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BB BIOTECH AG
> VRTX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 03/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,300,000 | -70,445 | 239,135,000 | 12,039,000 | $183.95 |
| 12/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,370,445 | 0 | 227,096,000 | -37,044,000 | $165.71 |
| 09/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,370,445 | -30,000 | 264,140,000 | 26,120,000 | $192.74 |
| 06/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,400,445 | -75,000 | 238,020,000 | -2,448,000 | $169.96 |
| 03/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,475,445 | 0 | 240,468,000 | 19,358,000 | $162.98 |
| 12/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,475,445 | 0 | 221,110,000 | -3,217,000 | $149.86 |
| 09/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,475,445 | 0 | 224,327,000 | 34,186,000 | $152.04 |
| 06/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,475,445 | 20,000 | 190,141,000 | 30,988,000 | $128.87 |
| 03/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,455,445 | 40,000 | 159,153,000 | 54,877,000 | $109.35 |
| 12/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,415,445 | 0 | 104,276,000 | -19,165,000 | $73.67 |
| 09/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,415,445 | 0 | 123,441,000 | 1,684,000 | $87.21 |
| 06/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,415,445 | 11,000 | 121,757,000 | 15,272,000 | $86.02 |
| 03/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,365,445 | -39,000 | 108,539,000 | 2,054,000 | $79.49 |
| 12/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,365,445 | 0 | 171,814,000 | 29,617,000 | $125.83 |
| 09/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,365,445 | -39,000 | 142,197,000 | 35,712,000 | $104.14 |
| 06/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,334,445 | -70,000 | 164,777,000 | 65,455,000 | $123.48 |
| 03/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,334,445 | -20,000 | 157,424,000 | -3,484,000 | $117.97 |
| 12/31/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,354,445 | -50,000 | 160,908,000 | 61,586,000 | $118.80 |
| 09/30/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,354,445 | -50,000 | 152,118,000 | 52,796,000 | $112.31 |
| 06/30/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,404,445 | 0 | 132,973,000 | 33,651,000 | $94.68 |
| 03/31/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,404,445 | 0 | 99,322,000 | -7,163,000 | $70.72 |
| 12/31/2013 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,404,445 | 0 | 104,350,000 | -2,135,000 | $74.30 |
| 09/30/2013 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,404,445 | -270,000 | 106,485,000 | 14,441,000 | $75.82 |
| 06/30/2013 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,404,445 | -270,000 | 112,440,000 | 20,396,000 | $80.06 |
| 03/31/2013 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,674,445 | -358,640 | 92,044,000 | 6,858,000 | $54.97 |
| 12/31/2012 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,033,085 | -294,815 | 85,186,000 | -44,920,000 | $41.90 |
| 09/30/2012 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,327,900 | 0 | 130,106,000 | -70,000 | $55.89 |
| 06/30/2012 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,327,900 | -494,784 | 130,176,000 | 14,418,000 | $55.92 |
| 03/31/2012 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,822,684 | 98,031 | 115,758,000 | -5,380,000 | $41.01 |
| 12/31/2011 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,997,684 | 273,031 | 99,553,000 | -21,585,000 | $33.21 |
| 09/30/2011 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,724,653 | -560,250 | 121,138,000 | -49,644,000 | $44.46 |
| 06/30/2011 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,284,903 | -665,097 | 170,782,000 | -18,542,000 | $51.99 |
| 03/31/2011 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,950,000 | -1,067,408 | 189,324,000 | 13,564,000 | $47.93 |
| 12/31/2010 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 5,017,408 | 0 | 175,760,000 | 2,308,000 | $35.03 |
| 09/30/2010 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 5,017,408 | 200,000 | 173,452,000 | 14,959,000 | $34.57 |
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