| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 08/22/2023 | Collard Craig A | CEO | Payment of Exercise | Common Stock | 692 | $1.65 | $1.1k | | 08/22/2023 |
| 07/17/2023 | Peraza Lisa | VP, Chief Accounting Officer | Grant | Employee Stock Option (Right to Buy) | 150k | $1.32 | $198k | | 07/17/2023 |
| 07/13/2023 | Peraza Lisa | VP, Chief Accounting Officer | Payment of Exercise | Common Stock | 860 | $1.31 | $1.1k | | 07/13/2023 |
| 07/13/2023 | Peraza Lisa | VP, Chief Accounting Officer | Exercise | Restricted Stock Units | 552 | $0.00 | $0 | | 07/13/2023 |
| 07/13/2023 | Peraza Lisa | VP, Chief Accounting Officer | Exercise | Restricted Stock Units | 1.9k | $0.00 | $0 | | 07/13/2023 |
| 07/13/2023 | Szekeres David Leslie | EVP, COO | Payment of Exercise | Common Stock | 2k | $1.31 | $2.6k | | 07/13/2023 |
| 07/13/2023 | Szekeres David Leslie | EVP, COO | Exercise | Restricted Stock Units | 1.2k | $0.00 | $0 | | 07/13/2023 |
| 07/13/2023 | Szekeres David Leslie | EVP, COO | Exercise | Restricted Stock Units | 4.6k | $0.00 | $0 | | 07/13/2023 |
| 05/22/2023 | Collard Craig A | CEO | Payment of Exercise | Common Stock | 691 | $1.45 | $1k | | 05/22/2023 |
| 04/03/2023 | Collard Craig A | CEO | Grant | Employee Stock Option (Right to Buy) | 3M | $1.78 | $5.3M | | 04/03/2023 |
| 04/03/2023 | Collard Craig A | CEO | Grant | Restricted Stock Units | 250k | $0.00 | $0 | | 04/03/2023 |
| 04/03/2023 | Collard Craig A | CEO | Grant | Employee Performance Stock Option (Right to Buy) | 4.2M | $1.78 | $7.6M | | 04/03/2023 |
| 02/22/2023 | Morgan Adam | Director | Grant | Common Stock | 37.9k | $0.00 | $0 | | 02/22/2023 |
| 02/22/2023 | Morgan Adam | Director | Grant | Stock Option (Right to Buy) | 227.3k | $2.70 | $613.6k | | 02/22/2023 |
| 01/18/2023 | Quart Barry D | CEO | Grant | Employee Stock Option (Right to Buy) | 850k | $3.13 | $2.7M | | 01/18/2023 |
| 01/18/2023 | MANHARD KIMBERLY | EVP, Drug Development | Grant | Performance Stock Units | 149.4k | $0.00 | $0 | | 01/18/2023 |
| 01/18/2023 | POYHONEN JOHN | President & CCO | Grant | Performance Stock Units | 66.4k | $0.00 | $0 | | 01/18/2023 |
| 01/18/2023 | Peraza Lisa | VP, Chief Accounting Officer | Grant | Performance Stock Units | 42.6k | $0.00 | $0 | | 01/18/2023 |
| 01/18/2023 | Szekeres David Leslie | EVP, COO | Grant | Performance Stock Units | 49.8k | $0.00 | $0 | | 01/18/2023 |
| 12/16/2022 | Dissanaike Sharmila | Director | Grant | Common Stock | 38.6k | $0.00 | $0 | | 12/16/2022 |
| 12/16/2022 | Dissanaike Sharmila | Director | Grant | Stock Option (Right to Buy) | 77.2k | $2.74 | $211.4k | | 12/16/2022 |
| 12/16/2022 | Rodriguez Susan | Director | Grant | Common Stock | 38.6k | $0.00 | $0 | | 12/16/2022 |
| 12/16/2022 | Rodriguez Susan | Director | Grant | Stock Option (Right to Buy) | 77.2k | $2.74 | $211.4k | | 12/16/2022 |
| 12/16/2022 | Christian Waage | Director | Grant | Common Stock | 38.6k | $0.00 | $0 | | 12/16/2022 |
| 12/16/2022 | Christian Waage | Director | Grant | Stock Option (Right to Buy) | 77.2k | $2.74 | $211.4k | | 12/16/2022 |
| 12/16/2022 | Johnson Craig A | Director | Grant | Common Stock | 38.6k | $0.00 | $0 | | 12/16/2022 |
| 12/16/2022 | Johnson Craig A | Director | Grant | Stock Option (Right to Buy) | 77.2k | $2.74 | $211.4k | | 12/16/2022 |
| 12/16/2022 | DAVIS STEPHEN | Director | Grant | Common Stock | 38.6k | $0.00 | $0 | | 12/16/2022 |
| 12/16/2022 | DAVIS STEPHEN | Director | Grant | Stock Option (Right to Buy) | 77.2k | $2.74 | $211.4k | | 12/16/2022 |
| 10/13/2022 | Szekeres David Leslie | EVP, COO | Exercise | Restricted Stock Units | 1.2k | $0.00 | $0 | | 10/13/2022 |
| 10/13/2022 | Szekeres David Leslie | EVP, COO | Exercise | Restricted Stock Units | 4.6k | $0.00 | $0 | | 10/13/2022 |
| 10/13/2022 | Peraza Lisa | VP, Chief Accounting Officer | Payment of Exercise | Common Stock | 861 | $3.76 | $3.2k | | 10/13/2022 |
| 10/13/2022 | Peraza Lisa | VP, Chief Accounting Officer | Exercise | Restricted Stock Units | 553 | $0.00 | $0 | | 10/13/2022 |
| 10/13/2022 | Peraza Lisa | VP, Chief Accounting Officer | Exercise | Restricted Stock Units | 1.9k | $0.00 | $0 | | 10/13/2022 |
| 10/13/2022 | Quart Barry D | CEO | Payment of Exercise | Common Stock | 5.2k | $3.76 | $19.6k | | 10/13/2022 |
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