The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10X GENOMICS INC CL A COM 88025U109 62,957 444,609 SH   DFND 1 443,454 0 1,155
3M CO COM 88579Y101 1,527 8,734 SH   DFND 1 8,734 0 0
908 DEVICES INC COM 65443P102 2,848 50,000 SH   DFND 1 50,000 0 0
ABBOTT LABS COM 002824100 62,565 571,425 SH   DFND 1 569,863 0 1,562
ABBVIE INC COM 00287Y109 71,176 664,265 SH   DFND 1 660,812 0 3,453
ABCAM PLC ADS 000380204 6,563 304,563 SH   DFND 1 303,670 0 893
ABCELLERA BIOLOGICS INC COM 00288U106 706 17,541 SH   DFND 1 17,541 0 0
ACADIA HEALTHCARE COMPANY IN COM 00404A109 50,535 1,005,467 SH   DFND 1 1,005,467 0 0
ACADIA HEALTHCARE COMPANY IN COM 00404A109 8,629 171,693 SH   OTR 2 171,693 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 31,037 580,567 SH   DFND 1 580,567 0 0
ACCENTURE PLC IRELAND SHS CLASS A G1151C101 3,138 12,012 SH   DFND 1 12,012 0 0
ACCOLADE INC COM 00437E102 24,162 555,446 SH   DFND 1 555,446 0 0
ACCOLADE INC COM 00437E102 3,842 88,330 SH   OTR 2 88,330 0 0
ADECOAGRO S A COM L00849106 14,418 2,120,408 SH   DFND 1 2,120,408 0 0
ADECOAGRO S A COM L00849106 2,912 428,192 SH   OTR 2 428,192 0 0
ADOBE SYSTEMS INCORPORATED COM 00724F101 3,489,880 6,978,085 SH   DFND 1 6,733,652 0 244,433
ADOBE SYSTEMS INCORPORATED COM 00724F101 55,991 111,956 SH   OTR 2 111,956 0 0
ADVANCE AUTO PARTS INC COM 00751Y106 41,279 262,073 SH   DFND 1 262,073 0 0
ADVANCED DRAIN SYS INC DEL COM 00790R104 1,280 15,318 SH   DFND 1 15,318 0 0
ADVANCED MICRO DEVICES INC COM 007903107 633 6,901 SH   DFND 1 6,809 0 92
AES CORP COM 00130H105 78,701 3,348,983 SH   DFND 1 3,348,983 0 0
AGILENT TECHNOLOGIES INC COM 00846U101 53,759 453,702 SH   DFND 1 451,513 0 2,189
AGNICO EAGLE MINES LTD COM 008474108 35,098 497,771 SH   DFND 1 497,679 0 92
AIRBNB INC COM CL A 009066101 73,787 502,634 SH   DFND 1 475,211 0 27,423
AIRBNB INC COM CL A 009066101 1,888 12,864 SH   OTR 2 12,864 0 0
ALCON AG ORD SHS H01301128 55,440 836,029 SH   DFND 1 835,877 0 152
ALCON AG ORD SHS H01301128 732 11,001 SH   OTR 2 11,001 0 0
ALEXANDRIA REAL ESTATE EQ IN COM 015271109 18,207 102,159 SH   DFND 1 102,159 0 0
ALEXION PHARMACEUTICALS INC CALL OPTIONS 015351109 15,624 100,000 SH Call DFND 1 0 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 3,371 21,575 SH   DFND 1 21,575 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 3,362 14,447 SH   DFND 1 3,183 0 11,264
ALIGN TECHNOLOGY INC COM 016255101 68,742 128,639 SH   DFND 1 127,980 0 659
ALLEGHANY CORP DEL COM 017175100 13,547 22,441 SH   DFND 1 22,441 0 0
ALLIANT ENERGY CORP COM 018802108 98,631 1,914,054 SH   DFND 1 1,914,054 0 0
ALPHABET INC CAP STK CL A 02079K305 2,148,891 1,226,088 SH   DFND 1 1,181,053 0 45,035
ALPHABET INC CAP STK CL A 02079K305 22,360 12,758 SH   OTR 2 12,758 0 0
ALPHABET INC CAP STK CL C 02079K107 2,039,004 1,163,895 SH   DFND 1 1,107,321 0 56,574
ALPHABET INC CAP STK CL C 02079K107 22,263 12,708 SH   OTR 2 12,708 0 0
ALTRIA GROUP INC COM 02209S103 712 17,363 SH   DFND 1 17,363 0 0
AMAZON COM INC COM 023135106 9,297,793 2,854,772 SH   DFND 1 2,749,888 0 104,884
AMAZON COM INC COM 023135106 183,212 56,253 SH   OTR 2 56,253 0 0
AMEREN CORP COM 023608102 186,798 2,393,009 SH   DFND 1 2,393,009 0 0
AMERICAN CAMPUS CMNTYS INC COM 024835100 63,596 1,486,936 SH   DFND 1 1,486,936 0 0
AMERICAN ELEC PWR CO INC COM 025537101 198,694 2,386,138 SH   DFND 1 2,386,138 0 0
AMERICAN ELEC PWR CO INC UNIT 08/01/2021 025537127 7,623 152,152 SH   DFND 1 152,152 0 0
AMERICAN EXPRESS CO COM 025816109 656 5,422 SH   DFND 1 5,422 0 0
AMERICAN TOWER CORP NEW COM 03027X100 156,610 697,720 SH   DFND 1 577,629 0 120,091
AMERICAN WTR WKS CO INC NEW COM 030420103 84,739 552,152 SH   DFND 1 552,152 0 0
AMERIS BANCORP COM 03076K108 28,051 736,815 SH   DFND 1 736,815 0 0
AMERIS BANCORP COM 03076K108 5,414 142,218 SH   OTR 2 142,218 0 0
AMETEK INC COM 031100100 28,717 237,445 SH   DFND 1 236,174 0 1,271
AMICUS THERAPEUTICS INC COM 03152W109 100,356 4,346,301 SH   DFND 1 4,346,301 0 0
AMICUS THERAPEUTICS INC COM 03152W109 8,227 356,282 SH   OTR 2 356,282 0 0
AMICUS THERAPEUTICS INC PUT OPTIONS 03152W109 5,542 240,000 SH Put DFND 1 240,000 0 0
AMKOR TECHNOLOGY INC COM 031652100 2,231 147,913 SH   DFND 1 147,913 0 0
AMN HEALTHCARE SVCS INC COM 001744101 1,121 16,422 SH   DFND 1 16,422 0 0
AMPHENOL CORP NEW CL A 032095101 60,840 465,246 SH   DFND 1 463,110 0 2,136
ANTHEM INC COM 036752103 47,843 149,002 SH   DFND 1 149,002 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 151,987 2,657,125 SH   DFND 1 2,657,125 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 6,595 115,295 SH   OTR 2 115,295 0 0
APOLLO GLOBAL MGMT INC COM CL A 03768E105 31,049 633,905 SH   DFND 1 630,824 0 3,081
APPLE INC COM 037833100 8,708,730 65,632,155 SH   DFND 1 63,487,570 0 2,144,585
APPLE INC COM 037833100 165,707 1,248,826 SH   OTR 2 1,248,826 0 0
APTIV PLC SHS G6095L109 46,962 360,445 SH   DFND 1 358,877 0 1,568
ARBOR REALTY TRUST INC COM 038923108 1,421 100,234 SH   DFND 1 100,234 0 0
ARCTURUS THERAPEUTICS HLDGS COM 03969T109 961 22,143 SH   DFND 1 22,143 0 0
ARCTURUS THERAPEUTICS HLDGS PUT OPTIONS 03969T109 954 22,000 SH Put DFND 1 22,000 0 0
ARES MANAGEMENT CORPORATION CL A COM STK 03990B101 41,361 879,087 SH   DFND 1 876,123 0 2,964
ARGENX SE SPONSORED ADR 04016X101 122,820 417,627 SH   DFND 1 416,990 0 637
ARTISAN PARTNERS ASSET MGMT CL A 04316A108 2,385 47,382 SH   DFND 1 47,382 0 0
ARVINAS INC COM 04335A105 7,389 87,000 SH   DFND 1 87,000 0 0
ASBURY AUTOMOTIVE GROUP INC COM 043436104 1,150 7,894 SH   DFND 1 7,894 0 0
ASML HOLDING N V N Y REGISTRY SHS N07059210 8,039 16,483 SH   DFND 1 16,450 0 33
ASSETMARK FINL HLDGS INC COM 04546L106 12,855 531,189 SH   DFND 1 531,189 0 0
ASSETMARK FINL HLDGS INC COM 04546L106 2,406 99,439 SH   OTR 2 99,439 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 496,164 9,925,270 SH   DFND 1 9,451,923 0 473,347
ATKORE INTL GROUP INC COM 047649108 1,142 27,768 SH   DFND 1 27,768 0 0
ATLANTIC UN BANKSHARES CORP COM 04911A107 19,974 606,370 SH   DFND 1 606,370 0 0
ATLANTIC UN BANKSHARES CORP COM 04911A107 3,429 104,109 SH   OTR 2 104,109 0 0
ATLASSIAN CORP PLC CL A G06242104 1,438,120 6,149,225 SH   DFND 1 5,963,757 0 185,468
ATLASSIAN CORP PLC CL A G06242104 31,495 134,670 SH   OTR 2 134,670 0 0
AVALARA INC COM 05338G106 51,947 315,042 SH   DFND 1 313,498 0 1,544
AVANGRID INC COM 05351W103 45,401 998,916 SH   DFND 1 998,916 0 0
AVANTOR INC COM 05352A100 34,254 1,216,824 SH   DFND 1 1,216,824 0 0
AVERY DENNISON CORP COM 053611109 2,434 15,695 SH   DFND 1 15,695 0 0
AVIENT CORPORATION COM 05368V106 61,964 1,538,324 SH   DFND 1 1,538,324 0 0
AVIENT CORPORATION COM 05368V106 9,877 245,219 SH   OTR 2 245,219 0 0
AXCELIS TECHNOLOGIES INC COM NEW 054540208 1,410 48,435 SH   DFND 1 48,435 0 0
AXIS CAP HLDGS LTD SHS G0692U109 29,359 582,651 SH   DFND 1 582,651 0 0
AXIS CAP HLDGS LTD SHS G0692U109 3,640 72,228 SH   OTR 2 72,228 0 0
AXOS FINANCIAL INC COM 05465C100 2,310 61,560 SH   DFND 1 61,560 0 0
AZEK CO INC CL A 05478C105 52,419 1,363,302 SH   DFND 1 1,358,255 0 5,047
AZEK CO INC CL A 05478C105 2,121 55,163 SH   OTR 2 55,163 0 0
BANDWIDTH INC COM CL A 05988J103 57,433 373,742 SH   DFND 1 373,742 0 0
BANDWIDTH INC COM CL A 05988J103 13,642 88,777 SH   OTR 2 88,777 0 0
BANKUNITED INC COM 06652K103 54,792 1,575,386 SH   DFND 1 1,575,386 0 0
BANKUNITED INC COM 06652K103 8,973 257,989 SH   OTR 2 257,989 0 0
BARRICK GOLD CORP COM 067901108 9,927 435,783 SH   DFND 1 435,614 0 169
BEAZER HOMES USA INC COM NEW 07556Q881 798 52,690 SH   DFND 1 52,690 0 0
BECTON DICKINSON & CO CALL OPTIONS 075887109 10,009 40,000 SH Call DFND 1 0 0 0
