IONIS PHARMACEUTICALS INC (IONS) [Rocket]

In millions, except per share items	Jun-30-23	Mar-31-23	Dec-31-22	Sep-30-22	Jun-30-22	Mar-31-22	Dec-31-21	Sep-30-21
	10-Q	8-K	10-K	10-Q	10-Q	10-Q	10-K	10-Q
Revenue:
Revenue	631.1	576.4	587.4	875.5	848.8	840.8	810.5	660.7
Revenue growth	-25.7%	-31.4%	-27.5%	32.5%	23.4%	18.8%	11.1%	-29.2%
Expenses:
Cost of sales	7.7		14.1	12.7	14.2	12.4	10.8	11.9
Research, development and patent	919.2	870.0	833.1	704.4	706.2	664.8	643.5	634.7
Selling, general and administrative	174.5	162.2	150.3	139.9	136.6	159.3	186.3	287.6
Total operating expenses	1,103.4	1,044.1	997.6	857.1	857.1	836.5	840.6	934.2
Loss from operations	-471.4	-466.7	-410.2	18.4	-8.3	4.3	-30.2	-273.5
Operating margin	-74.7%	-81.0%	-69.8%	2.1%	-1.0%	0.5%	-3.7%	-41.4%

Other income (expense):
Investment income	40.2		24.8	14.7	8.1	7.4	10.1	12.9
Interest expense	-6.2		-8.1	-8.6	-8.8	-9.1	-9.3	-9.5
Gain (loss) on investments	6.3		-7.3	-5.4	-3.7	3.5	10.1	10.7
Other income (expense)	33.5	10.1	-6.7	-7.9	-13.1	-9.6	-9.8	-9.2
Loss before income tax expense	-168.5		-258.0	11.3	-25.8	-3.5	-29.1	-268.6
Income tax expense	-27.2	-21.6	-11.7	-3.9	-2.4	-0.4	0.5	-340.3
Net loss	-308.7	-328.6	-269.7	7.3	-28.2	-3.9	-28.6	-607.7

Basic net loss per share (in dollars per share)	($2.17)	($2.31)	($1.90)	$0.07	($0.18)	($0.01)	($0.19)	($4.33)
Diluted net loss per share (in dollars per share)	($2.17)	($2.31)	($1.90)	$0.07	($0.18)	($0.01)	($0.19)	($4.33)

Shares used in computing basic net loss per share (in shares)	142.5	142.1	141.8	141.6	141.4	141.2	141.0	140.6
Shares used in computing diluted net loss per share (in shares)	142.5	142.1	141.8	141.6	141.4	141.2	141.0	140.6