The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
21VIANET GROUP INC SPONSORED ADS A 90138A103 3,420 147,699 SH   DFND 4 0 147,699 0
3M CO COM 88579Y101 96,449 602,149 SH   DFND 2 4 9 0 211,955 390,194
89BIO INC COM 282559103 1,556 60,650 SH   DFND 10 0 60,650 0
ABB LTD SPONSORED ADR 000375204 557 21,905 SH   DFND 4 10 0 21,905 0
ABBOTT LABS COM 002824100 1,154,355 10,607,026 SH   DFND 4 9 10 0 10,348,839 258,187
ABBVIE INC COM 00287Y109 1,486,298 16,968,979 SH   DFND 4 9 10 0 14,032,211 2,936,768
ABIOMED INC COM 003654100 38,387 138,560 SH   DFND 4 9 10 0 45,846 92,714
ACADIA PHARMACEUTICALS INC COM 004225108 235,378 5,706,104 SH   DFND 9 10 0 5,374,091 332,013
ACCELERON PHARMA INC COM 00434H108 200,745 1,783,939 SH   DFND 9 10 0 1,721,528 62,411
ACCENTURE PLC IRELAND SHS CLASS A G1151C101 1,119,409 4,953,409 SH   DFND 4 9 10 0 4,104,998 848,411
ACI WORLDWIDE INC COM 004498101 76,099 2,912,336 SH   DFND 4 10 0 2,809,811 102,525
ACM RESEARCH INC COM CL A 00108J109 1,257 18,195 SH   DFND 10 0 18,195 0
ACTIVISION BLIZZARD INC COM 00507V109 201,865 2,493,745 SH   DFND 4 9 10 0 1,827,069 666,676
ACUITY BRANDS INC COM 00508Y102 472 4,608 SH   DFND 9 10 0 4,488 120
ADDUS HOMECARE CORP COM 006739106 323 3,414 SH   DFND 10 0 3,414 0
ADOBE SYSTEMS INCORPORATED COM 00724F101 3,312,792 6,755,875 SH   DFND 4 9 10 0 6,217,117 538,758
ADT INC DEL COM 00090Q103 6,463 790,572 SH   DFND 4 9 0 789,473 1,099
ADVANCE AUTO PARTS INC COM 00751Y106 2,754 17,938 SH   DFND 4 9 0 17,938 0
ADVANCED MICRO DEVICES INC COM 007903107 229,377 2,797,737 SH   DFND 4 9 0 1,362,798 1,434,939
AERCAP HOLDINGS NV SHS N00985106 1,057 41,963 SH   DFND 4 9 0 18,572 23,391
AEROJET ROCKETDYNE HLDGS INC COM 007800105 352 8,821 SH   DFND 10 0 8,821 0
AES CORP COM 00130H105 30,047 1,659,157 SH   DFND 4 9 0 1,535,247 123,910
AFLAC INC COM 001055102 6,471 178,023 SH   DFND 4 9 10 0 178,023 0
AFYA LTD CL A COM G01125106 13,055 478,833 SH   DFND 4 0 478,833 0
AGILENT TECHNOLOGIES INC COM 00846U101 42,142 417,518 SH   DFND 2 4 9 10 0 404,674 12,844
AGNC INVT CORP COM 00123Q104 2,449 176,056 SH   DFND 4 9 0 176,056 0
AGNICO EAGLE MINES LTD COM 008474108 13,068 164,514 SH   DFND 4 9 0 93,139 71,375
AIR PRODS & CHEMS INC COM 009158106 587,493 1,972,361 SH   DFND 4 9 10 11 0 1,461,889 510,472
AKAMAI TECHNOLOGIES INC COM 00971T101 10,885 98,475 SH   DFND 4 9 0 69,715 28,760
AKERO THERAPEUTICS INC COM 00973Y108 108,856 3,535,455 SH   DFND 10 0 3,423,625 111,830
ALAMO GROUP INC COM 011311107 19,210 177,819 SH   DFND 10 0 169,776 8,043
ALARM COM HLDGS INC COM 011642105 80,917 1,464,562 SH   DFND 10 0 1,413,015 51,547
ALBANY INTL CORP CL A 012348108 266 5,365 SH   DFND 4 10 0 5,365 0
ALBEMARLE CORP COM 012653101 5,185 58,082 SH   DFND 4 9 11 0 57,208 874
ALCON AG ORD SHS H01301128 10,157 178,448 SH   DFND 4 9 10 0 86,193 92,255
ALEXANDRIA REAL ESTATE EQ IN COM 015271109 64,145 401,142 SH   DFND 4 9 10 12 0 378,780 22,362
ALEXION PHARMACEUTICALS INC COM 015351109 177,060 1,547,353 SH   DFND 4 9 10 0 1,410,972 136,381
ALGONQUIN PWR UTILS CORP COM 015857105 177 12,257 SH   DFND 4 9 0 12,257 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 407,945 1,388,116 SH   DFND 4 9 10 12 0 1,297,783 90,333
ALIGN TECHNOLOGY INC COM 016255101 431,017 1,316,661 SH   DFND 4 9 10 0 1,219,116 97,545
ALLEGHANY CORP DEL COM 017175100 3,426 6,582 SH   DFND 4 9 0 6,581 1
ALLEGIANT TRAVEL CO COM 01748X102 522 4,356 SH   DFND 10 0 4,356 0
ALLEGION PLC ORD SHS G0176J109 4,366 44,163 SH   DFND 4 9 0 44,163 0
ALLIANT ENERGY CORP COM 018802108 304,336 5,892,251 SH   DFND 2 4 9 10 0 5,639,248 253,003
ALLISON TRANSMISSION HLDGS I COM 01973R101 446 12,701 SH   DFND 10 0 12,701 0
ALLSTATE CORP COM 020002101 30,665 325,777 SH   DFND 4 9 0 272,856 52,921
ALLY FINL INC COM 02005N100 12,349 492,585 SH   DFND 4 9 0 189,002 303,583
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 23,669 162,569 SH   DFND 4 9 10 0 147,877 14,692
ALPHABET INC CAP STK CL A 02079K305 647,540 441,934 SH   DFND 2 4 9 10 0 408,684 33,250
ALPHABET INC CAP STK CL C 02079K107 3,293,938 2,241,519 SH   DFND 4 9 10 0 2,077,428 164,091
ALTAIR ENGR INC COM CL A 021369103 99,092 2,360,453 SH   DFND 10 0 2,280,486 79,967
ALTERYX INC COM CL A 02156B103 2,014 17,737 SH   DFND 10 0 17,737 0
ALTICE USA INC CL A 02156K103 4,215 162,127 SH   DFND 4 9 0 162,127 0
ALTRIA GROUP INC COM 02209S103 159,646 4,131,701 SH   DFND 4 9 10 0 4,010,141 121,560
ALX ONCOLOGY HLDGS INC COM 00166B105 16,221 429,802 SH   DFND 10 0 405,504 24,298
AMAZON COM INC COM 023135106 7,203,374 2,287,791 SH   DFND 4 9 10 0 2,068,613 219,178
AMAZON COM INC COM 023135106 54 300 SH Call DFND 10 0 3 0
AMBARELLA INC SHS G037AX101 65,616 1,257,364 SH   DFND 4 0 1,257,364 0
AMCOR PLC ORD G0250X107 22,370 2,024,609 SH   DFND 4 9 0 1,129,426 895,183
AMDOCS LTD SHS G02602103 390,989 6,810,470 SH   DFND 4 9 10 0 6,624,874 185,596
AMEDISYS INC COM 023436108 4,439 18,774 SH   DFND 9 10 0 18,272 502
AMERCO COM 023586100 23,518 66,066 SH   DFND 4 9 10 0 58,099 7,967
AMEREN CORP COM 023608102 15,310 193,601 SH   DFND 4 9 0 193,601 0
AMERICAN AIRLS GROUP INC COM 02376R102 117 362,500 SH Call DFND 10 0 3,625 0
AMERICAN AIRLS GROUP INC COM 02376R102 118 365,700 SH Call DFND 10 0 3,657 0
AMERICAN AIRLS GROUP INC COM 02376R102 1 3,200 SH Call DFND 10 0 32 0
AMERICAN AIRLS GROUP INC COM 02376R102 697 56,735 SH   DFND 4 9 0 56,735 0
AMERICAN ELEC PWR CO INC COM 025537101 146,022 1,786,632 SH   DFND 4 9 10 0 1,600,062 186,570
AMERICAN ELEC PWR CO INC UNIT 99/99/9999 02557T307 1,957 40,000 SH   DFND 10 0 40,000 0
AMERICAN EXPRESS CO COM 025816109 444,180 4,430,821 SH   DFND 4 9 10 0 4,276,125 154,696
AMERICAN FINL GROUP INC OHIO COM 025932104 873 13,042 SH   DFND 4 9 0 13,042 0
AMERICAN HOMES 4 RENT CL A 02665T306 38,241 1,342,951 SH   DFND 4 10 12 0 1,305,240 37,711
AMERICAN INTL GROUP INC COM NEW 026874784 24,522 890,770 SH   DFND 2 4 9 0 708,957 181,813
AMERICAN TOWER CORP NEW COM 03027X100 944,933 3,909,255 SH   DFND 4 9 10 12 0 3,534,919 374,336
AMERICAN VANGUARD CORP COM 030371108 19,653 1,495,670 SH   DFND 2 0 1,495,670 0
AMERICAN WELL CORP CL A 03044L105 1,378 46,508 SH   DFND 10 0 34,648 11,860
AMERICAN WOODMARK CORPORATIO COM 030506109 358 4,557 SH   DFND 10 0 4,557 0
AMERICAN WTR WKS CO INC NEW COM 030420103 47,015 324,544 SH   DFND 4 9 0 305,557 18,987
AMERICOLD RLTY TR COM 03064D108 91,642 2,563,649 SH   DFND 2 4 9 10 12 0 2,534,889 28,760
AMERIPRISE FINL INC COM 03076C106 7,573 49,143 SH   DFND 4 9 0 38,278 10,865
AMERISOURCEBERGEN CORP COM 03073E105 35,132 362,484 SH   DFND 4 9 10 0 195,945 166,539
AMETEK INC COM 031100100 55,133 554,662 SH   DFND 2 4 9 0 554,662 0
AMGEN INC COM 031162100 235,699 927,404 SH   DFND 4 9 10 0 384,953 542,451
AMICUS THERAPEUTICS INC COM 03152W109 199,181 14,106,259 SH   DFND 10 0 13,620,865 485,394
AMN HEALTHCARE SVCS INC COM 001744101 2,514 43,009 SH   DFND 4 10 0 43,009 0
AMPHENOL CORP NEW CL A 032095101 100,155 925,411 SH   DFND 4 9 0 925,411 0
ANALOG DEVICES INC COM 032654105 209,186 1,792,311 SH   DFND 2 4 9 0 1,696,457 95,854
ANNALY CAPITAL MANAGEMENT IN COM 035710409 3,441 483,147 SH   DFND 4 9 0 483,147 0
ANNEXON INC COM 03589W102 49,446 1,727,448 SH   DFND 10 0 1,727,448 0
ANSYS INC COM 03662Q105 24,968 76,306 SH   DFND 4 9 0 69,112 7,194
ANTHEM INC COM 036752103 191,919 714,583 SH   DFND 4 9 10 0 538,378 176,205
ANWORTH MTG ASSET CORP COM 037347101 155 94,219 SH   DFND 2 0 94,219 0
AON PLC SHS CL A G0403H108 945,239 4,582,125 SH   DFND 4 9 10 0 4,368,786 213,339
APACHE CORP COM 037411105 11,068 1,168,705 SH   DFND 9 0 1,088,273 80,432
APOLLO GLOBAL MGMT INC COM CL A 03768E105 212,746 4,754,108 SH   DFND 4 9 10 0 4,052,630 701,478
APPFOLIO INC COM CL A 03783C100 2,149 15,157 SH   DFND 10 0 15,157 0
APPLE INC COM 037833100 52 7,000 SH Call DFND 10 0 70 0
APPLE INC COM 037833100 8,156,963 70,447,468 SH   DFND 4 9 10 0 60,987,483 9,459,985
APPLIED MATLS INC COM 038222105 19,944 335,609 SH   DFND 4 9 0 335,090 519
APREA THERAPEUTICS INC COM 03836J102 20,479 851,180 SH   DFND 10 0 821,321 29,859
APTARGROUP INC COM 038336103 6,120 54,065 SH   DFND 9 0 35,967 18,098
APTIV PLC SHS G6095L109 275,587 3,006,043 SH   DFND 2 4 9 10 0 2,943,927 62,116
ARAMARK COM 03852U106 258,667 9,779,454 SH   DFND 4 9 10 0 9,562,866 216,588
ARCH CAP GROUP LTD ORD G0450A105 5,197 177,673 SH   DFND 4 9 0 177,673 0
ARCHER DANIELS MIDLAND CO COM 039483102 89,760 1,930,774 SH   DFND 4 9 11 0 1,464,834 465,940
ARCTURUS THERAPEUTICS HLDGS COM 03969T109 20,724 483,078 SH   DFND 10 0 464,369 18,709
ARENA PHARMACEUTICALS INC COM NEW 040047607 1,677 22,418 SH   DFND 10 0 22,418 0
ARES MANAGEMENT CORPORATION CL A COM STK 03990B101 2,281 56,437 SH   DFND 4 9 0 31,513 24,924
ARGENX SE SPONSORED ADR 04016X101 63,784 242,964 SH   DFND 10 0 234,328 8,636
ARGO GROUP INTL HLDGS LTD COM G0464B107 41,160 1,195,483 SH   DFND 2 0 1,195,483 0
ARISTA NETWORKS INC COM 040413106 19,552 94,487 SH   DFND 4 9 0 44,753 49,734
ARROW ELECTRS INC COM 042735100 1,404 17,850 SH   DFND 4 9 0 17,850 0
ARROWHEAD PHARMACEUTICALS IN COM 04280A100 49,883 1,158,462 SH   DFND 10 0 1,105,343 53,119
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 457,800 2,966,606 SH   DFND 10 0 2,832,928 133,678
ASGN INC COM 00191U102 895 14,083 SH   DFND 10 0 14,083 0
ASML HOLDING N V N Y REGISTRY SHS N07059210 405,158 1,097,204 SH   DFND 10 0 1,046,032 51,172
ASPEN TECHNOLOGY INC COM 045327103 2,842 22,451 SH   DFND 10 0 22,451 0
ASSETMARK FINL HLDGS INC COM 04546L106 14,548 669,197 SH   DFND 4 10 0 640,625 28,572
ASSURANT INC COM 04621X108 34,913 287,798 SH   DFND 4 9 0 80,227 207,571
ASSURED GUARANTY LTD COM G0585R106 1,704 79,327 SH   DFND 9 0 52,921 26,406
ASTRAZENECA PLC SPONSORED ADR 046353108 33,217 606,158 SH   DFND 10 0 606,158 0
AT&T INC COM 00206R102 65,203 2,288,132 SH   DFND 4 9 0 1,746,662 541,470
ATHENE HOLDING LTD CL A G0684D107 839 24,619 SH   DFND 4 9 10 0 23,071 1,548
ATHIRA PHARMA INC COM 04746L104 18,053 1,003,198 SH   DFND 10 0 1,003,198 0
ATKORE INTL GROUP INC COM 047649108 288 12,677 SH   DFND 10 0 12,677 0
ATLANTIC UN BANKSHARES CORP COM 04911A107 60,155 2,814,947 SH   DFND 2 0 2,814,947 0
ATLASSIAN CORP PLC CL A G06242104 654,809 3,602,064 SH   DFND 4 9 10 0 3,333,200 268,864
ATMOS ENERGY CORP COM 049560105 16,642 174,097 SH   DFND 4 9 0 82,426 91,671
AUTODESK INC COM 052769106 530,640 2,297,293 SH   DFND 4 9 10 0 1,959,928 337,365
AUTOHOME INC SP ADR RP CL A 05278C107 501 5,220 SH   DFND 9 0 5,220 0
AUTOLIV INC COM 052800109 1,713 23,506 SH   DFND 4 9 0 23,506 0
AUTOMATIC DATA PROCESSING IN COM 053015103 151,193 1,083,901 SH   DFND 4 9 10 0 471,425 612,476
AUTOZONE INC COM 053332102 30,112 25,569 SH   DFND 4 9 0 25,569 0
AVALARA INC COM 05338G106 517,192 4,061,600 SH   DFND 4 9 10 0 3,740,588 321,012
AVALONBAY CMNTYS INC COM 053484101 5,725 38,340 SH   DFND 4 9 0 38,340 0
AVANGRID INC COM 05351W103 883 17,500 SH   DFND 4 10 0 17,500 0
AVANTOR INC COM 05352A100 934 41,572 SH   DFND 4 9 0 41,572 0
AVERY DENNISON CORP COM 053611109 46,316 362,299 SH   DFND 4 9 10 0 302,964 59,335
AVIDITY BIOSCIENCES INC COM 05370A108 5,080 180,446 SH   DFND 10 0 159,938 20,508
AVNET INC COM 053807103 54,168 2,096,275 SH   DFND 2 0 2,096,275 0
AVROBIO INC COM 05455M100 834 63,937 SH   DFND 10 0 63,937 0
AXALTA COATING SYS LTD COM G0750C108 33,258 1,500,152 SH   DFND 2 4 9 0 1,497,066 3,086
AXIS CAP HLDGS LTD SHS G0692U109 40,770 925,747 SH   DFND 2 9 0 869,173 56,574
AXOGEN INC COM 05463X106 15,077 1,296,412 SH   DFND 10 0 1,237,895 58,517
AXON ENTERPRISE INC COM 05464C101 132,359 1,459,306 SH   DFND 10 0 1,409,393 49,913
AXSOME THERAPEUTICS INC COM 05464T104 36,686 514,883 SH   DFND 10 0 496,852 18,031
B2GOLD CORP COM 11777Q209 3,827 589,127 SH   DFND 4 9 11 0 589,127 0
BAIDU INC SPON ADR REP A 056752108 591 4,670 SH   DFND 9 0 4,670 0
BAKER HUGHES COMPANY CL A 05722G100 1,854 139,524 SH   DFND 4 9 0 139,524 0
BALL CORP COM 058498106 110,546 1,329,985 SH   DFND 4 9 10 0 1,310,594 19,391
BANK HAWAII CORP COM 062540109 32,874 650,720 SH   DFND 2 0 650,720 0
BANK MONTREAL QUE COM 063671101 8,459 145,192 SH   DFND 4 9 0 145,192 0
BANK NEW YORK MELLON CORP COM 064058100 7,505 218,572 SH   DFND 4 9 10 0 214,740 3,832
BANK NOVA SCOTIA B C COM 064149107 11,438 276,314 SH   DFND 4 9 0 276,314 0
BARRICK GOLD CORP COM 067901108 118 4,237 SH   DFND 4 0 4,237 0
BARRICK GOLD CORP COM 067901108 37,647 1,343,280 SH   DFND 4 9 0 1,343,280 0
BAUSCH HEALTH COS INC COM 071734107 2,508 161,974 SH   DFND 4 9 0 161,974 0
BAXTER INTL INC COM 071813109 153,786 1,912,292 SH   DFND 4 9 10 0 1,869,043 43,249
BCE INC COM NEW 05534B760 2,874 69,525 SH   DFND 4 9 0 69,525 0
BCTG ACQUISITION CORP COM 05492W103 2,311 218,282 SH   DFND 10 0 218,282 0
BECTON DICKINSON & CO COM 075887109 54,197 232,901 SH   DFND 4 9 0 119,249 113,652
BEIGENE LTD SPONSORED ADR 07725L102 27,239 95,096 SH   DFND 4 9 10 0 4,167 90,929
BELDEN INC COM 077454106 9,371 301,134 SH   DFND 10 0 301,134 0
BELLRING BRANDS INC COM CL A 079823100 18,443 889,243 SH   DFND 10 0 801,453 87,790
BENCHMARK ELECTRS INC COM 08160H101 13,320 661,048 SH   DFND 2 0 661,048 0
BERKELEY LTS INC COM 084310101 4,389 57,482 SH   DFND 10 0 24,200 33,282
BERKLEY W R CORP COM 084423102 406,051 6,640,241 SH   DFND 4 9 10 0 6,441,697 198,544
BERKSHIRE HATHAWAY INC DEL CL B NEW 084670702 184,956 868,641 SH   DFND 2 4 9 10 0 799,479 69,162
BERKSHIRE HATHAWAY INC DEL CL A 084670108 11,519 36 SH   DFND 4 0 36 0