BECTON DICKINSON & CO COM 075887109 44,221 176,728 SH   DFND 1 176,728 0 0
BEIGENE LTD SPONSORED ADR 07725L102 1,910 7,391 SH   DFND 1 7,391 0 0
BERKELEY LTS INC COM 084310101 3,758 42,032 SH   DFND 1 42,032 0 0
BEST BUY INC COM 086516101 1,522 15,256 SH   DFND 1 15,256 0 0
BHP GROUP LTD SPONSORED ADS 088606108 18,519 283,420 SH   DFND 1 283,307 0 113
BILIBILI INC SPONS ADS REP Z 090040106 8,454 98,619 SH   DFND 1 98,619 0 0
BIO RAD LABS INC CL A 090572207 8,676 14,883 SH   DFND 1 14,842 0 41
BIOGEN INC CALL OPTIONS 09062X103 4,897 20,000 SH Call DFND 1 0 0 0
BIOGEN INC COM 09062X103 8,265 33,756 SH   DFND 1 33,756 0 0
BIOLIFE SOLUTIONS INC COM NEW 09062W204 14,883 373,096 SH   DFND 1 373,096 0 0
BIOLIFE SOLUTIONS INC COM NEW 09062W204 3,051 76,478 SH   OTR 2 76,478 0 0
BIOMARIN PHARMACEUTICAL INC CALL OPTIONS 09061G101 4,385 50,000 SH Call DFND 1 0 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 39,811 453,994 SH   DFND 1 453,994 0 0
BJS WHSL CLUB HLDGS INC COM 05550J101 45,382 1,217,337 SH   DFND 1 1,217,337 0 0
BJS WHSL CLUB HLDGS INC COM 05550J101 7,206 193,285 SH   OTR 2 193,285 0 0
BK OF AMERICA CORP COM 060505104 138,728 4,576,966 SH   DFND 1 4,562,077 0 14,889
BLACK DIAMOND THERAPEUTICS I COM 09203E105 11,680 364,416 SH   DFND 1 364,416 0 0
BLACKLINE INC COM 09239B109 11,393 85,413 SH   DFND 1 85,413 0 0
BLACKLINE INC COM 09239B109 3,144 23,574 SH   OTR 2 23,574 0 0
BLACKSTONE GROUP INC COM CL A 09260D107 42,260 652,056 SH   DFND 1 652,056 0 0
BLOCK H & R INC COM 093671105 3,155 198,946 SH   DFND 1 198,946 0 0
BLOOMIN BRANDS INC COM 094235108 15,647 805,727 SH   DFND 1 805,727 0 0
BLOOMIN BRANDS INC COM 094235108 3,276 168,677 SH   OTR 2 168,677 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 2,393 21,341 SH   DFND 1 21,341 0 0
BOISE CASCADE CO DEL COM 09739D100 1,631 34,119 SH   DFND 1 34,119 0 0
BOOT BARN HLDGS INC COM 099406100 20,435 471,293 SH   DFND 1 471,293 0 0
BOOT BARN HLDGS INC COM 099406100 4,554 105,025 SH   OTR 2 105,025 0 0
BOSTON BEER INC CL A 100557107 3,643 3,664 SH   DFND 1 3,664 0 0
BOSTON SCIENTIFIC CORP COM 101137107 66,441 1,848,151 SH   DFND 1 1,848,151 0 0
BRIGHTSPHERE INVT GROUP INC COM 10948W103 64,064 3,322,829 SH   DFND 1 3,322,829 0 0
BRIGHTSPHERE INVT GROUP INC COM 10948W103 9,040 468,872 SH   OTR 2 468,872 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 114,014 1,838,039 SH   DFND 1 1,838,039 0 0
BROADCOM INC COM 11135F101 125,245 286,045 SH   DFND 1 285,254 0 791
BROOKDALE SR LIVING INC COM 112463104 2,115 477,358 SH   DFND 1 477,358 0 0
BROOKFIELD RENEWABLE CORP CL A SUB VTG 11284V105 3,514 60,305 SH   DFND 1 60,305 0 0
BROOKLINE BANCORP INC DEL COM 11373M107 11,658 968,250 SH   DFND 1 968,250 0 0
BROOKLINE BANCORP INC DEL COM 11373M107 3,983 330,815 SH   OTR 2 330,815 0 0
BROOKS AUTOMATION INC NEW COM 114340102 56,955 839,423 SH   DFND 1 839,423 0 0
BROOKS AUTOMATION INC NEW COM 114340102 10,120 149,156 SH   OTR 2 149,156 0 0
BRUNSWICK CORP COM 117043109 73,928 969,676 SH   DFND 1 969,676 0 0
BRUNSWICK CORP COM 117043109 11,574 151,808 SH   OTR 2 151,808 0 0
BUCKLE INC COM 118440106 1,499 51,335 SH   DFND 1 51,335 0 0
BUNGE LIMITED COM G16962105 4,924 75,079 SH   DFND 1 75,053 0 26
BURLINGTON STORES INC COM 122017106 72,961 278,955 SH   DFND 1 278,031 0 924
BURNING ROCK BIOTECH LTD SPONSORED ADS 12233L107 42,130 1,823,823 SH   DFND 1 1,823,823 0 0
BYLINE BANCORP INC COM 124411109 10,858 702,746 SH   DFND 1 702,746 0 0
BYLINE BANCORP INC COM 124411109 3,164 204,795 SH   OTR 2 204,795 0 0
C4 THERAPEUTICS INC COM STK 12529R107 5,743 173,352 SH   DFND 1 173,352 0 0
CABOT OIL & GAS CORP COM 127097103 4,948 303,950 SH   DFND 1 303,857 0 93
CACTUS INC CL A 127203107 2,183 83,743 SH   DFND 1 83,743 0 0
CADENCE DESIGN SYSTEM INC COM 127387108 5,919 43,385 SH   DFND 1 43,385 0 0
CALIFORNIA WTR SVC GROUP COM 130788102 874 16,170 SH   DFND 1 16,170 0 0
CAMPING WORLD HLDGS INC CL A 13462K109 832 31,926 SH   DFND 1 31,926 0 0
CANADIAN NATL RY CO COM 136375102 9,398 85,529 SH   DFND 1 85,529 0 0
CAPITAL ONE FINL CORP COM 14040H105 82,256 832,131 SH   DFND 1 832,131 0 0
CARDLYTICS INC COM 14161W105 37,985 266,058 SH   DFND 1 266,058 0 0
CARDLYTICS INC COM 14161W105 7,319 51,263 SH   OTR 2 51,263 0 0
CARVANA CO CL A 146869102 751,617 3,137,754 SH   DFND 1 3,088,979 0 48,775
CARVANA CO CL A 146869102 15,454 64,514 SH   OTR 2 64,514 0 0
CATALENT INC COM 148806102 80,488 773,407 SH   DFND 1 771,087 0 2,320
CATERPILLAR INC COM 149123101 11,350 62,358 SH   DFND 1 62,358 0 0
CBIZ INC COM 124805102 949 35,675 SH   DFND 1 35,675 0 0
CDW CORP COM 12514G108 24,835 188,447 SH   DFND 1 188,416 0 31
CENTENE CORP DEL COM 15135B101 25,863 430,834 SH   DFND 1 430,834 0 0
CENTERPOINT ENERGY INC COM 15189T107 93,122 4,303,233 SH   DFND 1 4,303,233 0 0
CERTARA INC COM 15687V109 2,595 76,966 SH   DFND 1 76,966 0 0
CHAMPIONX CORPORATION COM 15872M104 1,371 89,597 SH   DFND 1 89,597 0 0
CHANGE HEALTHCARE INC COM 15912K100 9,683 519,171 SH   DFND 1 519,171 0 0
CHANNELADVISOR CORP COM 159179100 826 51,676 SH   DFND 1 51,676 0 0
CHART INDS INC COM PAR $0.01 16115Q308 16,741 142,128 SH   DFND 1 142,074 0 54
CHARTER COMMUNICATIONS INC N CL A 16119P108 4,305 6,507 SH   DFND 1 6,507 0 0
CHENIERE ENERGY INC COM NEW 16411R208 114,963 1,915,095 SH   DFND 1 1,915,028 0 67
CHEVRON CORP NEW COM 166764100 198,493 2,350,419 SH   DFND 1 2,346,609 0 3,810
CHEWY INC CL A 16679L109 302,618 3,366,537 SH   DFND 1 3,010,924 0 355,613
CHIPOTLE MEXICAN GRILL INC COM 169656105 1,091,976 787,458 SH   DFND 1 754,284 0 33,174
CHIPOTLE MEXICAN GRILL INC COM 169656105 15,983 11,526 SH   OTR 2 11,526 0 0
CHUBB LIMITED COM H1467J104 155,411 1,009,690 SH   DFND 1 1,009,690 0 0
CIGNA CORP NEW COM 125523100 147,078 706,492 SH   DFND 1 706,492 0 0
CISCO SYS INC COM 17275R102 16,109 359,967 SH   DFND 1 351,703 0 8,264
CITIGROUP INC COM NEW 172967424 101,118 1,639,932 SH   DFND 1 1,639,932 0 0
CLEARWATER PAPER CORP COM 18538R103 1,564 41,433 SH   DFND 1 41,433 0 0
CLEARWAY ENERGY INC CL C 18539C204 3,409 106,772 SH   DFND 1 106,772 0 0
CMS ENERGY CORP COM 125896100 139,507 2,286,623 SH   DFND 1 2,286,623 0 0
CNO FINL GROUP INC COM 12621E103 2,187 98,379 SH   DFND 1 98,379 0 0
COGENT COMMUNICATIONS HLDGS COM NEW 19239V302 255 4,263 SH   DFND 1 4,263 0 0
COGNEX CORP COM 192422103 71,384 889,132 SH   DFND 1 886,105 0 3,027
COLFAX CORP COM 194014106 23,331 610,119 SH   DFND 1 610,119 0 0
COLFAX CORP COM 194014106 4,017 105,043 SH   OTR 2 105,043 0 0
COMCAST CORP NEW CL A 20030N101 25,203 480,967 SH   DFND 1 472,037 0 8,930
COMMUNITY BK SYS INC COM 203607106 564 9,059 SH   DFND 1 9,059 0 0
CONCHO RES INC COM 20605P101 12,754 218,575 SH   DFND 1 218,503 0 72
CONOCOPHILLIPS COM 20825C104 33,356 834,120 SH   DFND 1 834,029 0 91
CONSTELLATION PHARMCETICLS I COM 210373106 30,473 1,058,096 SH   DFND 1 1,058,096 0 0
CONSTELLATION PHARMCETICLS I COM 210373106 3,695 128,283 SH   OTR 2 128,283 0 0
CONSTELLIUM SE CL A SHS F21107101 7,930 566,809 SH   DFND 1 566,571 0 238
COOPER COS INC COM NEW 216648402 41,163 113,298 SH   DFND 1 112,739 0 559
COOPER TIRE & RUBR CO COM 216831107 840 20,751 SH   DFND 1 20,751 0 0
CORNING INC COM 219350105 10,287 285,757 SH   DFND 1 285,757 0 0
COSTAR GROUP INC COM 22160N109 66,318 71,751 SH   DFND 1 71,397 0 354
COSTCO WHSL CORP NEW COM 22160K105 1,255,176 3,331,323 SH   DFND 1 3,169,294 0 162,029
COSTCO WHSL CORP NEW COM 22160K105 16,056 42,614 SH   OTR 2 42,614 0 0
COUPA SOFTWARE INC COM 22266L106 1,340,111 3,954,181 SH   DFND 1 3,834,890 0 119,291
COUPA SOFTWARE INC COM 22266L106 13,854 40,878 SH   OTR 2 40,878 0 0
COUSINS PPTYS INC COM NEW 222795502 45,458 1,356,953 SH   DFND 1 1,356,953 0 0
