| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 07/17/2023 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Grant | Employee Stock Option (Right to Buy) | 150k | $1.32 | $198k | | 07/17/2023 |
| 07/13/2023 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Payment of Exercise | Common Stock | 860 | $1.31 | $1.1k | | 07/13/2023 |
| 07/13/2023 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Exercise | Restricted Stock Units | 552 | $0.00 | $0 | | 07/13/2023 |
| 07/13/2023 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Exercise | Restricted Stock Units | 1.9k | $0.00 | $0 | | 07/13/2023 |
| 01/18/2023 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Grant | Performance Stock Units | 42.6k | $0.00 | $0 | | 01/18/2023 |
| 10/13/2022 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Payment of Exercise | Common Stock | 861 | $3.76 | $3.2k | | 10/13/2022 |
| 10/13/2022 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Exercise | Restricted Stock Units | 553 | $0.00 | $0 | | 10/13/2022 |
| 10/13/2022 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Exercise | Restricted Stock Units | 1.9k | $0.00 | $0 | | 10/13/2022 |
| 07/25/2022 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Grant | Employee Stock Option (Right to Buy) | 60.9k | $3.17 | $193.1k | | 07/25/2022 |
| 07/13/2022 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Payment of Exercise | Common Stock | 860 | $3.01 | $2.6k | | 07/13/2022 |
| 07/13/2022 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Exercise | Restricted Stock Units | 552 | $0.00 | $0 | | 07/13/2022 |
| 07/13/2022 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Exercise | Restricted Stock Units | 1.9k | $0.00 | $0 | | 07/13/2022 |
| 04/13/2022 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Payment of Exercise | Common Stock | 860 | $6.07 | $5.2k | | 04/13/2022 |
| 04/13/2022 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Exercise | Restricted Stock Units | 552 | $0.00 | $0 | | 04/13/2022 |
| 04/13/2022 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Exercise | Restricted Stock Units | 1.9k | $0.00 | $0 | | 04/13/2022 |
| 01/13/2022 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Payment of Exercise | Common Stock | 966 | $8.30 | $8k | | 01/13/2022 |
| 01/13/2022 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Exercise | Restricted Stock Units | 552 | $0.00 | $0 | | 01/13/2022 |
| 01/13/2022 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Exercise | Restricted Stock Units | 1.9k | $0.00 | $0 | | 01/13/2022 |
| 10/13/2021 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Payment of Exercise | Common Stock | 191 | $10.55 | $2k | | 10/13/2021 |
| 10/13/2021 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Exercise | Restricted Stock Units | 552 | $0.00 | $0 | | 10/13/2021 |
| 10/13/2021 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Grant | Employee Stock Option (Right to Buy) | 13k | $10.55 | $137.3k | | 10/13/2021 |
| 10/13/2021 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Grant | Restricted Stock Units | 23.4k | $0.00 | $0 | | 10/13/2021 |
| 07/13/2021 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Payment of Exercise | Common Stock | 191 | $13.48 | $2.6k | | 07/13/2021 |
| 07/13/2021 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Exercise | Restricted Stock Units | 552 | $0.00 | $0 | | 07/13/2021 |
| 04/30/2021 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Other (acquisition) | Common Stock | 1.5k | $13.90 | $21.3k | | 07/13/2021 |
| 04/13/2021 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Payment of Exercise | Common Stock | 191 | $16.66 | $3.2k | | 04/13/2021 |
| 04/13/2021 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Exercise | Restricted Stock Units | 552 | $0.00 | $0 | | 04/13/2021 |
| 01/13/2021 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Payment of Exercise | Common Stock | 227 | $18.16 | $4.1k | | 01/13/2021 |
| 01/13/2021 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Exercise | Restricted Stock Units | 552 | $0.00 | $0 | | 01/13/2021 |
| 10/13/2020 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Grant | Employee Stock Option (Right to Buy) | 103k | $15.72 | $1.6M | | 10/13/2020 |
| 10/13/2020 | HERON THERAPEUTICS, INC. /DE/ | HRTX | Grant | Restricted Stock Units | 8.8k | $0.00 | $0 | | 10/13/2020 |