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The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
89bio, Inc. Common 282559103   2,006,767 105,898 SH   SOLE   2,006,767 0 0
Abbott Laboratories Common 002824100   60,228,644 552,455 SH   SOLE   60,228,644 0 0
AbbVie Inc. Common 00287Y109   73,512,595 545,629 SH   SOLE   73,512,595 0 0
Acadia Healthcare Company, Inc. Common 00404A109   8,036,632 100,912 SH   SOLE   8,036,632 0 0
Adaptive Biotechnologies Corp. Common 00650F109   2,833,506 422,281 SH   SOLE   2,833,506 0 0
Adicet Bio, Inc. Common 007002108   97,999 40,329 SH   SOLE   97,999 0 0
Affimed N.V. Common N01045108   350,568 586,038 SH   SOLE   350,568 0 0
Agilent Technologies, Inc. Common 00846U101   5,193,718 43,191 SH   SOLE   5,193,718 0 0
Akero Therapeutics, Inc. Common 00973Y108   2,871,295 61,497 SH   SOLE   2,871,295 0 0
Alkermes plc Shares G01767105   9,690,887 309,613 SH   SOLE   9,690,887 0 0
Alnylam Pharmaceuticals, Inc. Common 02043Q107   27,202,067 143,214 SH   SOLE   27,202,067 0 0
Altimmune, Inc. Common 02155H200   264,750 75,000 SH   SOLE   264,750 0 0
ALX Oncology Holdings Inc. Common 00166B105   497,245 66,211 SH   SOLE   497,245 0 0
Amerisourcebergen Corp. Common 03073E105   3,928,843 20,417 SH   SOLE   3,928,843 0 0
Amgen Inc. Common 031162100   136,883,989 616,539 SH   SOLE   136,883,989 0 0
Amylyx Pharmaceuticals, Inc. Common 03237H101   2,243,431 104,007 SH   SOLE   2,243,431 0 0
Apellis Pharmaceuticals, Inc. Common 03753U106   15,782,893 173,248 SH   SOLE   15,782,893 0 0
ARCA biopharma, Inc. Common 00211Y506   65,896 32,461 SH   SOLE   65,896 0 0
Arcus Biosciences, Inc. Common 03969F109   666,960 32,839 SH   SOLE   666,960 0 0
Arcutis Biotherapeutics, Inc. Common 03969K108   1,418,769 148,874 SH   SOLE   1,418,769 0 0
Ardelyx, Inc. Common 039697107   1,828,593 539,408 SH   SOLE   1,828,593 0 0
argenx SE Sponsored ADR 04016X101   25,547,971 65,553 SH   SOLE   25,547,971 0 0
Ascendis Pharma A/S Sponsored ADR 04351P101   12,387,097 138,791 SH   SOLE   12,387,097 0 0
Assertio Holdings, Inc. Common 04546C205   2,225,317 410,575 SH   SOLE   2,225,317 0 0
AstraZeneca PLC Sponsored ADR 046353108   69,900,701 976,676 SH   SOLE   69,900,701 0 0
Avantor, Inc. Common 05352A100   9,437,884 459,488 SH   SOLE   9,437,884 0 0
Baxter International, Inc. Common 071813109   14,778,297 324,370 SH   SOLE   14,778,297 0 0
Beam Therapeutics Inc. Common 07373V105   505,037 15,817 SH   SOLE   505,037 0 0
BeiGene, Ltd. Sponsored ADR 07725L102   3,735,742 20,952 SH   SOLE   3,735,742 0 0
Bellicum Pharmaceuticals, Inc. Common 079481404   2,220 6,000 SH   SOLE   2,220 0 0
Bicycle Therapeutics PLC Sponsored ADS 088786108   1,131,506 44,338 SH   SOLE   1,131,506 0 0
BioCryst Pharmaceuticals, Inc. Common 09058V103   3,551,877 504,528 SH   SOLE   3,551,877 0 0
Biogen Inc. Common 09062X103   70,626,564 247,943 SH   SOLE   70,626,564 0 0
