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TEKLA HEALTHCARE INVESTORS
> DRRX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2004 | DURECT CORP | DRRX | 1,530,400 | 1,530,400 | 5,341,000 | 5,341,000 | $3.49 |
| 03/31/2004 | DURECT CORP | DRRX | 1,530,400 | 1,530,400 | 5,203,360 | 5,203,360 | $3.40 |
| 12/31/2003 | DURECT CORP | DRRX | 1,230,400 | 1,230,400 | 3,174,432 | 3,174,432 | $2.58 |
| 09/30/2003 | DURECT CORP | DRRX | 886,800 | 886,800 | 2,979,648 | 2,979,648 | $3.36 |
| 06/30/2003 | DURECT CORP | DRRX | 262,000 | 262,000 | 631,420 | 631,420 | $2.41 |
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