COUSINS PPTYS INC COM NEW 222795502 5,779 172,513 SH   OTR 2 172,513 0 0
COVETRUS INC COM 22304C100 9,006 313,380 SH   DFND 1 313,380 0 0
COVETRUS INC COM 22304C100 3,093 107,617 SH   OTR 2 107,617 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 42,456 277,294 SH   DFND 1 277,294 0 0
CROCS INC COM 227046109 916 14,625 SH   DFND 1 14,625 0 0
CROWDSTRIKE HLDGS INC CL A 22788C105 1,404,956 6,632,782 SH   DFND 1 6,562,715 0 70,067
CROWDSTRIKE HLDGS INC CL A 22788C105 16,532 78,046 SH   OTR 2 78,046 0 0
CROWN CASTLE INTL CORP NEW COM 22822V101 16,741 105,163 SH   DFND 1 105,163 0 0
CROWN HLDGS INC COM 228368106 141,015 1,407,333 SH   DFND 1 1,405,601 0 1,732
CURTISS WRIGHT CORP COM 231561101 37,209 319,799 SH   DFND 1 319,799 0 0
CURTISS WRIGHT CORP COM 231561101 6,152 52,876 SH   OTR 2 52,876 0 0
CYBERARK SOFTWARE LTD SHS M2682V108 30,739 190,227 SH   DFND 1 190,227 0 0
CYBERARK SOFTWARE LTD SHS M2682V108 4,626 28,631 SH   OTR 2 28,631 0 0
D R HORTON INC COM 23331A109 76,147 1,104,867 SH   DFND 1 1,104,867 0 0
DANAHER CORPORATION COM 235851102 736,811 3,316,877 SH   DFND 1 3,150,255 0 166,622
DANAHER CORPORATION COM 235851102 6,190 27,864 SH   OTR 2 27,864 0 0
DARLING INGREDIENTS INC COM 237266101 71,385 1,237,610 SH   DFND 1 1,237,518 0 92
DARLING INGREDIENTS INC COM 237266101 10,018 173,676 SH   OTR 2 173,676 0 0
DATADOG INC CL A COM 23804L103 21,907 222,545 SH   DFND 1 221,454 0 1,091
DAVITA INC COM 23918K108 1,552 13,216 SH   DFND 1 13,216 0 0
DCP MIDSTREAM LP COM UT LTD PTN 23311P100 6,054 326,883 SH   DFND 1 326,883 0 0
DEERE & CO COM 244199105 45,324 168,460 SH   DFND 1 168,460 0 0
DENALI THERAPEUTICS INC COM 24823R105 31,620 377,512 SH   DFND 1 377,512 0 0
DEXCOM INC COM 252131107 727,093 1,966,605 SH   DFND 1 1,882,644 0 83,961
DEXCOM INC COM 252131107 8,732 23,617 SH   OTR 2 23,617 0 0
DIAGEO PLC SPON ADR NEW 25243Q205 228 1,438 SH   DFND 1 1,438 0 0
DIAMONDBACK ENERGY INC COM 25278X109 13,043 269,489 SH   DFND 1 269,407 0 82
DIAMONDROCK HOSPITALITY CO COM 252784301 1,536 186,206 SH   DFND 1 186,206 0 0
DIGITAL TURBINE INC COM NEW 25400W102 1,427 25,226 SH   DFND 1 25,226 0 0
DISNEY WALT CO COM 254687106 165,899 915,659 SH   DFND 1 912,118 0 3,541
DOCUSIGN INC COM 256163106 394,277 1,773,624 SH   DFND 1 1,632,725 0 140,899
DOCUSIGN INC COM 256163106 34,168 153,704 SH   OTR 2 153,704 0 0
DOLLAR GEN CORP NEW COM 256677105 55,829 265,475 SH   DFND 1 264,323 0 1,152
DOMINION ENERGY INC COM 25746U109 289,283 3,846,843 SH   DFND 1 3,846,843 0 0
DOMINOS PIZZA INC COM 25754A201 3,902 10,177 SH   DFND 1 10,177 0 0
DOUGLAS EMMETT INC COM 25960P109 6,371 218,334 SH   DFND 1 218,334 0 0
DOVER CORP COM 260003108 836 6,618 SH   DFND 1 6,618 0 0
DOW INC COM 260557103 57,089 1,028,637 SH   DFND 1 1,028,602 0 35
DTE ENERGY CO COM 233331107 105,444 868,494 SH   DFND 1 868,494 0 0
DUKE ENERGY CORP NEW COM NEW 26441C204 89,106 973,201 SH   DFND 1 973,201 0 0
DYNATRACE INC COM NEW 268150109 358,600 8,287,498 SH   DFND 1 7,625,729 0 661,769
DYNATRACE INC COM NEW 268150109 31,290 723,131 SH   OTR 2 723,131 0 0
E L F BEAUTY INC COM 26856L103 9,138 362,758 SH   DFND 1 362,758 0 0
E L F BEAUTY INC COM 26856L103 3,169 125,819 SH   OTR 2 125,819 0 0
EAST WEST BANCORP INC COM 27579R104 48,324 952,947 SH   DFND 1 952,947 0 0
EAST WEST BANCORP INC COM 27579R104 8,819 173,918 SH   OTR 2 173,918 0 0
EASTERN BANKSHARES INC COM 27627N105 20,767 1,273,229 SH   DFND 1 1,273,229 0 0
EASTERN BANKSHARES INC COM 27627N105 3,369 206,572 SH   OTR 2 206,572 0 0
EBAY INC. COM 278642103 3,742 74,475 SH   DFND 1 74,475 0 0
EBIX INC COM NEW 278715206 1,279 33,686 SH   DFND 1 33,686 0 0
EDISON INTL COM 281020107 78,357 1,247,326 SH   DFND 1 1,247,326 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 238,527 2,614,569 SH   DFND 1 2,198,918 0 415,651
EGAIN CORP COM NEW 28225C806 653 55,273 SH   DFND 1 55,273 0 0
EHEALTH INC COM 28238P109 25,272 357,910 SH   DFND 1 357,910 0 0
EMERGENT BIOSOLUTIONS INC COM 29089Q105 29,432 328,477 SH   DFND 1 328,477 0 0
EMERGENT BIOSOLUTIONS INC COM 29089Q105 5,913 65,997 SH   OTR 2 65,997 0 0
EMERSON ELEC CO COM 291011104 33,220 413,334 SH   DFND 1 413,334 0 0
ENBRIDGE INC COM 29250N105 78,022 2,440,708 SH   DFND 1 2,440,708 0 0
ENERGY TRANSFER LP COM UT LTD PTN 29273V100 18,996 3,073,867 SH   DFND 1 3,073,867 0 0
ENERPAC TOOL GROUP CORP CL A COM 292765104 11,419 505,015 SH   DFND 1 505,015 0 0
ENERPAC TOOL GROUP CORP CL A COM 292765104 3,940 174,274 SH   OTR 2 174,274 0 0
ENPHASE ENERGY INC COM 29355A107 42,370 241,467 SH   DFND 1 240,474 0 993
ENSIGN GROUP INC COM 29358P101 1,177 16,136 SH   DFND 1 16,136 0 0
ENSTAR GROUP LIMITED SHS G3075P101 2,143 10,457 SH   DFND 1 10,457 0 0
ENTEGRIS INC COM 29362U104 5,002 52,045 SH   DFND 1 52,045 0 0
ENTERGY CORP NEW COM 29364G103 119,054 1,192,451 SH   DFND 1 1,192,451 0 0
ENTERPRISE FINL SVCS CORP COM 293712105 13,740 393,125 SH   DFND 1 393,125 0 0
ENTERPRISE FINL SVCS CORP COM 293712105 2,663 76,197 SH   OTR 2 76,197 0 0
ENTERPRISE PRODS PARTNERS L COM 293792107 22,580 1,152,623 SH   DFND 1 1,152,623 0 0
EPAM SYS INC COM 29414B104 2,319 6,470 SH   DFND 1 6,470 0 0
EQT CORP COM 26884L109 1,699 133,700 SH   DFND 1 133,640 0 60
EQUINIX INC COM 29444U700 90,989 127,404 SH   DFND 1 127,402 0 2
EQUITRANS MIDSTREAM CORP COM 294600101 18,535 2,305,327 SH   DFND 1 2,305,327 0 0
ESSENT GROUP LTD COM G3198U102 990 22,907 SH   DFND 1 22,907 0 0
ESSENTIAL UTILS INC COM 29670G102 104,016 2,199,542 SH   DFND 1 2,199,542 0 0
ETSY INC COM 29786A106 48,747 273,998 SH   DFND 1 272,636 0 1,362
EVERBRIDGE INC COM 29978A104 43,663 292,900 SH   DFND 1 292,900 0 0
EVERBRIDGE INC COM 29978A104 8,863 59,455 SH   OTR 2 59,455 0 0
EVERGY INC COM 30034W106 33,390 601,518 SH   DFND 1 601,518 0 0
EVERSOURCE ENERGY COM 30040W108 36,353 420,222 SH   DFND 1 420,222 0 0
EVO PMTS INC CL A COM 26927E104 27,149 1,005,120 SH   DFND 1 1,005,120 0 0
EVO PMTS INC CL A COM 26927E104 8,696 321,971 SH   OTR 2 321,971 0 0
EVOQUA WATER TECHNOLOGIES CO COM 30057T105 1,870 69,309 SH   DFND 1 69,309 0 0
EXELON CORP COM 30161N101 32,446 768,496 SH   DFND 1 768,496 0 0
FACEBOOK INC CL A 30303M102 4,293,217 15,716,856 SH   DFND 1 15,166,121 0 550,735
FACEBOOK INC CL A 30303M102 52,719 192,998 SH   OTR 2 192,998 0 0
FARFETCH LTD ORD SH CL A 30744W107 846,922 13,272,571 SH   DFND 1 12,950,202 0 322,369
FARFETCH LTD ORD SH CL A 30744W107 26,953 422,389 SH   OTR 2 422,389 0 0
FATE THERAPEUTICS INC COM 31189P102 70,503 775,357 SH   DFND 1 775,357 0 0
FATE THERAPEUTICS INC PUT OPTIONS 31189P102 2,273 25,000 SH Put DFND 1 25,000 0 0
FEDERATED HERMES INC CL B 314211103 1,254 43,419 SH   DFND 1 43,419 0 0
FEDEX CORP COM 31428X106 69,320 267,007 SH   DFND 1 267,007 0 0
FERRARI N V COM N3167Y103 35,222 153,458 SH   DFND 1 152,049 0 1,409
FIRST BANCORP N C COM 318910106 19,677 581,648 SH   DFND 1 581,648 0 0
FIRST BANCORP N C COM 318910106 5,867 173,426 SH   OTR 2 173,426 0 0
FIRST FNDTN INC COM 32026V104 29,179 1,458,986 SH   DFND 1 1,458,986 0 0
FIRST FNDTN INC COM 32026V104 4,945 247,235 SH   OTR 2 247,235 0 0
FIRSTENERGY CORP COM 337932107 76,651 2,504,111 SH   DFND 1 2,504,111 0 0
FIRSTSERVICE CORP NEW COM 33767E202 221 1,618 SH   DFND 1 1,618 0 0
FIVE BELOW INC COM 33829M101 95,274 544,485 SH   DFND 1 542,941 0 1,544
FIVE BELOW INC COM 33829M101 6,435 36,774 SH   OTR 2 36,774 0 0
FIVE PRIME THERAPEUTICS INC COM 33830X104 552 32,438 SH   DFND 1 32,438 0 0
FIVE9 INC COM 338307101 38,198 219,025 SH   DFND 1 217,954 0 1,071
FLUIDIGM CORP DEL COM 34385P108 885 147,471 SH   DFND 1 147,471 0 0
FMC CORP COM NEW 302491303 148,139 1,288,949 SH   DFND 1 1,287,438 0 1,511