BioMarin Pharmaceutical Inc. Common 09061G101   18,271,191 210,789 SH   SOLE   18,271,191 0 0
BioNTech SE Sponsored ADS 09075V102   11,209,394 103,858 SH   SOLE   11,209,394 0 0
Black Diamond Therapeutics, Inc. Common 09203E105   666,550 131,990 SH   SOLE   666,550 0 0
Boston Scientific Corp. Common 101137107   35,579,861 657,790 SH   SOLE   35,579,861 0 0
Bridgebio Pharma, Inc. Common 10806X102   2,595,841 150,921 SH   SOLE   2,595,841 0 0
Bristol-Myers Squibb Company Common 110122108   29,320,947 458,498 SH   SOLE   29,320,947 0 0
Caribou Biosciences, Inc. Common 142038108   2,410,375 567,147 SH   SOLE   2,410,375 0 0
Cerevel Therapeutics Holdings, Inc. Common 15678U128   5,610,395 176,483 SH   SOLE   5,610,395 0 0
Charles River Laboratories International, Inc. Common 159864107   23,376,226 111,183 SH   SOLE   23,376,226 0 0
Chinook Therapeutics, Inc. Common 16961L106   5,796,156 150,863 SH   SOLE   5,796,156 0 0
Codexis Inc Common 192005106   193,550 69,125 SH   SOLE   193,550 0 0
Community Health Systems, Inc. Common 203668108   388,674 88,335 SH   SOLE   388,674 0 0
Community Healthcare Trust Inc. Common 20369C106   491,998 14,900 SH   SOLE   491,998 0 0
Corbus Pharmaceuticals Holdings, Inc. Common 21833P301   40,321 5,143 SH   SOLE   40,321 0 0
Crinetics Pharmaceuticals, Inc. Common 22663K107   1,415,093 78,529 SH   SOLE   1,415,093 0 0
CRISPR Therapeutics AG Namen AKT H17182108   1,267,136 22,571 SH   SOLE   1,267,136 0 0
CVS Health Corp. Common 126650100   6,472,020 93,621 SH   SOLE   6,472,020 0 0
Cytokinetics, Inc. Common 23282W605   7,144,596 219,025 SH   SOLE   7,144,596 0 0
Danaher Corp. Common 235851102   34,275,120 142,813 SH   SOLE   34,275,120 0 0
Denali Therapeutics, Inc. Common 24823R105   9,585,704 324,829 SH   SOLE   9,585,704 0 0
Dexcom, Inc. Common 252131107   29,396,277 228,747 SH   SOLE   29,396,277 0 0
Diversified Healthcare Trust Common 25525P107   804,870 357,720 SH   SOLE   804,870 0 0
Edgewise Therapeutics, Inc. Common 28036F105   1,165,740 150,418 SH   SOLE   1,165,740 0 0
Edwards Lifesciences Corp. Common 28176E108   17,884,685 189,597 SH   SOLE   17,884,685 0 0
Elevance Health, Inc. Common 036752103   50,680,160 114,070 SH   SOLE   50,680,160 0 0
Eli Lilly and Company Common 532457108   100,057,821 213,352 SH   SOLE   100,057,821 0 0
Exelixis, Inc. Common 30161Q104   13,886,071 726,639 SH   SOLE   13,886,071 0 0
Fulcrum Therapeutics, Inc. Common 359616109   847,730 256,888 SH   SOLE   847,730 0 0
Fusion Pharmaceuticals Inc. Common 36118A100   203,084 43,394 SH   SOLE   203,084 0 0
G1 Therapeutics, Inc. Common 3621LQ109   1,055,434 423,869 SH   SOLE   1,055,434 0 0
Galera Therapeutics, Inc. Common 36338D108   2,802,927 898,374 SH   SOLE   2,802,927 0 0
Gilead Sciences, Inc. Common 375558103   118,216,440 1,533,884 SH   SOLE   118,216,440 0 0