BERRY GLOBAL GROUP INC COM 08579W103 3,271 67,703 SH   DFND 10 0 67,703 0
BEST BUY INC COM 086516101 287,769 2,585,762 SH   DFND 4 9 10 0 1,148,182 1,437,580
BHP GROUP PLC SPONSORED ADR 05545E209 9,736 228,253 SH   DFND 4 0 228,253 0
BILL COM HLDGS INC COM 090043100 4,253 42,395 SH   DFND 10 0 42,395 0
BIO RAD LABS INC CL A 090572207 22,835 44,302 SH   DFND 4 9 0 24,209 20,093
BIOGEN INC COM 09062X103 34,016 119,930 SH   DFND 4 9 10 0 76,213 43,717
BIOMARIN PHARMACEUTICAL INC COM 09061G101 396,730 5,214,710 SH   DFND 4 9 10 0 4,820,843 393,867
BIONTECH SE SPONSORED ADS 09075V102 56,177 811,468 SH   DFND 10 0 787,084 24,384
BIOSPECIFICS TECHNOLOGIES CO COM 090931106 15,919 301,321 SH   DFND 2 10 0 301,321 0
BIO-TECHNE CORP COM 09073M104 183,524 740,821 SH   DFND 9 10 0 708,667 32,154
BIOTELEMETRY INC COM 090672106 1,986 43,573 SH   DFND 10 0 43,573 0
BK OF AMERICA CORP COM 060505104 334,269 13,876,724 SH   DFND 4 9 10 0 13,855,823 20,901
BLACK HILLS CORP COM 092113109 58,082 1,085,847 SH   DFND 2 0 1,085,847 0
BLACK KNIGHT INC COM 09215C105 1,279 14,698 SH   DFND 4 9 0 14,698 0
BLACKBAUD INC COM 09227Q100 175,590 3,145,087 SH   DFND 10 0 3,024,340 120,747
BLACKBERRY LTD COM 09228F103 371 80,973 SH   DFND 4 9 0 80,973 0
BLACKROCK INC COM 09247X101 19,605 34,791 SH   DFND 4 9 0 34,791 0
BLACKSTONE GROUP INC COM CL A 09260D107 1,001,911 19,193,787 SH   DFND 4 9 10 0 16,949,521 2,244,266
BMC STK HLDGS INC COM 05591B109 771 17,995 SH   DFND 10 0 17,995 0
BOEING CO COM 097023105 20,092 121,574 SH   DFND 4 9 0 121,221 353
BOOKING HOLDINGS INC COM 09857L108 809,351 473,126 SH   DFND 4 9 10 0 463,155 9,971
BOOZ ALLEN HAMILTON HLDG COR CL A 099502106 7,768 93,614 SH   DFND 4 9 0 33,448 60,166
BORGWARNER INC COM 099724106 2,418 62,412 SH   DFND 4 9 0 62,412 0
BOSTON BEER INC CL A 100557107 7,546 8,542 SH   DFND 9 0 6,667 1,875
BOSTON PROPERTIES INC COM 101121101 3,083 38,374 SH   DFND 4 9 0 38,374 0
BOSTON SCIENTIFIC CORP COM 101137107 1,860,903 48,702,542 SH   DFND 4 9 10 0 47,122,973 1,579,569
BOSTON SCIENTIFIC CORP 5.50% CNV PFD A 101137206 1,668 14,971 SH   DFND 10 0 14,971 0
BP PLC SPONSORED ADR 055622104 3,032 173,668 SH   DFND 2 0 104,135 69,533
BRADY CORP CL A 104674106 97,282 2,430,835 SH   DFND 10 0 2,322,760 108,075
BRIDGEBIO PHARMA INC COM 10806X102 63,464 1,691,461 SH   DFND 10 0 1,618,402 73,059
BRIGHAM MINERALS INC CL A COM 10918L103 909 101,947 SH   DFND 2 0 101,947 0
BRISTOL-MYERS SQUIBB CO RIGHT 99/99/9999 110122157 54,255 24,112,077 SH   DFND 10 0 23,409,411 702,666
BRISTOL-MYERS SQUIBB CO COM 110122108 1,431,491 23,744,270 SH   DFND 4 9 10 0 22,288,149 1,456,121
BRITISH AMERN TOB PLC SPONSORED ADR 110448107 579 16,018 SH   DFND 4 10 0 16,018 0
BROADCOM INC COM 11135F101 625,819 1,718,342 SH   DFND 4 9 0 1,421,203 297,139
BROADRIDGE FINL SOLUTIONS IN COM 11133T103 867,313 6,570,549 SH   DFND 4 9 10 0 6,173,101 397,448
BROOKDALE SR LIVING INC COM 112463104 109 42,815 SH   DFND 10 0 42,815 0
BROOKFIELD ASSET MGMT INC CL A LTD VT SH 112585104 9,309 282,235 SH   DFND 4 9 0 282,235 0
BROOKFIELD ASSET MGMT INC CL A LTD VT SH 112585104 1,958 59,243 SH   DFND 4 10 0 59,243 0
BROOKS AUTOMATION INC NEW COM 114340102 65,193 1,409,278 SH   DFND 10 0 1,346,151 63,127
BROWN & BROWN INC COM 115236101 21,342 471,446 SH   DFND 4 9 0 438,363 33,083
BROWN FORMAN CORP CL B 115637209 11,502 152,722 SH   DFND 4 9 0 152,722 0
BRUKER CORP COM 116794108 112,278 2,824,606 SH   DFND 4 10 0 2,724,136 100,470
BUILDERS FIRSTSOURCE INC COM 12008R107 1,080 33,094 SH   DFND 4 10 0 33,094 0
BUNGE LIMITED COM G16962105 50,599 1,107,215 SH   DFND 4 9 0 322,641 784,574
BURLINGTON STORES INC COM 122017106 252,554 1,225,453 SH   DFND 4 9 10 0 1,193,912 31,541
BWX TECHNOLOGIES INC COM 05605H100 147,691 2,622,816 SH   DFND 2 9 0 2,622,622 194
C H ROBINSON WORLDWIDE INC COM NEW 12541W209 77,842 761,740 SH   DFND 4 9 0 322,947 438,793
CABLE ONE INC COM 12685J105 87,537 46,429 SH   DFND 4 9 10 0 42,875 3,554
CABOT OIL & GAS CORP COM 127097103 19,659 1,132,481 SH   DFND 4 9 11 0 715,035 417,446
CADENCE DESIGN SYSTEM INC COM 127387108 332,457 3,118,007 SH   DFND 4 9 10 0 2,085,458 1,032,549
CAE INC COM 124765108 43,733 2,998,754 SH   DFND 4 9 10 0 2,859,105 139,649
CAESARS ENTERTAINMENT INC NE COM 12769G100 194,858 3,475,888 SH   DFND 10 0 3,381,487 94,401
CAL MAINE FOODS INC COM NEW 128030202 36,647 955,086 SH   DFND 2 0 955,086 0
CALAVO GROWERS INC COM 128246105 646 9,755 SH   DFND 10 0 9,755 0
CALLAWAY GOLF CO COM 131193104 313 16,375 SH   DFND 10 0 16,375 0
CAMDEN PPTY TR SH BEN INT 133131102 77,004 865,412 SH   DFND 2 4 9 0 856,187 9,225
CAMECO CORP COM 13321L108 1,185 117,603 SH   DFND 4 9 11 0 117,603 0
CAMPBELL SOUP CO COM 134429109 103,028 2,130,002 SH   DFND 4 9 10 0 766,756 1,363,246
CANADIAN IMP BK COMM COM 136069101 10,756 144,281 SH   DFND 4 9 0 131,190 13,091
CANADIAN NAT RES LTD COM 136385101 50,874 3,177,657 SH   DFND 10 0 3,169,383 8,274
CANADIAN NAT RES LTD COM 136385101 27,601 1,727,571 SH   DFND 4 9 10 0 1,172,213 555,358
CANADIAN NATL RY CO COM 136375102 17,380 163,751 SH   DFND 4 9 0 163,751 0
CANADIAN PAC RY LTD COM 13645T100 149 488 SH   DFND 10 0 488 0
CANADIAN PAC RY LTD COM 13645T100 11,632 38,356 SH   DFND 4 9 10 0 38,356 0
CANOPY GROWTH CORP COM 138035100 671 46,982 SH   DFND 4 9 0 46,982 0
CANTEL MED CORP COM 138098108 50,188 1,142,205 SH   DFND 10 0 1,102,906 39,299
CAPITAL ONE FINL CORP COM 14040H105 7,725 107,505 SH   DFND 4 9 0 107,505 0
CARDIFF ONCOLOGY INC COM 14147L108 14,368 1,012,818 SH   DFND 10 0 986,610 26,208
CARDINAL HEALTH INC COM 14149Y108 106,313 2,264,394 SH   DFND 4 9 0 526,310 1,738,084
CARDIOVASCULAR SYS INC DEL COM 141619106 53,426 1,357,701 SH   DFND 10 0 1,335,896 21,805
CARETRUST REIT INC COM 14174T107 782 43,973 SH   DFND 10 0 43,973 0
CARGURUS INC COM CL A 141788109 303 13,988 SH   DFND 10 0 13,988 0
CARLISLE COS INC COM 142339100 129,278 1,056,450 SH   DFND 2 9 10 0 1,026,206 30,244
CARLYLE GROUP INC COM 14316J108 5,568 225,714 SH   DFND 4 9 0 107,973 117,741
CARMAX INC COM 143130102 410,070 4,461,654 SH   DFND 4 9 10 0 4,244,651 217,003
CARNIVAL PLC ADR 14365C103 7,311 566,060 SH   DFND 4 0 566,060 0
CARRIER GLOBAL CORPORATION COM 14448C104 23,938 783,845 SH   DFND 4 9 10 0 588,430 195,415
CARTERS INC COM 146229109 100,671 1,162,750 SH   DFND 2 10 0 1,139,472 23,278
CARVANA CO CL A 146869102 7,246 32,486 SH   DFND 9 0 18,947 13,539
CASEYS GEN STORES INC COM 147528103 207,622 1,168,713 SH   DFND 2 9 10 0 1,143,115 25,598
CASS INFORMATION SYS INC COM 14808P109 26,240 652,089 SH   DFND 2 0 652,089 0
CASTLE BIOSCIENCES INC COM 14843C105 1,291 25,087 SH   DFND 10 0 25,087 0
CATALENT INC COM 148806102 1,124,316 13,125,337 SH   DFND 4 9 10 0 12,655,660 469,677
CATERPILLAR INC DEL COM 149123101 30,860 207,004 SH   DFND 4 9 10 0 207,004 0
CAVCO INDS INC DEL COM 149568107 288 1,595 SH   DFND 10 0 1,595 0
CBOE GLOBAL MARKETS INC COM 12503M108 272,411 3,104,757 SH   DFND 4 9 10 0 3,014,127 90,630
CBRE GROUP INC CL A 12504L109 171,469 3,650,613 SH   DFND 4 9 10 0 3,650,613 0
CDK GLOBAL INC COM 12508E101 70,288 1,612,467 SH   DFND 2 4 9 0 1,612,467 0
CDW CORP COM 12514G108 114,627 958,586 SH   DFND 4 9 0 912,434 46,152
CELANESE CORP DEL COM 150870103 24,526 228,257 SH   DFND 4 9 0 64,100 164,157
CENOVUS ENERGY INC COM 15135U109 13,029 3,353,042 SH   DFND 4 9 0 305,766 3,047,276
CENTENE CORP DEL COM 15135B101 275,403 4,721,464 SH   DFND 4 9 10 0 4,554,183 167,281
CENTERPOINT ENERGY INC COM 15189T107 4,674 241,583 SH   DFND 2 4 9 0 241,583 0
CENTURY CASINOS INC COM 156492100 12,520 2,284,685 SH   DFND 2 0 2,284,685 0
CERIDIAN HCM HLDG INC COM 15677J108 418,188 5,059,743 SH   DFND 9 10 0 4,681,917 377,826
CERNER CORP COM 156782104 42,148 583,061 SH   DFND 2 4 9 0 535,155 47,906
CF INDS HLDGS INC COM 125269100 2,074 67,538 SH   DFND 4 9 0 67,538 0
CGI INC CL A SUB VTG 12532H104 5,203 76,962 SH   DFND 4 9 0 76,962 0
CHANNELADVISOR CORP COM 159179100 33,558 2,319,116 SH   DFND 10 0 2,151,461 167,655
CHARTER COMMUNICATIONS INC N CL A 16119P108 156,460 250,608 SH   DFND 4 9 10 0 194,084 56,524
CHASE CORP COM 16150R104 14,518 152,183 SH   DFND 10 0 145,725 6,458
CHECK POINT SOFTWARE TECH LT ORD M22465104 58,110 482,884 SH   DFND 2 4 9 10 0 473,125 9,759
CHEGG INC COM 163092109 54,317 760,369 SH   DFND 4 0 760,369 0
CHEMED CORP NEW COM 16359R103 91,767 191,042 SH   DFND 4 9 10 0 183,583 7,459
CHENIERE ENERGY INC COM NEW 16411R208 18,760 405,400 SH   DFND 4 9 10 0 388,120 17,280
CHEVRON CORP NEW COM 166764100 64,510 896,042 SH   DFND 2 4 9 10 0 632,828 263,214
CHEWY INC CL A 16679L109 47,973 874,937 SH   DFND 10 0 858,935 16,002
CHIPOTLE MEXICAN GRILL INC COM 169656105 71,408 57,424 SH   DFND 4 9 10 0 36,111 21,313
CHOICE HOTELS INTL INC COM 169905106 356 4,141 SH   DFND 10 0 4,141 0
CHUBB LIMITED COM H1467J104 22,328 192,298 SH   DFND 2 4 9 0 166,035 26,263
CHURCH & DWIGHT INC COM 171340102 23,898 255,038 SH   DFND 4 9 0 226,960 28,078
CHURCHILL DOWNS INC COM 171484108 58,488 357,028 SH   DFND 4 10 0 344,306 12,722
CIENA CORP COM NEW 171779309 68,071 1,715,272 SH   DFND 4 9 10 0 1,711,138 4,134
CIGNA CORP NEW COM 125523100 11,348 67,013 SH   DFND 4 0 67,013 0
CIMPRESS PLC SHS EURO G2143T103 252,441 3,358,709 SH   DFND 10 0 3,255,495 103,214
CINCINNATI FINL CORP COM 172062101 55,344 709,803 SH   DFND 4 9 0 568,612 141,191
CINTAS CORP COM 172908105 138,100 414,921 SH   DFND 4 9 0 117,115 297,806
CISCO SYS INC COM 17275R102 505,264 12,828,367 SH   DFND 2 4 9 10 0 6,415,234 6,413,133
CITIGROUP INC COM NEW 172967424 172,285 3,996,902 SH   DFND 2 4 9 10 0 3,834,734 162,168
CITIZENS FINL GROUP INC COM 174610105 57,772 2,285,314 SH   DFND 2 4 9 0 2,285,314 0
CITRIX SYS INC COM 177376100 68,744 499,204 SH   DFND 2 4 9 0 416,351 82,853
CLARIVATE PLC ORD SHS G21810109 210,802 6,802,256 SH   DFND 10 0 6,531,416 270,840
CLOROX CO DEL COM 189054109 187,818 893,649 SH   DFND 4 9 10 0 733,633 160,016
CLOUDFLARE INC CL A COM 18915M107 2,484 60,506 SH   DFND 9 0 51,195 9,311
CME GROUP INC COM 12572Q105 602,263 3,600,223 SH   DFND 4 9 10 0 3,473,750 126,473
CMS ENERGY CORP COM 125896100 44,049 717,293 SH   DFND 4 9 0 263,265 454,028
CNA FINL CORP COM 126117100 1,125 37,505 SH   DFND 9 0 21,697 15,808
CNH INDL N V SHS N20944109 2,083 267,092 SH   DFND 4 9 0 78,611 188,481
COCA COLA CO COM 191216100 281,366 5,701,774 SH   DFND 2 4 9 10 0 5,091,896 609,878
COCA COLA EUROPEAN PARTNERS SHS G25839104 9,558 246,342 SH   DFND 4 9 0 220,999 25,343
COCA-COLA FEMSA SAB DE CV SPONSORD ADR REP 191241108 21,471 527,159 SH   DFND 4 0 527,159 0
CODEXIS INC COM 192005106 17,960 1,529,770 SH   DFND 10 0 1,426,081 103,689
COGNEX CORP COM 192422103 316,716 4,865,084 SH   DFND 4 9 10 0 4,410,098 454,986
COGNIZANT TECHNOLOGY SOLUTIO CL A 192446102 26,678 384,329 SH   DFND 2 4 9 0 280,877 103,452
COHEN & STEERS INC COM 19247A100 371 6,658 SH   DFND 2 10 0 6,658 0
COHERUS BIOSCIENCES INC COM 19249H103 27,961 1,524,587 SH   DFND 2 0 1,524,587 0
COLGATE PALMOLIVE CO COM 194162103 64,774 839,621 SH   DFND 2 4 9 10 0 478,130 361,491
COLLEGIUM PHARMACEUTICAL INC COM 19459J104 106,647 5,122,359 SH   DFND 10 0 5,034,687 87,672
COLUMBIA SPORTSWEAR CO COM 198516106 87,267 1,003,300 SH   DFND 2 9 10 0 1,002,919 381
COMCAST CORP NEW CL A 20030N101 725,476 15,682,917 SH   DFND 2 4 9 10 0 15,588,735 94,182
COMERICA INC COM 200340107 1,461 38,191 SH   DFND 4 9 0 38,191 0
COMFORT SYS USA INC COM 199908104 37,946 736,678 SH   DFND 2 4 10 0 736,678 0
COMMERCE BANCSHARES INC COM 200525103 10,718 190,409 SH   DFND 4 9 0 174,484 15,925
COMMERCIAL METALS CO COM 201723103 46,028 2,303,727 SH   DFND 2 11 0 2,303,727 0
CONAGRA BRANDS INC COM 205887102 91,811 2,570,995 SH   DFND 4 9 10 0 437,748 2,133,247
CONCHO RES INC COM 20605P101 1,861 42,190 SH   DFND 4 9 0 42,190 0
CONOCOPHILLIPS COM 20825C104 8,971 273,195 SH   DFND 2 4 9 11 0 254,707 18,488
CONSOLIDATED EDISON INC COM 209115104 132,359 1,701,278 SH   DFND 4 9 10 0 753,126 948,152
CONSTELLATION BRANDS INC CL A 21036P108 315,887 1,666,866 SH   DFND 4 9 10 0 1,605,971 60,895
CONSTELLIUM SE CL A SHS F21107101 66,471 8,467,591 SH   DFND 10 0 8,467,591 0
CONSTRUCTION PARTNERS INC COM CL A 21044C107 18,585 1,021,142 SH   DFND 10 0 975,084 46,058
CONTINENTAL RES INC COM 212015101 1,159 94,389 SH   DFND 9 0 94,389 0
COOPER COS INC COM NEW 216648402 723,537 2,146,258 SH   DFND 4 9 10 0 2,078,150 68,108
COPA HOLDINGS SA CL A P31076105 1,435 28,514 SH   DFND 9 0 12,810 15,704
COPART INC COM 217204106 59,384 564,711 SH   DFND 4 9 0 295,243 269,468
CORCEPT THERAPEUTICS INC COM 218352102 2,084 119,737 SH   DFND 10 0 119,737 0
CORELOGIC INC COM 21871D103 264 3,905 SH   DFND 4 9 0 1,626 2,279
CORESITE RLTY CORP COM 21870Q105 3,763 31,654 SH   DFND 9 0 26,543 5,111
CORNING INC COM 219350105 385,731 11,901,682 SH   DFND 4 9 10 0 8,726,750 3,174,932
CORTEVA INC COM 22052L104 34,170 1,186,077 SH   DFND 2 4 9 0 1,130,563 55,514
COSTAR GROUP INC COM 22160N109 1,136,488 1,339,425 SH   DFND 4 9 10 0 1,241,836 97,589
COSTCO WHSL CORP NEW COM 22160K105 724,257 2,040,194 SH   DFND 4 9 10 0 1,930,656 109,538
COUPA SOFTWARE INC COM 22266L106 6,770 24,699 SH   DFND 4 9 0 22,803 1,896
CRACKER BARREL OLD CTRY STOR COM 22410J106 33,802 294,801 SH   DFND 2 0 294,801 0
CRANE CO COM 224399105 2,695 53,767 SH   DFND 4 9 0 27,744 26,023
CREDICORP LTD COM G2519Y108 1,296 10,455 SH   DFND 4 9 0 10,455 0
CREDIT ACCEP CORP MICH COM 225310101 289 853 SH   DFND 9 10 0 665 188
