The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Agenus Inc COM 00847G705   7,854,611 4,909,132 SH   SOLE   4,909,132 0 0
Allakos Inc COM 01671P100   272,347 62,465 SH   SOLE   62,465 0 0
AstraZeneca PLC SPONSORED ADR 046353108   121,491,292 1,697,517 SH   SOLE   1,697,517 0 0
Axsome Therapeutics Inc COM 05464T104   12,880,330 179,242 SH   SOLE   179,242 0 0
Baxter Intl Inc COM 071813109   16,501,832 362,200 SH   SOLE   362,200 0 0
Boston Scientific Corp COM 101137107   32,933,291 608,861 SH   SOLE   608,861 0 0
Celldex Therapeutics Inc COM 15117B202   6,709,929 197,758 SH   SOLE   197,758 0 0
Cytokinetics Inc COM 23282W605   27,506,097 843,228 SH   SOLE   843,228 0 0
Dexcom Inc COM 252131107   47,641,227 370,720 SH   SOLE   370,720 0 0
Dyne Therapeutics Inc COM 26818M108   4,961,790 441,048 SH   SOLE   441,048 0 0
Exelixis Inc COM 30161Q104   48,935,703 2,560,738 SH   SOLE   2,560,738 0 0
FibroGen Inc COM 31572Q808   675,000 250,000 SH Put SOLE   250,000 0 0
FibroGen Inc COM 31572Q808   1,721,431 637,567 SH   SOLE   637,567 0 0
FibroGen Inc COM 31572Q808   405,000 150,000 SH Put SOLE   150,000 0 0
FibroGen Inc COM 31572Q808   675,000 250,000 SH Call SOLE   250,000 0 0
FibroGen Inc COM 31572Q808   675,000 250,000 SH Put SOLE   250,000 0 0
Geron Corp COM 374163103   17,427,588 5,429,155 SH   SOLE   5,429,155 0 0
IDEAYA Biosciences Inc COM 45166A102   15,621,531 664,746 SH   SOLE   664,746 0 0
IDEXX Laboratories Inc COM 45168D104   35,494,603 70,674 SH   SOLE   70,674 0 0
Immatics NV SHS N44445109   35,098,760 3,041,487 SH   SOLE   3,041,487 0 0
ImmunoGen Inc COM 45253H101   15,611,491 827,318 SH   SOLE   827,318 0 0
Inhibrx Inc COM 45720L107   25,915,427 998,283 SH   SOLE   998,283 0 0
Intuitive Surgical Inc COM 46120E602   68,792,173 201,182 SH   SOLE   201,182 0 0
Karuna Therapeutics Inc COM 48576A100   148,109 683 SH   SOLE   683 0 0
Marinus Pharmaceuticals Inc COM 56854Q200   2,172,000 200,000 SH Call SOLE   200,000 0 0
Marinus Pharmaceuticals Inc COM 56854Q200   10,454,042 962,619 SH   SOLE   962,619 0 0
Merck & Co Inc COM 58933Y105   60,853,570 527,373 SH   SOLE   527,373 0 0
Mirum Pharmaceuticals Inc COM 604749101   235,132 9,089 SH   SOLE   9,089 0 0
PTC Therapeutics Inc COM 69366J200   10,592,217 260,443 SH   SOLE   260,443 0 0
Reata Pharmaceuticals Inc CL A 75615P103   32,879,143 322,471 SH   SOLE   322,471 0 0
Replimune Group Inc COM 76029N106   8,101,203 348,889 SH   SOLE   348,889 0 0
Revolution Medicines Inc COM 76155X100   13,920,085 520,377 SH   SOLE   520,377 0 0
Savara Inc COM 805111101   307,512 96,248 SH   SOLE   96,248 0 0
Spruce Biosciences Inc COM 85209E109   124,762 58,029 SH   SOLE   58,029 0 0
Syndax Pharmaceuticals Inc COM 87164F105   33,117,351 1,582,291 SH   SOLE   1,582,291 0 0
Vertex Pharmaceuticals Inc COM 92532F100   51,132,523 145,300 SH   SOLE   145,300 0 0
Vir Biotechnology Inc COM 92764N102   7,359,000 300,000 SH Put SOLE   300,000 0 0
Vir Biotechnology Inc COM 92764N102   11,973,510 488,117 SH   SOLE   488,117 0 0
Zentalis Pharmaceuticals Inc COM 98943L107   23,358,021 828,005 SH   SOLE   828,005 0 0
argenx SE SPONSORED ADR 04016X101   15,558,411 39,921 SH   SOLE   39,921 0 0
Aerovate Therapeutics Inc COM 008064107   64,461,465 3,758,686 SH   SOLE   3,758,686 0 0
Ascendis Pharma A/S SPONSORED ADR 04351P101   67,297,356 754,032 SH   SOLE   754,032 0 0
Bolt Biotherapeutics Inc COM 097702104   3,525,679 2,754,437 SH   SOLE   2,754,437 0 0
Fusion Pharmaceuticals Inc COM 36118A100   546,852 117,099 SH   SOLE   117,099 0 0
Galera Therapeutics Inc COM 36338D108   9,621,181 3,083,712 SH   SOLE   3,083,712 0 0
Inozyme Pharma Inc COM 45790W108   20,360,066 3,655,308 SH   SOLE   3,655,308 0 0
Karuna Therapeutics Inc COM 48576A100   299,354,052 1,380,466 SH   SOLE   1,380,466 0 0
Natera Inc COM 632307104   150,873,250 3,100,560 SH   SOLE   3,100,560 0 0
Nextcure Inc COM 65343E108   4,809,341 2,671,856 SH   SOLE   2,671,856 0 0
Nucana PLC SPONSORED ADR 67022C106   4,423,999 5,599,999 SH   SOLE   5,599,999 0 0
Nucana PLC COMMON SHARES GB00BYWYV   1,896,000 2,400,000 SH   SOLE   2,400,000 0 0
PDS Biotechnology Corp COM 70465T107   717,454 142,635 SH   SOLE   142,635 0 0
Synlogic Inc COM 87166L100   247,238 574,972 SH   SOLE   574,972 0 0
Vera Therapeutics Inc CL A 92337R101   55,647,854 3,467,156 SH   SOLE   3,467,156 0 0
Y-mAbs Therapeutics Inc COM 984241109   14,899,148 2,194,278 SH   SOLE   2,194,278 0 0