FOCUS FINL PARTNERS INC COM CL A 34417P100 42,562 978,443 SH   DFND 1 978,443 0 0
FOCUS FINL PARTNERS INC COM CL A 34417P100 7,153 164,426 SH   OTR 2 164,426 0 0
FORMFACTOR INC COM 346375108 1,098 25,513 SH   DFND 1 25,513 0 0
FORTIVE CORP COM 34959J108 54,850 774,494 SH   DFND 1 774,494 0 0
FOUR CORNERS PPTY TR INC COM 35086T109 1,207 40,552 SH   DFND 1 40,552 0 0
FREEPORT-MCMORAN INC CL B 35671D857 21,636 831,506 SH   DFND 1 831,189 0 317
FRESHPET INC COM 358039105 59,324 417,805 SH   DFND 1 416,643 0 1,162
FRESHPET INC COM 358039105 7,544 53,130 SH   OTR 2 53,130 0 0
GAMING & LEISURE PPTYS INC COM 36467J108 38,378 905,134 SH   DFND 1 905,134 0 0
GENERAC HLDGS INC COM 368736104 2,940 12,927 SH   DFND 1 12,927 0 0
GENERAL MTRS CO COM 37045V100 142,045 3,411,260 SH   DFND 1 3,411,260 0 0
GENETRON HLDGS LTD ADS 37186H100 24,788 1,770,594 SH   DFND 1 1,770,594 0 0
GENMAB A/S SPONSORED ADS 372303206 58,137 1,429,842 SH   DFND 1 1,425,749 0 4,093
GFL ENVIRONMENTAL INC SUB VTG SHS 36168Q104 41,749 1,430,725 SH   DFND 1 1,425,509 0 5,216
GFL ENVIRONMENTAL INC UNIT 99/99/9999T 36168Q120 35,846 508,737 SH   DFND 1 508,737 0 0
GLACIER BANCORP INC NEW COM 37637Q105 1,030 22,378 SH   DFND 1 22,378 0 0
GLOBANT S A COM L44385109 73,145 336,128 SH   DFND 1 335,093 0 1,035
GLOBANT S A COM L44385109 3,183 14,629 SH   OTR 2 14,629 0 0
GOLDMAN SACHS GROUP INC COM 38141G104 173,634 658,428 SH   DFND 1 658,409 0 19
GOOSEHEAD INS INC COM CL A 38267D109 23,361 187,244 SH   DFND 1 187,244 0 0
GOOSEHEAD INS INC COM CL A 38267D109 7,139 57,225 SH   OTR 2 57,225 0 0
GOSSAMER BIO INC COM 38341P102 14,098 1,457,886 SH   DFND 1 1,457,886 0 0
GRACO INC COM 384109104 3,556 49,149 SH   DFND 1 49,149 0 0
GRAY TELEVISION INC COM 389375106 1,129 63,104 SH   DFND 1 63,104 0 0
GREAT LAKES DREDGE & DOCK CO COM 390607109 58,187 4,418,157 SH   DFND 1 4,418,157 0 0
GREAT LAKES DREDGE & DOCK CO COM 390607109 8,500 645,401 SH   OTR 2 645,401 0 0
GRIFFON CORP COM 398433102 1,543 75,728 SH   DFND 1 75,728 0 0
GUARDANT HEALTH INC COM 40131M109 383,577 2,976,238 SH   DFND 1 2,893,278 0 82,960
GUARDANT HEALTH INC COM 40131M109 3,962 30,739 SH   OTR 2 30,739 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 17,906 155,154 SH   DFND 1 155,154 0 0
GW PHARMACEUTICALS PLC ADS 36197T103 3,648 31,606 SH   OTR 2 31,606 0 0
HAMILTON LANE INC CL A 407497106 18,699 239,575 SH   DFND 1 239,575 0 0
HAMILTON LANE INC CL A 407497106 5,108 65,446 SH   OTR 2 65,446 0 0
HANNON ARMSTRONG SUST INFR C COM 41068X100 6,948 109,533 SH   DFND 1 109,493 0 40
HARSCO CORP COM 415864107 35,819 1,992,149 SH   DFND 1 1,992,149 0 0
HARSCO CORP COM 415864107 6,180 343,736 SH   OTR 2 343,736 0 0
HCA HEALTHCARE INC COM 40412C101 2,324 14,130 SH   DFND 1 14,130 0 0
HDFC BANK LTD SPONSORED ADS 40415F101 5,634 77,966 SH   DFND 1 77,966 0 0
HEALTHCARE SVCS GROUP INC COM 421906108 5,972 212,510 SH   DFND 1 212,510 0 0
HEALTHCARE SVCS GROUP INC COM 421906108 2,081 74,068 SH   OTR 2 74,068 0 0
HEALTHEQUITY INC COM 42226A107 11,739 168,389 SH   DFND 1 168,389 0 0
HEALTHEQUITY INC COM 42226A107 4,073 58,433 SH   OTR 2 58,433 0 0
HENRY JACK & ASSOC INC COM 426281101 12,149 74,996 SH   DFND 1 74,628 0 368
HERBALIFE NUTRITION LTD COM SHS G4412G101 1,564 32,552 SH   DFND 1 32,552 0 0
HERC HLDGS INC COM 42704L104 2,231 33,600 SH   DFND 1 33,600 0 0
HERSHEY CO COM 427866108 1,418 9,311 SH   DFND 1 9,311 0 0
HESS CORP COM 42809H107 14,543 275,494 SH   DFND 1 275,390 0 104
HILL ROM HLDGS INC COM 431475102 11,811 120,561 SH   DFND 1 120,561 0 0
HILLTOP HOLDINGS INC COM 432748101 2,216 80,544 SH   DFND 1 80,544 0 0
HOLOGIC INC COM 436440101 2,239 30,746 SH   DFND 1 30,746 0 0
HOME BANCSHARES INC COM 436893200 2,432 124,831 SH   DFND 1 124,831 0 0
HOME DEPOT INC COM 437076102 1,148,375 4,323,377 SH   DFND 1 4,097,884 0 225,493
HOME DEPOT INC COM 437076102 14,524 54,678 SH   OTR 2 54,678 0 0
HONEYWELL INTL INC COM 438516106 374 1,757 SH   DFND 1 1,757 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 62,086 848,747 SH   DFND 1 846,720 0 2,027
HOULIHAN LOKEY INC CL A 441593100 20,748 308,618 SH   DFND 1 308,618 0 0
HOULIHAN LOKEY INC CL A 441593100 6,333 94,195 SH   OTR 2 94,195 0 0
HOWARD HUGHES CORP COM 44267D107 10,032 127,104 SH   DFND 1 127,104 0 0
HUBSPOT INC COM 443573100 48,777 123,037 SH   DFND 1 122,426 0 611
HUMANA INC COM 444859102 538,326 1,312,125 SH   DFND 1 1,250,547 0 61,578
HUMANA INC COM 444859102 5,869 14,306 SH   OTR 2 14,306 0 0
HUNT J B TRANS SVCS INC COM 445658107 57,887 423,613 SH   DFND 1 421,934 0 1,679
HURON CONSULTING GROUP INC COM 447462102 14,635 248,267 SH   DFND 1 248,267 0 0
HURON CONSULTING GROUP INC COM 447462102 5,081 86,185 SH   OTR 2 86,185 0 0
IDEX CORP COM 45167R104 36,659 184,031 SH   DFND 1 183,155 0 876
IHS MARKIT LTD SHS G47567105 19,848 220,954 SH   DFND 1 219,817 0 1,137
ILLUMINA INC COM 452327109 30,487 82,397 SH   DFND 1 82,397 0 0
IMMATICS N.V *W EXP 07/01/202 N44445117 1,112 386,035 SH   DFND 1 386,035 0 0
INDEPENDENCE RLTY TR INC COM 45378A106 35,248 2,624,536 SH   DFND 1 2,624,536 0 0
INDEPENDENCE RLTY TR INC COM 45378A106 7,069 526,388 SH   OTR 2 526,388 0 0
INPHI CORP COM 45772F107 28,702 178,858 SH   DFND 1 178,858 0 0
INPHI CORP COM 45772F107 8,829 55,022 SH   OTR 2 55,022 0 0
INSPIRE MED SYS INC COM 457730109 30,258 160,874 SH   DFND 1 160,874 0 0
INSPIRE MED SYS INC COM 457730109 9,121 48,491 SH   OTR 2 48,491 0 0
INSULET CORP COM 45784P101 61,708 241,395 SH   DFND 1 240,664 0 731
INTEGRA LIFESCIENCES HLDGS C COM NEW 457985208 22,019 339,179 SH   DFND 1 339,179 0 0
INTEGRA LIFESCIENCES HLDGS C COM NEW 457985208 4,346 66,939 SH   OTR 2 66,939 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 8,274 152,098 SH   DFND 1 152,098 0 0
INTERNATIONAL BANCSHARES COR COM 459044103 2,147 57,345 SH   DFND 1 57,345 0 0
INTERSECT ENT INC COM 46071F103 18,490 807,410 SH   DFND 1 807,410 0 0
INTERSECT ENT INC COM 46071F103 5,394 235,541 SH   OTR 2 235,541 0 0
INTUIT COM 461202103 540 1,421 SH   DFND 1 1,421 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 790,254 965,963 SH   DFND 1 915,799 0 50,164
INTUITIVE SURGICAL INC COM NEW 46120E602 6,573 8,034 SH   OTR 2 8,034 0 0
INVESTORS BANCORP INC NEW COM 46146L101 1,289 122,047 SH   DFND 1 122,047 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 15,636 336,986 SH   DFND 1 336,986 0 0
IQVIA HLDGS INC COM 46266C105 97,810 545,905 SH   DFND 1 544,397 0 1,508
IROBOT CORP COM 462726100 767 9,551 SH   DFND 1 9,551 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 1,263 110,854 SH   DFND 1 110,854 0 0
ISHARES TR MSCI ACWI ETF 464288257 2,500 27,555 SH   DFND 1 27,376 0 179
ISHARES TR MSCI ACWI EX US 464288240 1,494 28,176 SH   DFND 1 28,026 0 150
ISHARES TR NORTH AMERN NAT 464287374 424 18,222 SH   DFND 1 17,861 0 361
ISHARES TR RUS 1000 GRW ETF 464287614 5,768 23,918 SH   DFND 1 22,731 0 1,187
JACK IN THE BOX INC COM 466367109 59,059 636,410 SH   DFND 1 636,410 0 0
JACK IN THE BOX INC COM 466367109 10,131 109,172 SH   OTR 2 109,172 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 33,170 200,967 SH   DFND 1 200,967 0 0
JELD-WEN HLDG INC COM 47580P103 37,726 1,487,618 SH   DFND 1 1,487,618 0 0
JELD-WEN HLDG INC COM 47580P103 6,531 257,531 SH   OTR 2 257,531 0 0
JOHNSON & JOHNSON COM 478160104 1,866 11,855 SH   DFND 1 11,855 0 0
JOHNSON CTLS INTL PLC SHS G51502105 152,951 3,282,915 SH   DFND 1 3,282,915 0 0
JPMORGAN CHASE & CO COM 46625H100 266,883 2,100,286 SH   DFND 1 2,094,324 0 5,962
KAMAN CORP COM 483548103 22,919 401,159 SH   DFND 1 401,159 0 0
KAMAN CORP COM 483548103 3,801 66,539 SH   OTR 2 66,539 0 0
KB HOME COM 48666K109 2,883 86,002 SH   DFND 1 86,002 0 0