Global Medical REIT Inc. Common 37954A204   1,596,810 174,897 SH   SOLE   1,596,810 0 0
GSK plc Sponsored ADR 37733W204   1,491,605 41,852 SH   SOLE   1,491,605 0 0
Guardant Health, Inc. Common 40131M109   12,389,807 346,084 SH   SOLE   12,389,807 0 0
Harpoon Therapeutics, Inc. Common 41358P106   184,536 259,910 SH   SOLE   184,536 0 0
HCA Healthcare, Inc. Common 40412C101   25,007,662 82,403 SH   SOLE   25,007,662 0 0
Healthcare Realty Trust Inc. Common 42226K105   3,294,578 174,686 SH   SOLE   3,294,578 0 0
Healthpeak Properties, Inc. Common 42250P103   3,022,879 150,392 SH   SOLE   3,022,879 0 0
HilleVax, Inc. Common 43157M102   464,130 27,000 SH   SOLE   464,130 0 0
Horizon Therapeutics plc Common G46188101   7,448,911 72,425 SH   SOLE   7,448,911 0 0
Humana Inc. Common 444859102   16,451,701 36,794 SH   SOLE   16,451,701 0 0
I-Mab Sponsored ADS 44975P103   486,114 162,580 SH   SOLE   486,114 0 0
Icon plc Shares G4705A100   2,335,367 9,334 SH   SOLE   2,335,367 0 0
IDEXX Laboratories, Inc. Common 45168D104   29,428,167 58,595 SH   SOLE   29,428,167 0 0
Illumina, Inc. Common 452327109   63,180,193 336,979 SH   SOLE   63,180,193 0 0
Immunovant, Inc. Common 45258J102   6,377,714 336,200 SH   SOLE   6,377,714 0 0
Inspire Medical Systems, Inc. Common 457730109   7,147,924 22,018 SH   SOLE   7,147,924 0 0
Insulet Corp. Common 45784P101   12,642,844 43,847 SH   SOLE   12,642,844 0 0
Intellia Therapeutics, Inc. Common 45826J105   6,291,090 154,269 SH   SOLE   6,291,090 0 0
Intercept Pharmaceuticals, Inc. Common 45845P108   575,861 52,067 SH   SOLE   575,861 0 0
Intra-Cellular Therapies, Inc. Common 46116X101   8,322,464 131,435 SH   SOLE   8,322,464 0 0
Intuitive Surgical, Inc. Common 46120E602   28,716,121 83,980 SH   SOLE   28,716,121 0 0
Ionis Pharmaceuticals, Inc. Common 462222100   3,604,075 87,840 SH   SOLE   3,604,075 0 0
IQVIA Holdings Inc. Common 46266C105   24,528,925 109,129 SH   SOLE   24,528,925 0 0
Ishares Biothechnology ETF Common 464287556   3,119,280 24,569 SH   SOLE   3,119,280 0 0
iTeos Therapeutics, Inc. Common 46565G104   605,531 45,735 SH   SOLE   605,531 0 0
Jazz Pharmaceuticals plc Shares G50871105   18,320,163 147,779 SH   SOLE   18,320,163 0 0
Johnson & Johnson Common 478160104   119,468,860 721,779 SH   SOLE   119,468,860 0 0
Karuna Therapeutics, Inc. Common 48576A100   12,702,422 58,577 SH   SOLE   12,702,422 0 0
Koninklijke Philips N.V. NY Reg Shares 500472303   2,489,253 114,765 SH   SOLE   2,489,253 0 0
LivaNova plc Common G5509L101   5,579,126 108,480 SH   SOLE   5,579,126 0 0
LTC Properties, Inc. Common 502175102   6,019,315 182,293 SH   SOLE   6,019,315 0 0
Madrigal Pharmaceuticals, Inc. Common 558868105   7,954,254 34,434 SH   SOLE   7,954,254 0 0
Mallinckrodt plc Shares G5890A102   41,357 35,048 SH   SOLE   41,357 0 0
Marinus Pharmaceuticals, Inc. Common 56854Q200   4,464,557 411,101 SH   SOLE   4,464,557 0 0
