The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| Agios Pharmaceuticals, Inc. | COM | 00847X104 | 200,845 | 2,978,134 | SH | DFND | 3 | 2,978,134 | 0 | 0 | |
| Akcea Therapeutics, Inc. | COM | 00972L107 | 67,358 | 2,377,638 | SH | DFND | 3 | 2,377,638 | 0 | 0 | |
| Alder Biopharmaceuticals Inc. | COM | 014339105 | 37,756 | 2,766,008 | SH | DFND | 3 | 2,766,008 | 0 | 0 | |
| Alexion Pharmaceuticals, Inc. | COM | 015351109 | 177,684 | 1,314,428 | SH | DFND | 2 | 1,314,428 | 0 | 0 | |
| Alnylam Pharmaceuticals, Inc. | COM | 02043Q107 | 152,425 | 1,631,089 | SH | DFND | 3 | 1,631,089 | 0 | 0 | |
| Argenx SE | SPONSORED ADR | 04016X101 | 112,948 | 904,739 | SH | DFND | 3 | 904,739 | 0 | 0 | |
| Audentes Therapeutics, Inc. | COM | 05070R104 | 53,442 | 1,369,604 | SH | DFND | 3 | 1,369,604 | 0 | 0 | |
| Celgene Corp | COM | 151020104 | 207,548 | 2,200,000 | SH | DFND | 2 | 2,200,000 | 0 | 0 | |
| Cidara Therapeutics, Inc. | COM | 171757107 | 6,082 | 2,295,272 | SH | DFND | 3 | 2,295,272 | 0 | 0 | |
| Crispr Therapeutics AG | NAMEN AKT | H17182108 | 28,950 | 810,462 | SH | DFND | 3 | 810,462 | 0 | 0 | |
| Esperion Therapeutics, Inc. | COM | 29664W105 | 141,447 | 3,522,964 | SH | DFND | 3 | 3,522,964 | 0 | 0 | |
| Exelixis, Inc. | COM | 30161Q104 | 67,473 | 2,835,000 | SH | DFND | 3 | 2,835,000 | 0 | 0 | |
| G1 Therapeutics, Inc. | COM | 3621LQ109 | 11,154 | 671,925 | SH | DFND | 3 | 671,925 | 0 | 0 | |
| Gilead Sciences Inc. | COM | 375558103 | 74,255 | 1,142,204 | SH | DFND | 1 | 1,142,204 | 0 | 0 | |
| Halozyme Therapeutics Inc. | COM | 40637H109 | 133,998 | 8,322,860 | SH | DFND | 3 | 8,322,860 | 0 | 0 | |
| Homology Medicines, Inc. | COM | 438083107 | 2,533 | 91,336 | SH | DFND | 3 | 91,336 | 0 | 0 | |
| Incyte Corp. | COM | 45337C102 | 311,356 | 3,620,000 | SH | DFND | 3 | 3,620,000 | 0 | 0 | |
| Intercept Pharmaceuticals, Inc. | COM | 45845P108 | 77,964 | 696,976 | SH | DFND | 3 | 696,976 | 0 | 0 | |
| Intra-Cellular Therapies, Inc. | COM | 46116X101 | 26,796 | 2,200,000 | SH | DFND | 3 | 2,200,000 | 0 | 0 | |
| Ionis Pharmaceuticals Inc. | COM | 462222100 | 627,038 | 7,725,000 | SH | DFND | 3 | 7,725,000 | 0 | 0 | |
| Kezar Life Sciences, Inc. | COM | 49372L100 | 21,652 | 1,220,503 | SH | DFND | 4 | 1,220,503 | 0 | 0 | |
| MacroGenics Inc. | COM | 556099109 | 61,132 | 3,400,000 | SH | DFND | 3 | 3,400,000 | 0 | 0 | |
| Moderna, Inc. | COM | 60770K107 | 97,389 | 4,785,681 | SH | DFND | 4 | 4,785,681 | 0 | 0 | |
| Myokardia Inc. | COM | 62857M105 | 65,763 | 1,264,913 | SH | DFND | 3 | 1,264,913 | 0 | 0 | |
| Myovant Sciences Ltd. | COM | G637AM102 | 85,881 | 3,597,882 | SH | DFND | 3 | 3,597,882 | 0 | 0 | |
| Nektar Therapeutics | COM | 640268108 | 67,895 | 2,020,676 | SH | DFND | 3 | 2,020,676 | 0 | 0 | |
| Neurocrine Biosciences Inc. | COM | 64125C109 | 296,614 | 3,366,786 | SH | DFND | 3 | 3,366,786 | 0 | 0 | |
| Novavax Inc. | COM | 670002104 | 4,589 | 8,330,000 | SH | DFND | 3 | 8,330,000 | 0 | 0 | |
| Radius Health, Inc. | COM NEW | 750469207 | 135,227 | 6,781,685 | SH | DFND | 4 | 6,781,685 | 0 | 0 | |
| Sage Therapeutics, Inc. | COM | 78667J108 | 218,730 | 1,375,229 | SH | DFND | 3 | 1,375,229 | 0 | 0 | |
| Sangamo Therapeutics, Inc | COM | 800677106 | 25,281 | 2,650,000 | SH | DFND | 3 | 2,650,000 | 0 | 0 | |
| Scholar Rock Holding Corp | COM | 80706P103 | 27,750 | 1,476,839 | SH | DFND | 3 | 1,476,839 | 0 | 0 | |
| Vertex Pharmaceuticals Inc | COM | 92532F100 | 239,135 | 1,300,000 | SH | DFND | 3 | 1,300,000 | 0 | 0 | |
| Voyager Therapeutics, Inc. | COM | 92915B106 | 54,852 | 2,865,841 | SH | DFND | 3 | 2,865,841 | 0 | 0 | |
| Wave Life Sciences Ltd. | SHS | Y95308105 | 56,915 | 1,465,002 | SH | DFND | 3 | 1,465,002 | 0 | 0 | |