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JANUS HENDERSON GROUP PLC
> RYTM
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 1,078,207 | -161,946 | 17,779,404,000 | -18,333,613,000 | $16,489.79 |
| 12/31/2022 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 1,240,153 | -320,930 | 36,113,017,000 | 36,074,770,000 | $29,119.81 |
| 09/30/2022 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 1,561,083 | -518,994 | 38,247,000 | 29,615,000 | $24.50 |
| 06/30/2022 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 2,080,077 | -870,925 | 8,632,000 | -25,363,000 | $4.15 |
| 03/31/2022 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 2,951,002 | -182,933 | 33,995,000 | 2,718,000 | $11.52 |
| 12/31/2021 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 3,133,935 | -48,447 | 31,277,000 | -10,285,000 | $9.98 |
| 09/30/2021 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 3,182,382 | -743,668 | 41,562,000 | -35,310,000 | $13.06 |
| 06/30/2021 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 3,926,050 | -161,973 | 76,872,000 | -10,079,000 | $19.58 |
| 03/31/2021 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 4,088,023 | -403,742 | 86,951,000 | -46,591,000 | $21.27 |
| 02/11/2021 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 4,491,765 | 0 | 137,717,515 | 4,175,515 | $30.66 |
| 12/31/2020 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 4,491,765 | 105,395 | 133,542,000 | 38,489,000 | $29.73 |
| 09/30/2020 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 4,386,370 | -24,118 | 95,053,000 | -3,300,000 | $21.67 |
| 06/30/2020 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 4,410,488 | 91,455 | 98,353,000 | 32,618,000 | $22.30 |
| 03/31/2020 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 4,319,033 | 13,785 | 65,735,000 | -33,113,000 | $15.22 |
| 02/13/2020 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 4,305,248 | 0 | 76,073,732 | -22,774,268 | $17.67 |
| 12/31/2019 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 4,305,248 | 898,500 | 98,848,000 | 25,296,000 | $22.96 |
| 09/30/2019 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 3,406,748 | 3,406,748 | 73,552,000 | 73,552,000 | $21.59 |
| 06/30/2019 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 0 | -3,281,769 | 0 | -89,953,000 | |
| 03/31/2019 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 3,281,769 | 18,594 | 89,953,000 | 2,239,000 | $27.41 |
| 02/12/2019 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 3,263,175 | 0 | 96,948,929 | 9,234,929 | $29.71 |
| 12/31/2018 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 3,263,175 | 212,337 | 87,714,000 | -1,279,000 | $26.88 |
| 09/30/2018 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 3,050,838 | 759,053 | 88,993,000 | 17,352,000 | $29.17 |
| 06/30/2018 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 2,291,785 | 1,197,165 | 71,641,000 | 49,858,000 | $31.26 |
| 03/31/2018 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 1,094,620 | 339,460 | 21,783,000 | -162,000 | $19.90 |
| 12/31/2017 | RHYTHM PHARMACEUTICALS, INC. | RYTM | 755,160 | 755,160 | 21,945,000 | 21,945,000 | $29.06 |
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