CREE INC COM 225447101 66,164 1,038,032 SH   DFND 9 10 0 1,004,204 33,828
CRITEO S A SPONS ADS 226718104 23,575 1,935,560 SH   DFND 4 0 1,935,560 0
CROWDSTRIKE HLDGS INC CL A 22788C105 1,958 14,257 SH   DFND 4 9 0 14,257 0
CROWN CASTLE INTL CORP NEW COM 22822V101 1,022,005 6,138,370 SH   DFND 2 4 9 10 0 5,625,818 512,552
CROWN HLDGS INC COM 228368106 558,977 7,272,673 SH   DFND 4 9 10 0 7,116,521 156,152
CRYOPORT INC COM PAR $0.001 229050307 51,246 1,081,140 SH   DFND 10 0 1,008,206 72,934
CSW INDUSTRIALS INC COM 126402106 52,426 678,654 SH   DFND 10 0 634,374 44,280
CSX CORP COM 126408103 341,066 4,391,342 SH   DFND 4 9 10 0 4,148,915 242,427
CUBESMART COM 229663109 256 7,928 SH   DFND 4 10 0 7,928 0
CUBIC CORP COM 229669106 77,348 1,329,691 SH   DFND 10 0 1,278,845 50,846
CUMMINS INC COM 231021106 31,236 147,928 SH   DFND 4 9 10 0 110,696 37,232
CVS HEALTH CORP COM 126650100 191,085 3,272,041 SH   DFND 4 9 0 1,303,766 1,968,275
CYBERARK SOFTWARE LTD SHS M2682V108 2,132 20,612 SH   DFND 4 9 0 19,540 1,072
CYRUSONE INC COM 23283R100 51,513 735,480 SH   DFND 4 9 0 695,394 40,086
D R HORTON INC COM 23331A109 7,479 98,888 SH   DFND 4 9 0 98,198 690
DANAHER CORPORATION COM 235851102 1,057,534 4,911,263 SH   DFND 4 9 10 0 4,505,102 406,161
DARDEN RESTAURANTS INC COM 237194105 123,743 1,228,343 SH   DFND 4 9 0 374,142 854,201
DATADOG INC CL A COM 23804L103 2,598 25,428 SH   DFND 4 9 0 25,428 0
DAVITA INC COM 23918K108 28,752 335,696 SH   DFND 4 9 0 83,639 252,057
DBX ETF TR XTRACK HRVST CSI 233051879 613 17,776 SH   DFND 10 0 17,776 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 17,201 335,306 SH   DFND 10 0 320,203 15,103
DEERE & CO COM 244199105 522,307 2,356,686 SH   DFND 4 9 10 0 2,347,075 9,611
DELEK US HLDGS INC NEW COM 24665A103 23,501 2,111,485 SH   DFND 2 0 2,111,485 0
DELL TECHNOLOGIES INC CL C 24703L202 4,200 62,055 SH   DFND 4 9 10 0 62,055 0
DELTA AIR LINES INC DEL COM NEW 247361702 11,896 389,004 SH   DFND 4 9 10 0 332,415 56,589
DENISON MINES CORP COM 248356107 219 523,174 SH   DFND 11 0 523,174 0
DENTSPLY SIRONA INC COM 24906P109 360,912 8,253,208 SH   DFND 4 9 10 0 7,621,325 631,883
DESCARTES SYS GROUP INC COM 249906108 68,115 1,199,535 SH   DFND 10 0 1,147,515 52,020
DEUTSCHE BANK A G NAMEN AKT D18190898 5,572 657,918 SH   DFND 4 9 0 287,776 370,142
DEVON ENERGY CORP NEW COM 25179M103 208 21,967 SH   DFND 9 0 21,967 0
DEXCOM INC COM 252131107 201,339 488,423 SH   DFND 4 9 10 0 274,306 214,117
DIAGEO PLC SPON ADR NEW 25243Q205 540 3,919 SH   DFND 4 10 0 3,919 0
DIAMONDBACK ENERGY INC COM 25278X109 4,110 136,428 SH   DFND 4 9 11 0 136,428 0
DIGITAL RLTY TR INC COM 253868103 59,257 403,817 SH   DFND 4 9 0 237,285 166,532
DISCOVER FINL SVCS COM 254709108 50,043 866,099 SH   DFND 2 4 9 10 0 741,661 124,438
DISCOVERY INC COM SER A 25470F104 296 13,648 SH   DFND 4 9 0 11,153 2,495
DISCOVERY INC COM SER C 25470F302 8,019 409,048 SH   DFND 4 9 0 406,802 2,246
DISH NETWORK CORPORATION CL A 25470M109 5,984 206,156 SH   DFND 4 9 0 191,718 14,438
DISNEY WALT CO COM DISNEY 254687106 842,068 6,786,053 SH   DFND 4 9 10 0 6,165,483 620,570
DIVERSIFIED HEALTHCARE TR COM SH BEN INT 25525P107 198 56,117 SH   DFND 10 0 56,117 0
DMC GLOBAL INC COM 23291C103 6,856 208,130 SH   DFND 2 0 208,130 0
DOCUSIGN INC COM 256163106 75,671 351,582 SH   DFND 4 9 0 178,387 173,195
DOLBY LABORATORIES INC COM CL A 25659T107 241,603 3,645,180 SH   DFND 9 10 0 3,537,117 108,063
DOLLAR GEN CORP NEW COM 256677105 431,139 2,056,770 SH   DFND 4 9 10 0 1,982,311 74,459
DOLLAR TREE INC COM 256746108 10,852 118,813 SH   DFND 4 9 0 114,568 4,245
DOMINION ENERGY INC COM 25746U109 106,129 1,344,849 SH   DFND 4 9 0 1,203,134 141,715
DOMINOS PIZZA INC COM 25754A201 38,732 91,077 SH   DFND 4 9 0 46,177 44,900
DONALDSON INC COM 257651109 97,393 2,098,083 SH   DFND 2 10 0 2,018,769 79,314
DOUGLAS EMMETT INC COM 25960P109 33,631 1,340,397 SH   DFND 4 10 12 0 1,299,853 40,544
DOVER CORP COM 260003108 30,628 282,701 SH   DFND 4 9 0 240,477 42,224
DOW INC COM 260557103 9,749 207,272 SH   DFND 4 9 0 207,266 6
DRAGONEER GROWTH OPPORTUN CO UNIT 08/18/2027 G28302126 67,375 5,500,000 SH   DFND 10 0 5,500,000 0
DROPBOX INC CL A 26210C104 3,806 197,622 SH   DFND 4 9 0 165,074 32,548
DTE ENERGY CO COM 233331107 66,395 577,174 SH   DFND 4 9 0 577,174 0
DUKE ENERGY CORP NEW COM NEW 26441C204 42,560 480,626 SH   DFND 4 9 0 318,604 162,022
DUKE REALTY CORP COM NEW 264411505 64,351 1,744,520 SH   DFND 4 9 10 12 0 1,622,725 121,795
DUNKIN BRANDS GROUP INC COM 265504100 475,508 5,805,255 SH   DFND 10 0 5,617,305 187,950
DUPONT DE NEMOURS INC COM 26614N102 12,310 221,948 SH   DFND 2 4 9 0 194,599 27,349
DYNATRACE INC COM NEW 268150109 240,311 5,858,380 SH   DFND 4 9 10 0 5,281,596 576,784
DYNE THERAPEUTICS INC COM 26818M108 19,912 985,963 SH   DFND 10 0 954,699 31,264
E TRADE FINANCIAL CORP COM NEW 269246401 3,259 65,130 SH   DFND 4 9 0 65,130 0
EAGLE MATLS INC COM 26969P108 32,289 374,059 SH   DFND 2 9 0 373,681 378
EAGLE PHARMACEUTICALS INC COM 269796108 72,162 1,698,737 SH   DFND 10 0 1,630,984 67,753
EAST WEST BANCORP INC COM 27579R104 637 19,452 SH   DFND 4 9 0 19,452 0
EASTERLY GOVT PPTYS INC COM 27616P103 28,306 1,263,118 SH   DFND 10 0 1,166,578 96,540
EASTMAN CHEM CO COM 277432100 2,915 37,320 SH   DFND 4 9 0 37,320 0
EATON CORP PLC SHS G29183103 94,210 923,364 SH   DFND 4 9 10 0 231,746 691,618
EATON VANCE CORP COM NON VTG 278265103 4,199 110,058 SH   DFND 9 0 56,977 53,081
EBAY INC. COM 278642103 121,829 2,338,379 SH   DFND 4 9 10 0 817,788 1,520,591
EBIX INC COM NEW 278715206 1,563 75,882 SH   DFND 10 0 75,882 0
ECOLAB INC COM 278865100 30,200 151,169 SH   DFND 4 9 11 0 92,503 58,666
EDISON INTL COM 281020107 142,041 2,793,926 SH   DFND 4 9 0 966,054 1,827,872
EDWARDS LIFESCIENCES CORP COM 28176E108 588,746 7,376,000 SH   DFND 4 9 10 0 5,130,347 2,245,653
ELANCO ANIMAL HEALTH INC COM 28414H103 1,002,161 35,881,245 SH   DFND 4 9 10 0 34,754,727 1,126,518
ELBIT SYS LTD ORD M3760D101 213 1,754 SH   DFND 9 0 1,754 0
ELECTRONIC ARTS INC COM 285512109 151,827 1,164,257 SH   DFND 2 4 9 0 752,526 411,731
EMCOR GROUP INC COM 29084Q100 61,270 904,891 SH   DFND 2 10 0 904,891 0
EMERSON ELEC CO COM 291011104 56,675 864,374 SH   DFND 4 9 0 759,746 104,628
ENBRIDGE INC COM 29250N105 2,577 88,219 SH   DFND 4 0 88,219 0
ENBRIDGE INC COM 29250N105 77,026 2,643,832 SH   DFND 4 9 0 1,760,696 883,136
ENCOMPASS HEALTH CORP COM 29261A100 63,676 979,875 SH   DFND 4 9 10 0 889,535 90,340
ENCORE WIRE CORP COM 292562105 51,189 1,102,734 SH   DFND 2 0 1,102,734 0
ENERGIZER HLDGS INC NEW COM 29272W109 2,568 65,611 SH   DFND 9 0 35,158 30,453
ENERSYS COM 29275Y102 106,395 1,585,150 SH   DFND 10 0 1,527,659 57,491
ENSIGN GROUP INC COM 29358P101 689 12,071 SH   DFND 10 0 12,071 0
ENTEGRIS INC COM 29362U104 164,294 2,210,033 SH   DFND 9 10 0 2,119,617 90,416
ENTERGY CORP NEW COM 29364G103 122,023 1,238,442 SH   DFND 2 4 9 0 1,111,398 127,044
ENTERPRISE FINL SVCS CORP COM 293712105 24,076 882,882 SH   DFND 2 10 0 882,882 0
ENTERPRISE PRODS PARTNERS L COM 293792107 17,519 1,109,517 SH   DFND 10 0 1,109,517 0
ENVESTNET INC COM 29404K106 172,201 2,231,740 SH   DFND 10 0 2,144,352 87,388
ENVISTA HOLDINGS CORPORATION COM 29415F104 44,534 1,804,456 SH   DFND 2 0 1,804,456 0
EOG RES INC COM 26875P101 12,828 356,949 SH   DFND 4 9 0 317,504 39,445
EPAM SYS INC COM 29414B104 4,336 13,414 SH   DFND 4 9 0 13,414 0
EQT CORP COM 26884L109 3,381 261,504 SH   DFND 9 0 219,750 41,754
EQUIFAX INC COM 294429105 6,554 41,786 SH   DFND 4 9 10 0 41,260 526
EQUINIX INC COM 29444U700 407,690 536,421 SH   DFND 4 9 10 0 427,995 108,426
EQUITABLE HLDGS INC COM 29452E101 11,492 630,079 SH   DFND 4 9 0 218,325 411,754
EQUITY COMWLTH COM SH BEN INT 294628102 97,296 3,653,622 SH   DFND 2 9 0 3,578,391 75,231
EQUITY LIFESTYLE PPTYS INC COM 29472R108 145,550 2,374,688 SH   DFND 2 4 9 10 12 0 2,354,478 20,210
EQUITY RESIDENTIAL SH BEN INT 29476L107 8,542 166,428 SH   DFND 2 4 9 0 145,095 21,333
ERIE INDTY CO CL A 29530P102 20,362 96,834 SH   DFND 4 9 0 28,951 67,883
ESSA PHARMA INC COM NEW 29668H708 3,256 475,688 SH   DFND 10 0 475,688 0
ESSENTIAL UTILS INC COM 29670G102 814 20,231 SH   DFND 4 9 0 20,231 0
ESSEX PPTY TR INC COM 297178105 4,309 21,464 SH   DFND 4 9 0 21,464 0
ETSY INC COM 29786A106 312,364 2,568,151 SH   DFND 4 9 10 0 2,400,893 167,258
EURONAV NV SHS B38564108 17,569 1,990,822 SH   DFND 4 0 1,990,822 0
EURONET WORLDWIDE INC COM 298736109 263,506 2,892,492 SH   DFND 10 0 2,789,346 103,146
EVERBRIDGE INC COM 29978A104 34,826 276,990 SH   DFND 9 10 0 262,234 14,756
EVERCORE INC CLASS A 29977A105 35,202 537,761 SH   DFND 2 9 10 0 536,944 817
EVEREST RE GROUP LTD COM G3223R108 68,110 344,790 SH   DFND 4 9 0 203,698 141,092
EVERGY INC COM 30034W106 82,760 1,628,493 SH   DFND 2 4 9 0 1,511,937 116,556
EVERSOURCE ENERGY COM 30040W108 43,342 518,773 SH   DFND 4 9 0 257,903 260,870
EVOQUA WATER TECHNOLOGIES CO COM 30057T105 15,369 724,450 SH   DFND 4 10 0 724,450 0
EXACT SCIENCES CORP COM 30063P105 6,309 61,876 SH   DFND 4 9 10 0 53,149 8,727
EXELIXIS INC COM 30161Q104 107,826 4,410,094 SH   DFND 9 10 0 4,255,563 154,531
EXELON CORP COM 30161N101 39,605 1,107,601 SH   DFND 2 4 9 10 0 973,656 133,945
EXPEDIA GROUP INC COM NEW 30212P303 3,902 42,563 SH   DFND 4 9 0 42,330 233
EXPEDITORS INTL WASH INC COM 302130109 35,978 397,469 SH   DFND 4 9 0 127,090 270,379
EXTRA SPACE STORAGE INC COM 30225T102 24,480 228,823 SH   DFND 4 9 0 172,629 56,194
EXXON MOBIL CORP COM 30231G102 37,093 1,080,672 SH   DFND 2 4 9 0 1,017,664 63,008
F M C CORP COM NEW 302491303 30,799 290,817 SH   DFND 4 9 11 0 271,959 18,858
F5 NETWORKS INC COM 315616102 58,742 478,472 SH   DFND 2 4 9 0 469,790 8,682
FABRINET SHS G3323L100 31,191 494,865 SH   DFND 2 0 494,865 0
FACEBOOK INC CL A 30303M102 3,194,297 12,198,111 SH   DFND 4 9 10 0 10,806,599 1,391,512
FACTSET RESH SYS INC COM 303075105 16,600 49,570 SH   DFND 4 9 0 12,729 36,841
FAIR ISAAC CORP COM 303250104 2,079 4,887 SH   DFND 4 9 0 4,887 0
FASTENAL CO COM 311900104 317,206 7,034,969 SH   DFND 4 9 10 0 3,197,671 3,837,298
FATE THERAPEUTICS INC COM 31189P102 126,574 3,166,709 SH   DFND 10 0 3,055,046 111,663
FB FINL CORP COM 30257X104 37,702 1,500,893 SH   DFND 2 10 0 1,500,893 0
FEDERAL RLTY INVT TR SH BEN INT NEW 313747206 1,672 22,774 SH   DFND 4 9 0 22,774 0
FEDEX CORP COM 31428X106 12,980 51,633 SH   DFND 4 9 0 51,633 0
FERRARI N V COM N3167Y103 14,924 81,232 SH   DFND 4 9 0 43,341 37,891
FIAT CHRYSLER AUTOMOBILES N SHS N31738102 4,478 364,884 SH   DFND 4 9 0 163,914 200,970
FIBROGEN INC COM 31572Q808 136,065 3,308,965 SH   DFND 10 0 3,190,865 118,100
FIDELITY NATIONAL FINANCIAL FNF GROUP COM 31620R303 5,284 168,783 SH   DFND 4 9 0 157,023 11,760
FIDELITY NATL INFORMATION SV COM 31620M106 1,034,332 7,026,345 SH   DFND 4 9 10 0 6,421,898 604,447
FIFTH THIRD BANCORP COM 316773100 36,485 1,711,253 SH   DFND 2 4 9 0 1,464,848 246,405
FIRST AMERN FINL CORP COM 31847R102 45,555 894,805 SH   DFND 2 0 894,805 0
FIRST HORIZON NATL CORP COM 320517105 81,144 8,604,901 SH   DFND 2 0 8,604,901 0
FIRST REP BK SAN FRANCISCO C COM 33616C100 14,277 130,898 SH   DFND 4 9 0 127,404 3,494
FIRST SOLAR INC COM 336433107 264 3,982 SH   DFND 9 0 1,013 2,969
FIRSTENERGY CORP COM 337932107 22,514 784,245 SH   DFND 4 9 0 657,097 127,148
FIRSTSERVICE CORP NEW COM 33767E202 35,085 266,016 SH   DFND 10 0 253,801 12,215
FISERV INC COM 337738108 145,753 1,414,845 SH   DFND 4 9 0 1,414,845 0
FIVE BELOW INC COM 33829M101 529 4,169 SH   DFND 10 0 4,169 0
FIVE9 INC COM 338307101 1,739 13,410 SH   DFND 9 0 8,103 5,307
FLEETCOR TECHNOLOGIES INC COM 339041105 17,768 74,625 SH   DFND 4 9 0 51,614 23,011
FLEX LNG LTD SHS G35947202 12,040 2,139,649 SH   DFND 4 0 2,139,649 0
FLEX LTD ORD Y2573F102 267,284 23,993,192 SH   DFND 4 9 10 0 23,319,418 673,774
FLIR SYS INC COM 302445101 2,152 60,026 SH   DFND 4 9 0 59,493 533
FLOOR & DECOR HLDGS INC CL A 339750101 580 7,759 SH   DFND 10 0 7,759 0
FLOWERS FOODS INC COM 343498101 4,089 168,054 SH   DFND 9 0 137,016 31,038
FOCUS FINL PARTNERS INC COM CL A 34417P100 602 18,363 SH   DFND 4 0 18,363 0
FORD MTR CO DEL COM 345370860 12,219 1,835,201 SH   DFND 4 9 10 0 1,812,533 22,668
FORMA THERAPEUTICS HLDGS INC SHS 34633R104 72,169 1,479,342 SH   DFND 10 0 1,437,849 41,493
FORMFACTOR INC COM 346375108 1,597 64,066 SH   DFND 4 10 0 64,066 0
FORTINET INC COM 34959E109 17,582 149,264 SH   DFND 4 9 0 149,264 0
FORTIS INC COM 349553107 4,627 113,588 SH   DFND 4 9 0 113,588 0
FORTIVE CORP COM 34959J108 4,658 61,127 SH   DFND 4 9 0 61,127 0
FORTUNA SILVER MINES INC COM 349915108 608 95,847 SH   DFND 11 0 95,847 0
FORTUNE BRANDS HOME & SEC IN COM 34964C106 6,650 76,863 SH   DFND 4 9 10 0 76,863 0
FOX CORP CL B COM 35137L204 59,659 2,132,991 SH   DFND 2 4 9 0 2,080,767 52,224
FOX CORP CL A COM 35137L105 4,350 156,304 SH   DFND 4 9 0 155,134 1,170
FOX FACTORY HLDG CORP COM 35138V102 536 7,205 SH   DFND 10 0 7,205 0
FRANCO NEV CORP COM 351858105 16,939 121,636 SH   DFND 4 9 0 65,603 56,033
FRANKLIN RESOURCES INC COM 354613101 1,005 49,398 SH   DFND 4 9 0 49,398 0
FRANKLIN TEMPLETON ETF TR FTSE JAPAN ETF 35473P744 11,485 438,879 SH   DFND 10 0 438,879 0
FREEPORT-MCMORAN INC CL B 35671D857 127,124 8,129,138 SH   DFND 4 9 10 11 0 8,129,138 0
FRONTDOOR INC COM 35905A109 240,716 6,186,477 SH   DFND 9 10 0 5,964,291 222,186
FRONTLINE LTD SHS NEW G3682E192 11,125 1,710,191 SH   DFND 4 0 1,710,191 0
