The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
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COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
2SEVENTY BIO INC COMMON STOCK 901384107   5,023,730 496,416 SH   SOLE   496,416 0 0
ACCURAY INC COM 004397105   4,730,525 1,222,358 SH   SOLE   1,222,358 0 0
ACRIVON THERAPEUTICS INC COMMON STOCK 004890109   996,002 76,852 SH   SOLE   76,852 0 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107   324,734 351,064 SH   SOLE   351,064 0 0
ADICET BIO INC COM 007002108   1,936,841 797,054 SH   SOLE   797,054 0 0
ALECTOR INC COM 014442107   3,840,017 638,938 SH   SOLE   638,938 0 0
ARCUS BIOSCIENCES INC COM 03969F109   4,584,312 225,717 SH   SOLE   225,717 0 0
ASCENDIS PHARMA A/S NOTE 2.250% 4/0 04351PAD3   3,627,500 4,000,000 PRN   SOLE   4,000,000 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101   12,067,671 135,212 SH   SOLE   135,212 0 0
ASTRIA THERAPEUTICS INC COM 04635X102   1,063,349 127,653 SH   SOLE   127,653 0 0
ATRICURE INC COM 04963C209   6,196,111 125,529 SH   SOLE   125,529 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100   2,214,338 930,394 SH   SOLE   930,394 0 0
AXOGEN INC COM 05463X106   3,032,100 332,103 SH   SOLE   332,103 0 0
BICYCLE THERAPEUTICS PLC SPONSORED ADS 088786108   3,118,544 122,200 SH   SOLE   122,200 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103   4,005,760 569,000 SH   SOLE   569,000 0 0
BIOHAVEN LTD COM G1110E107   505,023 21,113 SH   SOLE   21,113 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109   15,896,127 251,521 SH   SOLE   251,521 0 0
BRAINSWAY LTD SPONSORED ADS 10501L106   1,150,673 504,681 SH   SOLE   504,681 0 0
CENTURY THERAPEUTICS INC COM 15673T100   4,131,406 1,307,407 SH   SOLE   1,307,407 0 0
COMPASS THERAPEUTICS INC COM 20454B104   371,685 116,882 SH   SOLE   116,882 0 0
COMPUGEN LTD ORD M25722105   233,930 205,202 SH   SOLE   205,202 0 0
CYTOKINETICS INC COM NEW 23282W605   10,853,783 332,734 SH   SOLE   332,734 0 0
DAY ONE BIOPHARMACEUTICALS I COM 23954D109   6,054,774 507,100 SH   SOLE   507,100 0 0
DEXCOM INC COM 252131107   8,681,108 67,552 SH   SOLE   67,552 0 0
DICE THERAPEUTICS INC COM 23345J104   5,927,599 127,585 SH   SOLE   127,585 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105   4,025,226 519,384 SH   SOLE   519,384 0 0
ELEVATION ONCOLOGY INC COM 28623U101   684,000 450,000 SH   SOLE   450,000 0 0
GALAPAGOS NV SPON ADR 36315X101   2,141,766 52,675 SH   SOLE   52,675 0 0
IDEAYA BIOSCIENCES INC COM 45166A102   11,275,770 479,820 SH   SOLE   479,820 0 0
INOGEN INC COM 45780L104   173,250 15,000 SH   SOLE   15,000 0 0
ISHARES NASDAQ BIOTECH INDX ETF 464287556   13,013,400 102,500 SH   SOLE   102,500 0 0
ITEOS THERAPEUTICS INC COM 46565G104   1,304,934 98,560 SH   SOLE   98,560 0 0
IVERIC BIO INC COM 46583P102   24,114,437 612,975 SH   SOLE   612,975 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103   5,499,288 611,032 SH   SOLE   611,032 0 0
KARUNA THERAPEUTICS INC COM 48576A100   9,145,215 42,173 SH   SOLE   42,173 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106   344,894 192,678 SH   SOLE   192,678 0 0