McKesson Corp. Common 58155Q103   26,473,991 61,955 SH   SOLE   26,473,991 0 0
Medical Properties Trust, Inc. Common 58463J304   3,812,740 411,743 SH   SOLE   3,812,740 0 0
Medpace Holdings, Inc. Common 58506Q109   6,464,896 26,918 SH   SOLE   6,464,896 0 0
Medtronic plc Shares G5960L103   30,343,138 344,417 SH   SOLE   30,343,138 0 0
Merck & Co., Inc. Common 58933Y105   84,021,690 728,154 SH   SOLE   84,021,690 0 0
Mereo BioPharma Group plc ADS 589492107   2,047,428 1,551,082 SH   SOLE   2,047,428 0 0
Mirati Therapeutics, Inc. Common 60468T105   2,366,154 65,490 SH   SOLE   2,366,154 0 0
Moderna, Inc. Common 60770K107   41,758,943 343,695 SH   SOLE   41,758,943 0 0
Molina Healthcare, Inc. Common 60855R100   18,633,501 61,856 SH   SOLE   18,633,501 0 0
MorphoSys AG Sponsored ADS 617760202   1,323,617 177,191 SH   SOLE   1,323,617 0 0
Natera, Inc. Common 632307104   1,198,788 24,636 SH   SOLE   1,198,788 0 0
National Health Investors, Inc. Common 63633D104   526,192 10,038 SH   SOLE   526,192 0 0
Neurocrine Biosciences, Inc. Common 64125C109   10,647,224 112,908 SH   SOLE   10,647,224 0 0
NexGel, Inc. Common 65344E107   10,650 4,243 SH   SOLE   10,650 0 0
Nkarta, Inc. Common 65487U108   63,484 28,988 SH   SOLE   63,484 0 0
Novartis AG Sponsored ADR 66987V109   13,746,465 136,225 SH   SOLE   13,746,465 0 0
Novavax, Inc. Common 670002401   474,034 63,800 SH   SOLE   474,034 0 0
Novo Nordisk A/S Sponsored ADR 670100205   19,869,002 122,777 SH   SOLE   19,869,002 0 0
Oculis Holding AG Common 952KVL905   18,823,020 1,690,741 SH   SOLE   18,823,020 0 0
Omega Healthcare Investors, Inc. Common 681936100   9,404,429 306,433 SH   SOLE   9,404,429 0 0
Perrigo Company plc Shares G97822103   1,739,055 51,224 SH   SOLE   1,739,055 0 0
Pfizer Inc. Common 717081103   59,585,780 1,624,476 SH   SOLE   59,585,780 0 0
Physicians Realty Trust Common 71943U104   12,222,433 873,655 SH   SOLE   12,222,433 0 0
Praxis Precision Medicines, Inc. Common 74006W108   86,250 75,000 SH   SOLE   86,250 0 0
Precision BioSciences, Inc. Common 74019P108   118,105 224,534 SH   SOLE   118,105 0 0
Pyxis Oncology, Inc. Common 747324101   1,813,256 708,303 SH   SOLE   1,813,256 0 0
R1 RCM Inc. Common 77634L105   6,583,901 356,851 SH   SOLE   6,583,901 0 0
Rallybio Corporation Common 75120L100   9,775,199 1,727,067 SH   SOLE   9,775,199 0 0
Reata Pharmaceuticals, Inc. Class A Class A 75615P103   3,492,130 34,250 SH   SOLE   3,492,130 0 0
Regeneron Pharmaceuticals, Inc. Common 75886F107   115,985,290 161,418 SH   SOLE   115,985,290 0 0
Repare Therapeutics Inc. Common 760273102   308,407 29,150 SH   SOLE   308,407 0 0
ResMed Inc. Common 761152107   7,582,824 34,704 SH   SOLE   7,582,824 0 0
Sabra Health Care REIT, Inc. Common 78573L106   6,010,468 510,660 SH   SOLE   6,010,468 0 0
Sanofi Sponsored ADR 80105N105   6,654,171 123,454 SH   SOLE   6,654,171 0 0
