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LAZARD ASSET MANAGEMENT LLC
> VRTX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 12/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 142,441 | -481,400 | 41,133,000 | -139,492,000 | $288.77 |
| 09/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 623,841 | -240,065 | 180,625,000 | -62,813,000 | $289.54 |
| 06/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 863,906 | -33,936 | 243,438,000 | 9,130,000 | $281.79 |
| 03/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 897,842 | -17,878 | 234,308,000 | 33,218,000 | $260.97 |
| 12/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 915,720 | 749,784 | 201,090,000 | 170,992,000 | $219.60 |
| 09/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 165,936 | 24,195 | 30,098,000 | 1,521,000 | $181.38 |
| 06/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 141,741 | 25,856 | 28,577,000 | 3,675,000 | $201.61 |
| 03/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 115,885 | -16,224 | 24,902,000 | -6,319,000 | $214.89 |
| 12/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 132,109 | -74,073 | 31,221,000 | -24,884,000 | $236.33 |
| 09/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 206,182 | 5,959 | 56,105,000 | -2,020,000 | $272.11 |
| 06/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 200,223 | 141,600 | 58,125,000 | 44,177,000 | $290.30 |
| 03/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 58,623 | 3,264 | 13,948,000 | 1,828,000 | $237.93 |
| 12/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 55,359 | 1,027 | 12,120,000 | 2,916,000 | $218.93 |
| 09/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 54,332 | -24,198 | 9,204,000 | -5,196,000 | $169.40 |
| 06/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 78,530 | -7,697 | 14,400,000 | -1,461,000 | $183.37 |
| 03/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 86,227 | 53,177 | 15,861,000 | 10,385,000 | $183.94 |
| 12/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 33,050 | -5,937 | 5,476,000 | -2,038,000 | $165.69 |
| 09/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 38,987 | 7,252 | 7,514,000 | 2,121,000 | $192.73 |
| 06/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 31,735 | -127,772 | 5,393,000 | -20,603,000 | $169.94 |
| 03/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 159,507 | -14,479 | 25,996,000 | -77,000 | $162.98 |
| 12/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 173,986 | 564 | 26,073,000 | -294,000 | $149.86 |
| 09/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 173,422 | -27,745 | 26,367,000 | 443,000 | $152.04 |
| 06/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 201,167 | -254,906 | 25,924,000 | -23,947,000 | $128.87 |
| 03/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 456,073 | -269,331 | 49,871,000 | -3,569,000 | $109.35 |
| 12/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 725,404 | -456,023 | 53,440,000 | -49,590,000 | $73.67 |
| 09/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,197,473 | -68,285 | 104,429,000 | -4,450,000 | $87.21 |
| 06/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,265,758 | 283,415 | 108,879,000 | 30,794,000 | $86.02 |
| 03/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 982,343 | 196,933 | 78,085,000 | -20,741,000 | $79.49 |
| 12/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 785,410 | -462,435 | 98,826,000 | -31,123,000 | $125.83 |
| 09/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,247,845 | -683,511 | 129,949,000 | -108,533,000 | $104.14 |
| 06/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,931,356 | -154,185 | 238,482,000 | -7,547,000 | $123.48 |
| 03/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,085,541 | -88,466 | 246,029,000 | -12,242,000 | $117.97 |
| 12/31/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,334,959 | -189,573 | 277,391,000 | -6,138,000 | $118.80 |
| 09/30/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,524,532 | 2,524,532 | 283,529,000 | 283,529,000 | $112.31 |
| 06/30/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,627,189 | 2,627,189 | 248,740,000 | 248,740,000 | $94.68 |
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