KENNAMETAL INC COM 489170100 22,661 625,297 SH   DFND 1 625,297 0 0
KENNAMETAL INC COM 489170100 6,245 172,323 SH   OTR 2 172,323 0 0
KEYSIGHT TECHNOLOGIES INC COM 49338L103 611 4,629 SH   DFND 1 4,629 0 0
KINDER MORGAN INC DEL COM 49456B101 13,668 999,843 SH   DFND 1 999,843 0 0
KINROSS GOLD CORP COM 496902404 14,107 1,921,910 SH   DFND 1 1,921,173 0 737
KKR & CO INC COM 48251W104 7,468 184,435 SH   DFND 1 184,435 0 0
KLA CORP COM NEW 482480100 3,359 12,974 SH   DFND 1 12,974 0 0
KNIGHT-SWIFT TRANSN HLDGS IN CL A 499049104 644 15,400 SH   DFND 1 15,400 0 0
KONTOOR BRANDS INC COM 50050N103 39,698 978,731 SH   DFND 1 978,731 0 0
KONTOOR BRANDS INC COM 50050N103 8,223 202,741 SH   OTR 2 202,741 0 0
KYMERA THERAPEUTICS INC COM 501575104 4,300 69,355 SH   DFND 1 69,355 0 0
L3HARRIS TECHNOLOGIES INC COM 502431109 40,063 211,953 SH   DFND 1 210,978 0 975
LABORATORY CORP AMER HLDGS COM NEW 50540R409 74,503 366,016 SH   DFND 1 366,016 0 0
LAM RESEARCH CORP COM 512807108 43,760 92,658 SH   DFND 1 92,463 0 195
LATTICE SEMICONDUCTOR CORP COM 518415104 43,282 944,631 SH   DFND 1 944,631 0 0
LATTICE SEMICONDUCTOR CORP COM 518415104 8,544 186,458 SH   OTR 2 186,458 0 0
LAUDER ESTEE COS INC CL A 518439104 1,623,167 6,097,773 SH   DFND 1 5,862,863 0 234,910
LAUDER ESTEE COS INC CL A 518439104 19,641 73,787 SH   OTR 2 73,787 0 0
LAZARD LTD SHS A G54050102 37,259 880,832 SH   DFND 1 880,832 0 0
LAZARD LTD SHS A G54050102 2,986 70,592 SH   OTR 2 70,592 0 0
LEGEND BIOTECH CORP SPONSORED ADS 52490G102 9,050 321,388 SH   DFND 1 321,388 0 0
LEIDOS HOLDINGS INC COM 525327102 4,658 44,307 SH   DFND 1 44,307 0 0
LEMONADE INC COM 52567D107 15,190 124,004 SH   DFND 1 124,004 0 0
LEMONADE INC COM 52567D107 2,525 20,611 SH   OTR 2 20,611 0 0
LEXINGTON REALTY TRUST COM 529043101 1,442 135,817 SH   DFND 1 135,817 0 0
LIBERTY OILFIELD SVCS INC COM CL A 53115L104 738 71,601 SH   DFND 1 71,601 0 0
LILLY ELI & CO COM 532457108 317,224 1,878,843 SH   DFND 1 1,698,884 0 179,959
LINCOLN ELEC HLDGS INC COM 533900106 17,413 149,790 SH   DFND 1 149,790 0 0
LINDE PLC SHS G5494J103 218,974 830,990 SH   DFND 1 830,971 0 19
LITTELFUSE INC COM 537008104 37,266 146,338 SH   DFND 1 146,338 0 0
LITTELFUSE INC COM 537008104 7,757 30,459 SH   OTR 2 30,459 0 0
LIVENT CORP COM 53814L108 309 16,420 SH   DFND 1 16,420 0 0
LOWES COS INC COM 548661107 143,850 896,204 SH   DFND 1 896,204 0 0
LTC PPTYS INC COM 502175102 1,756 45,140 SH   DFND 1 45,140 0 0
LULULEMON ATHLETICA INC COM 550021109 2,418,369 6,948,738 SH   DFND 1 6,665,060 0 283,678
LULULEMON ATHLETICA INC COM 550021109 49,895 143,364 SH   OTR 2 143,364 0 0
LYONDELLBASELL INDUSTRIES N SHS - A - N53745100 1,277 13,937 SH   DFND 1 13,937 0 0
M/I HOMES INC COM 55305B101 815 18,401 SH   DFND 1 18,401 0 0
MACOM TECH SOLUTIONS HLDGS I COM 55405Y100 16,027 291,182 SH   DFND 1 291,182 0 0
MACOM TECH SOLUTIONS HLDGS I COM 55405Y100 4,038 73,365 SH   OTR 2 73,365 0 0
MACROGENICS INC COM 556099109 747 32,667 SH   DFND 1 32,667 0 0
MAG SILVER CORP COM 55903Q104 8,985 439,023 SH   DFND 1 438,853 0 170
MAGELLAN MIDSTREAM PRTNRS LP COM UNIT RP LP 559080106 15,502 365,262 SH   DFND 1 365,262 0 0
MAKEMYTRIP LIMITED MAURITIUS SHS V5633W109 4,941 167,318 SH   DFND 1 167,318 0 0
MALIBU BOATS INC COM CL A 56117J100 937 15,010 SH   DFND 1 15,010 0 0
MARAVAI LIFESCIENCES HLDGS I COM CL A 56600D107 7,444 265,386 SH   DFND 1 265,386 0 0
MARINEMAX INC COM 567908108 1,262 36,034 SH   DFND 1 36,034 0 0
MARRIOTT INTL INC NEW CL A 571903202 8,081 61,254 SH   DFND 1 61,254 0 0
MARSH & MCLENNAN COS INC COM 571748102 67,565 577,475 SH   DFND 1 577,475 0 0
MARTEN TRANS LTD COM 573075108 662 38,405 SH   DFND 1 38,405 0 0
MARVELL TECHNOLOGY GROUP LTD ORD G5876H105 69,234 1,456,332 SH   DFND 1 1,449,212 0 7,120
MASTEC INC COM 576323109 1,379 20,231 SH   DFND 1 20,231 0 0
MASTERCARD INCORPORATED CL A 57636Q104 2,215,680 6,207,430 SH   DFND 1 5,951,711 0 255,719
MASTERCARD INCORPORATED CL A 57636Q104 36,369 101,890 SH   OTR 2 101,890 0 0
MATCH GROUP INC NEW COM 57667L107 3,230,823 21,369,294 SH   DFND 1 20,582,705 0 786,589
MATCH GROUP INC NEW COM 57667L107 81,329 537,923 SH   OTR 2 537,923 0 0
MAXAR TECHNOLOGIES INC COM 57778K105 1,362 35,304 SH   DFND 1 35,304 0 0
MAXLINEAR INC COM 57776J100 24,506 641,686 SH   DFND 1 641,686 0 0
MAXLINEAR INC COM 57776J100 8,122 212,684 SH   OTR 2 212,684 0 0
MAYVILLE ENGINEERING CO INC COM 578605107 10,108 753,210 SH   DFND 1 753,210 0 0
MAYVILLE ENGINEERING CO INC COM 578605107 3,420 254,812 SH   OTR 2 254,812 0 0
MCDONALDS CORP COM 580135101 84,493 393,762 SH   DFND 1 392,305 0 1,457
MEDPACE HLDGS INC COM 58506Q109 1,984 14,252 SH   DFND 1 14,252 0 0
MERCADOLIBRE INC COM 58733R102 1,847,836 1,103,041 SH   DFND 1 1,058,053 0 44,988
MERCADOLIBRE INC COM 58733R102 87,807 52,415 SH   OTR 2 52,415 0 0
MERIDIAN BIOSCIENCE INC COM 589584101 1,403 75,068 SH   DFND 1 75,068 0 0
MERITAGE HOMES CORP COM 59001A102 1,789 21,603 SH   DFND 1 21,603 0 0
METHODE ELECTRS INC COM 591520200 2,163 56,506 SH   DFND 1 56,506 0 0
METLIFE INC COM 59156R108 136,726 2,912,159 SH   DFND 1 2,912,159 0 0
MICHAELS COS INC COM 59408Q106 1,220 93,736 SH   DFND 1 93,736 0 0
MICROCHIP TECHNOLOGY INC. COM 595017104 54,166 392,193 SH   DFND 1 390,297 0 1,896
MICROSOFT CORP COM 594918104 5,066,245 22,777,830 SH   DFND 1 21,909,085 0 868,745
MICROSOFT CORP COM 594918104 88,418 397,529 SH   OTR 2 397,529 0 0
MOELIS & CO CL A 60786M105 10,870 232,469 SH   DFND 1 232,469 0 0
MOELIS & CO CL A 60786M105 3,618 77,364 SH   OTR 2 77,364 0 0
MOLINA HEALTHCARE INC COM 60855R100 84,211 395,953 SH   DFND 1 394,686 0 1,267
MONDELEZ INTL INC CL A 609207105 115,746 1,979,577 SH   DFND 1 1,979,577 0 0
MONOLITHIC PWR SYS INC COM 609839105 60,863 166,187 SH   DFND 1 165,606 0 581
MONRO INC COM 610236101 7,785 146,052 SH   DFND 1 146,052 0 0
MONRO INC COM 610236101 2,712 50,887 SH   OTR 2 50,887 0 0
MOODYS CORP COM 615369105 1,596 5,498 SH   DFND 1 5,498 0 0
MPLX LP COM UNIT REP LTD 55336V100 23,640 1,091,938 SH   DFND 1 1,091,938 0 0
MUELLER WTR PRODS INC COM SER A 624758108 7,386 596,577 SH   DFND 1 596,577 0 0
MUELLER WTR PRODS INC COM SER A 624758108 2,138 172,730 SH   OTR 2 172,730 0 0
NATERA INC COM 632307104 165,529 1,663,277 SH   DFND 1 1,663,277 0 0
NATERA INC COM 632307104 7,456 74,918 SH   OTR 2 74,918 0 0
NATIONAL ENERGY SERVICES REU SHS G6375R107 8,405 846,387 SH   DFND 1 846,053 0 334
NATIONAL HEALTH INVS INC COM 63633D104 2,435 35,205 SH   DFND 1 35,205 0 0
NATIONAL STORAGE AFFILIATES COM SHS BEN IN 637870106 26,572 737,507 SH   DFND 1 737,507 0 0
NATIONAL STORAGE AFFILIATES COM SHS BEN IN 637870106 7,269 201,738 SH   OTR 2 201,738 0 0
NATIONAL VISION HLDGS INC COM 63845R107 29,593 653,407 SH   DFND 1 653,407 0 0
NATIONAL VISION HLDGS INC COM 63845R107 9,240 204,012 SH   OTR 2 204,012 0 0
NAUTILUS INC COM 63910B102 738 40,679 SH   DFND 1 40,679 0 0
NEOGENOMICS INC COM NEW 64049M209 22,425 416,500 SH   DFND 1 416,500 0 0
NEOGENOMICS INC COM NEW 64049M209 6,664 123,782 SH   OTR 2 123,782 0 0
NETFLIX INC COM 64110L106 4,306,983 7,965,126 SH   DFND 1 7,616,555 0 348,571
NETFLIX INC COM 64110L106 93,372 172,678 SH   OTR 2 172,678 0 0
NEVRO CORP COM 64157F103 51,312 296,427 SH   DFND 1 296,427 0 0
NEVRO CORP COM 64157F103 8,963 51,781 SH   OTR 2 51,781 0 0
NEW FORTRESS ENERGY INC COM CL A 644393100 5,890 109,908 SH   DFND 1 109,867 0 41
NEW JERSEY RES CORP COM 646025106 1,261 35,484 SH   DFND 1 35,484 0 0
NEWMONT CORP COM 651639106 20,060 334,941 SH   DFND 1 334,821 0 120
NEXPOINT RESIDENTIAL TR INC COM 65341D102 1,142 26,999 SH   DFND 1 26,999 0 0
NEXTERA ENERGY INC COM 65339F101 332,138 4,305,097 SH   DFND 1 4,305,097 0 0
