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BB BIOTECH AG
> IONS
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 12/31/2021 | IONIS PHARMACEUTICALS INC | IONS | 10,232,973 | 2,507,973 | 311,389,368 | -315,648,632 | $30.43 |
| 12/31/2020 | IONIS PHARMACEUTICALS INC | IONS | 8,220,000 | 495,000 | 464,758,800 | -162,279,200 | $56.54 |
| 12/31/2019 | IONIS PHARMACEUTICALS INC | IONS | 7,994,955 | 269,955 | 482,975,232 | -144,062,768 | $60.41 |
| 03/31/2019 | IONIS PHARMACEUTICALS INC | IONS | 7,725,000 | -1,016,334 | 627,038,000 | 154,481,000 | $81.17 |
| 12/31/2018 | IONIS PHARMACEUTICALS INC | IONS | 8,741,334 | 75,000 | 472,556,516 | 25,546,516 | $54.06 |
| 09/30/2018 | IONIS PHARMACEUTICALS INC | IONS | 8,666,334 | 0 | 447,010,000 | 85,884,000 | $51.58 |
| 06/30/2018 | IONIS PHARMACEUTICALS INC | IONS | 8,666,334 | 150,000 | 361,126,000 | -14,274,000 | $41.67 |
| 03/31/2018 | IONIS PHARMACEUTICALS INC | IONS | 8,516,334 | 380,000 | 375,400,000 | -33,858,000 | $44.08 |
| 12/31/2017 | IONIS PHARMACEUTICALS INC | IONS | 8,136,334 | 274,400 | 409,257,600 | 10,657,600 | $50.30 |
| 09/30/2017 | IONIS PHARMACEUTICALS INC | IONS | 7,861,934 | 507,839 | 398,600,000 | 24,497,000 | $50.70 |
| 06/30/2017 | IONIS PHARMACEUTICALS INC | IONS | 7,354,095 | -107,200 | 374,103,000 | 74,159,000 | $50.87 |
| 03/31/2017 | IONIS PHARMACEUTICALS INC | IONS | 7,461,295 | 548,123 | 299,944,000 | -30,713,000 | $40.20 |
| 12/31/2016 | IONIS PHARMACEUTICALS INC | IONS | 6,913,172 | -250,000 | 330,657,000 | 68,198,000 | $47.83 |
| 09/30/2016 | IONIS PHARMACEUTICALS INC | IONS | 7,163,172 | 58,334 | 262,459,000 | 96,987,000 | $36.64 |
| 06/30/2016 | IONIS PHARMACEUTICALS INC | IONS | 7,104,838 | 7,104,838 | 165,472,000 | 165,472,000 | $23.29 |
| 03/31/2016 | IONIS PHARMACEUTICALS INC | IONS | 6,779,838 | 6,779,838 | 274,583,000 | 274,583,000 | $40.50 |
| 12/31/2015 | IONIS PHARMACEUTICALS INC | IONS | 6,529,838 | 6,529,838 | 404,393,000 | 404,393,000 | $61.93 |
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