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TEKLA HEALTHCARE INVESTORS
> GENZ
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2004 | GENZYME CORP | GENZ | 308,000 | 308,000 | 14,578,000 | 14,578,000 | $47.33 |
| 03/31/2004 | GENZYME CORP | GENZ | 308,000 | 308,000 | 14,488,320 | 14,488,320 | $47.04 |
| 12/31/2003 | GENZYME CORP | GENZ | 198,000 | 198,000 | 9,769,320 | 9,769,320 | $49.34 |
| 09/30/2003 | GENZYME CORP | GENZ | 198,000 | 198,000 | 9,157,500 | 9,157,500 | $46.25 |
| 06/30/2003 | GENZYME CORP | GENZ | 136,000 | 136,000 | 5,684,800 | 5,684,800 | $41.80 |
| 03/31/2003 | GENZYME CORP | GENZ | 136,000 | 136,000 | 4,957,200 | 4,957,200 | $36.45 |
| 12/31/2002 | GENZYME CORP | GENZ | 136,000 | 136,000 | 4,021,520 | 4,021,520 | $29.57 |
| 09/30/2002 | GENZYME CORP | GENZ | 269,000 | 269,000 | 5,544,090 | 5,544,090 | $20.61 |
| 06/30/2002 | GENZYME CORP | GENZ | 269,000 | 269,000 | 5,175,560 | 5,175,560 | $19.24 |
| 03/31/2002 | GENZYME CORP | GENZ | 269,000 | 269,000 | 11,747,499 | 11,747,499 | $43.67 |
| 12/31/2001 | GENZYME CORP | GENZ | 269,000 | 269,000 | 16,102,340 | 16,102,340 | $59.86 |
| 09/30/2001 | GENZYME CORP | GENZ | 269,000 | 269,000 | 12,217,980 | 12,217,980 | $45.42 |
| 06/30/2001 | GENZYME CORP | GENZ | 269,000 | 269,000 | 16,419,000 | 16,419,000 | $61.04 |
| 03/31/2001 | GENZYME CORP | GENZ | 192,500 | 192,500 | 17,388,525 | 17,388,525 | $90.33 |
| 12/31/2000 | GENZYME CORP | GENZ | 192,500 | 192,500 | 17,312,968 | 17,312,968 | $89.94 |
| 09/30/2000 | GENZYME CORP | GENZ | 192,500 | 192,500 | 13,126,094 | 13,126,094 | $68.19 |
| 06/30/2000 | GENZYME CORP | GENZ | 192,500 | 192,500 | 11,441,719 | 11,441,719 | $59.44 |
| 03/31/2000 | GENZYME CORP | GENZ | 192,500 | 192,500 | 9,649,063 | 9,649,063 | $50.13 |
| 12/31/1999 | GENZYME CORP | GENZ | 192,500 | 192,500 | 8,662,500 | 8,662,500 | $45.00 |
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