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BB BIOTECH AG
> AGIO
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 12/31/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | 4,312,292 | 1,334,158 | 141,745,038 | -59,099,962 | $32.87 |
| 12/31/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | 4,158,902 | 1,180,768 | 180,205,224 | -20,639,776 | $43.33 |
| 12/31/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 3,896,954 | 918,820 | 186,079,554 | -14,765,447 | $47.75 |
| 03/31/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 2,978,134 | 100,000 | 200,845,000 | 68,134,000 | $67.44 |
| 01/22/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 2,978,134 | 100,000 | 155,667,064 | 22,956,064 | $52.27 |
| 12/31/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 2,878,134 | 680,203 | 132,711,000 | -36,793,000 | $46.11 |
| 09/30/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 2,197,931 | 0 | 169,504,000 | -15,628,000 | $77.12 |
| 06/30/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 2,197,931 | -337,322 | 185,132,000 | -22,201,000 | $84.23 |
| 03/31/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 2,535,253 | -184,745 | 207,333,000 | 51,831,000 | $81.78 |
| 12/31/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | 2,719,998 | -30,000 | 155,502,286 | -28,059,714 | $57.17 |
| 09/30/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | 2,749,998 | -119,530 | 183,562,000 | 35,925,000 | $66.75 |
| 06/30/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | 2,869,528 | 30,000 | 147,637,000 | -18,191,000 | $51.45 |
| 03/31/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | 2,839,528 | 30,000 | 165,828,000 | 48,586,000 | $58.40 |
| 12/31/2016 | AGIOS PHARMACEUTICALS, INC. | AGIO | 2,809,528 | 160,000 | 117,242,000 | -22,706,000 | $41.73 |
| 09/30/2016 | AGIOS PHARMACEUTICALS, INC. | AGIO | 2,649,528 | 286,207 | 139,948,000 | 40,937,000 | $52.82 |
| 06/30/2016 | AGIOS PHARMACEUTICALS, INC. | AGIO | 2,363,321 | 2,363,321 | 99,011,000 | 99,011,000 | $41.89 |
| 03/31/2016 | AGIOS PHARMACEUTICALS, INC. | AGIO | 2,159,921 | 2,159,921 | 87,693,000 | 87,693,000 | $40.60 |
| 12/31/2015 | AGIOS PHARMACEUTICALS, INC. | AGIO | 2,159,921 | 50,000 | 140,222,000 | -8,717,000 | $64.92 |
| 09/30/2015 | AGIOS PHARMACEUTICALS, INC. | AGIO | 2,109,921 | 2,109,921 | 148,939,000 | 148,939,000 | $70.59 |
| 06/30/2015 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,989,921 | 1,989,921 | 221,160,000 | 221,160,000 | $111.14 |
| 03/31/2015 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,849,921 | -15,000 | 174,448,000 | -34,498,000 | $94.30 |
| 12/31/2014 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,864,921 | 1,864,921 | 208,946,000 | 208,946,000 | $112.04 |
| 09/30/2014 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,890,521 | 1,890,521 | 115,983,000 | 115,983,000 | $61.35 |
| 06/30/2014 | AGIOS PHARMACEUTICALS, INC. | AGIO | 506,000 | 506,000 | 23,185,000 | 23,185,000 | $45.82 |
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