FRONTLINE LTD SHS NEW G3682E192 11,849 1,819,856 SH   DFND 4 0 1,819,856 0
FRONTLINE LTD SHS NEW G3682E192 724 109,665 SH   DFND 4 0 109,665 0
FS DEV CORP COM CL A 303020101 2,134 191,414 SH   DFND 10 0 191,414 0
FTI CONSULTING INC COM 302941109 448 4,224 SH   DFND 9 10 0 4,134 90
FULCRUM THERAPEUTICS INC COM 359616109 1,403 177,166 SH   DFND 10 0 177,166 0
FULLER H B CO COM 359694106 77,669 1,696,569 SH   DFND 10 0 1,620,694 75,875
FULTON FINL CORP PA COM 360271100 42,220 4,525,191 SH   DFND 2 0 4,525,191 0
GALLAGHER ARTHUR J & CO COM 363576109 26,557 251,561 SH   DFND 4 9 0 219,389 32,172
GARMIN LTD SHS H2906T109 174,497 1,839,528 SH   DFND 4 9 10 0 1,140,803 698,725
GARTNER INC COM 366651107 4,964 39,733 SH   DFND 4 9 0 39,733 0
GATES INDUSTRIAL CORPRATIN P ORD SHS G39108108 82,980 7,462,256 SH   DFND 9 10 0 7,182,547 279,709
GATX CORP COM 361448103 112,041 1,757,509 SH   DFND 2 0 1,757,509 0
GCI LIBERTY INC COM CLASS A 36164V305 88,595 1,080,953 SH   DFND 9 10 0 1,036,422 44,531
GDS HLDGS LTD SPONSORED ADS 36165L108 32,703 399,627 SH   DFND 4 9 10 12 0 348,963 50,664
GENERAC HLDGS INC COM 368736104 1,575 8,134 SH   DFND 2 4 9 0 8,078 56
GENERAL DYNAMICS CORP COM 369550108 420,404 3,036,946 SH   DFND 4 9 10 0 3,035,918 1,028
GENERAL ELECTRIC CO COM 369604103 10,806 1,735,342 SH   DFND 4 9 0 1,691,516 43,826
GENERAL MLS INC COM 370334104 159,646 2,588,335 SH   DFND 4 9 10 0 1,082,261 1,506,074
GENERAL MTRS CO COM 37045V100 112,231 3,792,931 SH   DFND 4 9 0 2,759,986 1,032,945
GENERATION BIO CO COM 37148K100 1,169 37,806 SH   DFND 10 0 29,916 7,890
GENESIS HEALTHCARE INC CL A COM 37185X106 8 15,262 SH   DFND 10 0 15,262 0
GENTEX CORP COM 371901109 5,859 227,532 SH   DFND 4 9 0 201,117 26,415
GENUINE PARTS CO COM 372460105 2,976 31,269 SH   DFND 4 9 0 31,269 0
GEOPARK LTD USD SHS G38327105 3,268 443,254 SH   DFND 4 10 0 443,254 0
GILDAN ACTIVEWEAR INC COM 375916103 172,611 8,775,330 SH   DFND 10 0 8,381,145 394,185
GILDAN ACTIVEWEAR INC COM 375916103 826 42,059 SH   DFND 4 9 0 42,059 0
GILEAD SCIENCES INC COM 375558103 333,563 5,278,841 SH   DFND 2 4 9 10 0 4,579,710 699,131
GLAUKOS CORP COM 377322102 88,768 1,792,566 SH   DFND 10 0 1,726,728 65,838
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 299,207 5,426,282 SH   DFND 10 0 5,277,651 148,631
GLOBAL PMTS INC COM 37940X102 703,872 3,963,705 SH   DFND 2 4 9 10 0 3,677,299 286,406
GLOBANT S A COM L44385109 1,032 5,759 SH   DFND 4 9 0 5,759 0
GLOBE LIFE INC COM 37959E102 88,172 1,103,529 SH   DFND 2 4 9 0 1,103,529 0
GLOBUS MED INC CL A 379577208 314,696 6,354,926 SH   DFND 2 10 0 6,093,243 261,683
GMS INC COM 36251C103 276 11,465 SH   DFND 10 0 11,465 0
GODADDY INC CL A 380237107 558,031 7,345,413 SH   DFND 4 9 10 0 7,002,622 342,791
GOLDMAN SACHS GROUP INC COM 38141G104 98,058 487,952 SH   DFND 4 9 10 0 451,093 36,859
GRACE W R & CO DEL NEW COM 38388F108 6,409 159,068 SH   DFND 2 0 159,068 0
GRACO INC COM 384109104 2,778 45,277 SH   DFND 9 10 0 45,277 0
GRAHAM HLDGS CO COM CL B 384637104 14,249 35,261 SH   DFND 2 0 35,261 0
GRAINGER W W INC COM 384802104 66,154 185,424 SH   DFND 4 9 10 0 44,244 141,180
GRAND CANYON ED INC COM 38526M106 623 7,788 SH   DFND 4 9 0 7,691 97
GRANITE REAL ESTATE INVT TR UNIT 99/99/9999 387437114 29,962 517,885 SH   DFND 4 10 12 0 502,909 14,976
GRANITE REAL ESTATE INVT TR UNIT 99/99/9999 387437114 7 121 SH   DFND 10 0 121 0
GRAPHIC PACKAGING HLDG CO COM 388689101 48,893 3,470,057 SH   DFND 2 9 0 3,464,883 5,174
GREENSKY INC CL A 39572G100 819 184,520 SH   DFND 10 0 184,520 0
GRIFOLS S A SP ADR REP B NVT 398438408 59,499 3,427,369 SH   DFND 4 0 3,335,131 92,238
GSX TECHEDU INC SPONSORED ADS 36257Y109 11,042 122,542 SH   DFND 9 0 12,751 109,791
GUARDANT HEALTH INC COM 40131M109 8,134 72,772 SH   DFND 9 0 52,974 19,798
GUIDEWIRE SOFTWARE INC COM 40171V100 152,271 1,460,350 SH   DFND 4 9 10 0 1,279,034 181,316
GW PHARMACEUTICALS PLC ADS 36197T103 198,725 2,041,289 SH   DFND 10 0 1,980,130 61,159
H & E EQUIPMENT SERVICES INC COM 404030108 24,933 1,268,184 SH   DFND 2 0 1,268,184 0
HAIN CELESTIAL GROUP INC COM 405217100 24,018 700,226 SH   DFND 9 10 0 678,210 22,016
HALLIBURTON CO COM 406216101 6,144 509,945 SH   DFND 4 9 0 352,466 157,479
HALOZYME THERAPEUTICS INC COM 40637H109 23,371 889,303 SH   DFND 10 0 849,706 39,597
HANESBRANDS INC COM 410345102 242 15,385 SH   DFND 9 0 15,385 0
HANOVER INS GROUP INC COM 410867105 93,666 1,005,216 SH   DFND 2 9 0 1,003,045 2,171
HARMONY BIOSCIENCES HLDGS IN COM 413197104 29,661 874,909 SH   DFND 10 0 845,313 29,596
HARTFORD FINL SVCS GROUP INC COM 416515104 106,489 2,889,023 SH   DFND 2 4 9 0 2,294,369 594,654
HASBRO INC COM 418056107 523,429 6,327,713 SH   DFND 4 9 10 0 5,307,895 1,019,818
HAWAIIAN ELEC INDUSTRIES COM 419870100 1,665 50,080 SH   DFND 9 0 50,080 0
HCA HEALTHCARE INC COM 40412C101 12,519 100,419 SH   DFND 4 9 0 99,855 564
HD SUPPLY HLDGS INC COM 40416M105 1,321 32,016 SH   DFND 4 9 0 30,764 1,252
HDFC BANK LTD SPONSORED ADS 40415F101 12,839 256,977 SH   DFND 4 10 12 0 182,942 74,035
HEALTH CATALYST INC COM 42225T107 45,802 1,251,428 SH   DFND 10 0 1,207,534 43,894
HEALTH SCIENCES ACQ CORP 2 ORD SHS G4411D109 1,998 180,771 SH   DFND 10 0 180,771 0
HEALTHCARE SVCS GROUP INC COM 421906108 382 17,724 SH   DFND 10 0 17,724 0
HEALTHEQUITY INC COM 42226A107 73,914 1,438,853 SH   DFND 10 0 1,388,473 50,380
HEALTHPEAK PROPERTIES INC COM 42250P103 61,958 2,282,422 SH   DFND 4 9 10 12 0 2,220,915 61,507
HEICO CORP NEW COM 422806109 8,795 84,028 SH   DFND 4 9 10 0 69,351 14,677
HEICO CORP NEW CL A 422806208 150,650 1,699,187 SH   DFND 4 9 10 0 1,620,838 78,349
HENRY JACK & ASSOC INC COM 426281101 12,477 76,739 SH   DFND 4 9 10 0 64,033 12,706
HENRY SCHEIN INC COM 806407102 13,916 236,755 SH   DFND 4 9 0 56,229 180,526
HERBALIFE NUTRITION LTD COM SHS G4412G101 352 7,555 SH   DFND 4 0 7,555 0
HERON THERAPEUTICS INC COM 427746102 6,881 464,301 SH   DFND 10 0 444,664 19,637
HERSHEY CO COM 427866108 317,370 2,214,110 SH   DFND 4 9 10 0 2,008,973 205,137
HESKA CORP COM RESTRC NEW 42805E306 38,249 387,172 SH   DFND 10 0 379,330 7,842
HESS CORP COM 42809H107 3,190 77,963 SH   DFND 4 9 0 77,963 0
HEWLETT PACKARD ENTERPRISE C COM 42824C109 26,266 2,803,384 SH   DFND 4 9 0 336,323 2,467,061
HILTON WORLDWIDE HLDGS INC COM 43300A203 231,045 2,707,988 SH   DFND 4 9 10 0 2,526,463 181,525
HOLOGIC INC COM 436440101 46,367 697,552 SH   DFND 4 9 0 100,268 597,284
HOME DEPOT INC COM 437076102 1,505,185 5,420,058 SH   DFND 4 9 10 0 5,285,149 134,909
HONEYWELL INTL INC COM 438516106 795,899 4,835,128 SH   DFND 2 4 9 10 0 4,504,405 330,723
HORIZON THERAPEUTICS PUB L SHS G46188101 694,317 8,938,153 SH   DFND 9 10 0 8,658,982 279,171
HORMEL FOODS CORP COM 440452100 73,123 1,495,669 SH   DFND 4 9 10 0 607,399 888,270
HOST HOTELS & RESORTS INC COM 44107P104 6,560 608,005 SH   DFND 4 9 0 562,983 45,022
HOSTESS BRANDS INC CL A 44109J106 59,172 4,799,061 SH   DFND 10 0 4,621,397 177,664
HOVNANIAN ENTERPRISES INC CL A NEW 442487401 324 9,967 SH   DFND 10 0 9,967 0
HOWMET AEROSPACE INC COM 443201108 2,296 137,337 SH   DFND 4 9 10 0 135,298 2,039
HP INC COM 40434L105 289,964 15,269,355 SH   DFND 4 9 0 5,610,577 9,658,778
HUAZHU GROUP LTD SPONSORED ADS 44332N106 3,528 81,589 SH   DFND 9 0 15,167 66,422
HUBBELL INC COM 443510607 6,928 50,628 SH   DFND 9 0 24,466 26,162
HUBSPOT INC COM 443573100 16,121 55,165 SH   DFND 10 0 37,149 18,016
HUDBAY MINERALS INC COM 443628102 551 130,839 SH   DFND 11 0 130,839 0
HUMANA INC COM 444859102 790,374 1,909,680 SH   DFND 2 4 9 10 0 1,723,488 186,192
HUNT J B TRANS SVCS INC COM 445658107 7,959 62,987 SH   DFND 4 9 0 59,698 3,289
HUNTINGTON BANCSHARES INC COM 446150104 2,316 252,653 SH   DFND 4 9 0 252,653 0
HUNTINGTON INGALLS INDS INC COM 446413106 2,091 14,859 SH   DFND 4 9 0 14,859 0
IAA INC COM 449253103 139,045 2,670,347 SH   DFND 2 9 10 0 2,593,501 76,846
IAC INTERACTIVECORP NEW COM 44891N109 124,678 1,040,578 SH   DFND 4 9 0 1,000,539 40,039
ICON PLC SHS G4705A100 100,990 528,339 SH   DFND 4 10 0 522,207 6,132
ICU MED INC COM 44930G107 538,642 2,947,263 SH   DFND 9 10 0 2,857,512 89,751
IDEX CORP COM 45167R104 3,546 19,442 SH   DFND 4 9 0 19,442 0
IDEXX LABS INC COM 45168D104 16,716 42,527 SH   DFND 4 9 0 42,527 0
IGM BIOSCIENCES INC COM 449585108 62,366 844,935 SH   DFND 10 0 815,757 29,178
IHS MARKIT LTD SHS G47567105 226,258 2,881,909 SH   DFND 4 9 10 0 2,584,971 296,938
ILLINOIS TOOL WKS INC COM 452308109 16,029 83,035 SH   DFND 4 9 0 83,035 0
ILLUMINA INC COM 452327109 195,599 632,829 SH   DFND 4 9 10 0 561,426 71,403
IMPERIAL OIL LTD COM NEW 453038408 794 66,602 SH   DFND 4 9 0 66,602 0
INCYTE CORP COM 45337C102 10,613 118,260 SH   DFND 4 9 10 0 83,007 35,253
INDEPENDENCE RLTY TR INC COM 45378A106 209 18,036 SH   DFND 10 0 18,036 0
INDEPENDENT BANK CORP MASS COM 453836108 22,596 431,379 SH   DFND 2 10 0 431,379 0
INFOSYS LTD SPONSORED ADR 456788108 348 25,230 SH   DFND 2 0 25,230 0
INGERSOLL RAND INC COM 45687V106 345,508 9,705,296 SH   DFND 4 9 10 0 9,323,881 381,415
INGEVITY CORP COM 45688C107 837 16,923 SH   DFND 10 0 16,923 0
INGLES MKTS INC CL A 457030104 10,539 277,041 SH   DFND 2 0 277,041 0
INGREDION INC COM 457187102 1,559 20,611 SH   DFND 4 9 0 20,611 0
INNOSPEC INC COM 45768S105 47,713 753,528 SH   DFND 2 0 753,528 0
INNOVIVA INC COM 45781M101 1,351 129,238 SH   DFND 10 0 129,238 0
INOGEN INC COM 45780L104 816 28,125 SH   DFND 10 0 28,125 0
INSIGHT ENTERPRISES INC COM 45765U103 14,322 253,124 SH   DFND 2 10 0 253,124 0
INSMED INC COM PAR $.01 457669307 198,278 6,169,167 SH   DFND 10 0 5,964,812 204,355
INSPERITY INC COM 45778Q107 686 10,475 SH   DFND 10 0 10,475 0
INSTALLED BLDG PRODS INC COM 45780R101 527 5,181 SH   DFND 10 0 5,181 0
INSULET CORP COM 45784P101 129,488 547,292 SH   DFND 4 9 10 0 328,274 219,018
INTEGRA LIFESCIENCES HLDGS C COM NEW 457985208 191,235 4,049,872 SH   DFND 10 0 3,908,617 141,255
INTEL CORP COM 458140100 641,392 12,387,006 SH   DFND 2 4 9 10 0 11,633,277 753,729
INTELLIGENT SYS CORP NEW COM 45816D100 18,611 482,453 SH   DFND 10 0 466,834 15,619
INTERACTIVE BROKERS GROUP IN COM CL A 45841N107 2,741 56,708 SH   DFND 9 0 50,411 6,297
INTERCONTINENTAL EXCHANGE IN COM 45866F104 111,627 1,116,216 SH   DFND 4 9 10 0 1,018,476 97,740
INTERNATIONAL BUSINESS MACHS COM 459200101 325,192 2,672,767 SH   DFND 4 9 0 1,222,227 1,450,540
INTERNATIONAL FLAVORS&FRAGRA COM 459506101 26 208 SH   DFND 4 0 208 0
INTERNATIONAL FLAVORS&FRAGRA COM 459506101 20,654 168,678 SH   DFND 4 9 0 99,668 69,010
INTERNATIONAL PAPER CO COM 460146103 3,850 94,979 SH   DFND 4 9 0 94,179 800
INTERPUBLIC GROUP COS INC COM 460690100 32,507 1,950,082 SH   DFND 4 9 0 520,267 1,429,815
INTUIT COM 461202103 582,826 1,786,948 SH   DFND 4 9 10 0 1,221,301 565,647
INTUITIVE SURGICAL INC COM NEW 46120E602 698,556 984,537 SH   DFND 4 9 10 0 932,714 51,823
INVESCO LTD SHS G491BT108 935 81,919 SH   DFND 4 9 0 81,919 0
INVESCO QQQ TR UNIT SER 1 46090E103 3 400 SH Put DFND 10 0 4 0
INVESCO QQQ TR UNIT SER 1 46090E103 70 4,500 SH Call DFND 10 0 45 0
INVESCO QQQ TR UNIT SER 1 46090E103 36,586 131,681 SH   DFND 10 0 131,681 0
INVESCO QQQ TR UNIT SER 1 46090E103 3 200 SH Call DFND 10 0 2 0
INVESCO QQQ TR UNIT SER 1 46090E103 308 37,100 SH Put DFND 10 0 371 0
INVESCO QQQ TR UNIT SER 1 46090E103 304 36,700 SH Put DFND 10 0 367 0
INVESCO QQQ TR UNIT SER 1 46090E103 73 4,700 SH Call DFND 10 0 47 0
INVITATION HOMES INC COM 46187W107 62,126 2,220,738 SH   DFND 4 9 10 12 0 2,160,268 60,470
IONIS PHARMACEUTICALS INC COM 462222100 2,879 60,679 SH   DFND 4 9 10 0 56,828 3,851
IPG PHOTONICS CORP COM 44980X109 35,976 211,800 SH   DFND 4 9 10 0 211,619 181
IQVIA HLDGS INC COM 46266C105 517,480 3,282,866 SH   DFND 4 9 10 0 2,989,321 293,545
IRADIMED CORP COM 46266A109 267 12,483 SH   DFND 10 0 12,483 0
IRON MTN INC NEW COM 46284V101 3,663 136,752 SH   DFND 4 9 0 136,752 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 30,460 3,386,302 SH   DFND 10 0 3,267,029 119,273
ISHARES INC EM MKTS DIV ETF 464286319 145 149,500 SH Call DFND 10 0 1,495 0
ISHARES TR IBOXX INV CP ETF 464287242 440 3,265 SH   DFND 10 0 3,265 0
ISHARES TR RUSSELL 2000 ETF 464287655 145 26,000 SH Call DFND 10 0 260 0
ISHARES TR RUSSELL 2000 ETF 464287655 144 25,700 SH Call DFND 10 0 257 0
ISHARES TR AGENCY BOND ETF 464288166 409 3,381 SH   DFND 10 0 3,381 0
ISHARES TR CORE US AGGBD ET 464287226 92,055 779,730 SH   DFND 10 0 779,730 0
ISHARES TR BARCLAYS 7 10 YR 464287440 435 3,573 SH   DFND 10 0 3,573 0
ISHARES TR RUSSELL 2000 ETF 464287655 2 300 SH Call DFND 10 0 3 0
ISHARES TR 20 YR TR BD ETF 464287432 864 5,291 SH   DFND 10 0 5,291 0
ITAU UNIBANCO HLDG S A SPON ADR REP PFD 465562106 846 212,569 SH   DFND 4 10 0 212,569 0
ITEOS THERAPEUTICS INC COM 46565G104 24,666 999,832 SH   DFND 10 0 956,651 43,181
ITRON INC COM 465741106 69,808 1,149,292 SH   DFND 10 0 1,106,421 42,871
ITT INC COM 45073V108 121,933 2,064,913 SH   DFND 4 9 10 0 2,002,218 62,695
J P MORGAN EXCHANGE-TRADED F BETABULDR DEVE 46641Q688 11,504 509,012 SH   DFND 10 0 509,012 0
J2 GLOBAL INC COM 48123V102 127,675 1,844,487 SH   DFND 10 0 1,771,717 72,770
JACOBS ENGR GROUP INC COM 469814107 10,396 112,063 SH   DFND 4 9 0 105,547 6,516
JANUS DETROIT STR TR HENDRSN SHRT ETF 47103U886 23,481 465,990 SH   DFND 10 0 364,991 100,999
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 133,096 933,398 SH   DFND 4 9 10 0 905,258 28,140
JD.COM INC SPON ADR CL A 47215P106 67,924 875,229 SH   DFND 4 9 10 12 0 763,978 111,251
