Inc. Common 608550109 754 144,110 SH   SOLE   144,110 0 0
Mylan N.V. Shares N59465109 59,885 1,657,017 SH   SOLE   1,657,017 0 0
NanoString Technologies, Inc. Common 63009R109 1,016 74,250 SH   SOLE   74,250 0 0
Nektar Therapeutics Common 640268108 9,218 188,769 SH   SOLE   188,769 0 0
Neurocrine Biosciences, Inc. Common 64125C109 26,502 269,769 SH   SOLE   269,769 0 0
Nevro Corp. Common 64157F103 4,231 52,990 SH   SOLE   52,990 0 0
New Senior Investment Group Inc. Common 648691103 4,004 528,919 SH   SOLE   528,919 0 0
NewLink Genetics Corporation Common 651511107 976 205,026 SH   SOLE   205,026 0 0
Novartis AG Sponsored ADR 66987V109 22,346 295,820 SH   SOLE   295,820 0 0
Novavax, Inc. Common 670002104 765 571,000 SH   SOLE   571,000 0 0
Novo Nordisk A/S Sponsored ADR 670100205 6,268 135,900 SH   SOLE   135,900 0 0
NuCana plc Common 67022C106 187 9,823 SH   SOLE   9,823 0 0
NuVasive, Inc. Common 670704105 1,021 19,580 SH   SOLE   19,580 0 0
Omega Healthcare Investors, Inc. Common 681936100 17,973 579,785 SH   SOLE   579,785 0 0
Ovid Therapeutics Inc. Common 690469101 4,179 535,824 SH   SOLE   535,824 0 0
Perrigo Company plc Shares G97822103 2,720 37,300 SH   SOLE   37,300 0 0
Pfizer Inc. Common 717081103 85,609 2,359,687 SH   SOLE   2,359,687 0 0
Physicians Realty Trust Common 71943U104 6,233 391,016 SH   SOLE   391,016 0 0
Pieris Pharmaceuticals, Inc. Common 720795103 10,583 2,087,380 SH   SOLE   2,087,380 0 0
Portola Pharmaceuticals, Inc. Common 737010108 3,398 89,978 SH   SOLE   89,978 0 0
PRA Health Sciences, Inc. Common 69354M108 3,030 32,460 SH   SOLE   32,460 0 0
Protagonist Therapeutics, Inc. Common 74366E102 1,472 219,042 SH   SOLE   219,042 0 0
Puma Biotechnology, Inc. Common 74587V107 4,930 83,340 SH   SOLE   83,340 0 0
Quorum Health Corporation Common 74909E106 119 23,725 SH   SOLE   23,725 0 0
Ra Pharmaceuticals, Inc. Common 74933V108 2,189 219,952 SH   SOLE   219,952 0 0
Regeneron Pharmaceuticals, Inc. Common 75886F107 50,450 146,237 SH   SOLE   146,237 0 0
ResMed Inc. Common 761152107 6,073 58,630 SH   SOLE   58,630 0 0
Revance Therapeutics, Inc. Common 761330109 2,139 77,919 SH   SOLE   77,919 0 0
The RMR Group Inc. Class A 74967R106 584 7,441 SH   SOLE   7,441 0 0
Sabra Health Care REIT, Inc. Common 78573L106 15,746 724,606 SH   SOLE   724,606 0 0
Sage Therapeutics, Inc. Common 78667J108 22,480 143,614 SH   SOLE   143,614 0 0
Sangamo Therapeutics, Inc. Common 800677106 1,711 120,512 SH   SOLE   120,512 0 0
Sanofi Common 80105N105 7,198 179,900 SH   SOLE   179,900 0 0
Sarepta Therapeutics, Inc. Common 803607100 30,995 234,489 SH   SOLE   234,489 0 0
Seattle Genetics, Inc. Common 812578102 18,550 279,417 SH   SOLE   279,417 0 0
Senior Housing Properties Trust Shares 81721M109 11,696 646,554 SH   SOLE   646,554 0 0
Shire plc Shares 82481R106 6,113 36,216 SH   SOLE   36,216 0 0
Smith & Nephew plc Sponsored ADR 83175M205 1,657 44,148 SH   SOLE   44,148 0 0
Spark Therapeutics, Inc. Common 84652J103 1,825 22,046 SH   SOLE   22,046 0 0
SPDR S&P Biotech ETF S&P Biotech ETF 78464A870 23,841 250,460 SH   SOLE   250,460 0 0
STERIS plc Shares G84720104 2,353 22,403 SH   SOLE   22,403 0 0
Stryker Corporation Common 863667101 23,072 136,631 SH   SOLE   136,631 0 0
Syndax Pharmaceuticals, Inc. Common 87164F105 1,404 200,000 SH   SOLE   200,000 0 0
Teleflex Incorporated Common 879369106 1,711 6,379 SH   SOLE   6,379 0 0
Teligent, Inc. Common 87960W104 3,136 906,362 SH   SOLE   906,362 0 0
Tenet Healthcare Corporation Common 88033G407 5,522 164,500 SH   SOLE   164,500 0 0
TESARO, Inc. Common 881569107 4,223 94,970 SH   SOLE   94,970 0 0
Tetraphase Pharmaceuticals, Inc. Common 88165N105 3,068 859,322 SH   SOLE   859,322 0 0
Teva Pharmaceutical Industries Limited Sponsored ADR 881624209 26,359 1,083,843 SH   SOLE   1,083,843 0 0
TherapeuticsMD, Inc. Common 88338N107 1,463 234,384 SH   SOLE   234,384 0 0
Theravance Biopharma, Inc. Common G8807B106 183 8,083 SH   SOLE   8,083 0 0
Thermo Fisher Scientific Inc. Common 883556102 31,629 152,695 SH   SOLE   152,695 0 0
Trillium Therapeutics Inc. Common 89620X506 2,810 468,399 SH   SOLE   468,399 0 0
Ultragenyx Pharmaceutical Inc. Common 90400D108 5,916 76,958 SH   SOLE   76,958 0 0
uniQure N.V. Shares N90064101 1,427 37,741 SH   SOLE   37,741 0 0
United Therapeutics Corporation Class B 91307C102 4,669 41,261 SH   SOLE   41,261 0 0
Unitedhealth Group Incorporated Common 91324P102 104,347 425,317 SH   SOLE   425,317 0 0
Varian Medical Systems, Inc. Common 92220P105 2,983 26,227 SH   SOLE   26,227 0 0
Ventas, Inc. Common 92276F100 5,609 98,496 SH   SOLE   98,496 0 0
Verona Pharma plc Sponsored ADR 925050106 3,781 275,000 SH   SOLE   275,000 0 0
Vertex Pharmaceuticals Incorporated Common 92532F100 98,835 581,522 SH   SOLE   581,522 0 0
Welltower Inc. 6.50% Preferred Perpetual 95040Q203 11,890 200,000 SH   SOLE   200,000 0 0
Welltower Inc. Common 95040Q104 2,856 45,560 SH   SOLE   45,560 0 0
Wright Medical Group N.V. Ordinary Shares N96617118 6,926 266,781 SH   SOLE   266,781 0 0
Xenon Pharmaceuticals Inc. Common 98420N105 1,507 163,819 SH   SOLE   163,819 0 0
Zimmer Biomet Holdings, Inc. Common 98956P102 13,244 118,846 SH   SOLE   118,846 0 0
Zoetis, Inc. Class A 98978V103 3,046 35,760 SH   SOLE   35,760 0 0
Zogenix, Inc. Common 98978L204 1,563 35,352 SH   SOLE   35,352 0 0