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JPMORGAN CHASE & CO
> IONS
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | IONIS PHARMACEUTICALS INC | IONS | 1,067,723 | 10,328 | 43,808,674,000 | 6,017,280,000 | $41,030.00 |
| 03/31/2023 | IONIS PHARMACEUTICALS INC | IONS | 1,057,395 | 128,643 | 37,791,394,000 | 37,750,315,000 | $35,740.09 |
| 09/30/2022 | IONIS PHARMACEUTICALS INC | IONS | 928,752 | -110,818 | 41,079,000 | 2,595,000 | $44.23 |
| 06/30/2022 | IONIS PHARMACEUTICALS INC | IONS | 1,039,570 | -141,987 | 38,484,000 | -5,281,000 | $37.02 |
| 03/31/2022 | IONIS PHARMACEUTICALS INC | IONS | 1,181,557 | -87,095 | 43,765,000 | 5,160,000 | $37.04 |
| 12/31/2021 | IONIS PHARMACEUTICALS INC | IONS | 1,268,652 | -1,147,661 | 38,605,000 | -42,439,000 | $30.43 |
| 09/30/2021 | IONIS PHARMACEUTICALS INC | IONS | 2,416,313 | 140,607 | 81,044,000 | -9,734,000 | $33.54 |
| 06/30/2021 | IONIS PHARMACEUTICALS INC | IONS | 2,275,706 | 312,483 | 90,778,000 | 2,512,000 | $39.89 |
| 03/31/2021 | IONIS PHARMACEUTICALS INC | IONS | 1,963,223 | 89,891 | 88,266,000 | -17,652,000 | $44.96 |
| 12/31/2020 | IONIS PHARMACEUTICALS INC | IONS | 1,873,332 | 1,145,403 | 105,918,000 | 70,628,000 | $56.54 |
| 09/30/2020 | IONIS PHARMACEUTICALS INC | IONS | 727,929 | 209,760 | 35,290,000 | 4,739,000 | $48.48 |
| 06/30/2020 | IONIS PHARMACEUTICALS INC | IONS | 518,169 | 246,447 | 30,551,000 | 17,704,000 | $58.96 |
| 03/31/2020 | IONIS PHARMACEUTICALS INC | IONS | 271,722 | -265,229 | 12,847,000 | -19,590,000 | $47.28 |
| 12/31/2019 | IONIS PHARMACEUTICALS INC | IONS | 536,951 | 321,660 | 32,437,000 | 19,538,000 | $60.41 |
| 09/30/2019 | IONIS PHARMACEUTICALS INC | IONS | 215,291 | 36,553 | 12,899,000 | 1,337,000 | $59.91 |
| 06/30/2019 | IONIS PHARMACEUTICALS INC | IONS | 178,738 | 166,696 | 11,562,000 | 10,584,000 | $64.69 |
| 03/31/2019 | IONIS PHARMACEUTICALS INC | IONS | 12,042 | -136,616 | 978,000 | -7,059,000 | $81.22 |
| 12/31/2018 | IONIS PHARMACEUTICALS INC | IONS | 148,658 | 138,181 | 8,037,000 | 7,496,000 | $54.06 |
| 09/30/2018 | IONIS PHARMACEUTICALS INC | IONS | 10,477 | -1,037 | 541,000 | 61,000 | $51.64 |
| 06/30/2018 | IONIS PHARMACEUTICALS INC | IONS | 11,514 | 6,058 | 480,000 | 240,000 | $41.69 |
| 03/31/2018 | IONIS PHARMACEUTICALS INC | IONS | 5,456 | -56,651 | 240,000 | -2,884,000 | $43.99 |
| 12/31/2017 | IONIS PHARMACEUTICALS INC | IONS | 62,107 | -465 | 3,124,000 | -168,000 | $50.30 |
| 09/30/2017 | IONIS PHARMACEUTICALS INC | IONS | 62,572 | 60,763 | 3,292,000 | 3,200,000 | $52.61 |
| 06/30/2017 | IONIS PHARMACEUTICALS INC | IONS | 1,809 | 894 | 92,000 | 55,000 | $50.86 |
| 03/31/2017 | IONIS PHARMACEUTICALS INC | IONS | 915 | -360 | 37,000 | -24,000 | $40.44 |
| 12/31/2016 | IONIS PHARMACEUTICALS INC | IONS | 1,275 | -3,543 | 61,000 | -116,000 | $47.84 |
| 09/30/2016 | IONIS PHARMACEUTICALS INC | IONS | 4,818 | 4,818 | 177,000 | 177,000 | $36.74 |
| 06/30/2016 | IONIS PHARMACEUTICALS INC | IONS | 47,959 | 47,959 | 1,116,000 | 1,116,000 | $23.27 |
| 03/31/2016 | IONIS PHARMACEUTICALS INC | IONS | 8,539 | 8,539 | 346,000 | 346,000 | $40.52 |
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