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JENNISON ASSOCIATES LLC
> VRTX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,805,641 | -950,180 | 1,339,243,129,000 | 1,337,866,129,000 | $351,910.00 |
| 09/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,755,821 | 2,983,253 | 1,377,000,000 | 877,508,000 | $289.54 |
| 06/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,772,568 | 1,422,478 | 499,492,000 | 408,129,000 | $281.79 |
| 03/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 350,090 | -433,299 | 91,363,000 | -80,669,000 | $260.97 |
| 12/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 783,389 | -45,970 | 172,032,000 | 21,595,000 | $219.60 |
| 09/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 829,359 | 113,570 | 150,437,000 | -3,379,000 | $181.39 |
| 03/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 715,789 | -3,033,565 | 153,816,000 | -732,306,000 | $214.89 |
| 12/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,749,354 | 140,270 | 886,122,000 | -95,982,000 | $236.34 |
| 09/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,609,084 | -809,397 | 982,104,000 | -300,625,000 | $272.12 |
| 06/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,418,481 | 56,726 | 1,282,729,000 | 244,849,000 | $290.31 |
| 03/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,361,755 | 790,506 | 1,037,880,000 | 255,955,000 | $237.95 |
| 12/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,571,249 | -2,406,492 | 781,925,000 | -230,824,000 | $218.95 |
| 09/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 5,977,741 | -366,718 | 1,012,749,000 | -150,698,000 | $169.42 |
| 06/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 6,344,459 | -455,977 | 1,163,447,000 | -87,493,000 | $183.38 |
| 03/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 6,800,436 | -141,185 | 1,250,940,000 | 100,644,000 | $183.95 |
| 12/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 6,941,621 | 739,128 | 1,150,296,000 | -45,172,000 | $165.71 |
| 09/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 6,202,493 | 1,139,486 | 1,195,468,000 | 334,959,000 | $192.74 |
| 06/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 5,063,007 | -1,712,321 | 860,509,000 | -243,734,000 | $169.96 |
| 03/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 6,775,328 | 1,237,421 | 1,104,243,000 | 274,332,000 | $162.98 |
| 12/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 5,537,907 | -479,859 | 829,911,000 | -85,030,000 | $149.86 |
| 09/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 6,017,766 | 962,644 | 914,941,000 | 263,487,000 | $152.04 |
| 06/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 5,055,122 | 3,627,593 | 651,454,000 | 495,354,000 | $128.87 |
| 03/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,428,754 | 125,744 | 156,234 | 60,241 | $0.11 |
| 12/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,303,010 | -3,877,751 | 95,993 | -451,718,007 | $0.07 |
| 09/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 5,180,761 | 2,846,054 | 451,814,000 | 208,678,000 | $87.21 |
| 06/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,974,800 | 1,920,658 | 255,892,000 | 172,098,000 | $86.02 |
| 03/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,054,142 | -1,280,565 | 83,794,000 | -159,342,000 | $79.49 |
| 12/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,083,792 | -250,915 | 262,204,000 | 19,068,000 | $125.83 |
| 09/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,334,707 | -2,770,547 | 243,136,000 | -387,261,000 | $104.14 |
| 06/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 5,105,254 | -1,443,237 | 630,397,000 | -142,128,000 | $123.48 |
| 03/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 6,548,491 | -157,255 | 772,525,000 | -24,118,000 | $117.97 |
| 12/31/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 6,705,746 | -3,743,006 | 796,643,000 | -376,856,000 | $118.80 |
| 09/30/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 10,448,752 | -1,416,257 | 1,173,499,000 | 50,120,000 | $112.31 |
| 06/30/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 11,865,009 | -739,038 | 1,123,379,000 | 232,021,000 | $94.68 |
| 03/31/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 12,604,047 | -870,831 | 891,358,000 | -109,825,000 | $70.72 |
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