| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 08/11/2023 | Sigilon Therapeutics, Inc. | | Purchase | Common Stock | 1.7M | $14.92 | $25.6M | | 08/11/2023 |
| 12/08/2020 | Sigilon Therapeutics, Inc. | | Conversion | Common Stock | 2.4M | $0.00 | $0 | | 12/08/2020 |
| 12/08/2020 | Sigilon Therapeutics, Inc. | | Purchase | Common Stock | 300k | $18.00 | $5.4M | | 12/08/2020 |
| 12/08/2020 | Sigilon Therapeutics, Inc. | | Conversion | Series A-3 Convertible Preferred Stock | 1.6M | $0.00 | $0 | | 12/08/2020 |
| 12/08/2020 | Sigilon Therapeutics, Inc. | | Conversion | Series B Convertible Preferred Stock | 888.9k | $0.00 | $0 | | 12/08/2020 |
| 06/16/2020 | Avidity Biosciences, Inc. | RNA | Conversion | Series C Preferred Stock | 4.6M | $0.00 | $0 | | 06/16/2020 |
| 06/16/2020 | Avidity Biosciences, Inc. | RNA | Conversion | Common Stock | 2.2M | $0.00 | $0 | | 06/16/2020 |
| 03/11/2019 | Elanco Animal Health Inc | ELAN | Disposition | Common Stock | 293.3M | $0.00 | $0 | | 03/11/2019 |
| 01/31/2019 | Zymeworks BC Inc. | ZYME | Sale | Common Stock | 250k | $16.00 | $4M | | 01/31/2019 |
| 11/06/2018 | Zymeworks BC Inc. | ZYME | Sale | Common Stock | 700k | $14.00 | $9.8M | | 11/06/2018 |
| 09/24/2018 | Zymeworks BC Inc. | ZYME | Sale | Common Stock | 2k | $16.36 | $33.2k | | 09/24/2018 |
| 09/18/2018 | Zymeworks BC Inc. | ZYME | Sale | Common Stock | 6.9k | $14.56 | $100k | | 09/18/2018 |
| 09/17/2018 | Zymeworks BC Inc. | ZYME | Sale | Common Stock | 6.9k | $14.58 | $100.1k | | 09/14/2018 |
| 09/14/2018 | Zymeworks BC Inc. | ZYME | Sale | Common Stock | 9k | $14.58 | $131.4k | | 09/14/2018 |
| 09/13/2018 | Zymeworks BC Inc. | ZYME | Sale | Common Stock | 20.9k | $14.32 | $299.3k | | 09/12/2018 |
| 09/12/2018 | Zymeworks BC Inc. | ZYME | Sale | Common Stock | 10.1k | $14.83 | $149.2k | | 09/12/2018 |
| 09/11/2018 | Zymeworks BC Inc. | ZYME | Sale | Common Stock | 11.3k | $14.87 | $167.7k | | 09/10/2018 |
| 09/10/2018 | Zymeworks BC Inc. | ZYME | Sale | Common Stock | 4.5k | $14.44 | $65k | | 09/10/2018 |
| 08/31/2018 | Zymeworks BC Inc. | ZYME | Sale | Common Stock | 700 | $14.26 | $10k | | 08/31/2018 |
| 08/30/2018 | Zymeworks BC Inc. | ZYME | Sale | Common Stock | 3.4k | $14.35 | $49.4k | | 08/29/2018 |
| 08/29/2018 | Zymeworks BC Inc. | ZYME | Sale | Common Stock | 2.3k | $14.26 | $33k | | 08/29/2018 |
| 08/14/2018 | Zymeworks BC Inc. | ZYME | Sale | Common Stock | 3k | $14.28 | $42.8k | | 08/14/2018 |
| 08/13/2018 | Zymeworks BC Inc. | ZYME | Sale | Common Stock | 4.5k | $14.33 | $64.9k | | 08/10/2018 |
| 08/10/2018 | Zymeworks BC Inc. | ZYME | Sale | Common Stock | 1.9k | $14.28 | $27.1k | | 08/10/2018 |
| 08/03/2018 | Zymeworks BC Inc. | ZYME | Sale | Common Stock | 1.6k | $13.55 | $22.4k | | 08/03/2018 |
| 08/02/2018 | Zymeworks BC Inc. | ZYME | Sale | Common Stock | 19.4k | $13.31 | $258.2k | | 08/02/2018 |
| 07/30/2018 | LEAP THERAPEUTICS, INC. | LPTX | Grant | Warrant (right to buy) | 331.2k | $6.09 | $2M | | 07/30/2018 |
| 03/01/2017 | CoLucid Pharmaceuticals, Inc. | CLCD | Other (acquisition) | | 19.3M | $46.50 | $896.8M | | 03/01/2017 |
| 04/12/2016 | Aeglea BioTherapeutics, Inc. | AGLE | Conversion | Common Stock | 2M | $0.00 | $0 | by fund | 04/12/2016 |
| 04/12/2016 | Aeglea BioTherapeutics, Inc. | AGLE | Conversion | Common Stock | 2M | $0.00 | $0 | by fund | 04/12/2016 |
| 04/12/2016 | Aeglea BioTherapeutics, Inc. | AGLE | Purchase | Common Stock | 500k | $10.00 | $5M | by fund | 04/12/2016 |
| 04/12/2016 | Aeglea BioTherapeutics, Inc. | AGLE | Conversion | Series A Preferred Stock | 890.5k | $0.00 | $0 | by fund | 04/12/2016 |
| 04/12/2016 | Aeglea BioTherapeutics, Inc. | AGLE | Conversion | Series B Preferred Stock | 1.1M | $0.00 | $0 | by fund | 04/12/2016 |
| 09/09/2010 | UNITED THERAPEUTICS Corp | UTHR | Other (acquisition) | Obligation to Sell | 1 | $0.00 | $0 | | 09/09/2010 |