IONIS PHARMACEUTICALS INC (IONS) [Rocket]

Ownership

IONIS PHARMACEUTICALS INC (IONS)

Portfolio as of:

Name	Shares	Change	Value	% Port	% OS	Hist	Date
FMR LLC	21,463,816	27,482	880,660,371,000	0.07	15.01	Hist	06/30/2023
VANGUARD GROUP INC	14,523,266	1,717,243	595,889,604,000	0.01	10.16	Hist	06/30/2023
Bellevue Group AG	9,380,300	-131,600	384,873,709,000	5.49	6.56	Hist	06/30/2023
BlackRock Inc.	9,136,174	153,928	374,857,219,000	0.01	6.39	Hist	06/30/2023
Clearbridge Investments, LLC	5,187,204	-204,377	212,830,961,000	0.19	3.63	Hist	06/30/2023
STATE STREET CORP	3,974,453	-244,276	163,071,807,000	0.01	2.78	Hist	06/30/2023
PICTET ASSET MANAGEMENT SA	3,095,670	1,982,628	127,015,340,000	0.15	2.17	Hist	06/30/2023
BVF INC/IL	2,846,015	1,724,206	116,771,995,000	3.25	1.99	Hist	06/30/2023
Deep Track Capital, LP	2,834,069	1,628,296	116,281,851,000	5.38	1.98	Hist	06/30/2023
ARK Investment Management LLC	2,422,631	-250,907	99,400,562,000	0.66	1.69	Hist	06/30/2023
ORBIMED ADVISORS LLC	2,169,500	45,000	89,014,585,000	1.61	1.52	Hist	06/30/2023
GEODE CAPITAL MANAGEMENT, LLC	2,156,868	86,918	88,496,334,000	0.01	1.51	Hist	06/30/2023
MACQUARIE GROUP LTD	1,498,882	4,979	61,499,000,000	0.07	1.05	Hist	06/30/2023
FIRST TRUST ADVISORS LP	1,323,032	-315,911	54,284,002,000	0.06	0.93	Hist	06/30/2023
MORGAN STANLEY	1,128,888	192,179	46,318,275,000	0.00	0.79	Hist	06/30/2023
JPMORGAN CHASE & CO	1,067,723	10,328	43,808,674,000	0.00	0.75	Hist	06/30/2023
Woodline Partners LP	1,041,932	1,041,932	42,750,470,000	0.51	0.73	Hist	06/30/2023
WELLINGTON MANAGEMENT GROUP LLP	914,723	914,723	37,531,085,000	0.01	0.64	Hist	06/30/2023
Capital World Investors	839,463	839,463	34,443,167,000	0.01	0.59	Hist	06/30/2023
TD ASSET MANAGEMENT INC	785,208	-32,100	32,217,084,000	0.04	0.55	Hist	06/30/2023
CITADEL ADVISORS LLC	721,778	326,232	29,614,551,000	0.01	0.50	Hist	06/30/2023
NORTHERN TRUST CORP	671,078	12,612	27,534,330,000	0.01	0.47	Hist	06/30/2023
WELLS FARGO & COMPANY/MN	612,891	-13,259	25,146,917,000	0.01	0.43	Hist	06/30/2023
ROYAL BANK OF CANADA	577,138	70,293	23,680,000,000	0.01	0.40	Hist	06/30/2023
Bank of New York Mellon Corp	557,754	-8,341	22,884,647,000	0.00	0.39	Hist	06/30/2023
JACOBS LEVY EQUITY MANAGEMENT, INC	549,558	-140,163	22,548,365,000	0.13	0.38	Hist	06/30/2023
AXA S.A.	525,164	4,296	21,547,479,000	0.07	0.37	Hist	06/30/2023
Candriam S.C.A.	524,067	78,870	21,502,469,000	0.16	0.37	Hist	06/30/2023
BANK OF AMERICA CORP /DE/	459,319	-173,325	18,845,858,000	0.00	0.32	Hist	06/30/2023
PINNACLE ASSOCIATES LTD	494,750	-6,140	18,686,707,000			Hist	12/31/2022
NOMURA HOLDINGS INC	435,380	34,057	17,863,641,000	0.05	0.30	Hist	06/30/2023
MILLENNIUM MANAGEMENT LLC	418,913	303,407	17,188,000,000	0.01	0.29	Hist	06/30/2023
GOLDMAN SACHS GROUP INC	422,098	-868,467	15,085,783,000	0.00	0.30	Hist	03/31/2023
ALLIANCEBERNSTEIN L.P.	346,538	297,938	14,218,454,000	0.01	0.24	Hist	06/30/2023
TWO SIGMA ADVISERS, LP	344,211	-1,600	14,122,977,000	0.04	0.24	Hist	06/30/2023
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