| Date | Name | Title | Type | Security | Shares | Price | Value | Ownership | Reported |
| 02/08/2007 | MCLAUGHLIN KEVIN F | President and CEO | Other | Common Stock, par value $.01 per share | 45k | $5.00 | $225k | | 02/07/2007 |
| 02/08/2007 | SHARROCK DAVID B | Director | Other | Common Stock, par value $.01 per share | 12.8k | $5.00 | $63.8k | | 02/07/2007 |
| 02/07/2007 | ZENNER PATRICK J | Director | Disposition | Stock Option (Right to Buy) | 4k | $4.08 | $16.3k | | 02/07/2007 |
| 02/07/2007 | BAKER G LEONARD JR | Director | Other | Common | 20.6k | $5.00 | $102.9k | By Shares Held By Ltd Partnership (SND) | 02/07/2007 |
| 02/07/2007 | BAKER G LEONARD JR | Director | Other | Common | 14.7k | $5.00 | $73.4k | By Trust | 02/07/2007 |
| 02/07/2007 | BAKER G LEONARD JR | Director | Disposition | Stock Option (Right to Buy) | 4k | $4.08 | $16.3k | | 02/07/2007 |
| 02/07/2007 | POST LEONARD E | Director | Disposition | Stock Option (Right to Buy) | 4k | $4.08 | $16.3k | | 02/07/2007 |
| 02/07/2007 | MCCANCE HENRY F | Director | Other | Common Stock, par value $.01 per share | 14.1k | $5.00 | $70.3k | | 02/07/2007 |
| 02/07/2007 | MCCANCE HENRY F | Director | Disposition | Stock Option (Right to Buy) | 4k | $4.08 | $16.3k | | 02/07/2007 |
| 02/07/2007 | BOHLIN GAREN G | Director | Disposition | Stock Option (Right to Buy) | 4k | $4.08 | $16.3k | | 02/07/2007 |
| 02/07/2007 | WAGNER RICHARD W | EVP, Discovery Research | Other | Common Stock, par value $.01 per share | 4k | $5.00 | $20.2k | | 02/07/2007 |
| 02/07/2007 | WAGNER RICHARD W | EVP, Discovery Research | Disposition | Stock Option (Right to Buy) | 50k | $3.35 | $167.5k | | 02/07/2007 |
| 02/07/2007 | GEFTER MALCOLM L PHD | Chairman and CSO | Other | Common Stock, par value $.01 per share | 169k | $5.00 | $845.1k | | 02/07/2007 |
| 02/07/2007 | English Edward C | VP, CFO, Treasurer & Ass. Sec. | Other | Common Stock, par value $.01 per share | 2k | $5.00 | $9.8k | | 02/07/2007 |
| 02/07/2007 | English Edward C | VP, CFO, Treasurer & Ass. Sec. | Disposition | Stock Option (Right to Buy) | 20k | $3.35 | $67k | | 02/07/2007 |
| 02/07/2007 | GEFTER MALCOLM L PHD | Chairman and CSO | Other | Common Stock, par value $.01 per share | 1.3k | $5.00 | $6.5k | By self for son | 02/07/2007 |
| 02/07/2007 | SHARROCK DAVID B | Director | Disposition | Stock Option (Right to Buy) | 4k | $4.08 | $16.3k | | 02/07/2007 |
| 02/07/2007 | MCLAUGHLIN KEVIN F | President and CEO | Disposition | Stock Option (Right to Buy) | 80k | $3.35 | $268k | | 02/07/2007 |
| 02/07/2007 | BAKER G LEONARD JR | Director | Other | Common | 30.4k | $5.00 | $152.2k | | 02/07/2007 |
| 02/07/2007 | BAKER G LEONARD JR | Director | Other | Common | 26.2k | $5.00 | $130.9k | By Profit Sharing Plan Trust | 02/07/2007 |
| 02/07/2007 | BAKER G LEONARD JR | Director | Other | Common | 1.4k | $5.00 | $7.1k | By Shares Held By Ltd Partnership (SHAI) | 02/07/2007 |
| 02/07/2007 | BAKER G LEONARD JR | Director | Other | Common | 3.6k | $5.00 | $17.9k | By Shares Held By Ltd Partnership (SHQP) | 02/07/2007 |
| 02/07/2007 | BAKER G LEONARD JR | Director | Other | Common | 286.5k | $5.00 | $1.4M | By Shares Held By Ltd Partnership (SHV) | 02/07/2007 |
| 09/01/2006 | MCLAUGHLIN KEVIN F | President and CEO | Exercise | Common Stock, par value $.01 per share | 24.2k | $1.33 | $32.2k | | 09/01/2006 |
| 09/01/2006 | MCLAUGHLIN KEVIN F | President and CEO | Exercise | | 24.2k | $0.00 | $0 | | 09/01/2006 |
| 07/10/2006 | GEFTER MALCOLM L PHD | Chairman and CSO | Payment of Exercise | Common Stock, par value $.01 per share | 40.9k | $3.01 | $123k | | 07/10/2006 |
| 07/10/2006 | GEFTER MALCOLM L PHD | Chairman and CSO | Exercise | | 92.5k | $1.33 | $123k | | 07/10/2006 |
| 06/19/2006 | GARNICK MARC B | EVP and Chief Medical Officer | Disposition | | 14k | $0.00 | $0 | | 06/19/2006 |
| 06/19/2006 | GARNICK MARC B | EVP and Chief Medical Officer | Grant | | 14k | $0.00 | $0 | | 06/19/2006 |
| 06/19/2006 | GARNICK MARC B | EVP and Chief Medical Officer | Disposition | | 20k | $0.00 | $0 | | 06/19/2006 |
| 06/19/2006 | GARNICK MARC B | EVP and Chief Medical Officer | Grant | | 20k | $0.00 | $0 | | 06/19/2006 |
| 03/13/2006 | GEFTER MALCOLM L PHD | Chairman and CSO | Exercise | | 9.5k | $1.33 | $12.6k | | 03/09/2006 |
| 03/09/2006 | GEFTER MALCOLM L PHD | Chairman and CSO | Grant | | 8k | $5.99 | $47.9k | | 03/09/2006 |
| 11/11/2005 | BAKER G LEONARD JR | Director | Other (disposition) | | 718 | $0.00 | $0 | By Shares Held By Ltd Partnership (SHV) | 11/11/2005 |
| 11/10/2005 | BAKER G LEONARD JR | Director | Grant | Stock Option (Right to Buy) | 4k | $4.08 | $16.3k | | 11/10/2005 |
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