JEFFERIES FINL GROUP INC COM 47233W109 5,763 320,190 SH   DFND 9 0 176,085 144,105
JFROG LTD ORD SHS M6191J100 27,306 322,574 SH   DFND 10 0 289,232 33,342
JOHN BEAN TECHNOLOGIES CORP COM 477839104 71,425 777,292 SH   DFND 4 10 0 749,204 28,088
JOHNSON & JOHNSON COM 478160104 442,631 2,973,593 SH   DFND 2 4 9 10 0 2,594,735 378,858
JOHNSON CTLS INTL PLC SHS G51502105 139,771 3,421,605 SH   DFND 4 9 10 0 1,218,370 2,203,235
JOINT CORP COM 47973J102 311 17,858 SH   DFND 10 0 17,858 0
JONES LANG LASALLE INC COM 48020Q107 38,955 407,228 SH   DFND 4 9 10 0 397,006 10,222
JPMORGAN CHASE & CO COM 46625H100 391,291 4,064,787 SH   DFND 4 9 10 0 3,871,320 193,467
JUNIPER NETWORKS INC COM 48203R104 12,224 568,582 SH   DFND 4 9 0 389,084 179,498
K12 INC COM 48273U102 26,303 998,595 SH   DFND 10 0 956,845 41,750
KADANT INC COM 48282T104 410 3,744 SH   DFND 4 10 0 3,744 0
KALVISTA PHARMACEUTICALS INC COM 483497103 2,131 169,009 SH   DFND 10 0 169,009 0
KANSAS CITY SOUTHERN COM NEW 485170302 58,338 322,614 SH   DFND 4 9 10 0 317,107 5,507
KB HOME COM 48666K109 272 7,088 SH   DFND 10 0 7,088 0
KEARNY FINL CORP MD COM 48716P108 762 105,663 SH   DFND 10 0 76,148 29,515
KELLOGG CO COM 487836108 206,954 3,204,115 SH   DFND 4 9 10 0 1,158,551 2,045,564
KENSINGTON CAP ACQUISITION C COM CL A 490073103 1,666 99,457 SH   DFND 10 0 84,886 14,571
KEURIG DR PEPPER INC COM 49271V100 7,159 259,390 SH   DFND 4 9 10 0 213,132 46,258
KEYCORP COM 493267108 3,388 284,032 SH   DFND 4 9 0 284,032 0
KEYSIGHT TECHNOLOGIES INC COM 49338L103 110,679 1,120,784 SH   DFND 4 9 10 0 1,006,983 113,801
KIMBERLY CLARK CORP COM 494368103 154,801 1,048,374 SH   DFND 4 9 10 0 500,354 548,020
KIMCO RLTY CORP COM 49446R109 3,620 321,494 SH   DFND 4 9 0 317,580 3,914
KINDER MORGAN INC DEL COM 49456B101 8,095 656,625 SH   DFND 4 9 0 650,610 6,015
KINGSOFT CLOUD HLDGS LTD ADS 49639K101 737 25,000 SH   DFND 4 0 25,000 0
KINIKSA PHARMACEUTICALS LTD COM CL A G5269C101 17,132 1,118,261 SH   DFND 10 0 1,069,201 49,060
KINROSS GOLD CORP COM 496902404 7,746 880,546 SH   DFND 4 9 11 0 880,546 0
KINSALE CAP GROUP INC COM 49714P108 272 1,430 SH   DFND 10 0 1,430 0
KIRKLAND LAKE GOLD LTD COM 49741E100 1,633 33,580 SH   DFND 4 9 0 33,580 0
KKR & CO INC COM 48251W104 3,792 110,450 SH   DFND 4 9 10 0 110,450 0
KLA CORP COM NEW 482480100 700,816 3,617,309 SH   DFND 4 9 10 0 3,329,405 287,904
KNIGHT SWIFT TRANSN HLDGS IN CL A 499049104 3,312 81,390 SH   DFND 4 9 0 58,795 22,595
KORN FERRY COM NEW 500643200 45,305 1,562,243 SH   DFND 2 0 1,562,243 0
KORNIT DIGITAL LTD SHS M6372Q113 46,530 717,285 SH   DFND 4 10 0 687,406 29,879
KRAFT HEINZ CO COM 500754106 188,726 6,301,899 SH   DFND 4 9 0 2,517,341 3,784,558
KROGER CO COM 501044101 84,954 2,505,313 SH   DFND 4 9 10 0 957,492 1,547,821
L3HARRIS TECHNOLOGIES INC COM 502431109 1,120,458 6,597,192 SH   DFND 4 9 10 0 6,366,575 230,617
LABORATORY CORP AMER HLDGS COM NEW 50540R409 99,066 526,194 SH   DFND 2 4 9 0 517,484 8,710
LAIRD SUPERFOOD INC COM STK 50736T102 6,935 151,185 SH   DFND 10 0 99,025 52,160
LAM RESEARCH CORP COM 512807108 1,641,932 4,949,656 SH   DFND 4 9 10 0 4,612,464 337,192
LAMAR ADVERTISING CO NEW CL A 512816109 492,124 7,437,266 SH   DFND 2 4 9 10 0 7,242,532 194,734
LAMB WESTON HLDGS INC COM 513272104 56,610 854,226 SH   DFND 2 4 9 0 719,556 134,670
LANDSTAR SYS INC COM 515098101 4,091 32,603 SH   DFND 9 0 27,536 5,067
LARIMAR THERAPEUTICS INC COM 517125100 2,537 163,599 SH   DFND 10 0 163,599 0
LAS VEGAS SANDS CORP COM 517834107 18,459 395,683 SH   DFND 4 9 10 0 338,852 56,831
LAS VEGAS SANDS CORP COM 517834107 1 300 SH Call DFND 10 0 3 0
LAS VEGAS SANDS CORP COM 517834107 122 45,500 SH Call DFND 10 0 455 0
LAS VEGAS SANDS CORP COM 517834107 121 45,200 SH Call DFND 10 0 452 0
LAUDER ESTEE COS INC CL A 518439104 301,933 1,383,583 SH   DFND 4 9 10 0 1,036,800 346,783
LCI INDS COM 50189K103 465 4,373 SH   DFND 10 0 4,373 0
LEAR CORP COM NEW 521865204 1,592 14,601 SH   DFND 4 9 0 14,601 0
LEGGETT & PLATT INC COM 524660107 44,375 1,077,837 SH   DFND 2 9 10 0 1,002,911 74,926
LEIDOS HOLDINGS INC COM 525327102 76,756 860,975 SH   DFND 4 9 0 379,809 481,166
LEMAITRE VASCULAR INC COM 525558201 839 25,781 SH   DFND 10 0 25,781 0
LENDINGTREE INC NEW COM 52603B107 113,456 369,696 SH   DFND 10 0 356,068 13,628
LENNAR CORP CL A 526057104 25,291 309,658 SH   DFND 4 9 10 0 267,273 42,385
LENNOX INTL INC COM 526107107 1,602 5,876 SH   DFND 4 9 0 5,876 0
LEVI STRAUSS & CO NEW CL A COM STK 52736R102 36,735 2,741,413 SH   DFND 2 0 2,741,413 0
LGI HOMES INC COM 50187T106 507 4,362 SH   DFND 10 0 4,362 0
LHC GROUP INC COM 50187A107 2,801 13,178 SH   DFND 10 0 13,178 0
LIBERTY BROADBAND CORP COM SER C 530307305 30,013 210,063 SH   DFND 4 9 10 0 208,619 1,444
LIBERTY BROADBAND CORP COM SER A 530307107 2,023 14,267 SH   DFND 4 9 0 13,335 932
LIBERTY GLOBAL PLC SHS CL A G5480U104 13,342 635,032 SH   DFND 4 9 0 111,061 523,971
LIBERTY GLOBAL PLC SHS CL C G5480U120 14,977 729,318 SH   DFND 4 9 0 146,839 582,479
LIBERTY MEDIA CORP DEL COM A SIRIUSXM 531229409 445 13,410 SH   DFND 4 9 0 13,410 0
LIBERTY MEDIA CORP DEL COM SER C FRMLA 531229854 499,091 13,760,435 SH   DFND 4 9 10 0 13,101,185 659,250
LIBERTY MEDIA CORP DEL COM C SIRIUSXM 531229607 1,720 51,979 SH   DFND 4 9 0 51,979 0
LIGAND PHARMACEUTICALS INC COM NEW 53220K504 153,088 1,606,041 SH   DFND 10 0 1,542,524 63,517
LILLY ELI & CO COM 532457108 861,839 5,822,625 SH   DFND 4 9 10 0 5,636,792 185,833
LINCOLN ELEC HLDGS INC COM 533900106 114,877 1,248,122 SH   DFND 2 0 1,248,122 0
LINCOLN NATL CORP IND COM 534187109 1,542 49,217 SH   DFND 4 9 0 49,217 0
LINDE PLC SHS G5494J103 42,802 179,756 SH   DFND 4 9 0 168,755 11,001
LITHIA MTRS INC CL A 536797103 472 2,069 SH   DFND 4 10 0 2,069 0
LITTELFUSE INC COM 537008104 20,458 115,361 SH   DFND 2 9 0 115,309 52
LIVE NATION ENTERTAINMENT IN COM 538034109 19,009 352,806 SH   DFND 4 9 0 138,144 214,662
LIVENT CORP COM 53814L108 538 59,962 SH   DFND 10 0 59,962 0
LIVEPERSON INC COM 538146101 147,112 2,829,611 SH   DFND 10 0 2,712,371 117,240
LIVERAMP HLDGS INC COM 53815P108 118,952 2,297,694 SH   DFND 10 0 2,205,477 92,217
LIVONGO HEALTH INC COM 539183103 1,176 8,398 SH   DFND 9 0 8,398 0
LKQ CORP COM 501889208 1,760 63,477 SH   DFND 4 9 0 61,413 2,064
LOCKHEED MARTIN CORP COM 539830109 126,624 330,370 SH   DFND 4 9 10 0 327,535 2,835
LOEWS CORP COM 540424108 2,583 74,339 SH   DFND 4 9 0 74,339 0
LOGITECH INTL S A SHS H50430232 4,369 56,053 SH   DFND 4 9 0 25,924 30,129
LOVESAC COMPANY COM 54738L109 24,408 880,829 SH   DFND 10 0 840,660 40,169
LOWES COS INC COM 548661107 216,940 1,308,003 SH   DFND 4 9 10 0 943,725 364,278
LPL FINL HLDGS INC COM 50212V100 625,669 8,160,539 SH   DFND 9 10 0 7,877,130 283,409
LTC PPTYS INC COM 502175102 320 9,190 SH   DFND 10 0 9,190 0
LULULEMON ATHLETICA INC COM 550021109 172,202 522,827 SH   DFND 4 9 10 0 336,591 186,236
LUMEN TECHNOLOGIES INC COM 156700106 84,080 8,333,253 SH   DFND 4 9 0 2,536,580 5,796,673
LUMENTUM HLDGS INC COM 55024U109 80,118 1,066,460 SH   DFND 4 0 1,066,460 0
LYFT INC CL A COM 55087P104 554 20,100 SH   DFND 4 0 20,100 0
LYONDELLBASELL INDUSTRIES N SHS - A - N53745100 21,172 300,334 SH   DFND 4 9 0 257,120 43,214
M & T BK CORP COM 55261F104 61,954 672,760 SH   DFND 2 4 9 0 660,684 12,076
M D C HLDGS INC COM 552676108 519 11,025 SH   DFND 10 0 11,025 0
M/I HOMES INC COM 55305B101 229 4,963 SH   DFND 10 0 4,963 0
MACQUARIE INFRASTRUCTURE COR COM 55608B105 2,398 89,192 SH   DFND 9 0 48,045 41,147
MADDEN STEVEN LTD COM 556269108 42,094 2,158,680 SH   DFND 2 0 2,158,680 0
MADISON SQUARE GRDN ENTERTNM CL A 55826T102 1,573 22,960 SH   DFND 9 0 10,848 12,112
MADISON SQUARE GRDN SPRT COR CL A 55825T103 27,990 186,006 SH   DFND 2 9 0 180,822 5,184
MAGELLAN MIDSTREAM PRTNRS LP COM UNIT RP LP 559080106 262,069 7,662,826 SH   DFND 10 0 7,662,826 0
MAGNA INTL INC COM 559222401 3,828 83,969 SH   DFND 4 9 0 83,969 0
MANCHESTER UTD PLC NEW ORD CL A G5784H106 15,870 1,091,467 SH   DFND 10 0 1,042,571 48,896
MANPOWERGROUP INC COM 56418H100 2,368 32,298 SH   DFND 9 0 16,202 16,096
MANULIFE FINL CORP COM 56501R106 151,482 10,925,567 SH   DFND 4 9 0 7,172,607 3,752,960
MANULIFE FINL CORP COM 56501R106 1 107 SH   DFND 4 0 107 0
MARATHON OIL CORP COM 565849106 287 70,251 SH   DFND 9 0 70,251 0
MARATHON PETE CORP COM 56585A102 24,564 837,224 SH   DFND 2 4 9 10 0 732,469 104,755
MARCUS & MILLICHAP INC COM 566324109 42,309 1,537,407 SH   DFND 2 0 1,537,407 0
MARKEL CORP COM 570535104 2,770 2,840 SH   DFND 4 9 0 2,840 0
MARKETAXESS HLDGS INC COM 57060D108 44,745 92,908 SH   DFND 4 9 10 0 37,527 55,381
MARRIOTT INTL INC NEW CL A 571903202 6,391 69,057 SH   DFND 4 9 0 69,057 0
MARSH & MCLENNAN COS INC COM 571748102 233,187 2,033,247 SH   DFND 4 9 10 0 1,986,561 46,686
MARTEN TRANS LTD COM 573075108 362 22,176 SH   DFND 10 0 22,176 0
MARTIN MARIETTA MATLS INC COM 573284106 52,309 222,249 SH   DFND 2 4 9 0 211,501 10,748
MARVELL TECHNOLOGY GROUP LTD ORD G5876H105 245,067 6,173,957 SH   DFND 4 9 10 0 6,173,957 0
MASCO CORP COM 574599106 5,734 104,014 SH   DFND 4 9 0 103,859 155
MASIMO CORP COM 574795100 11,159 47,270 SH   DFND 4 9 0 29,054 18,216
MASTERCARD INCORPORATED CL A 57636Q104 3,758,648 11,115,130 SH   DFND 4 9 10 0 10,161,646 953,484
MATCH GROUP INC NEW COM 57667L107 377,759 3,413,806 SH   DFND 4 9 10 0 2,980,701 433,105
MAXIM INTEGRATED PRODS INC COM 57772K101 80,896 1,196,520 SH   DFND 2 4 9 0 1,070,862 125,658
MAXIMUS INC COM 577933104 64,318 940,187 SH   DFND 10 0 904,852 35,335
MCCORMICK & CO INC COM NON VTG 579780206 87,975 453,297 SH   DFND 4 9 10 0 392,345 60,952
MCDONALDS CORP COM 580135101 1,361,056 6,201,077 SH   DFND 4 9 10 0 5,440,437 760,640
MCGRATH RENTCORP COM 580589109 385 6,461 SH   DFND 10 0 6,461 0
MCKESSON CORP COM 58155Q103 11,053 74,225 SH   DFND 4 9 10 0 56,770 17,455
MEDALLIA INC COM 584021109 28,444 1,037,330 SH   DFND 10 0 948,090 89,240
MEDICAL PPTYS TRUST INC COM 58463J304 17,117 970,893 SH   DFND 4 9 0 389,543 581,350
MEDIFAST INC COM 58470H101 1,070 6,507 SH   DFND 10 0 6,507 0
MEDPACE HLDGS INC COM 58506Q109 2,401 21,488 SH   DFND 10 0 21,488 0
MEDTRONIC PLC SHS G5960L103 750,430 7,222,280 SH   DFND 2 4 9 10 0 6,457,014 765,266
MELCO RESORTS AND ENTMNT LTD ADR 585464100 16,564 994,555 SH   DFND 4 9 12 0 994,555 0
MERCADOLIBRE INC COM 58733R102 81,538 75,333 SH   DFND 4 9 10 0 74,157 1,176
MERCK & CO. INC COM 58933Y105 2,300,923 27,740,360 SH   DFND 2 4 9 10 0 25,129,137 2,611,223
MERCURY GENL CORP NEW COM 589400100 450 10,888 SH   DFND 9 0 9,120 1,768
MERSANA THERAPEUTICS INC COM 59045L106 16,922 908,845 SH   DFND 10 0 870,908 37,937
METLIFE INC COM 59156R108 7,321 196,970 SH   DFND 4 9 0 196,970 0
METTLER TOLEDO INTERNATIONAL COM 592688105 13,705 14,199 SH   DFND 4 9 0 8,284 5,915
MGIC INVT CORP WIS COM 552848103 45,413 5,125,595 SH   DFND 10 0 5,094,140 31,455
MGM GROWTH PPTYS LLC CL A COM 55303A105 199,424 7,127,564 SH   DFND 4 10 12 0 6,646,988 480,576
MGM RESORTS INTERNATIONAL COM 552953101 3,734 171,688 SH   DFND 4 9 10 0 171,688 0
MGP INGREDIENTS INC NEW COM 55303J106 372 9,355 SH   DFND 10 0 9,355 0
MICROCHIP TECHNOLOGY INC. COM 595017104 1,129,555 10,991,759 SH   DFND 4 9 10 0 10,301,473 690,286
MICRON TECHNOLOGY INC COM 595112103 103,843 2,211,185 SH   DFND 4 9 10 0 2,091,447 119,738
MICROSOFT CORP COM 594918104 9,860,307 46,883,536 SH   DFND 2 4 9 10 0 40,907,991 5,975,545
MID-AMER APT CMNTYS INC COM 59522J103 57,983 500,076 SH   DFND 4 9 0 280,315 219,761
MIDDLEBY CORP COM 596278101 118,736 1,323,556 SH   DFND 10 0 1,284,442 39,114
MIRATI THERAPEUTICS INC COM 60468T105 311,970 1,878,780 SH   DFND 10 0 1,818,895 59,885
MOBILE TELESYSTEMS PJSC SPONSORED ADR 607409109 578 66,176 SH   DFND 9 0 66,176 0
MODERNA INC COM 60770K107 7,349 103,900 SH   DFND 4 9 10 0 103,900 0
MOHAWK INDS INC COM 608190104 1,654 16,954 SH   DFND 4 9 0 16,954 0
MOLINA HEALTHCARE INC COM 60855R100 1,121 6,125 SH   DFND 4 9 0 5,581 544
MOLSON COORS BEVERAGE CO CL B 60871R209 2,609 77,749 SH   DFND 4 9 0 76,876 873
MOMO INC ADR 60879B107 463 33,647 SH   DFND 9 0 33,647 0
MONARCH CASINO & RESORT INC COM 609027107 39,066 875,918 SH   DFND 10 0 861,588 14,330
MONDELEZ INTL INC CL A 609207105 40,826 710,782 SH   DFND 4 9 10 0 679,961 30,821
MONGODB INC CL A 60937P106 56,433 243,758 SH   DFND 4 9 10 0 103,358 140,400
MONOLITHIC PWR SYS INC COM 609839105 3,652 13,062 SH   DFND 10 0 13,062 0
MONSTER BEVERAGE CORP NEW COM 61174X109 373,671 4,659,243 SH   DFND 4 9 10 0 4,248,971 410,272
MONTROSE ENVIRONMENTAL GROUP COM 615111101 16,689 700,646 SH   DFND 10 0 670,380 30,266
MOODYS CORP COM 615369105 69,536 239,928 SH   DFND 4 9 0 235,655 4,273
MORGAN STANLEY COM NEW 617446448 476,000 9,844,955 SH   DFND 4 9 10 0 9,781,845 63,110
MORNINGSTAR INC COM 617700109 3,779 23,531 SH   DFND 9 0 8,856 14,675
MOSAIC CO NEW COM 61945C103 7,515 411,628 SH   DFND 4 9 11 0 411,628 0
MOTOROLA SOLUTIONS INC COM NEW 620076307 322,332 2,055,727 SH   DFND 2 4 9 10 0 1,997,879 57,848
MSC INDL DIRECT INC CL A 553530106 43,964 694,750 SH   DFND 2 0 694,750 0
MSCI INC COM 55354G100 179,547 503,248 SH   DFND 4 9 10 0 468,451 34,797
MYLAN NV SHS EURO N59465109 8,518 574,408 SH   DFND 4 9 0 509,146 65,262
MYOKARDIA INC COM 62857M105 98,701 723,989 SH   DFND 10 0 695,223 28,766
MYOVANT SCIENCES LTD COM G637AM102 55,686 3,963,483 SH   DFND 10 0 3,826,664 136,819
NAPCO SEC TECHNOLOGIES INC COM 630402105 3,195 135,971 SH   DFND 10 0 131,950 4,021
