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ESSEX INVESTMENT MANAGEMENT CO LLC
> REGN
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | REGENERON PHARMACEUTICALS, INC. | REGN | 1,371 | -595 | 985,118,000 | -630,285,000 | $718,539.75 |
| 03/31/2023 | REGENERON PHARMACEUTICALS, INC. | REGN | 1,966 | -139 | 1,615,403,000 | 1,613,884,000 | $821,669.89 |
| 12/31/2022 | REGENERON PHARMACEUTICALS, INC. | REGN | 2,105 | -4,115 | 1,519,000 | -2,766,000 | $721.62 |
| 09/30/2022 | REGENERON PHARMACEUTICALS, INC. | REGN | 6,220 | -386 | 4,285,000 | 380,000 | $688.91 |
| 06/30/2022 | REGENERON PHARMACEUTICALS, INC. | REGN | 6,606 | -285 | 3,905,000 | -908,000 | $591.13 |
| 03/31/2022 | REGENERON PHARMACEUTICALS, INC. | REGN | 6,891 | 447 | 4,813,000 | 743,000 | $698.45 |
| 12/31/2021 | REGENERON PHARMACEUTICALS, INC. | REGN | 6,444 | 0 | 4,070,000 | 170,000 | $631.60 |
| 09/30/2021 | REGENERON PHARMACEUTICALS, INC. | REGN | 6,444 | 21 | 3,900,000 | 312,000 | $605.21 |
| 06/30/2021 | REGENERON PHARMACEUTICALS, INC. | REGN | 6,423 | -853 | 3,588,000 | 73,000 | $558.62 |
| 12/31/2020 | REGENERON PHARMACEUTICALS, INC. | REGN | 7,276 | -222 | 3,515,000 | -682,000 | $483.10 |
| 09/30/2020 | REGENERON PHARMACEUTICALS, INC. | REGN | 7,498 | -79 | 4,197,000 | -528,000 | $559.75 |
| 06/30/2020 | REGENERON PHARMACEUTICALS, INC. | REGN | 7,577 | -6,647 | 4,725,000 | -2,220,000 | $623.60 |
| 03/31/2020 | REGENERON PHARMACEUTICALS, INC. | REGN | 14,224 | 4,224 | 6,945,000 | 3,190,000 | $488.26 |
| 12/31/2019 | REGENERON PHARMACEUTICALS, INC. | REGN | 10,000 | 10,000 | 3,755,000 | 3,755,000 | $375.50 |
| 12/31/2018 | REGENERON PHARMACEUTICALS, INC. | REGN | 0 | -12,613 | 0 | -5,096,000 | |
| 09/30/2018 | REGENERON PHARMACEUTICALS, INC. | REGN | 12,613 | 4,509 | 5,096,000 | 2,300,000 | $404.03 |
| 06/30/2018 | REGENERON PHARMACEUTICALS, INC. | REGN | 8,104 | 4,256 | 2,796,000 | 1,471,000 | $345.01 |
| 03/31/2018 | REGENERON PHARMACEUTICALS, INC. | REGN | 3,848 | 3,848 | 1,325,000 | 1,325,000 | $344.33 |
| 03/31/2017 | REGENERON PHARMACEUTICALS, INC. | REGN | 0 | -5,375 | 0 | -1,973,000 | |
| 12/31/2016 | REGENERON PHARMACEUTICALS, INC. | REGN | 5,375 | 0 | 1,973,000 | -188,000 | $367.07 |
| 09/30/2016 | REGENERON PHARMACEUTICALS, INC. | REGN | 5,375 | 0 | 2,161,000 | 284,000 | $402.05 |
| 06/30/2016 | REGENERON PHARMACEUTICALS, INC. | REGN | 5,375 | 3,827 | 1,877,000 | 1,393,000 | $349.21 |
| 03/31/2016 | REGENERON PHARMACEUTICALS, INC. | REGN | 0 | -1,548 | 0 | -484,000 | |
| 12/31/2015 | REGENERON PHARMACEUTICALS, INC. | REGN | 0 | -1,445 | 0 | -672,000 | |
| 09/30/2015 | REGENERON PHARMACEUTICALS, INC. | REGN | 1,445 | -103 | 672,000 | 188,000 | $465.05 |
| 06/30/2015 | REGENERON PHARMACEUTICALS, INC. | REGN | 1,445 | -4,906 | 737,000 | -1,868,000 | $510.03 |
| 03/31/2015 | REGENERON PHARMACEUTICALS, INC. | REGN | 7,112 | 761 | 3,211,000 | 606,000 | $451.49 |
| 12/31/2014 | REGENERON PHARMACEUTICALS, INC. | REGN | 6,351 | 4,803 | 2,605,000 | 2,121,000 | $410.17 |
| 09/30/2014 | REGENERON PHARMACEUTICALS, INC. | REGN | 935 | 0 | 337,000 | 73,000 | $360.43 |
| 06/30/2014 | REGENERON PHARMACEUTICALS, INC. | REGN | 935 | -613 | 264,000 | -220,000 | $282.35 |
| 03/31/2014 | REGENERON PHARMACEUTICALS, INC. | REGN | 1,195 | -353 | 359,000 | -125,000 | $300.42 |
| 12/31/2013 | REGENERON PHARMACEUTICALS, INC. | REGN | 1,684 | 136 | 464,000 | -20,000 | $275.53 |
| 09/30/2013 | REGENERON PHARMACEUTICALS, INC. | REGN | 1,548 | 1,548 | 484,000 | 484,000 | $312.66 |
| 06/30/2013 | REGENERON PHARMACEUTICALS, INC. | REGN | 1,604 | 1,604 | 361,000 | 361,000 | $225.06 |
| 12/31/2012 | REGENERON PHARMACEUTICALS, INC. | REGN | 0 | -800 | 0 | -122,128 | |
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