SPRUCE BIOSCIENCES, INC. (SPRB) [Rocket]

Ownership

SPRUCE BIOSCIENCES, INC. (SPRB)

Portfolio as of:

Name	Shares	Change	Value	% Port	% OS	Hist	Date
Novo Holdings A/S	6,722,336	0	14,453,022,000	1.12	16.91	Hist	06/30/2023
ARMISTICE CAPITAL, LLC	3,498,000	-430,000	7,520,700,000	0.11	8.80	Hist	06/30/2023
RiverVest Venture Management LLC	2,936,281	788,000	6,313,005,000	7.00	7.39	Hist	06/30/2023
Carlyle Group Inc.	2,896,518	0	6,227,514,000	0.22	7.29	Hist	06/30/2023
Rock Springs Capital Management LP	2,728,125	0	5,865,469,000	0.14	6.86	Hist	06/30/2023
5AM Venture Management, LLC	2,364,000	2,364,000	5,082,600,000	1.27	5.95	Hist	06/30/2023
Omega Fund Management, LLC	2,161,022	0	4,646,197,000	2.60	5.44	Hist	06/30/2023
Aisling Capital Management LP	1,205,511	0	2,591,849,000	1.27	3.03	Hist	06/30/2023
AIGH Capital Management LLC	1,111,000	7,000	2,388,650,000	0.97	2.80	Hist	06/30/2023
Verition Fund Management LLC	1,083,730	121,831	2,330,020,000	0.03	2.73	Hist	06/30/2023
Alyeska Investment Group, L.P.	1,000,000	0	2,150,000,000	0.02	2.52	Hist	06/30/2023
Sands Capital Ventures, LLC	787,007	0	1,692,065,000	0.50	1.98	Hist	06/30/2023
MILLENNIUM MANAGEMENT LLC	577,658	430,162	1,241,965,000	0.00	1.45	Hist	06/30/2023
DAFNA Capital Management LLC	312,000	0	670,800,000	0.18	0.78	Hist	06/30/2023
Worth Venture Partners, LLC	277,624	277,624	596,892,000	0.33	0.70	Hist	06/30/2023
Acuitas Investments, LLC	275,006	275,006	591,263,000	0.34	0.69	Hist	06/30/2023
VANGUARD GROUP INC	261,954	136,975	563,202,000	0.00	0.66	Hist	06/30/2023
BlackRock Inc.	260,979	109,666	561,105,000	0.00	0.66	Hist	06/30/2023
TWO SIGMA ADVISERS, LP	240,000	202,400	516,000,000	0.00	0.60	Hist	06/30/2023
TWO SIGMA INVESTMENTS, LP	228,130	64,965	490,480,000	0.00	0.57	Hist	06/30/2023
GEODE CAPITAL MANAGEMENT, LLC	217,911	157,290	468,508,000	0.00	0.55	Hist	06/30/2023
GOLDMAN SACHS GROUP INC	182,656	163,103	403,670,000	0.00	0.46	Hist	03/31/2023
Bank of New York Mellon Corp	91,455	-622	196,628,000	0.00	0.23	Hist	06/30/2023
BRIDGEWAY CAPITAL MANAGEMENT, LLC	85,000	0	182,750,000	0.00	0.21	Hist	06/30/2023
CITADEL ADVISORS LLC	71,277	-1,676,114	153,246,000	0.00	0.18	Hist	06/30/2023
STATE STREET CORP	58,793	-34,307	126,405,000	0.00	0.15	Hist	06/30/2023
Sofinnova Investments, Inc.	58,029	58,029	124,762,000	0.01	0.15	Hist	06/30/2023
NORTHERN TRUST CORP	57,097	43,356	122,759,000	0.00	0.14	Hist	06/30/2023
Marquette Asset Management, LLC	68,357	4,267	75,015,000	0.02	0.29	Hist	12/31/2022
DIMENSIONAL FUND ADVISORS LP	32,440	-6,728	69,746,000	0.00	0.08	Hist	06/30/2023
JPMORGAN CHASE & CO	23,560	-34,619	50,654,000	0.00	0.06	Hist	06/30/2023
Tower Research Capital LLC (TRC)	2,358	-1,522	5,070,000	0.00	0.01	Hist	06/30/2023
ROYAL BANK OF CANADA	2,531	2,531	5,000,000	0.00	0.01	Hist	06/30/2023
MORGAN STANLEY	2,131	-1,208	4,582,000	0.00	0.01	Hist	06/30/2023
Abingworth LLP	1,792,518	1,792,518	2,474,000	0.85	7.61	Hist	09/30/2022
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