NASDAQ INC COM 631103108 4,119 33,571 SH   DFND 4 9 0 33,571 0
NATERA INC COM 632307104 62,885 870,497 SH   DFND 10 0 833,880 36,617
NATIONAL BEVERAGE CORP COM 635017106 1,754 25,792 SH   DFND 10 0 25,792 0
NATIONAL GEN HLDGS CORP COM 636220303 242 7,185 SH   DFND 10 0 7,185 0
NATIONAL GRID PLC SPONSORED ADR NE 636274409 289 5,000 SH   DFND 4 0 5,000 0
NATIONAL HEALTH INVS INC COM 63633D104 612 10,147 SH   DFND 10 0 10,147 0
NATIONAL INSTRS CORP COM 636518102 319,459 8,948,432 SH   DFND 9 10 0 8,661,486 286,946
NATIONAL OILWELL VARCO INC COM 637071101 1,041 114,987 SH   DFND 4 9 0 114,987 0
NATIONAL RESH CORP COM NEW 637372202 1,583 32,172 SH   DFND 10 0 32,172 0
NATIONAL RETAIL PROPERTIES I COM 637417106 745 21,593 SH   DFND 4 9 0 21,593 0
NATIONAL STORAGE AFFILIATES COM SHS BEN IN 637870106 6,541 200,000 SH   DFND 4 0 200,000 0
NATIONAL VISION HLDGS INC COM 63845R107 108,031 2,825,074 SH   DFND 10 0 2,728,947 96,127
NATUS MED INC DEL COM 639050103 13,079 763,502 SH   DFND 2 0 763,502 0
NCR CORP NEW COM 62886E108 58,508 2,642,632 SH   DFND 10 0 2,548,822 93,810
NEKTAR THERAPEUTICS COM 640268108 827 49,839 SH   DFND 9 0 47,789 2,050
NEOGENOMICS INC COM NEW 64049M209 98,866 2,680,031 SH   DFND 4 10 0 2,573,537 106,494
NETAPP INC COM 64110D104 18,798 428,799 SH   DFND 4 9 0 268,906 159,893
NETEASE INC SPONSORED ADS 64110W102 66,706 146,729 SH   DFND 4 9 12 0 116,709 30,020
NETFLIX INC COM 64110L106 1,783,528 3,567,013 SH   DFND 4 9 10 0 2,994,522 572,491
NEUROCRINE BIOSCIENCES INC COM 64125C109 629,695 6,548,393 SH   DFND 4 9 10 0 6,175,028 373,365
NEW ORIENTAL ED & TECHNOLOGY SPON ADR 647581107 80,825 540,617 SH   DFND 4 9 10 12 0 508,903 31,714
NEW RESIDENTIAL INVT CORP COM NEW 64828T201 3,716 467,429 SH   DFND 9 0 241,788 225,641
NEW SR INVT GROUP INC COM 648691103 73 18,280 SH   DFND 10 0 18,280 0
NEW YORK CMNTY BANCORP INC COM 649445103 5,750 695,253 SH   DFND 9 0 622,548 72,705
NEW YORK TIMES CO CL A 650111107 9,114 212,994 SH   DFND 9 0 139,930 73,064
NEWELL BRANDS INC COM 651229106 54,572 3,180,149 SH   DFND 4 9 0 1,040,961 2,139,188
NEWMARK GROUP INC CL A 65158N102 153 35,349 SH   DFND 10 0 35,349 0
NEWMARKET CORP COM 651587107 99,358 290,248 SH   DFND 2 0 290,248 0
NEWMONT CORP COM 651639106 3,614 57,207 SH   DFND 4 0 57,207 0
NEWMONT CORP COM 651639106 227,142 3,579,806 SH   DFND 4 9 0 1,865,927 1,713,879
NEWS CORP NEW CL A 65249B109 5,299 378,047 SH   DFND 4 9 0 274,593 103,454
NEXGEN ENERGY LTD COM 65340P106 4,481 2,582,944 SH   DFND 11 0 2,582,944 0
NEXPOINT RESIDENTIAL TR INC COM 65341D102 241 5,436 SH   DFND 10 0 5,436 0
NEXTERA ENERGY INC COM 65339F101 129,848 467,894 SH   DFND 4 9 0 266,977 200,917
NICE LTD SPONSORED ADR 653656108 955,641 4,209,315 SH   DFND 10 0 3,990,523 218,792
NIELSEN HLDGS PLC SHS EUR G6518L108 34,875 2,459,480 SH   DFND 4 9 0 617,832 1,841,648
NIKE INC CL B 654106103 1,510,609 12,032,910 SH   DFND 4 9 10 0 10,439,600 1,593,310
NIO INC SPON ADS 62914V106 848 39,970 SH   DFND 9 10 0 39,970 0
NISOURCE INC COM 65473P105 3,576 162,552 SH   DFND 4 9 0 162,552 0
NOMAD FOODS LTD USD ORD SHS G6564A105 52,070 2,043,558 SH   DFND 2 0 2,043,558 0
NORDSON CORP COM 655663102 157,866 822,991 SH   DFND 4 9 10 0 791,519 31,472
NORFOLK SOUTHN CORP COM 655844108 14,981 70,007 SH   DFND 4 9 0 67,236 2,771
NORTHERN TR CORP COM 665859104 5,150 66,063 SH   DFND 4 9 0 66,063 0
NORTHROP GRUMMAN CORP COM 666807102 24,596 77,967 SH   DFND 4 9 10 0 67,067 10,900
NORTHWESTERN CORP COM NEW 668074305 23,695 487,150 SH   DFND 2 0 487,150 0
NORTONLIFELOCK INC COM 668771108 39,487 1,894,880 SH   DFND 4 9 0 621,981 1,272,899
NORWEGIAN CRUISE LINE HLDG L SHS G66721104 662 38,690 SH   DFND 9 10 0 38,690 0
NOVANTA INC COM 67000B104 31,977 303,561 SH   DFND 10 0 281,680 21,881
NOVARTIS AG SPONSORED ADR 66987V109 403,469 4,639,707 SH   DFND 4 10 0 4,495,568 144,139
NOVO-NORDISK A S ADR 670100205 16,632 239,554 SH   DFND 10 0 239,554 0
NOW INC COM 67011P100 57 12,500 SH   DFND 4 0 12,500 0
NRG ENERGY INC COM NEW 629377508 264,923 8,618,191 SH   DFND 4 9 10 0 7,982,486 635,705
NUCOR CORP COM 670346105 5,607 125,026 SH   DFND 4 9 11 0 125,026 0
NUTRIEN LTD COM 67077M108 35,753 911,360 SH   DFND 2 0 886,045 25,315
NUTRIEN LTD COM 67077M108 95,744 2,448,024 SH   DFND 2 4 9 11 0 2,166,922 281,102
NVIDIA CORPORATION COM 67066G104 2,349,232 4,340,804 SH   DFND 4 9 10 0 3,948,785 392,019
NVR INC COM 62944T105 39,566 9,679 SH   DFND 4 9 10 12 0 9,424 255
NXP SEMICONDUCTORS N V COM N6596X109 95,141 762,731 SH   DFND 4 9 10 0 762,731 0
OAK STR HEALTH INC COM 67181A107 21,326 399,066 SH   DFND 10 0 369,130 29,936
OCCIDENTAL PETE CORP COM 674599105 2,378 237,603 SH   DFND 4 9 0 237,603 0
ODONATE THERAPEUTICS INC COM 676079106 35,346 2,631,829 SH   DFND 10 0 2,549,328 82,501
OGE ENERGY CORP COM 670837103 405 13,508 SH   DFND 4 9 0 13,508 0
OKTA INC CL A 679295105 88,159 412,243 SH   DFND 4 9 10 0 176,509 235,734
OLD DOMINION FREIGHT LINE IN COM 679580100 29,485 162,981 SH   DFND 4 9 0 123,985 38,996
OLD REP INTL CORP COM 680223104 2,146 145,600 SH   DFND 9 0 66,144 79,456
OLLIES BARGAIN OUTLET HLDGS COM 681116109 778 8,905 SH   DFND 9 10 0 8,905 0
OMEGA HEALTHCARE INVS INC COM 681936100 2,745 91,673 SH   DFND 4 9 10 0 91,673 0
OMNICELL COM COM 68213N109 19,045 255,084 SH   DFND 2 4 0 255,084 0
OMNICOM GROUP INC COM 681919106 64,732 1,307,714 SH   DFND 4 9 0 572,856 734,858
ON SEMICONDUCTOR CORP COM 682189105 457,143 21,076,198 SH   DFND 4 9 10 0 20,391,075 685,123
ONEMAIN HLDGS INC COM 68268W103 2,420 77,425 SH   DFND 4 9 0 41,024 36,401
ONEOK INC NEW COM 682680103 2,973 114,438 SH   DFND 4 9 0 114,438 0
OPEN TEXT CORP COM 683715106 3,017 71,614 SH   DFND 4 9 0 71,614 0
ORACLE CORP COM 68389X105 297,907 4,990,379 SH   DFND 2 4 9 10 0 3,917,826 1,072,553
ORCHARD THERAPEUTICS PLC ADS 68570P101 2,781 676,753 SH   DFND 10 0 646,048 30,705
OREILLY AUTOMOTIVE INC COM 67103H107 34,407 74,630 SH   DFND 2 4 9 10 0 74,630 0
OSI SYSTEMS INC COM 671044105 142,535 1,836,560 SH   DFND 10 0 1,766,592 69,968
OSISKO GOLD ROYALTIES LTD COM 68827L101 6,497 551,025 SH   DFND 11 0 551,025 0
OTIS WORLDWIDE CORP COM 68902V107 101,124 1,620,126 SH   DFND 4 9 0 479,373 1,140,753
OUTFRONT MEDIA INC COM 69007J106 3,312 227,638 SH   DFND 9 0 114,930 112,708
OUTSET MED INC COM 690145107 5,383 107,651 SH   DFND 10 0 66,042 41,609
OWENS CORNING NEW COM 690742101 1,194 17,351 SH   DFND 4 9 0 17,351 0
PACCAR INC COM 693718108 14,230 166,852 SH   DFND 4 9 0 148,162 18,690
PACKAGING CORP AMER COM 695156109 21,034 192,876 SH   DFND 4 9 0 130,752 62,124
PAGERDUTY INC COM 69553P100 71,354 2,632,015 SH   DFND 10 0 2,529,944 102,071
PALO ALTO NETWORKS INC COM 697435105 36,915 150,827 SH   DFND 4 9 0 83,241 67,586
PAN AMERN SILVER CORP COM 697900108 6,207 193,651 SH   DFND 4 9 11 0 193,651 0
PANACEA ACQUISITION CORP UNIT 99/99/9999 698102209 2,088 176,103 SH   DFND 10 0 176,103 0
PARKER-HANNIFIN CORP COM 701094104 180,164 890,403 SH   DFND 4 9 10 0 861,823 28,580
PARSLEY ENERGY INC CL A 701877102 17,427 1,861,845 SH   DFND 2 9 11 0 1,858,602 3,243
PARSONS CORPORATION COM 70202L102 906 27,021 SH   DFND 10 0 27,021 0
PATRICK INDS INC COM 703343103 362 6,291 SH   DFND 10 0 6,291 0
PAYCHEX INC COM 704326107 10,760 134,893 SH   DFND 4 9 0 134,893 0
PAYCOM SOFTWARE INC COM 70432V102 17,299 55,590 SH   DFND 4 9 0 40,893 14,697
PAYLOCITY HLDG CORP COM 70438V106 91,622 567,602 SH   DFND 10 0 485,383 82,219
PAYPAL HLDGS INC COM 70450Y103 734,956 3,730,541 SH   DFND 4 9 10 0 3,663,094 67,447
PEBBLEBROOK HOTEL TR COM 70509V100 33,859 2,703,319 SH   DFND 4 10 12 0 2,628,859 74,460
PEGASYSTEMS INC COM 705573103 6,399 52,866 SH   DFND 9 0 34,995 17,871
PELOTON INTERACTIVE INC CL A COM 70614W100 23,113 232,905 SH   DFND 4 9 10 0 227,386 5,519
PEMBINA PIPELINE CORP COM 706327103 2,929 138,466 SH   DFND 4 9 0 138,448 18
PENN NATL GAMING INC COM 707569109 3,632 50,000 SH   DFND 4 0 50,000 0
PENNANT GROUP INC COM 70805E109 231 5,988 SH   DFND 10 0 5,988 0
PENNYMAC FINL SVCS INC NEW COM 70932M107 267 4,586 SH   DFND 10 0 4,586 0
PENTAIR PLC SHS G7S00T104 2,879 62,911 SH   DFND 4 9 0 62,911 0
PENUMBRA INC COM 70975L107 1,791 9,216 SH   DFND 10 0 9,216 0
PEOPLES UNITED FINANCIAL INC COM 712704105 715 69,347 SH   DFND 4 9 0 69,347 0
PEPSICO INC COM 713448108 164,333 1,186,290 SH   DFND 2 4 9 10 0 604,706 581,584
PERKINELMER INC COM 714046109 473,188 3,770,126 SH   DFND 4 9 10 0 3,652,746 117,380
PERRIGO CO PLC SHS G97822103 2,291 49,920 SH   DFND 4 9 0 49,107 813
PFIZER INC COM 717081103 185,504 5,056,099 SH   DFND 2 4 9 10 0 4,711,134 344,965
PG&E CORP COM 69331C108 327 34,833 SH   DFND 4 9 0 31,976 2,857
PGT INNOVATIONS INC COM 69336V101 20,667 1,179,651 SH   DFND 2 10 0 1,179,651 0
PHATHOM PHARMACEUTICALS INC COM 71722W107 57,538 1,568,796 SH   DFND 10 0 1,512,018 56,778
PHIBRO ANIMAL HEALTH CORP CL A COM 71742Q106 12,877 740,085 SH   DFND 2 0 740,085 0
PHILIP MORRIS INTL INC COM 718172109 34,844 464,691 SH   DFND 4 9 10 0 366,230 98,461
PHILLIPS 66 COM 718546104 29,006 559,550 SH   DFND 4 9 0 97,387 462,163
PHREESIA INC COM 71944F106 7,323 227,923 SH   DFND 10 0 217,847 10,076
PHYSICIANS RLTY TR COM 71943U104 24,392 1,363,063 SH   DFND 4 10 0 1,363,063 0
PINDUODUO INC SPONSORED ADS 722304102 28,636 386,184 SH   DFND 9 0 59,611 326,573
PINNACLE FINL PARTNERS INC COM 72346Q104 860 24,164 SH   DFND 2 0 24,164 0
PINNACLE WEST CAP CORP COM 723484101 21,507 288,489 SH   DFND 4 9 0 271,624 16,865
PINTEREST INC CL A 72352L106 45,293 1,091,524 SH   DFND 4 9 0 1,091,524 0
PIONEER NAT RES CO COM 723787107 22,370 260,146 SH   DFND 2 4 9 0 260,146 0
PLANET FITNESS INC CL A 72703H101 369 5,984 SH   DFND 10 0 5,984 0
PMV PHARMACEUTICALS INC COM 69353Y103 12,841 361,724 SH   DFND 10 0 342,738 18,986
PNC FINL SVCS GROUP INC COM 693475105 16,421 149,423 SH   DFND 2 4 9 0 137,315 12,108
POLARIS INC COM 731068102 694 7,355 SH   DFND 4 0 7,355 0
POOL CORP COM 73278L105 5,447 16,281 SH   DFND 9 10 0 16,218 63
POPULAR INC COM NEW 733174700 2,698 74,395 SH   DFND 9 0 33,409 40,986
PPD INC COM 69355F102 2,774 75,000 SH   DFND 4 0 75,000 0
PPG INDS INC COM 693506107 8,927 73,127 SH   DFND 4 9 0 72,672 455
PPL CORP COM 69351T106 14,257 523,974 SH   DFND 2 4 9 10 0 385,624 138,350
PQ GROUP HLDGS INC COM 73943T103 3,255 317,287 SH   DFND 10 0 317,287 0
PRA HEALTH SCIENCES INC COM 69354M108 242,664 2,392,187 SH   DFND 10 0 2,330,190 61,997
PRESTIGE CONSMR HEALTHCARE I COM 74112D101 24,404 670,070 SH   DFND 10 0 640,957 29,113
PRETIUM RES INC COM 74139C102 409 32,026 SH   DFND 11 0 32,026 0
PRICE T ROWE GROUP INC COM 74144T108 106,526 830,824 SH   DFND 4 9 0 307,078 523,746
PRINCIPAL FINANCIAL GROUP IN COM 74251V102 3,130 77,741 SH   DFND 4 9 0 77,741 0
PROCTER AND GAMBLE CO COM 742718109 1,793,625 12,904,959 SH   DFND 2 4 9 10 0 11,225,088 1,679,871
PROGRESSIVE CORP COM 743315103 1,072,315 11,326,912 SH   DFND 4 9 10 0 9,656,633 1,670,279
PROLOGIS INC. COM 74340W103 163,086 1,620,949 SH   DFND 4 9 10 12 0 1,520,459 100,490
PROOFPOINT INC COM 743424103 52,226 494,725 SH   DFND 4 0 494,725 0
PROSPERITY BANCSHARES INC COM 743606105 54,079 1,043,390 SH   DFND 2 9 0 1,043,390 0
PROTO LABS INC COM 743713109 908 7,011 SH   DFND 10 0 7,011 0
PROVIDENCE SVC CORP COM 743815102 1,282 13,800 SH   DFND 10 0 13,190 610
PRUDENTIAL FINL INC COM 744320102 6,398 100,741 SH   DFND 4 9 0 100,741 0
PTC INC COM 69370C100 1,820 22,014 SH   DFND 4 9 0 22,014 0
PTC THERAPEUTICS INC COM 69366J200 94,367 2,018,563 SH   DFND 10 0 1,947,816 70,747
PUBLIC STORAGE COM 74460D109 150,321 674,942 SH   DFND 2 4 9 0 512,936 162,006
PUBLIC SVC ENTERPRISE GRP IN COM 744573106 8,510 154,982 SH   DFND 4 9 0 154,982 0
PULTE GROUP INC COM 745867101 76,224 1,646,662 SH   DFND 4 9 10 0 1,561,359 85,303
QIAGEN NV SHS NEW N72482123 28,696 552,511 SH   DFND 4 9 0 64,136 488,375
QIAGEN NV SHS NEW N72482123 6,860 131,275 SH   DFND 9 0 116,939 14,336
QORVO INC COM 74736K101 138,658 1,075,480 SH   DFND 4 9 0 969,250 106,230
QUALCOMM INC COM 747525103 639,473 5,434,063 SH   DFND 4 9 10 0 3,527,426 1,906,637
QUALYS INC COM 74758T303 1,275 13,011 SH   DFND 10 0 13,011 0
QUEST DIAGNOSTICS INC COM 74834L100 152,674 1,333,518 SH   DFND 2 4 9 10 0 1,031,870 301,648
QUIDEL CORP COM 74838J101 61,589 280,743 SH   DFND 9 10 0 266,962 13,781
QURATE RETAIL INC COM SER A 74915M100 10,428 1,452,385 SH   DFND 2 0 1,452,385 0
RALPH LAUREN CORP CL A 751212101 11,300 166,253 SH   DFND 4 9 0 158,998 7,255
RAYMOND JAMES FINL INC COM 754730109 2,553 35,093 SH   DFND 4 9 0 35,093 0
RAYTHEON TECHNOLOGIES CORP COM 75513E101 127,126 2,209,433 SH   DFND 2 4 9 0 1,253,457 955,976
RBC BEARINGS INC COM 75524B104 341 2,813 SH   DFND 10 0 2,813 0
REALPAGE INC COM 75606N109 195,699 3,395,193 SH   DFND 10 0 3,121,951 273,242
REALTY INCOME CORP COM 756109104 24,143 397,447 SH   DFND 4 9 0 311,899 85,548
REDBALL ACQUISITION CORP UNIT 99/99/9999 G7417R121 21,141 2,000,100 SH   DFND 10 0 2,000,100 0
REDBALL ACQUISITION CORP UNIT 99/99/9999 G7417R121 25 2,339 SH   DFND 10 0 2,339 0
REDBALL ACQUISITION CORP UNIT 99/99/9999 G7417R121 21,166 2,002,439 SH   DFND 10 0 2,002,439 0
REDFIN CORP COM 75737F108 57,074 1,143,079 SH   DFND 10 0 1,090,091 52,988
REGENCY CTRS CORP COM 758849103 1,536 40,403 SH   DFND 4 9 0 40,403 0
REGENERON PHARMACEUTICALS COM 75886F107 191,208 341,587 SH   DFND 4 9 10 0 211,063 130,524
REGIONS FINANCIAL CORP NEW COM 7591EP100 39,483 3,424,453 SH   DFND 2 4 9 0 3,424,453 0