NEXTERA ENERGY INC UNIT 99/99/9999 65339F739 10,176 198,096 SH   DFND 1 198,096 0 0
NEXTERA ENERGY PARTNERS LP COM UNIT PART IN 65341B106 210,877 3,145,081 SH   DFND 1 3,144,996 0 85
NEXTERA ENERGY PARTNERS LP COM UNIT PART IN 65341B106 10,949 163,290 SH   OTR 2 163,290 0 0
NICE LTD SPONSORED ADR 653656108 149,958 528,881 SH   DFND 1 528,791 0 90
NICE LTD SPONSORED ADR 653656108 2,759 9,729 SH   OTR 2 9,729 0 0
NIKE INC CL B 654106103 2,827,588 19,987,189 SH   DFND 1 19,092,189 0 895,000
NIKE INC CL B 654106103 64,917 458,874 SH   OTR 2 458,874 0 0
NLIGHT INC COM 65487K100 31,605 968,008 SH   DFND 1 968,008 0 0
NLIGHT INC COM 65487K100 6,549 200,583 SH   OTR 2 200,583 0 0
NORDSON CORP COM 655663102 37,013 184,189 SH   DFND 1 183,284 0 905
NORFOLK SOUTHN CORP COM 655844108 22,170 93,305 SH   DFND 1 93,305 0 0
NORTHROP GRUMMAN CORP COM 666807102 16,041 52,643 SH   DFND 1 52,643 0 0
NORTONLIFELOCK INC COM 668771108 1,508 72,589 SH   DFND 1 72,589 0 0
NOVAVAX INC COM NEW 670002401 25,000 224,197 SH   DFND 1 224,197 0 0
NOVO-NORDISK A S ADR 670100205 46,643 667,765 SH   DFND 1 667,765 0 0
NURIX THERAPEUTICS INC COM 67080M103 6,518 198,251 SH   DFND 1 198,251 0 0
NUSTAR ENERGY LP UNIT COM 67058H102 2,935 203,697 SH   DFND 1 203,697 0 0
NUTRIEN LTD COM 67077M108 7,093 147,272 SH   DFND 1 147,215 0 57
NVIDIA CORPORATION COM 67066G104 3,737,662 7,157,530 SH   DFND 1 6,854,506 0 303,024
NVIDIA CORPORATION COM 67066G104 75,135 143,882 SH   OTR 2 143,882 0 0
O-I GLASS INC COM 67098H104 2,012 169,105 SH   DFND 1 169,105 0 0
OGE ENERGY CORP COM 670837103 31,722 995,667 SH   DFND 1 995,667 0 0
OKTA INC CL A 679295105 101,340 398,570 SH   DFND 1 397,535 0 1,035
OLD DOMINION FREIGHT LINE IN COM 679580100 4,405 22,570 SH   DFND 1 22,570 0 0
ON SEMICONDUCTOR CORP COM 682189105 26,864 820,766 SH   DFND 1 818,871 0 1,895
ONEOK INC NEW COM 682680103 14,474 377,124 SH   DFND 1 377,124 0 0
OPEN LENDING CORP COM CL A 68373J104 11,134 318,466 SH   DFND 1 318,466 0 0
OPEN LENDING CORP COM CL A 68373J104 1,871 53,531 SH   OTR 2 53,531 0 0
ORACLE CORP COM 68389X105 8,243 127,421 SH   DFND 1 127,421 0 0
OREILLY AUTOMOTIVE INC COM 67103H107 53,640 118,522 SH   DFND 1 117,996 0 526
ORIC PHARMACEUTICALS INC COM 68622P109 17,720 523,480 SH   DFND 1 523,480 0 0
OTIS WORLDWIDE CORP COM 68902V107 73,478 1,087,754 SH   DFND 1 1,087,754 0 0
OUTSET MED INC COM 690145107 12,567 221,106 SH   DFND 1 221,106 0 0
OUTSET MED INC COM 690145107 1,244 21,878 SH   OTR 2 21,878 0 0
OVERSTOCK COM INC DEL COM 690370101 571 11,898 SH   DFND 1 11,898 0 0
PAGERDUTY INC COM 69553P100 27,887 668,751 SH   DFND 1 668,751 0 0
PAGERDUTY INC COM 69553P100 4,608 110,507 SH   OTR 2 110,507 0 0
PALO ALTO NETWORKS INC COM 697435105 57,595 162,061 SH   DFND 1 161,265 0 796
PARKER-HANNIFIN CORP COM 701094104 219 805 SH   DFND 1 805 0 0
PARSLEY ENERGY INC CL A 701877102 23,013 1,620,632 SH   DFND 1 1,620,279 0 353
PARSLEY ENERGY INC CL A 701877102 2,656 187,041 SH   OTR 2 187,041 0 0
PATRICK INDS INC COM 703343103 1,735 25,383 SH   DFND 1 25,383 0 0
PAYCOM SOFTWARE INC COM 70432V102 41,131 90,947 SH   DFND 1 90,479 0 468
PAYPAL HLDGS INC COM 70450Y103 3,062,871 13,078,015 SH   DFND 1 12,626,760 0 451,255
PAYPAL HLDGS INC COM 70450Y103 35,552 151,802 SH   OTR 2 151,802 0 0
PDC ENERGY INC COM 69327R101 51,247 2,496,213 SH   DFND 1 2,495,959 0 254
PDC ENERGY INC COM 69327R101 7,919 385,713 SH   OTR 2 385,713 0 0
PELOTON INTERACTIVE INC CL A COM 70614W100 1,798,982 11,857,249 SH   DFND 1 11,476,264 0 380,985
PELOTON INTERACTIVE INC CL A COM 70614W100 67,758 446,602 SH   OTR 2 446,602 0 0
PEMBINA PIPELINE CORP COM 706327103 18,361 776,307 SH   DFND 1 776,307 0 0
PENN NATL GAMING INC COM 707569109 37,237 431,134 SH   DFND 1 431,134 0 0
PENN NATL GAMING INC COM 707569109 4,383 50,752 SH   OTR 2 50,752 0 0
PENTAIR PLC SHS G7S00T104 21,341 401,987 SH   DFND 1 401,987 0 0
PEPSICO INC COM 713448108 98,255 662,540 SH   DFND 1 659,837 0 2,703
PERFORMANCE FOOD GROUP CO COM 71377A103 66,314 1,392,849 SH   DFND 1 1,392,849 0 0
PERFORMANCE FOOD GROUP CO COM 71377A103 12,809 269,041 SH   OTR 2 269,041 0 0
PETROLEO BRASILEIRO SA PETRO SPONSORED ADR 71654V408 4,240 377,526 SH   DFND 1 377,383 0 143
PG&E CORP COM 69331C108 38,193 3,065,269 SH   DFND 1 3,065,269 0 0
PHILIP MORRIS INTL INC COM 718172109 746 9,015 SH   DFND 1 9,015 0 0
PHILLIPS 66 PARTNERS LP COM UNIT REP INT 718549207 3,859 146,101 SH   DFND 1 146,101 0 0
PHREESIA INC COM 71944F106 76,050 1,401,585 SH   DFND 1 1,401,585 0 0
PHREESIA INC COM 71944F106 8,736 161,005 SH   OTR 2 161,005 0 0
PHYSICIANS RLTY TR COM 71943U104 17,579 987,581 SH   DFND 1 987,581 0 0
PHYSICIANS RLTY TR COM 71943U104 3,143 176,566 SH   OTR 2 176,566 0 0
PINNACLE FINL PARTNERS INC COM 72346Q104 59,884 929,877 SH   DFND 1 929,877 0 0
PINNACLE FINL PARTNERS INC COM 72346Q104 10,505 163,119 SH   OTR 2 163,119 0 0
PINTEREST INC CL A 72352L106 61,175 928,304 SH   DFND 1 923,673 0 4,631
PIONEER NAT RES CO COM 723787107 11,268 98,938 SH   DFND 1 98,902 0 36
PLAINS ALL AMERN PIPELINE L UNIT LTD PARTN 726503105 6,387 775,104 SH   DFND 1 775,104 0 0
PLAINS GP HLDGS L P LTD PARTNR INT A 72651A207 14,205 1,681,094 SH   DFND 1 1,681,094 0 0
PLEXUS CORP COM 729132100 2,250 28,767 SH   DFND 1 28,767 0 0
PLUG POWER INC COM NEW 72919P202 1,231 36,310 SH   DFND 1 36,310 0 0
PMV PHARMACEUTICALS INC COM 69353Y103 9,140 148,594 SH   DFND 1 148,594 0 0
PNC FINL SVCS GROUP INC COM 693475105 150,061 1,007,119 SH   DFND 1 1,007,119 0 0
PNM RES INC COM 69349H107 27,721 571,204 SH   DFND 1 571,204 0 0
PNM RES INC COM 69349H107 5,355 110,347 SH   OTR 2 110,347 0 0
POOL CORP COM 73278L105 5,321 14,285 SH   DFND 1 14,285 0 0
POWER INTEGRATIONS INC COM 739276103 1,065 13,006 SH   DFND 1 13,006 0 0
PPD INC COM 69355F102 90,787 2,653,050 SH   DFND 1 2,645,368 0 7,682
PRA GROUP INC COM 69354N106 1,085 27,353 SH   DFND 1 27,353 0 0
PRAXIS PRECISION MEDICINES I COM 74006W108 10,959 199,175 SH   DFND 1 199,175 0 0
PRESTIGE CONSMR HEALTHCARE I COM 74112D101 14,485 415,396 SH   DFND 1 415,396 0 0
PRESTIGE CONSMR HEALTHCARE I COM 74112D101 3,930 112,707 SH   OTR 2 112,707 0 0
PRICE T ROWE GROUP INC COM 74144T108 4,968 32,815 SH   DFND 1 32,815 0 0
PRIMERICA INC COM 74164M108 1,583 11,823 SH   DFND 1 11,823 0 0
PRIMORIS SVCS CORP COM 74164F103 2,180 78,944 SH   DFND 1 78,944 0 0
PROCTER AND GAMBLE CO COM 742718109 99,230 713,165 SH   DFND 1 708,315 0 4,850
PROLOGIS INC. COM 74340W103 31,289 313,953 SH   DFND 1 313,953 0 0
PROOFPOINT INC COM 743424103 5,316 38,972 SH   DFND 1 38,972 0 0
PROOFPOINT INC COM 743424103 1,649 12,086 SH   OTR 2 12,086 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 10,989 2,616,473 SH   DFND 1 2,616,473 0 0
PROSIGHT GLOBAL INC COM 74349J103 8,951 697,631 SH   DFND 1 697,631 0 0
PROSIGHT GLOBAL INC COM 74349J103 1,481 115,458 SH   OTR 2 115,458 0 0
PTC INC COM 69370C100 54,980 459,662 SH   DFND 1 459,662 0 0
PUBLIC SVC ENTERPRISE GRP IN COM 744573106 86,130 1,477,353 SH   DFND 1 1,477,353 0 0
Q2 HLDGS INC COM 74736L109 38,728 306,075 SH   DFND 1 306,075 0 0
Q2 HLDGS INC COM 74736L109 12,448 98,379 SH   OTR 2 98,379 0 0
QTS RLTY TR INC COM CL A 74736A103 29,680 479,633 SH   DFND 1 479,633 0 0
QTS RLTY TR INC COM CL A 74736A103 7,244 117,070 SH   OTR 2 117,070 0 0
QUALCOMM INC COM 747525103 161,245 1,058,452 SH   DFND 1 1,056,240 0 2,212
QUANTA SVCS INC COM 74762E102 79,520 1,104,134 SH   DFND 1 1,101,091 0 3,043
RAYTHEON TECHNOLOGIES CORP COM 75513E101 128,819 1,801,415 SH   DFND 1 1,801,415 0 0
REDFIN CORP COM 75737F108 626 9,118 SH   DFND 1 9,118 0 0
RENAISSANCERE HLDGS LTD COM G7496G103 37,374 225,391 SH   DFND 1 225,391 0 0
