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WELLCOME TRUST LTD (THE) as trustee of the WELLCOME TRUST
> MBRX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 12/31/2009 | METABASIS THERAPEUTICS INC | MBRX | 474,833 | 0 | 183,000 | -21,000 | $0.39 |
| 09/30/2009 | METABASIS THERAPEUTICS INC | MBRX | 474,833 | 0 | 204,000 | -62,000 | $0.43 |
| 06/30/2009 | METABASIS THERAPEUTICS INC | MBRX | 474,833 | 0 | 266,000 | -71,000 | $0.56 |
| 03/31/2009 | METABASIS THERAPEUTICS INC | MBRX | 474,833 | 0 | 337,000 | 185,000 | $0.71 |
| 12/31/2008 | METABASIS THERAPEUTICS INC | MBRX | 474,833 | 474,833 | 152,000 | 152,000 | $0.32 |
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