REINSURANCE GRP OF AMERICA I COM NEW 759351604 23,524 247,122 SH   DFND 4 9 0 19,451 227,671
RELAY THERAPEUTICS INC COM 75943R102 20,726 486,611 SH   DFND 10 0 407,459 79,152
RELIANCE STEEL & ALUMINUM CO COM 759509102 3,722 36,477 SH   DFND 4 9 0 21,281 15,196
RENAISSANCERE HLDGS LTD COM G7496G103 130,269 767,462 SH   DFND 2 4 9 0 694,520 72,942
REPAY HLDGS CORP COM CL A 76029L100 22,606 961,985 SH   DFND 4 10 0 924,804 37,181
REPLIGEN CORP COM 759916109 3,385 22,942 SH   DFND 9 0 19,943 2,999
REPUBLIC SVCS INC COM 760759100 47,163 505,234 SH   DFND 2 4 9 0 460,226 45,008
RESMED INC COM 761152107 253,318 1,477,691 SH   DFND 4 9 0 513,107 964,584
RESTAURANT BRANDS INTL INC COM 76131D103 3,560 62,142 SH   DFND 4 9 0 62,142 0
RETROPHIN INC COM 761299106 67,510 3,657,157 SH   DFND 10 0 3,526,007 131,150
REXFORD INDL RLTY INC COM 76169C100 51,648 1,129,415 SH   DFND 4 9 10 12 0 1,097,565 31,850
REXNORD CORP COM 76169B102 336,032 11,261,129 SH   DFND 10 0 10,867,169 393,960
REYNOLDS CONSUMER PRODS INC COM 76171L106 44,446 1,451,529 SH   DFND 10 0 1,451,529 0
RHYTHM PHARMACEUTICALS INC COM 76243J105 95,053 4,386,370 SH   DFND 10 0 4,242,577 143,793
RINGCENTRAL INC CL A 76680R206 282,466 1,028,614 SH   DFND 4 9 10 0 781,339 247,275
RITCHIE BROS AUCTIONEERS COM 767744105 118 2,004 SH   DFND 4 9 0 2,004 0
RITCHIE BROS AUCTIONEERS COM 767744105 370,079 6,246,065 SH   DFND 10 0 6,040,403 205,662
RLI CORP COM 749607107 35,675 426,073 SH   DFND 10 0 399,952 26,121
ROBERT HALF INTL INC COM 770323103 8,380 158,289 SH   DFND 4 9 0 39,723 118,566
ROCKET PHARMACEUTICALS INC COM 77313F106 1,789 78,267 SH   DFND 10 0 78,267 0
ROCKWELL AUTOMATION INC COM 773903109 116,837 529,430 SH   DFND 4 9 10 0 405,283 124,147
ROGERS COMMUNICATIONS INC CL B 775109200 33,866 856,405 SH   DFND 2 4 9 0 154,239 702,166
ROGERS CORP COM 775133101 76,323 778,330 SH   DFND 2 10 0 753,800 24,530
ROKU INC COM CL A 77543R102 32,219 170,652 SH   DFND 4 9 10 0 114,977 55,675
ROLLINS INC COM 775711104 26,235 484,139 SH   DFND 4 9 10 0 282,218 201,921
ROPER TECHNOLOGIES INC COM 776696106 94,966 240,279 SH   DFND 4 9 0 219,825 20,454
ROSS STORES INC COM 778296103 34,344 368,014 SH   DFND 2 4 9 0 363,306 4,708
ROYAL BK CDA COM 780087102 58,612 837,400 SH   DFND 4 9 0 500,347 337,053
ROYAL CARIBBEAN GROUP COM V7780T103 29,151 450,362 SH   DFND 4 9 0 411,648 38,714
ROYAL GOLD INC COM 780287108 707 5,880 SH   DFND 9 0 5,880 0
ROYALTY PHARMA PLC SHS CL A G7709Q104 198,766 4,724,644 SH   DFND 10 0 4,566,619 158,025
RPM INTL INC COM 749685103 21,067 254,307 SH   DFND 4 9 0 153,645 100,662
RYANAIR HOLDINGS PLC SPONSORED ADS 783513203 238,525 2,917,375 SH   DFND 10 0 2,818,809 98,566
S&P GLOBAL INC COM 78409V104 208,459 578,138 SH   DFND 4 9 10 0 578,138 0
SABRA HEALTH CARE REIT INC COM 78573L106 28,472 2,065,454 SH   DFND 4 10 12 0 2,007,993 57,461
SABRE CORP COM 78573M104 2,397 367,888 SH   DFND 4 9 0 364,310 3,578
SAFEGUARD SCIENTIFICS INC COM NEW 786449207 1,708 310,246 SH   DFND 4 10 0 310,246 0
SAFEHOLD INC COM 78645L100 710 11,436 SH   DFND 10 0 11,436 0
SAGE THERAPEUTICS INC COM 78667J108 98,995 1,619,701 SH   DFND 10 0 1,569,678 50,023
SAIA INC COM 78709Y105 147,309 1,167,822 SH   DFND 10 0 1,127,366 40,456
SAILPOINT TECHNLGIES HLDGS I COM 78781P105 99,899 2,524,619 SH   DFND 10 0 2,002,257 522,362
SALESFORCE COM INC COM 79466L302 2,599,352 10,344,339 SH   DFND 4 9 10 0 9,452,775 891,564
SANDERSON FARMS INC COM 800013104 54,741 464,026 SH   DFND 2 0 464,026 0
SANOFI SPONSORED ADR 80105N105 26,571 529,604 SH   DFND 4 10 0 529,604 0
SANTANDER CONSUMER USA HDG I COM 80283M101 1,799 98,923 SH   DFND 9 0 93,069 5,854
SAREPTA THERAPEUTICS INC COM 803607100 554,781 3,950,552 SH   DFND 4 9 10 0 3,833,989 116,563
SBA COMMUNICATIONS CORP NEW CL A 78410G104 69,844 219,417 SH   DFND 4 9 10 12 0 193,741 25,676
SCHLUMBERGER LTD COM 806857108 11,204 720,202 SH   DFND 2 4 9 11 0 720,202 0
SCHWAB CHARLES CORP COM 808513105 19,016 524,908 SH   DFND 2 4 9 0 476,118 48,790
SCOTTS MIRACLE GRO CO CL A 810186106 10,740 70,239 SH   DFND 4 9 0 46,356 23,883
SEAGATE TECHNOLOGY PLC SHS G7945M107 110,617 2,245,119 SH   DFND 4 9 0 707,656 1,537,463
SEALED AIR CORP NEW COM 81211K100 359,205 9,255,478 SH   DFND 4 9 10 0 8,996,879 258,599
SEATTLE GENETICS INC COM 812578102 109,154 557,785 SH   DFND 4 9 10 0 161,599 396,186
SEI INVTS CO COM 784117103 1,965 38,760 SH   DFND 4 9 0 38,329 431
SELECT SECTOR SPDR TR SBI INT-FINL 81369Y605 285 488,800 SH Call DFND 10 0 4,888 0
SELECT SECTOR SPDR TR SBI INT-FINL 81369Y605 1,873 77,822 SH   DFND 10 0 77,822 0
SELECT SECTOR SPDR TR SBI INT-FINL 81369Y605 3 4,600 SH Call DFND 10 0 46 0
SELECT SECTOR SPDR TR SBI INT-INDS 81369Y704 802 10,419 SH   DFND 10 0 10,419 0
SELECT SECTOR SPDR TR SBI INT-FINL 81369Y605 288 493,400 SH Call DFND 10 0 4,934 0
SELECT SECTOR SPDR TR TECHNOLOGY 81369Y803 5,616 48,126 SH   DFND 10 0 48,126 0
SELECTIVE INS GROUP INC COM 816300107 58,691 1,139,847 SH   DFND 10 0 1,111,432 28,415
SELECTQUOTE INC COM 816307300 208 10,252 SH   DFND 10 0 10,252 0
SEMPRA ENERGY COM 816851109 332,024 2,805,220 SH   DFND 4 9 10 0 2,777,026 28,194
SENSATA TECHNOLOGIES HLDNG P SHS G8060N102 432,083 10,015,731 SH   DFND 4 9 10 0 9,703,131 312,600
SENSIENT TECHNOLOGIES CORP COM 81725T100 233,896 4,050,841 SH   DFND 10 0 3,893,138 157,703
SERES THERAPEUTICS INC COM 81750R102 54,185 1,914,077 SH   DFND 10 0 1,844,854 69,223
SERVICEMASTER GLOBAL HLDGS I COM 81761R109 784,363 19,668,083 SH   DFND 9 10 0 19,139,745 528,338
SERVICENOW INC COM 81762P102 178,510 368,187 SH   DFND 4 9 10 0 367,455 732
SHAKE SHACK INC CL A 819047101 429 6,649 SH   DFND 10 0 6,649 0
SHAW COMMUNICATIONS INC CL B CONV 82028K200 51,274 2,818,550 SH   DFND 4 9 0 776,429 2,042,121
SHERWIN WILLIAMS CO COM 824348106 789,408 1,133,012 SH   DFND 4 9 10 0 1,099,255 33,757
SHIFT4 PMTS INC CL A 82452J109 5,513 114,005 SH   DFND 10 0 109,082 4,923
SHOPIFY INC CL A 82509L107 24,206 23,763 SH   DFND 4 9 0 23,763 0
SHOTSPOTTER INC COM 82536T107 870 28,037 SH   DFND 10 0 28,037 0
SHUTTERSTOCK INC COM 825690100 19,637 377,343 SH   DFND 2 0 377,343 0
SIGNATURE BK NEW YORK N Y COM 82669G104 681 8,204 SH   DFND 4 9 0 8,204 0
SILK RD MED INC COM 82710M100 69,445 1,033,251 SH   DFND 10 0 1,000,541 32,710
SIMON PPTY GROUP INC NEW COM 828806109 4,635 71,679 SH   DFND 4 9 0 71,679 0
SIMPLY GOOD FOODS CO COM 82900L102 78,848 3,575,884 SH   DFND 10 0 3,442,983 132,901
SIMPSON MANUFACTURING CO INC COM 829073105 474 4,878 SH   DFND 10 0 4,878 0
SIRIUS XM HOLDINGS INC COM 82968B103 3,690 688,638 SH   DFND 4 9 10 0 688,638 0
SITEONE LANDSCAPE SUPPLY INC COM 82982L103 604 4,954 SH   DFND 10 0 4,954 0
SK TELECOM LTD SPONSORED ADR 78440P108 33,627 1,500,550 SH   DFND 4 12 0 1,500,550 0
SKECHERS U S A INC CL A 830566105 388 12,828 SH   DFND 4 10 0 12,828 0
SKYLINE CHAMPION CORPORATION COM 830830105 12,330 460,581 SH   DFND 2 10 0 460,581 0
SKYWORKS SOLUTIONS INC COM 83088M102 21,496 147,738 SH   DFND 4 9 0 140,236 7,502
SL GREEN RLTY CORP COM 78440X101 28,233 609,000 SH   DFND 4 10 12 0 591,373 17,627
SLACK TECHNOLOGIES INC COM CL A 83088V102 1,729 64,374 SH   DFND 4 9 0 64,374 0
SMARTSHEET INC COM CL A 83200N103 1,530 30,956 SH   DFND 9 0 21,379 9,577
SMITH A O CORP COM 831865209 7,212 136,600 SH   DFND 4 9 0 36,788 99,812
SMUCKER J M CO COM NEW 832696405 60,059 519,898 SH   DFND 2 4 9 10 0 293,997 225,901
SNAP INC CL A 83304A106 467,726 17,913,732 SH   DFND 4 9 10 0 16,426,940 1,486,792
SNAP ON INC COM 833034101 39,407 267,840 SH   DFND 4 9 0 51,304 216,536
SNOWFLAKE INC CL A 833445109 5,648 22,504 SH   DFND 10 0 19,619 2,885
SONOCO PRODS CO COM 835495102 65,546 1,283,447 SH   DFND 2 9 0 1,211,995 71,452
SONY CORP SPONSORED ADR 835699307 279 3,631 SH   DFND 10 0 3,631 0
SOUTHERN CO COM 842587107 147,142 2,713,813 SH   DFND 4 9 0 1,723,196 990,617
SOUTHERN COPPER CORP COM 84265V105 1,183 26,128 SH   DFND 4 9 0 26,128 0
SOUTHWEST AIRLS CO COM 844741108 2,125 56,680 SH   DFND 4 9 10 0 56,149 531
SOUTHWEST GAS HOLDINGS INC COM 844895102 92,657 1,468,416 SH   DFND 2 0 1,468,416 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 171 13,900 SH Call DFND 10 0 139 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 4 2,000 SH Call DFND 10 0 20 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 32 3,300 SH Put DFND 10 0 33 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 42 4,000 SH Put DFND 10 0 40 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 175 15,900 SH Call DFND 10 0 159 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 10 700 SH Put DFND 10 0 7 0
SPDR SER TR S&P HOMEBUILD 78464A888 1,386 25,722 SH   DFND 10 0 25,722 0
SPECTRUM BRANDS HLDGS INC NE COM 84790A105 3,517 61,528 SH   DFND 4 9 0 21,655 39,873
SPIRIT RLTY CAP INC NEW COM NEW 84860W300 36,475 1,080,887 SH   DFND 4 9 10 12 0 989,975 90,912
SPLUNK INC COM 848637104 172,731 918,053 SH   DFND 4 9 10 0 530,755 387,298
SPOTIFY TECHNOLOGY S A SHS L8681T102 8,284 34,154 SH   DFND 4 9 0 27,378 6,776
SPS COMMERCE INC COM 78463M107 2,482 31,876 SH   DFND 10 0 31,876 0
SPX CORP COM 784635104 2,760 59,515 SH   DFND 4 10 0 56,924 2,591
SQUARE INC CL A 852234103 13,446 82,666 SH   DFND 4 9 0 82,666 0
SS&C TECHNOLOGIES HLDGS INC COM 78467J100 1,118,227 18,476,205 SH   DFND 4 9 10 0 18,001,602 474,603
SSR MNG INC COM 784730103 6,364 341,551 SH   DFND 11 0 341,551 0
STAG INDL INC COM 85254J102 97,382 3,193,893 SH   DFND 2 10 0 3,193,893 0
STANDEX INTL CORP COM 854231107 20,317 343,190 SH   DFND 10 0 328,452 14,738
STANLEY BLACK & DECKER INC COM 854502101 56,257 346,844 SH   DFND 4 9 10 0 346,844 0
STARBUCKS CORP COM 855244109 342,195 3,982,829 SH   DFND 2 4 9 10 0 3,829,185 153,644
STATE STR CORP COM 857477103 8,446 142,367 SH   DFND 4 9 0 141,466 901
STEEL DYNAMICS INC COM 858119100 1,311 45,783 SH   DFND 4 9 0 45,783 0
STERIS PLC SHS USD G8473T100 715,548 4,061,229 SH   DFND 4 9 10 0 3,916,752 144,477
STERLING BANCORP DEL COM 85917A100 130 12,322 SH   DFND 10 0 12,322 0
STITCH FIX INC COM CL A 860897107 269 9,914 SH   DFND 10 0 9,914 0
STONERIDGE INC COM 86183P102 32,577 1,773,364 SH   DFND 2 0 1,773,364 0
STORE CAP CORP COM 862121100 232 8,467 SH   DFND 10 0 8,467 0
STRYKER CORPORATION COM 863667101 257,737 1,236,946 SH   DFND 2 4 9 10 0 1,223,728 13,218
SUMMIT MATLS INC CL A 86614U100 96,451 5,831,391 SH   DFND 10 0 5,724,152 107,239
SUN CMNTYS INC COM 866674104 77,705 552,364 SH   DFND 4 9 10 12 0 540,427 11,937
SUN LIFE FINANCIAL INC. COM 866796105 21,345 525,417 SH   DFND 4 9 0 227,171 298,246
SUNCOR ENERGY INC NEW COM 867224107 20,148 1,655,257 SH   DFND 4 9 10 0 1,563,057 92,200
SUNSTONE HOTEL INVS INC NEW COM 867892101 51,507 6,487,083 SH   DFND 2 0 6,487,083 0
SUPERNUS PHARMACEUTICALS INC COM 868459108 1,399 67,127 SH   DFND 10 0 67,127 0
SURMODICS INC COM 868873100 17,403 447,264 SH   DFND 10 0 411,606 35,658
SUTRO BIOPHARMA INC COM 869367102 1,566 156,017 SH   DFND 10 0 156,017 0
SVB FINANCIAL GROUP COM 78486Q101 166,295 691,113 SH   DFND 4 9 10 0 669,017 22,096
SYNCHRONY FINANCIAL COM 87165B103 133,470 5,100,190 SH   DFND 2 4 9 10 0 2,310,266 2,789,924
SYNEOS HEALTH INC CL A 87166B102 1,415 26,618 SH   DFND 10 0 26,618 0
SYNNEX CORP COM 87162W100 2,391 17,072 SH   DFND 10 0 17,072 0
SYNOPSYS INC COM 871607107 166,842 779,720 SH   DFND 2 4 9 0 572,282 207,438
SYSCO CORP COM 871829107 393,843 6,329,875 SH   DFND 4 9 10 0 3,254,505 3,075,370
TACTILE SYS TECHNOLOGY INC COM 87357P100 905 24,744 SH   DFND 10 0 24,744 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 485,381 5,986,493 SH   DFND 4 10 12 0 5,700,597 285,896
TAKEDA PHARMACEUTICAL CO LTD SPONSORED ADS 874060205 12,509 701,149 SH   DFND 10 0 701,149 0
TAKE-TWO INTERACTIVE SOFTWAR COM 874054109 231,495 1,401,141 SH   DFND 4 9 0 651,984 749,157
TAL EDUCATION GROUP SPONSORED ADS 874080104 16,112 211,884 SH   DFND 9 0 41,357 170,527
TAPESTRY INC COM 876030107 10,895 697,025 SH   DFND 9 0 642,119 54,906
TARGET CORP COM 87612E106 397,991 2,528,241 SH   DFND 4 9 10 0 1,701,514 826,727
TC ENERGY CORP COM 87807B107 9,227 220,265 SH   DFND 4 9 0 220,265 0
TD AMERITRADE HLDG CORP COM 87236Y108 158,791 4,055,962 SH   DFND 4 9 10 0 3,911,000 144,962
TE CONNECTIVITY LTD REG SHS H84989104 664,826 6,802,040 SH   DFND 4 9 10 0 6,607,436 194,604
TECK RESOURCES LTD CL B 878742204 110,549 7,964,492 SH   DFND 4 9 10 11 0 7,897,224 67,268
TELADOC HEALTH INC COM 87918A105 29,858 136,192 SH   DFND 4 9 10 0 47,139 89,053
TELECOM ARGENTINA S A SPON ADR REP B 879273209 272 41,586 SH   DFND 9 0 41,586 0
TELEDYNE TECHNOLOGIES INC COM 879360105 403,176 1,299,694 SH   DFND 4 9 10 0 1,264,832 34,862
TELEFLEX INCORPORATED COM 879369106 283,169 831,826 SH   DFND 4 9 10 0 806,187 25,639
TELEPHONE & DATA SYS INC COM NEW 879433829 2,829 153,396 SH   DFND 9 0 69,898 83,498
TELUS CORPORATION COM 87971M103 2 120 SH   DFND 4 0 120 0
TELUS CORPORATION COM 87971M103 21,741 1,237,335 SH   DFND 4 0 1,189,011 48,324
TELUS CORPORATION COM 87971M103 21,743 1,237,455 SH   DFND 4 0 1,189,131 48,324
TERADYNE INC COM 880770102 2,627 33,067 SH   DFND 4 9 0 33,067 0
TESLA INC COM 88160R101 1,230 15,200 SH Put DFND 10 0 152 0
TESLA INC COM 88160R101 213,357 497,369 SH   DFND 4 9 10 0 413,262 84,107
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209 2,021 224,391 SH   DFND 4 9 0 220,898 3,493
TEXAS INSTRS INC COM 882508104 1,852,530 12,974,212 SH   DFND 2 4 9 10 0 11,689,150 1,285,062
TEXAS ROADHOUSE INC COM 882681109 316 5,191 SH   DFND 10 0 5,191 0