RENEWABLE ENERGY GROUP INC COM NEW 75972A301 7,514 106,094 SH   DFND 1 106,055 0 39
REPLIGEN CORP COM 759916109 37,317 194,734 SH   DFND 1 194,734 0 0
RETAIL OPPORTUNITY INVTS COR COM 76131N101 20,594 1,537,995 SH   DFND 1 1,537,995 0 0
RETAIL OPPORTUNITY INVTS COR COM 76131N101 3,273 244,447 SH   OTR 2 244,447 0 0
RETAIL PPTYS AMER INC CL A 76131V202 1,495 174,680 SH   DFND 1 174,680 0 0
REVANCE THERAPEUTICS INC COM 761330109 56,308 1,986,877 SH   DFND 1 1,986,877 0 0
REVANCE THERAPEUTICS INC COM 761330109 6,083 214,631 SH   OTR 2 214,631 0 0
REXNORD CORP COM 76169B102 65,120 1,649,019 SH   DFND 1 1,649,019 0 0
REXNORD CORP COM 76169B102 11,236 284,536 SH   OTR 2 284,536 0 0
RINGCENTRAL INC CL A 76680R206 1,499,941 3,957,941 SH   DFND 1 3,754,242 0 203,699
RINGCENTRAL INC CL A 76680R206 54,880 144,813 SH   OTR 2 144,813 0 0
RIO TINTO PLC SPONSORED ADR 767204100 398 5,292 SH   DFND 1 5,256 0 36
ROKU INC COM CL A 77543R102 1,835 5,526 SH   DFND 1 5,526 0 0
ROSS STORES INC COM 778296103 108,177 880,847 SH   DFND 1 880,840 0 7
ROYAL CARIBBEAN GROUP COM V7780T103 32,028 428,811 SH   DFND 1 428,811 0 0
ROYAL GOLD INC COM 780287108 13,211 124,210 SH   DFND 1 124,210 0 0
RUSH ENTERPRISES INC CL A 781846209 25,822 623,419 SH   DFND 1 623,419 0 0
RUSH ENTERPRISES INC CL A 781846209 5,024 121,283 SH   OTR 2 121,283 0 0
RUSH STREET INTERACTIVE INC COM 782011100 2,837 131,022 SH   DFND 1 131,022 0 0
RUSH STREET INTERACTIVE INC COM 782011100 531 24,549 SH   OTR 2 24,549 0 0
S&P GLOBAL INC COM 78409V104 1,017,621 3,095,614 SH   DFND 1 2,977,984 0 117,630
S&P GLOBAL INC COM 78409V104 11,153 33,927 SH   OTR 2 33,927 0 0
SAGE THERAPEUTICS INC COM 78667J108 48,789 563,968 SH   DFND 1 563,968 0 0
SAIA INC COM 78709Y105 81,734 452,069 SH   DFND 1 452,069 0 0
SAIA INC COM 78709Y105 15,433 85,360 SH   OTR 2 85,360 0 0
SALESFORCE COM INC COM 79466L302 2,196,249 9,869,450 SH   DFND 1 9,283,907 0 585,543
SALESFORCE COM INC COM 79466L302 24,732 111,140 SH   OTR 2 111,140 0 0
SANDSTORM GOLD LTD COM NEW 80013R206 7,591 1,058,612 SH   DFND 1 1,058,612 0 0
SANDSTORM GOLD LTD COM NEW 80013R206 2,298 320,547 SH   OTR 2 320,547 0 0
SAP SE SPON ADR 803054204 58,687 450,085 SH   DFND 1 450,085 0 0
SAREPTA THERAPEUTICS INC COM 803607100 409,803 2,403,679 SH   DFND 1 2,383,868 0 19,811
SAREPTA THERAPEUTICS INC COM 803607100 4,128 24,213 SH   OTR 2 24,213 0 0
SAREPTA THERAPEUTICS INC PUT OPTIONS 803607100 10,570 62,000 SH Put DFND 1 62,000 0 0
SBA COMMUNICATIONS CORP NEW CL A 78410G104 89,733 318,056 SH   DFND 1 317,546 0 510
SCHLUMBERGER LTD COM 806857108 5,437 249,041 SH   DFND 1 248,962 0 79
SCHWEITZER-MAUDUIT INTL INC COM 808541106 753 18,725 SH   DFND 1 18,725 0 0
SEA LTD SPONSORD ADS 81141R100 279,223 1,402,779 SH   DFND 1 1,402,544 0 235
SEA LTD SPONSORD ADS 81141R100 4,909 24,663 SH   OTR 2 24,663 0 0
SEACOAST BKG CORP FLA COM NEW 811707801 15,220 516,819 SH   DFND 1 516,819 0 0
SEACOAST BKG CORP FLA COM NEW 811707801 2,478 84,132 SH   OTR 2 84,132 0 0
SEAGEN INC COM 81181C104 55,138 314,821 SH   DFND 1 313,875 0 946
SEER INC COM CL A 81578P106 8,506 151,519 SH   DFND 1 151,519 0 0
SEER INC COM CL A 81578P106 790 14,071 SH   OTR 2 14,071 0 0
SELECT MED HLDGS CORP COM 81619Q105 2,506 90,606 SH   DFND 1 90,606 0 0
SELECT SECTOR SPDR TR ENERGY 81369Y506 331 8,741 SH   DFND 1 8,688 0 53
SELECTQUOTE INC COM 816307300 12,323 593,861 SH   DFND 1 593,861 0 0
SEMPRA ENERGY COM 816851109 72,729 570,824 SH   DFND 1 570,824 0 0
SERVICE CORP INTL COM 817565104 2,138 43,541 SH   DFND 1 43,541 0 0
SERVICENOW INC COM 81762P102 873,615 1,587,150 SH   DFND 1 1,557,021 0 30,129
SERVICENOW INC COM 81762P102 9,149 16,621 SH   OTR 2 16,621 0 0
SHIFT4 PMTS INC CL A 82452J109 70,669 937,245 SH   DFND 1 936,239 0 1,006
SHIFT4 PMTS INC CL A 82452J109 9,247 122,645 SH   OTR 2 122,645 0 0
SHOCKWAVE MED INC COM 82489T104 59,857 577,106 SH   DFND 1 577,106 0 0
SHOPIFY INC CL A 82509L107 4,747,099 4,193,735 SH   DFND 1 4,080,269 0 113,466
SHOPIFY INC CL A 82509L107 108,729 96,055 SH   OTR 2 96,055 0 0
SILK RD MED INC COM 82710M100 64,792 1,028,775 SH   DFND 1 1,028,775 0 0
SILK RD MED INC COM 82710M100 6,015 95,505 SH   OTR 2 95,505 0 0
SIMULATIONS PLUS INC COM 829214105 1,155 16,061 SH   DFND 1 16,061 0 0
SIX FLAGS ENTMT CORP NEW COM 83001A102 950 27,849 SH   DFND 1 27,849 0 0
SLM CORP COM 78442P106 67,544 5,451,498 SH   DFND 1 5,451,498 0 0
SMARTSHEET INC COM CL A 83200N103 19,664 283,799 SH   DFND 1 283,799 0 0
SNOWFLAKE INC CL A 833445109 996,262 3,540,378 SH   DFND 1 3,388,079 0 152,299
SNOWFLAKE INC CL A 833445109 31,506 111,962 SH   OTR 2 111,962 0 0
SOUTHERN COPPER CORP COM 84265V105 21,148 324,752 SH   DFND 1 324,617 0 135
SOUTHWEST GAS HOLDINGS INC COM 844895102 1,253 20,618 SH   DFND 1 20,618 0 0
SPARTANNASH CO COM 847215100 689 39,554 SH   DFND 1 39,554 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 233 623 SH   DFND 1 623 0 0
SPDR SER TR PUT OPTIONS 78464A870 35,195 250,000 SH Put DFND 1 250,000 0 0
SPDR SER TR S&P METALS MNG 78464A755 4,460 133,361 SH   DFND 1 132,484 0 877
SPDR SER TR SPDR BLOOMBERG 78468R663 277 3,023 SH   DFND 1 3,023 0 0
SPLUNK INC COM 848637104 624,230 3,674,319 SH   DFND 1 3,431,629 0 242,690
SPLUNK INC COM 848637104 8,918 52,494 SH   OTR 2 52,494 0 0
SPOTIFY TECHNOLOGY S A SHS L8681T102 1,878,285 5,969,254 SH   DFND 1 5,853,232 0 116,022
SPOTIFY TECHNOLOGY S A SHS L8681T102 21,080 66,993 SH   OTR 2 66,993 0 0
SPROUTS FMRS MKT INC COM 85208M102 20,046 997,316 SH   DFND 1 997,316 0 0
SPROUTS FMRS MKT INC COM 85208M102 2,638 131,227 SH   OTR 2 131,227 0 0
SQUARE INC CL A 852234103 1,848,329 8,492,598 SH   DFND 1 8,226,529 0 266,069
SQUARE INC CL A 852234103 22,210 102,048 SH   OTR 2 102,048 0 0
SSR MNG INC COM 784730103 5,537 275,853 SH   DFND 1 275,773 0 80
STAG INDL INC COM 85254J102 2,156 68,851 SH   DFND 1 68,851 0 0
STAMPS COM INC COM NEW 852857200 25,552 130,241 SH   DFND 1 130,241 0 0
STAMPS COM INC COM NEW 852857200 4,415 22,506 SH   OTR 2 22,506 0 0
STARWOOD PPTY TR INC COM 85571B105 10,389 538,312 SH   DFND 1 538,312 0 0
STEELCASE INC CL A 858155203 624 46,035 SH   DFND 1 46,035 0 0
STRYKER CORPORATION COM 863667101 446 1,821 SH   DFND 1 1,821 0 0
SUMMIT HOTEL PPTYS INC COM 866082100 6,014 667,554 SH   DFND 1 667,554 0 0
SUMMIT HOTEL PPTYS INC COM 866082100 1,975 219,177 SH   OTR 2 219,177 0 0
SUMMIT MATLS INC CL A 86614U100 60,890 3,032,356 SH   DFND 1 3,032,356 0 0
SUMMIT MATLS INC CL A 86614U100 9,686 482,387 SH   OTR 2 482,387 0 0
SUNCOR ENERGY INC NEW COM 867224107 26,779 1,595,861 SH   DFND 1 1,595,660 0 201
SUNNOVA ENERGY INTL INC. COM 86745K104 21,535 477,182 SH   DFND 1 477,005 0 177
SUNPOWER CORP COM 867652406 21,472 837,450 SH   DFND 1 837,375 0 75
SUNPOWER CORP COM 867652406 2,629 102,527 SH   OTR 2 102,527 0 0
SUNRUN INC COM 86771W105 15,033 216,682 SH   DFND 1 216,596 0 86
SUPER MICRO COMPUTER INC COM 86800U104 2,003 63,251 SH   DFND 1 63,251 0 0
SYKES ENTERPRISES INC COM 871237103 1,941 51,521 SH   DFND 1 51,521 0 0
SYNEOS HEALTH INC CL A 87166B102 28,362 416,286 SH   DFND 1 416,286 0 0
SYNEOS HEALTH INC CL A 87166B102 6,157 90,375 SH   OTR 2 90,375 0 0
SYNOPSYS INC COM 871607107 5,857 22,594 SH   DFND 1 22,594 0 0
SYSCO CORP COM 871829107 450 6,057 SH   DFND 1 6,057 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 1,038,568 9,524,651 SH   DFND 1 9,404,182 0 120,469
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 18,602 170,594 SH   OTR 2 170,594 0 0
TAKE-TWO INTERACTIVE SOFTWAR COM 874054109 53,005 255,087 SH   DFND 1 253,828 0 1,259