Sarepta Therapeutics, Inc. Common 803607100   20,549,125 179,437 SH   SOLE   20,549,125 0 0
Scholar Rock Holding Corp. Common 80706P103   820,601 108,833 SH   SOLE   820,601 0 0
Seagen Inc. Common 81181C104   21,619,224 112,331 SH   SOLE   21,619,224 0 0
Smith & Nephew plc Sponsored ADR 83175M205   5,860,148 181,710 SH   SOLE   5,860,148 0 0
SPDR S&P Biotech ETF S&P Biotech ETF 78464A870   12,286,726 147,677 SH   SOLE   12,286,726 0 0
Spectrum Pharmaceuticals, Inc. Common 84763A108   110,083 114,670 SH   SOLE   110,083 0 0
STERIS plc Shares G8473T100   6,990,579 31,072 SH   SOLE   6,990,579 0 0
Stryker Corp. Common 863667101   24,751,342 81,128 SH   SOLE   24,751,342 0 0
Sutro Biopharma, Inc. Common 869367102   457,346 98,354 SH   SOLE   457,346 0 0
Tactile Systems Technology, Inc. Common 87357P100   1,457,707 58,472 SH   SOLE   1,457,707 0 0
Takeda Pharmaceutical Company Ltd. Sponsored ADS 874060205   1,650,697 105,073 SH   SOLE   1,650,697 0 0
Tenet Healthcare Corp. Common 88033G407   12,131,317 149,070 SH   SOLE   12,131,317 0 0
Teva Pharmaceutical Industries Ltd. Sponsored ADR 881624209   3,461,172 459,651 SH   SOLE   3,461,172 0 0
The Cigna Group Common 125523100   27,032,723 96,339 SH   SOLE   27,032,723 0 0
Thermo Fisher Scientific Inc. Common 883556102   51,646,467 98,987 SH   SOLE   51,646,467 0 0
Theseus Pharmaceuticals, Inc. Common 88369M101   699,750 75,000 SH   SOLE   699,750 0 0
TScan Therapeutics, Inc. Common 89854M101   500,000 200,000 SH   SOLE   500,000 0 0
uniQure N.V. Shares N90064101   4,082,969 356,280 SH   SOLE   4,082,969 0 0
United Therapeutics Corp. Common 91307C102   9,153,399 41,465 SH   SOLE   9,153,399 0 0
Unitedhealth Group Inc. Common 91324P102   99,473,735 206,961 SH   SOLE   99,473,735 0 0
Universal Health Realty Income Trust Common 91359E105   535,656 11,258 SH   SOLE   535,656 0 0
Vaxcyte, Inc. Common 92243G108   9,699,946 194,232 SH   SOLE   9,699,946 0 0
Ventas, Inc. Common 92276F100   3,152,011 66,681 SH   SOLE   3,152,011 0 0
Veradigm, Inc. Common 01988P108   5,400,108 428,580 SH   SOLE   5,400,108 0 0
Vertex Pharmaceuticals Inc. Common 92532F100   111,922,512 318,043 SH   SOLE   111,922,512 0 0
VYNE Therapeutics, Inc. Common 92941V308   30,531 7,520 SH   SOLE   30,531 0 0
Welltower Inc. Common 95040Q104   3,355,641 41,484 SH   SOLE   3,355,641 0 0
West Pharmaceutical Services, Inc. Common 955306105   5,750,819 15,036 SH   SOLE   5,750,819 0 0
Xencor, Inc. Common 98401F105   1,415,175 56,675 SH   SOLE   1,415,175 0 0
Xenon Pharmaceuticals Inc. Common 98420N105   2,598,981 67,506 SH   SOLE   2,598,981 0 0
Zentalis Pharmaceuticals, Inc. Common 98943L107   1,132,801 40,156 SH   SOLE   1,132,801 0 0
Zimmer Biomet Holdings, Inc. Common 98956P102   9,807,034 67,356 SH   SOLE   9,807,034 0 0
Zoetis Inc. Class A 98978V103   23,577,960 136,914 SH   SOLE   23,577,960 0 0