KEROS THERAPEUTICS INC COM 492327101   1,915,019 47,661 SH   SOLE   47,661 0 0
KINNATE BIOPHARMA INC COM 49705R105   242,942 80,179 SH   SOLE   80,179 0 0
KURA ONCOLOGY INC COM 50127T109   3,785,355 357,784 SH   SOLE   357,784 0 0
LARIMAR THERAPEUTICS INC COM 517125100   1,096,667 350,373 SH   SOLE   350,373 0 0
LINEAGE CELL THERAPEUTICS IN COM 53566P109   197,400 140,000 SH   SOLE   140,000 0 0
LYRA THERAPEUTICS INC COM 55234L105   1,484,055 361,084 SH   SOLE   361,084 0 0
MASIMO CORP COM 574795100   493,650 3,000 SH   SOLE   3,000 0 0
MEDICENNA THERAPEUTICS CORP COM 58490H107   317,922 660,000 SH   SOLE   660,000 0 0
MEDIWOUND LTD SHS NEW M68830112   2,746,581 257,653 SH   SOLE   257,653 0 0
MEREO BIOPHARMA GROUP PLC SPON ADS 589492107   1,331,897 1,009,013 SH   SOLE   1,009,013 0 0
MERSANA THERAPEUTICS INC COM 59045L106   2,667,680 810,845 SH   SOLE   810,845 0 0
MERUS N V COM N5749R100   10,133,627 384,870 SH   SOLE   384,870 0 0
MIRATI THERAPEUTICS INC COM 60468T105   3,421,511 94,700 SH   SOLE   94,700 0 0
MORPHIC HOLDING INC COM 61775R105   11,852,863 206,748 SH   SOLE   206,748 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109   7,036,195 74,615 SH   SOLE   74,615 0 0
NEURONETICS INC COM 64131A105   674,492 313,717 SH   SOLE   313,717 0 0
NEVRO CORP COM 64157F103   711,760 28,000 SH   SOLE   28,000 0 0
NEXTCURE INC COM 65343E108   337,853 187,696 SH   SOLE   187,696 0 0
NURIX THERAPEUTICS INC COM 67080M103   5,561,383 556,695 SH   SOLE   556,695 0 0
PARDES BIOSCIENCES INC COM 69945Q105   778,827 430,291 SH   SOLE   430,291 0 0
PROCEPT BIOROBOTICS CORP COM 74276L105   282,800 8,000 SH   SOLE   8,000 0 0
PROQR THERAPEUTICS N V SHS EURO N71542109   1,523,743 940,582 SH   SOLE   940,582 0 0
REGULUS THERAPEUTICS INC COM 75915K309   1,633,242 1,111,049 SH   SOLE   1,111,049 0 0
REVOLUTION MEDICINES INC COM 76155X100   13,703,624 512,285 SH   SOLE   512,285 0 0
SAGE THERAPEUTICS INC COM 78667J108   8,477,988 180,306 SH   SOLE   180,306 0 0
SPDR S&P BIOTECH ETF ETF 78464A870   47,008,000 565,000 SH   SOLE   565,000 0 0
SPERO THERAPEUTICS INC COM 84833T103   181,250 125,000 SH   SOLE   125,000 0 0
SPRUCE BIOSCIENCES INC COM 85209E109   670,800 312,000 SH   SOLE   312,000 0 0
STEREOTAXIS INC COM NEW 85916J409   20,931,248 13,680,554 SH   SOLE   13,680,554 0 0
SURFACE ONCOLOGY INC COM 86877M209   956,560 1,100,000 SH   SOLE   1,100,000 0 0
SUTRO BIOPHARMA INC COM 869367102   1,128,922 242,779 SH   SOLE   242,779 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105   9,436,772 450,873 SH   SOLE   450,873 0 0
SYROS PHARMACEUTICALS INC COM NEW 87184Q206   837,516 265,878 SH   SOLE   265,878 0 0
TANDEM DIABETES CARE INC COM NEW 875372203   2,699,400 110,000 SH   SOLE   110,000 0 0
VIGIL NEUROSCIENCE INC COM 92673K108   1,619,695 172,308 SH   SOLE   172,308 0 0
VIKING THERAPEUTICS INC COM 92686J106   4,760,148 293,655 SH   SOLE   293,655 0 0
XENON PHARMACEUTICALS INC COM 98420N105   10,800,713 280,538 SH   SOLE   280,538 0 0