TANDEM DIABETES CARE INC COM NEW 875372203 46,513 486,138 SH   DFND 1 486,138 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 5,783 60,438 SH   OTR 2 60,438 0 0
TARGA RES CORP COM 87612G101 43,388 1,644,722 SH   DFND 1 1,644,722 0 0
TARGET CORP COM 87612E106 46,095 261,120 SH   DFND 1 243,932 0 17,188
TARGET CORP COM 87612E106 1,845 10,451 SH   OTR 2 10,451 0 0
TC ENERGY CORP COM 87807B107 13,365 328,884 SH   DFND 1 328,884 0 0
TC PIPELINES LP UT COM LTD PRT 87233Q108 2,398 81,425 SH   DFND 1 81,425 0 0
TELADOC HEALTH INC COM 87918A105 1,084,598 5,424,072 SH   DFND 1 5,122,966 0 301,106
TELADOC HEALTH INC COM 87918A105 28,411 142,085 SH   OTR 2 142,085 0 0
TELEFLEX INCORPORATED COM 879369106 49,796 120,991 SH   DFND 1 120,565 0 426
TEMPUR SEALY INTL INC COM 88023U101 1,528 56,590 SH   DFND 1 56,590 0 0
TESLA INC COM 88160R101 8,388,302 11,887,004 SH   DFND 1 11,416,933 0 470,071
TESLA INC COM 88160R101 165,535 234,578 SH   OTR 2 234,578 0 0
TEXAS INSTRS INC COM 882508104 198,290 1,208,125 SH   DFND 1 1,208,125 0 0
TFI INTL INC COM 87241L109 22,028 427,063 SH   DFND 1 427,063 0 0
TFI INTL INC COM 87241L109 3,493 67,727 SH   OTR 2 67,727 0 0
THE TRADE DESK INC COM CL A 88339J105 1,723,620 2,151,835 SH   DFND 1 2,047,990 0 103,845
THE TRADE DESK INC COM CL A 88339J105 46,233 57,719 SH   OTR 2 57,719 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 48,771 104,709 SH   DFND 1 104,709 0 0
TIMKEN CO COM 887389104 1,206 15,591 SH   DFND 1 15,591 0 0
TJX COS INC NEW COM 872540109 1,035,289 15,160,173 SH   DFND 1 14,608,289 0 551,884
TJX COS INC NEW COM 872540109 13,112 192,011 SH   OTR 2 192,011 0 0
TOLL BROTHERS INC COM 889478103 301 6,921 SH   DFND 1 6,921 0 0
TOTAL SE SPONSORED ADS 89151E109 27,150 647,823 SH   DFND 1 647,717 0 106
TOWER SEMICONDUCTOR LTD SHS NEW M87915274 39,968 1,547,938 SH   DFND 1 1,547,938 0 0
TOWER SEMICONDUCTOR LTD SHS NEW M87915274 7,242 280,497 SH   OTR 2 280,497 0 0
TPI COMPOSITES INC COM 87266J104 10,081 190,992 SH   DFND 1 190,918 0 74
TRANE TECHNOLOGIES PLC SHS G8994E103 43,295 298,256 SH   DFND 1 296,841 0 1,415
TRI POINTE GROUP INC COM 87265H109 801 46,407 SH   DFND 1 46,407 0 0
TRINET GROUP INC COM 896288107 2,047 25,392 SH   DFND 1 25,392 0 0
TRINITY INDS INC COM 896522109 16,659 631,279 SH   DFND 1 631,279 0 0
TRINITY INDS INC COM 896522109 5,212 197,490 SH   OTR 2 197,490 0 0
TRITON INTL LTD CL A G9078F107 683 14,077 SH   DFND 1 14,077 0 0
TRONOX HOLDINGS PLC SHS G9087Q102 1,117 76,404 SH   DFND 1 76,404 0 0
TRUIST FINL CORP COM 89832Q109 107,610 2,245,156 SH   DFND 1 2,245,156 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 95,710 785,472 SH   DFND 1 785,472 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 5,742 47,124 SH   OTR 2 47,124 0 0
TWILIO INC CL A 90138F102 2,650,189 7,829,213 SH   DFND 1 7,504,133 0 325,080
TWILIO INC CL A 90138F102 63,363 187,189 SH   OTR 2 187,189 0 0
TWIST BIOSCIENCE CORP COM 90184D100 34,947 247,341 SH   DFND 1 247,341 0 0
TWIST BIOSCIENCE CORP COM 90184D100 6,181 43,749 SH   OTR 2 43,749 0 0
U S CONCRETE INC COM 90333L201 725 18,131 SH   DFND 1 18,131 0 0
UBER TECHNOLOGIES INC COM 90353T100 2,041,151 40,022,555 SH   DFND 1 38,441,588 0 1,580,967
UBER TECHNOLOGIES INC COM 90353T100 25,280 495,693 SH   OTR 2 495,693 0 0
UFP INDUSTRIES INC COM 90278Q108 1,410 25,385 SH   DFND 1 25,385 0 0
UMB FINL CORP COM 902788108 1,351 19,580 SH   DFND 1 19,580 0 0
UNION PAC CORP COM 907818108 1,149,277 5,519,530 SH   DFND 1 5,347,251 0 172,279
UNION PAC CORP COM 907818108 15,582 74,836 SH   OTR 2 74,836 0 0
UNITED PARCEL SERVICE INC CL B 911312106 19,132 113,609 SH   DFND 1 113,609 0 0
UNITED RENTALS INC COM 911363109 72,481 312,538 SH   DFND 1 312,538 0 0
UNITEDHEALTH GROUP INC COM 91324P102 175,562 500,632 SH   DFND 1 499,820 0 812
UNIVERSAL DISPLAY CORP COM 91347P105 14,118 61,438 SH   DFND 1 61,438 0 0
UPWORK INC COM 91688F104 723 20,947 SH   DFND 1 20,947 0 0
UTZ BRANDS INC COM CL A 918090101 13,421 608,401 SH   DFND 1 608,401 0 0
UTZ BRANDS INC COM CL A 918090101 4,182 189,574 SH   OTR 2 189,574 0 0
VALE S A SPONSORED ADS 91912E105 10,297 614,384 SH   DFND 1 614,155 0 229
VALERO ENERGY CORP COM 91913Y100 2,848 50,337 SH   DFND 1 50,316 0 21
VALLEY NATL BANCORP COM 919794107 1,537 157,615 SH   DFND 1 157,615 0 0
VANGUARD INDEX FDS GROWTH ETF 922908736 294 1,160 SH   DFND 1 1,160 0 0
VARONIS SYS INC COM 922280102 51,914 317,305 SH   DFND 1 317,305 0 0
VARONIS SYS INC COM 922280102 11,825 72,273 SH   OTR 2 72,273 0 0
VEEVA SYS INC CL A COM 922475108 2,593 9,525 SH   DFND 1 9,525 0 0
VERIZON COMMUNICATIONS INC COM 92343V104 118,011 2,008,696 SH   DFND 1 2,000,602 0 8,094
VERTEX INC CL A 92538J106 11,902 341,538 SH   DFND 1 341,538 0 0
VERTEX INC CL A 92538J106 3,722 106,796 SH   OTR 2 106,796 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 876,511 3,708,689 SH   DFND 1 3,565,032 0 143,657
VERTEX PHARMACEUTICALS INC COM 92532F100 9,611 40,665 SH   OTR 2 40,665 0 0
VISA INC COM CL A 92826C839 2,923,267 13,364,728 SH   DFND 1 12,870,121 0 494,607
VISA INC COM CL A 92826C839 34,595 158,163 SH   OTR 2 158,163 0 0
VITAL FARMS INC COM 92847W103 7,782 307,454 SH   DFND 1 307,454 0 0
VITAL FARMS INC COM 92847W103 1,730 68,366 SH   OTR 2 68,366 0 0
VROOM INC COM 92918V109 24,627 601,102 SH   DFND 1 601,102 0 0
VROOM INC COM 92918V109 3,866 94,364 SH   OTR 2 94,364 0 0
WABTEC COM 929740108 7,815 106,757 SH   DFND 1 106,757 0 0
WALMART INC COM 931142103 183,834 1,275,295 SH   DFND 1 1,272,583 0 2,712
WASTE CONNECTIONS INC COM 94106B101 10,338 100,786 SH   DFND 1 100,786 0 0
WERNER ENTERPRISES INC COM 950755108 1,090 27,798 SH   DFND 1 27,798 0 0
WEST PHARMACEUTICAL SVSC INC COM 955306105 5,121 18,075 SH   DFND 1 18,075 0 0
WESTERN MIDSTREAM PARTNERS L COM UNIT LP INT 958669103 9,914 717,389 SH   DFND 1 717,389 0 0
WHEATON PRECIOUS METALS CORP COM 962879102 5,106 122,337 SH   DFND 1 122,287 0 50
WILLIAMS COS INC COM 969457100 131,584 6,562,795 SH   DFND 1 6,562,795 0 0
WILLSCOT MOBIL MINI HLDNG CO COM CL A 971378104 72,201 3,116,122 SH   DFND 1 3,116,122 0 0
WILLSCOT MOBIL MINI HLDNG CO COM CL A 971378104 12,878 555,811 SH   OTR 2 555,811 0 0
WINGSTOP INC COM 974155103 31,224 235,564 SH   DFND 1 235,564 0 0
WINGSTOP INC COM 974155103 9,258 69,849 SH   OTR 2 69,849 0 0
WINTRUST FINL CORP COM 97650W108 37,431 612,713 SH   DFND 1 612,713 0 0
WINTRUST FINL CORP COM 97650W108 6,627 108,484 SH   OTR 2 108,484 0 0
WIX COM LTD SHS M98068105 103,299 413,262 SH   DFND 1 413,206 0 56
WIX COM LTD SHS M98068105 1,889 7,558 SH   OTR 2 7,558 0 0
WORKDAY INC CL A 98138H101 1,101,570 4,597,346 SH   DFND 1 4,377,343 0 220,003
WORKDAY INC CL A 98138H101 14,889 62,139 SH   OTR 2 62,139 0 0
WORLD WRESTLING ENTMT INC CL A 98156Q108 1,530 31,841 SH   DFND 1 31,841 0 0
WPX ENERGY INC COM 98212B103 36,171 4,438,131 SH   DFND 1 4,437,650 0 481
WSFS FINL CORP COM 929328102 36,911 822,436 SH   DFND 1 822,436 0 0
WSFS FINL CORP COM 929328102 8,470 188,731 SH   OTR 2 188,731 0 0
XCEL ENERGY INC COM 98389B100 55,219 828,243 SH   DFND 1 828,243 0 0
XILINX INC COM 983919101 47,456 334,738 SH   DFND 1 333,099 0 1,639
YETI HLDGS INC COM 98585X104 35,341 516,151 SH   DFND 1 514,429 0 1,722
YETI HLDGS INC COM 98585X104 1,968 28,739 SH   OTR 2 28,739 0 0
ZAI LAB LTD ADR 98887Q104 36,113 266,835 SH   DFND 1 266,835 0 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102 133,606 867,063 SH   DFND 1 867,063 0 0
ZOETIS INC CL A 98978V103 205,103 1,239,292 SH   DFND 1 1,191,858 0 47,434
ZOOM VIDEO COMMUNICATIONS IN CL A 98980L101 442,647 1,312,246 SH   DFND 1 1,276,253 0 35,993
ZOOM VIDEO COMMUNICATIONS IN CL A 98980L101 14,385 42,646 SH   OTR 2 42,646 0 0
ZUMIEZ INC COM 989817101 2,031 55,230 SH   DFND 1 55,230 0 0