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| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 12/31/2004 | LEXICON PHARMACEUTICALS, INC. | LXRX | 3,798,399 | 134,820 | 29,475,576 | 7,897,096 | $7.76 |
| 12/31/2003 | LEXICON PHARMACEUTICALS, INC. | LXRX | 3,663,579 | 205,335 | 21,578,480 | 5,220,986 | $5.89 |
| 12/31/2002 | LEXICON PHARMACEUTICALS, INC. | LXRX | 3,458,244 | 355,332 | 16,357,494 | -19,450,110 | $4.73 |
| 12/31/2001 | LEXICON PHARMACEUTICALS, INC. | LXRX | 3,102,912 | 3,102,912 | 35,807,604 | 35,807,604 | $11.54 |
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