In millions, except per share items | Jun-30-23 | Mar-31-23 | Dec-31-22 | Sep-30-22 | Jun-30-22 | Mar-31-22 | Dec-31-21 | Sep-30-21 |
| 10-Q | 8-K | 10-K | 10-Q | 10-Q | 10-Q | 10-K | 10-Q |
Operating activities: | | | | | | | | |
Net loss | -209.6 | | 217.3 | -47.0 | -105.1 | -65.2 | 253.2 | -82.5 |
Adjustments to reconcile net loss to net cash used in operating activities: | | | | | | | | |
Depreciation | 5.2 | | 3.0 | 3.8 | 3.8 | 3.7 | 3.8 | 3.7 |
Amortization of right-of-use operating lease assets | 4.8 | | 3.4 | 0.7 | 0.7 | 0.6 | 0.6 | 0.4 |
Amortization of other assets | 1.2 | | 0.6 | 0.6 | 0.6 | 0.6 | 0.6 | 0.6 |
Amortization of premium (discount) on investments, net | -12.5 | | -1.7 | 1.2 | 3.7 | 4.2 | 4.3 | 4.7 |
Amortization of debt issuance costs | 3.0 | | 1.3 | 1.3 | 1.3 | 1.3 | 1.4 | 1.4 |
Non-cash royalty revenue related to sale of royalties | -12.6 | | | | | | | |
Non-cash interest related to sale of future royalties | 32.9 | | | | | | | |
Stock-based compensation expense | 53.5 | | 25.7 | 23.8 | 24.5 | 26.2 | 22.3 | 30.5 |
Loss (gain) on investments | -0.3 | | 0.0 | 0.2 | 0.1 | 0.0 | -0.2 | -0.1 |
Gain on early retirement of debt | -11.3 | | | | | | | |
Changes in operating assets and liabilities: | | | | | | | | |
Contracts receivable | -2.3 | | -18.9 | 0.1 | 19.4 | 35.8 | -52.8 | 14.9 |
Inventories | -3.5 | | -1.4 | -0.8 | 4.2 | 0.8 | -1.9 | 1.2 |
Other current and long-term assets | -19.7 | | -23.7 | -0.9 | 7.2 | -7.2 | -11.2 | 1.2 |
Accounts payable | 5.5 | | -4.5 | 8.3 | -5.6 | 2.9 | 4.7 | -7.9 |
Accrued compensation | -19.9 | | 18.8 | 5.4 | 8.5 | -22.3 | 6.5 | 2.1 |
Deferred contract revenue | -27.7 | | -15.8 | -14.4 | -16.0 | -25.0 | -11.2 | -21.1 |
Net cash used in operating activities | -231.4 | | -200.2 | -24.4 | -18.1 | -31.7 | 203.7 | -55.6 |
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Investing activities: | | | | | | | | |
Purchases of short-term investments | -932.4 | | -262.0 | -560.6 | -200.3 | -462.9 | -193.2 | -190.2 |
Proceeds from sale of short-term investments | 701.0 | | 225.1 | 383.7 | 201.5 | 178.8 | 292.3 | 324.0 |
Purchases of property, plant and equipment | -22.5 | | -4.1 | -5.5 | -3.3 | -2.7 | -2.5 | -3.3 |
Net cash used in investing activities | -256.1 | | 212.1 | -183.9 | -3.3 | -287.5 | 95.1 | 122.0 |
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Financing activities: | | | | | | | | |
Proceeds from equity, net | 5.0 | | 0.3 | 2.6 | 1.6 | 1.8 | 0.0 | 1.9 |
Proceeds from issuance of 1.75 percent convertible senior notes | 575.0 | | | | | | | |
Repurchase of $434.1 million principal amount of 0.125 percent convertible senior notes | -420.2 | | | | | | | |
Proceeds from sale of future royalties | 500.0 | | | | | | | |
Payments of transaction costs related to sale of future royalties | -10.4 | | | | | | | |
Net cash provided by (used in) financing activities | 635.6 | | -51.0 | 1.8 | 1.2 | -7.3 | -62.5 | 1.5 |
Effects of exchange rates on cash | 0.2 | | 0.5 | -0.4 | -0.6 | | -0.1 | 0.0 |
Net increase (decrease) in cash and cash equivalents | 148.3 | | -592.7 | | -347.3 | | | |
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Supplemental disclosures of cash flow information: | | | | | | | | |
Interest paid | 0.5 | | 0.7 | 0.7 | 1.0 | 0.6 | 1.3 | 0.7 |
Supplemental disclosures of non-cash investing and financing activities: | | | | | | | | |
Amounts accrued for capital and patent expenditures | 0.3 | | 1.7 | 1.9 | -0.2 | 1.3 | -1.1 | 1.5 |