| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 08/23/2023 | LAWLOR AUGUSTINE | COO | Grant | Employee Stock Option (Right to Buy) | 70k | $2.21 | $154.7k | | 08/23/2023 |
| 08/23/2023 | CAVANAUGH JAMES H | Director | Grant | Stock Option (Right to Buy) | 15k | $2.21 | $33.2k | | 08/23/2023 |
| 08/23/2023 | LOSCALZO JOSEPH | Director | Grant | Stock Option (Right to Buy) | 15k | $2.21 | $33.2k | | 08/23/2023 |
| 08/23/2023 | Mirabelli Christopher | Chairman of the Board | Grant | Stock Option (Right to Buy) | 70k | $2.21 | $154.7k | | 08/23/2023 |
| 08/23/2023 | Dietz Thomas John | Director | Grant | Stock Option (Right to Buy) | 17.5k | $2.21 | $38.7k | | 08/23/2023 |
| 08/23/2023 | ONSI DOUGLAS E | CEO,CFO,Pres.,GC,Treas.,&Sec. | Grant | Employee Stock Option (Right to Buy) | 140k | $2.21 | $309.4k | | 08/23/2023 |
| 08/23/2023 | LI WILLIAM | Director | Grant | Stock Option (Right to Buy) | 15k | $2.21 | $33.2k | | 08/23/2023 |
| 08/23/2023 | Mashiach Nissim | Director | Grant | Stock Option (Right to Buy) | 15k | $2.21 | $33.2k | | 08/23/2023 |
| 08/23/2023 | O'Mahony John Mark | Chief Manufacturing Officer | Grant | Employee Stock Option (Right to Buy) | 70k | $2.21 | $154.7k | | 08/23/2023 |
| 08/23/2023 | Sirard Cynthia | Chief Medical Officer | Grant | Employee Stock Option (Right to Buy) | 70k | $2.21 | $154.7k | | 08/23/2023 |
| 08/23/2023 | Granfield Christine | VP, Head of Reg Affairs/Qual | Grant | Employee Stock Option (Right to Buy) | 70k | $2.21 | $154.7k | | 08/23/2023 |
| 08/23/2023 | Martin Patricia A. | Director | Grant | Stock Option (Right to Buy) | 15k | $2.21 | $33.2k | | 08/23/2023 |
| 08/23/2023 | Schilsky Richard | Director | Grant | Stock Option (Right to Buy) | 15k | $2.21 | $33.2k | | 08/23/2023 |
| 08/23/2023 | Richard Christian M | Director | Grant | Stock Option (Right to Buy) | 15k | $2.21 | $33.2k | | 08/23/2023 |
| 08/23/2023 | Baum Jason | Chief Scientific Officer | Grant | Employee Stock Option (Right to Buy) | 70k | $2.21 | $154.7k | | 08/23/2023 |
| 03/31/2023 | Martin Patricia A. | Director | Grant | Stock Option (Right to Buy) | 150k | $0.34 | $51k | | 03/31/2023 |
| 03/31/2023 | Schilsky Richard | Director | Grant | Stock Option (Right to Buy) | 150k | $0.34 | $51k | | 03/31/2023 |
| 03/31/2023 | Richard Christian M | Director | Grant | Stock Option (Right to Buy) | 150k | $0.34 | $51k | | 03/31/2023 |
| 03/31/2023 | Granfield Christine | VP, Head of Reg Affairs/Qual | Grant | Employee Stock Option (Right to Buy) | 500k | $0.34 | $170k | | 03/31/2023 |
| 03/31/2023 | O'Mahony John Mark | Chief Manufacturing Officer | Grant | Employee Stock Option (Right to Buy) | 500k | $0.34 | $170k | | 03/31/2023 |
| 03/31/2023 | Sirard Cynthia | Chief Medical Officer | Grant | Employee Stock Option (Right to Buy) | 500k | $0.34 | $170k | | 03/31/2023 |
| 03/31/2023 | Mashiach Nissim | Director | Grant | Stock Option (Right to Buy) | 150k | $0.34 | $51k | | 03/31/2023 |
| 03/31/2023 | LI WILLIAM | Director | Grant | Stock Option (Right to Buy) | 150k | $0.34 | $51k | | 03/31/2023 |
| 03/31/2023 | ONSI DOUGLAS E | CEO,CFO,Pres.,GC,Treas.,&Sec. | Grant | Employee Stock Option (Right to Buy) | 750k | $0.34 | $255k | | 03/31/2023 |
| 03/31/2023 | Dietz Thomas John | Director | Grant | Stock Option (Right to Buy) | 175k | $0.34 | $59.5k | | 03/31/2023 |
| 03/31/2023 | Mirabelli Christopher | Chairman of the Board | Grant | Stock Option (Right to Buy) | 500k | $0.34 | $170k | | 03/31/2023 |
| 03/31/2023 | LOSCALZO JOSEPH | Director | Grant | Stock Option (Right to Buy) | 150k | $0.34 | $51k | | 03/31/2023 |
| 03/31/2023 | LAWLOR AUGUSTINE | COO | Grant | Employee Stock Option (Right to Buy) | 500k | $0.34 | $170k | | 03/31/2023 |
| 03/31/2023 | CAVANAUGH JAMES H | Director | Grant | Stock Option (Right to Buy) | 150k | $0.34 | $51k | | 03/31/2023 |
| 03/17/2023 | ONSI DOUGLAS E | CEO,CFO,Pres.,GC,Treas.,&Sec. | Exercise | Restricted Stock Units | 660.6k | $0.00 | $0 | | 03/17/2023 |
| 09/06/2022 | Schilsky Richard | Director | Grant | Stock Option (Right to Buy) | 100k | $1.62 | $162k | | 09/06/2022 |
| 09/01/2022 | Sirard Cynthia | Chief Medical Officer | Grant | Employee Stock Option (Right to Buy) | 200k | $1.43 | $286k | | 09/01/2022 |
| 09/01/2022 | O'Mahony John Mark | Chief Manufacturing Officer | Grant | Employee Stock Option (Right to Buy) | 200k | $1.43 | $286k | | 09/01/2022 |
| 09/01/2022 | Granfield Christine | VP, Head of Reg Affairs/Qual | Grant | Employee Stock Option (Right to Buy) | 200k | $1.43 | $286k | | 09/01/2022 |
| 09/01/2022 | LI WILLIAM | Director | Grant | Stock Option (Right to Buy) | 25k | $1.43 | $35.8k | | 09/01/2022 |
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