TEXTRON INC COM 883203101 807 22,368 SH   DFND 4 9 0 22,158 210
THE TRADE DESK INC COM CL A 88339J105 149,359 287,909 SH   DFND 4 9 10 0 254,600 33,309
THERAPEUTICS ACQUISITION COR COM CL A 88339T103 1,790 124,666 SH   DFND 10 0 124,666 0
THERMO FISHER SCIENTIFIC INC COM 883556102 1,144,126 2,591,494 SH   DFND 4 9 10 0 2,539,875 51,619
THERMON GROUP HLDGS INC COM 88362T103 21,716 1,933,722 SH   DFND 2 0 1,933,722 0
THOMSON REUTERS CORP. COM NEW 884903709 9,726 122,288 SH   DFND 4 9 0 117,948 4,340
THOR INDS INC COM 885160101 79,259 832,023 SH   DFND 10 0 799,505 32,518
TIFFANY & CO NEW COM 886547108 73,455 634,056 SH   DFND 4 9 0 245,566 388,490
TJX COS INC NEW COM 872540109 37,179 668,142 SH   DFND 4 9 0 653,181 14,961
T-MOBILE US INC COM 872590104 1,098,811 9,608,411 SH   DFND 4 9 10 0 9,103,070 505,341
TOLL BROTHERS INC COM 889478103 520 10,692 SH   DFND 4 10 0 10,692 0
TOPBUILD CORP COM 89055F103 422 2,474 SH   DFND 10 0 2,474 0
TORO CO COM 891092108 12,537 149,342 SH   DFND 9 0 101,832 47,510
TORONTO DOMINION BK ONT COM NEW 891160509 76,356 1,654,236 SH   DFND 4 9 10 0 655,845 998,391
TRACTOR SUPPLY CO COM 892356106 8,859 61,812 SH   DFND 4 9 0 61,609 203
TRADEWEB MKTS INC CL A 892672106 742 12,788 SH   DFND 4 9 0 12,788 0
TRANE TECHNOLOGIES PLC SHS G8994E103 78,581 648,078 SH   DFND 4 9 10 0 564,393 83,685
TRANSDIGM GROUP INC COM 893641100 116,481 245,154 SH   DFND 4 9 0 180,146 65,008
TRANSUNION COM 89400J107 39,228 466,278 SH   DFND 4 9 0 91,831 374,447
TRAVELERS COMPANIES INC COM 89417E109 132,488 1,224,631 SH   DFND 4 9 10 0 1,212,873 11,758
TREX CO INC COM 89531P105 930 12,988 SH   DFND 10 0 12,988 0
TRI POINTE GROUP INC COM 87265H109 305 16,789 SH   DFND 10 0 16,789 0
TRIMBLE INC COM 896239100 74,357 1,527,905 SH   DFND 4 9 0 1,527,420 485
TRINET GROUP INC COM 896288107 47,973 808,715 SH   DFND 4 10 0 782,767 25,948
TRIP COM GROUP LTD ADS 89677Q107 267 8,572 SH   DFND 9 0 8,572 0
TRUIST FINL CORP COM 89832Q109 21,823 573,575 SH   DFND 2 4 9 10 0 470,174 103,401
TURQUOISE HILL RES LTD COM 900435108 232 274,148 SH   DFND 11 0 274,148 0
TWILIO INC CL A 90138F102 145,980 590,804 SH   DFND 4 9 10 0 325,267 265,537
TWITTER INC COM 90184L102 51,167 1,149,827 SH   DFND 4 9 0 998,472 151,355
TWITTER INC NOTE 0.250% 6/1 90184LAF9 6,715 6,006,000 SH   DFND 4 0 6,006,000 0
TYLER TECHNOLOGIES INC COM 902252105 270,727 776,709 SH   DFND 4 9 10 0 655,021 121,688
TYSON FOODS INC CL A 902494103 39,525 664,516 SH   DFND 2 4 9 0 651,304 13,212
U S PHYSICAL THERAPY INC COM 90337L108 1,137 13,092 SH   DFND 10 0 13,092 0
UBER TECHNOLOGIES INC COM 90353T100 253,116 6,939,110 SH   DFND 4 9 10 0 6,638,195 300,915
UBIQUITI INC COM 90353W103 4,696 28,176 SH   DFND 9 10 0 28,111 65
UBS GROUP AG SHS H42097107 104,858 9,354,621 SH   DFND 4 9 0 7,334,789 2,019,832
UBS GROUP AG SHS H42097107 3 266 SH   DFND 4 0 266 0
UDR INC COM 902653104 46,302 1,420,075 SH   DFND 4 9 10 12 0 1,361,820 58,255
UFP INDUSTRIES INC COM 90278Q108 927 16,409 SH   DFND 10 0 16,409 0
UFP TECHNOLOGIES INC COM 902673102 319 7,700 SH   DFND 10 0 7,700 0
UGI CORP NEW COM 902681105 1,071 32,484 SH   DFND 4 9 0 32,484 0
ULTA BEAUTY INC COM 90384S303 10,685 47,712 SH   DFND 4 9 0 38,189 9,523
UNDER ARMOUR INC CL C 904311206 86,274 8,767,686 SH   DFND 9 10 0 8,741,406 26,280
UNIFIRST CORP MASS COM 904708104 100,031 528,228 SH   DFND 2 0 528,228 0
UNILEVER N V N Y SHS NEW 904784709 372 6,153 SH   DFND 4 0 6,153 0
UNION PAC CORP COM 907818108 196,922 1,000,392 SH   DFND 2 4 9 10 0 938,590 61,802
UNIQURE NV SHS N90064101 25,851 701,901 SH   DFND 10 0 685,829 16,072
UNITED AIRLS HLDGS INC COM 910047109 1,108 31,886 SH   DFND 4 9 0 31,886 0
UNITED BANKSHARES INC WEST V COM 909907107 54,066 2,518,233 SH   DFND 2 0 2,518,233 0
UNITED CMNTY BKS BLAIRSVLE G COM 90984P303 58,047 3,428,643 SH   DFND 2 0 3,428,643 0
UNITED PARCEL SERVICE INC CL B 911312106 801,888 4,812,367 SH   DFND 2 4 9 10 0 4,068,785 743,582
UNITED RENTALS INC COM 911363109 3,959 22,697 SH   DFND 4 9 0 22,697 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 2,732 27,052 SH   DFND 9 0 21,146 5,906
UNITEDHEALTH GROUP INC COM 91324P102 1,506,930 4,833,630 SH   DFND 4 9 10 0 4,703,715 129,915
UNITY SOFTWARE INC COM 91332U101 31,068 355,958 SH   DFND 10 0 240,141 115,817
UNIVAR SOLUTIONS USA INC COM 91336L107 16,049 951,062 SH   DFND 4 9 0 950,571 491
UNIVERSAL DISPLAY CORP COM 91347P105 72,374 400,304 SH   DFND 4 10 0 400,304 0
UNIVERSAL HLTH SVCS INC CL B 913903100 1,698 15,869 SH   DFND 4 9 0 15,603 266
UNUM THERAPEUTICS INC COM 903214104 715 310,359 SH   DFND 10 0 310,359 0
US BANCORP DEL COM NEW 902973304 17,906 499,702 SH   DFND 2 4 9 10 0 454,515 45,187
V F CORP COM 918204108 147,106 2,094,037 SH   DFND 4 9 10 0 1,544,484 549,553
VAIL RESORTS INC COM 91879Q109 66,409 310,369 SH   DFND 4 9 10 0 96,260 214,109
VALERO ENERGY CORP COM 91913Y100 39,276 906,665 SH   DFND 2 4 9 11 0 262,541 644,124
VALVOLINE INC COM 92047W101 43,807 2,300,802 SH   DFND 9 10 0 2,195,442 105,360
VANDA PHARMACEUTICALS INC COM 921659108 673 69,660 SH   DFND 10 0 69,660 0
VANGUARD CHARLOTTE FDS INTL BD IDX ETF 92203J407 1,008 17,330 SH   DFND 10 0 17,330 0
VANGUARD INDEX FDS S&P 500 ETF SHS 922908363 92,994 302,273 SH   DFND 10 0 302,273 0
VANGUARD INDEX FDS SMALL CP ETF 922908751 32,697 212,591 SH   DFND 10 0 212,591 0
VANGUARD INTL EQUITY INDEX F FTSE PACIFIC ETF 922042866 1,503 22,087 SH   DFND 10 0 22,087 0
VANGUARD INTL EQUITY INDEX F ALLWRLD EX US 922042775 1,430 28,352 SH   DFND 10 0 28,352 0
VANGUARD INTL EQUITY INDEX F FTSE EUROPE ETF 922042874 23,013 438,931 SH   DFND 10 0 438,931 0
VANGUARD INTL EQUITY INDEX F FTSE EMR MKT ETF 922042858 834 19,295 SH   DFND 10 0 19,295 0
VANGUARD SCOTTSDALE FDS MORTG-BACK SEC 92206C771 279 5,132 SH   DFND 10 0 5,132 0
VANGUARD SCOTTSDALE FDS INT-TERM CORP 92206C870 3,226 33,677 SH   DFND 10 0 33,677 0
VAREX IMAGING CORP COM 92214X106 19,232 1,511,976 SH   DFND 2 0 1,511,976 0
VARIAN MED SYS INC COM 92220P105 234,727 1,364,695 SH   DFND 4 9 10 0 1,248,203 116,492
VAXCYTE INC COM 92243G108 199,839 4,196,429 SH   DFND 10 0 4,097,272 99,157
VEEVA SYS INC CL A COM 922475108 218,305 776,362 SH   DFND 4 9 0 307,091 469,271
VENTAS INC COM 92276F100 5,602 133,520 SH   DFND 4 9 10 0 133,520 0
VEREIT INC COM 92339V100 2,947 453,167 SH   DFND 4 9 0 453,167 0
VERISIGN INC COM 92343E102 99,647 486,128 SH   DFND 4 9 0 480,774 5,354
VERISK ANALYTICS INC COM 92345Y106 369,881 1,996,035 SH   DFND 4 9 10 0 1,938,776 57,259
VERITEX HLDGS INC COM 923451108 10,556 619,854 SH   DFND 2 10 0 619,854 0
VERIZON COMMUNICATIONS INC COM 92343V104 217,832 3,663,078 SH   DFND 4 9 10 0 3,072,488 590,590
VERTEX INC CL A 92538J106 15,355 667,613 SH   DFND 10 0 466,220 201,393
VERTEX PHARMACEUTICALS INC COM 92532F100 517,279 1,900,957 SH   DFND 4 9 10 0 1,596,224 304,733
VIA OPTRONICS AG SPONSORED ADS 91823Y109 2,687 300,000 SH   DFND 4 0 300,000 0
VIACOMCBS INC CL B 92556H206 3,577 127,713 SH   DFND 4 9 0 127,713 0
VIAVI SOLUTIONS INC COM 925550105 36,051 3,074,690 SH   DFND 4 0 3,074,690 0
VICI PPTYS INC COM 925652109 525,001 22,469,560 SH   DFND 4 9 10 12 0 22,287,162 182,398
VIPSHOP HOLDINGS LIMITED SPONSORED ADS A 92763W103 736 47,034 SH   DFND 9 0 47,034 0
VISA INC COM CL A 92826C839 1,705,076 8,530,706 SH   DFND 4 9 10 0 7,629,331 901,375
VISHAY INTERTECHNOLOGY INC COM 928298108 34,366 2,207,206 SH   DFND 2 0 2,207,206 0
VISTEON CORP COM NEW 92839U206 185,724 2,683,100 SH   DFND 10 0 2,612,015 71,085
VISTRA CORP COM 92840M102 39,652 2,102,488 SH   DFND 4 9 10 0 1,952,281 150,207
VIVINT SMART HOME INC COM CL A 928542109 552 32,307 SH   DFND 10 0 32,307 0
VMWARE INC CL A COM 928563402 51,108 355,734 SH   DFND 4 9 0 242,403 113,331
VODAFONE GROUP PLC NEW SPONSORED ADR 92857W308 148 11,000 SH   DFND 4 0 11,000 0
VONAGE HLDGS CORP COM 92886T201 159,795 15,620,231 SH   DFND 10 0 15,042,309 577,922
VORNADO RLTY TR SH BEN INT 929042109 1,893 56,166 SH   DFND 4 9 10 0 56,166 0
VOYA FINANCIAL INC COM 929089100 8,284 172,841 SH   DFND 4 9 0 105,701 67,140
VROOM INC COM 92918V109 29,190 563,736 SH   DFND 10 0 552,378 11,358
VULCAN MATLS CO COM 929160109 15,300 112,890 SH   DFND 2 4 9 11 0 112,684 206
WABTEC COM 929740108 323,192 5,223,055 SH   DFND 4 9 10 0 5,081,074 141,981
WALGREENS BOOTS ALLIANCE INC COM 931427108 46,543 1,295,750 SH   DFND 2 4 9 0 285,634 1,010,116
WALKER & DUNLOP INC COM 93148P102 36,257 684,035 SH   DFND 4 10 0 665,967 18,068
WALMART INC COM 931142103 364,663 2,606,446 SH   DFND 4 9 10 0 1,542,365 1,064,081
WARNER MUSIC GROUP CORP COM CL A 934550203 50,309 1,750,474 SH   DFND 10 0 1,750,474 0
WARRIOR MET COAL INC COM 93627C101 898 52,598 SH   DFND 10 0 52,598 0
WASHINGTON FED INC COM 938824109 87,167 4,178,657 SH   DFND 2 0 4,178,657 0
WASTE CONNECTIONS INC COM 94106B101 45,487 438,218 SH   DFND 2 4 9 0 438,218 0
WASTE CONNECTIONS INC COM 94106B101 2,748 26,521 SH   DFND 4 0 26,521 0
WASTE MGMT INC DEL COM 94106L109 94,329 833,513 SH   DFND 4 9 10 0 712,986 120,527
WATERS CORP COM 941848103 333,357 1,703,584 SH   DFND 4 9 10 0 1,450,203 253,381
WATSCO INC COM 942622200 2,640 11,334 SH   DFND 9 0 8,911 2,423
WATTS WATER TECHNOLOGIES INC CL A 942749102 33,823 337,725 SH   DFND 2 4 0 337,725 0
WAYFAIR INC CL A 94419L101 510,999 1,755,949 SH   DFND 4 9 10 0 1,704,992 50,957
WEC ENERGY GROUP INC COM 92939U106 50,682 523,054 SH   DFND 4 9 10 0 315,810 207,244
WELLS FARGO CO NEW COM 949746101 47,470 2,019,579 SH   DFND 2 4 9 10 0 1,724,591 294,988
WELLTOWER INC COM 95040Q104 10,928 198,378 SH   DFND 4 9 10 0 198,378 0
WENDYS CO COM 95058W100 98,710 4,427,451 SH   DFND 4 10 0 4,265,030 162,421
WEST PHARMACEUTICAL SVSC INC COM 955306105 184,715 671,942 SH   DFND 4 9 10 0 384,947 286,995
WESTERN DIGITAL CORP. COM 958102105 7,296 199,601 SH   DFND 4 9 0 192,148 7,453
WESTERN UN CO COM 959802109 86,829 4,051,858 SH   DFND 4 9 0 2,220,424 1,831,434
WESTLAKE CHEM CORP COM 960413102 29,543 467,306 SH   DFND 2 9 0 467,306 0
WESTLAKE CHEM PARTNERS LP COM UNIT RP LP 960417103 28,385 1,513,852 SH   DFND 2 0 1,513,852 0
WESTROCK CO COM 96145D105 4,342 124,996 SH   DFND 4 9 10 0 124,996 0
WEX INC COM 96208T104 462,190 3,325,826 SH   DFND 4 10 0 3,179,526 146,300
WEYERHAEUSER CO MTN BE COM NEW 962166104 85,670 3,003,890 SH   DFND 2 4 9 11 0 1,013,334 1,990,556
WHEATON PRECIOUS METALS CORP COM 962879102 9,846 201,281 SH   DFND 4 9 0 201,281 0
WHIRLPOOL CORP COM 963320106 16,270 88,476 SH   DFND 4 9 0 69,908 18,568
WILEY JOHN & SONS INC CL A 968223206 1,331 41,967 SH   DFND 9 0 17,026 24,941
WILLIAMS COS INC COM 969457100 24,905 1,267,713 SH   DFND 4 9 0 1,252,969 14,744
WILLIAMS SONOMA INC COM 969904101 90,425 999,836 SH   DFND 9 10 0 942,810 57,026
WILLIS TOWERS WATSON PLC LTD SHS G96629103 374,292 1,792,302 SH   DFND 4 9 10 0 1,315,954 476,348
WINGSTOP INC COM 974155103 302 2,213 SH   DFND 10 0 2,213 0
WINNEBAGO INDS INC COM 974637100 372 7,202 SH   DFND 4 10 0 7,202 0
WIX COM LTD SHS M98068105 83,582 327,959 SH   DFND 4 9 10 0 151,176 176,783
WNS HLDGS LTD SPON ADR 92932M101 115,404 1,804,317 SH   DFND 2 10 0 1,769,410 34,907
WORKDAY INC CL A 98138H101 377,519 1,754,855 SH   DFND 4 9 10 0 1,485,838 269,017
WORLD WRESTLING ENTMT INC CL A 98156Q108 284 7,022 SH   DFND 10 0 7,022 0
WP CAREY INC COM 92936U109 3,636 55,796 SH   DFND 4 9 0 55,796 0
WSFS FINL CORP COM 929328102 45,385 1,682,812 SH   DFND 2 0 1,682,812 0
WYNDHAM HOTELS & RESORTS INC COM 98311A105 352 6,968 SH   DFND 10 0 6,968 0
WYNN RESORTS LTD COM 983134107 2,401 33,438 SH   DFND 4 9 0 33,438 0
WYNN RESORTS LTD COM 983134107 83 26,300 SH Call DFND 10 0 263 0
XCEL ENERGY INC COM 98389B100 106,871 1,548,653 SH   DFND 4 9 10 0 899,520 649,133
XEROX HOLDINGS CORP COM NEW 98421M106 10,347 551,227 SH   DFND 9 0 445,215 106,012
XILINX INC COM 983919101 571,104 5,478,723 SH   DFND 4 9 10 0 4,207,179 1,271,544
XPO LOGISTICS INC COM 983793100 2,174 25,677 SH   DFND 4 9 0 25,533 144
XYLEM INC COM 98419M100 37,554 446,358 SH   DFND 4 9 10 0 446,358 0
YAMANA GOLD INC COM 98462Y100 503 88,891 SH   DFND 4 9 0 88,891 0
YANDEX N V SHS CLASS A N97284108 5,994 91,886 SH   DFND 4 9 0 91,886 0
YEXT INC COM 98585N106 79,114 5,211,722 SH   DFND 10 0 4,965,526 246,196
YUM BRANDS INC COM 988498101 7,294 79,892 SH   DFND 4 9 0 79,892 0
YUM CHINA HLDGS INC COM 98850P109 13,635 265,500 SH   DFND 10 0 265,500 0
YUM CHINA HLDGS INC COM 98850P109 66,598 1,257,827 SH   DFND 4 9 10 12 0 919,026 338,801
ZAI LAB LTD ADR 98887Q104 2,208 26,544 SH   DFND 9 0 26,544 0
ZEBRA TECHNOLOGIES CORPORATI CL A 989207105 95,781 379,467 SH   DFND 4 9 0 211,240 168,227
ZENDESK INC COM 98936J101 746,971 7,257,818 SH   DFND 4 10 0 6,488,150 769,668
ZILLOW GROUP INC CL C CAP STK 98954M200 68,731 676,550 SH   DFND 4 9 0 129,779 546,771
ZILLOW GROUP INC CL A 98954M101 8,241 81,159 SH   DFND 4 9 0 50,511 30,648
ZIMMER BIOMET HOLDINGS INC COM 98956P102 18,675 137,184 SH   DFND 4 9 0 123,269 13,915
ZIONS BANCORPORATION N A COM 989701107 1,127 38,564 SH   DFND 4 9 0 38,564 0
ZOETIS INC CL A 98978V103 445,812 2,695,863 SH   DFND 4 9 10 0 2,484,662 211,201
ZOGENIX INC COM NEW 98978L204 31,162 1,737,980 SH   DFND 10 0 1,642,124 95,856
ZOOM VIDEO COMMUNICATIONS IN CL A 98980L101 51,841 110,286 SH   DFND 4 9 0 44,334 65,952
ZSCALER INC COM 98980G102 11,455 81,421 SH   DFND 4 9 0 62,646 18,775
ZTO EXPRESS CAYMAN INC SPONSORED ADS A 98980A105 22,797 762,130 SH   DFND 4 9 12 0 522,398 239,732
ZYNGA INC CL A 98986T108 18,442 2,022,122 SH   DFND 9 0 1,358,757 663,365