| Date | Name | Symbol | Type | Security | Shares | Price | Value | Ownership | Reported |
| 05/24/2023 | Karyopharm Therapeutics Inc. | KPTI | Grant | Nonstatutory Stock Option (right to buy) | 34k | $2.50 | $85k | | 05/24/2023 |
| 05/18/2023 | COLLEGIUM PHARMACEUTICAL, INC | COLL | Grant | Common Stock | 9.8k | $0.00 | $0 | | 05/18/2023 |
| 05/19/2022 | COLLEGIUM PHARMACEUTICAL, INC | COLL | Grant | Common Stock | 14k | $0.00 | $0 | | 05/19/2022 |
| 05/19/2022 | Karyopharm Therapeutics Inc. | KPTI | Grant | Nonstatutory Stock Option (right to buy) | 23.9k | $5.65 | $135k | | 05/19/2022 |
| 05/21/2021 | Karyopharm Therapeutics Inc. | KPTI | Grant | Nonstatutory Stock Option (right to buy) | 23.9k | $9.42 | $225.1k | | 05/21/2021 |
| 05/20/2021 | COLLEGIUM PHARMACEUTICAL, INC | COLL | Grant | Common Stock | 9.9k | $0.00 | $0 | | 05/20/2021 |
| 05/06/2021 | Karyopharm Therapeutics Inc. | KPTI | Purchase | Common Stock | 4k | $7.82 | $31.3k | | 05/06/2021 |
| 05/21/2020 | Karyopharm Therapeutics Inc. | KPTI | Grant | Nonstatutory Stock Option (right to buy) | 16.4k | $19.11 | $313.4k | | 05/21/2020 |
| 05/20/2020 | COLLEGIUM PHARMACEUTICAL, INC | COLL | Grant | Common Stock | 4k | $0.00 | $0 | | 05/20/2020 |
| 05/20/2020 | COLLEGIUM PHARMACEUTICAL, INC | COLL | Grant | Stock Option (Right to Purchase) | 8.1k | $22.05 | $178.5k | | 05/20/2020 |
| 06/10/2019 | TETRAPHASE PHARMACEUTICALS INC | TTPH | Grant | Stock option (right to buy) | 16.5k | $0.77 | $12.7k | | 06/10/2019 |
| 06/06/2019 | Karyopharm Therapeutics Inc. | KPTI | Grant | Nonstatutory Stock Option (right to buy) | 25k | $5.43 | $135.8k | | 06/06/2019 |
| 04/25/2019 | COLLEGIUM PHARMACEUTICAL, INC | COLL | Grant | Stock Option (Right to Purchase) | 9.4k | $14.57 | $137.2k | | 04/25/2019 |
| 04/25/2019 | COLLEGIUM PHARMACEUTICAL, INC | COLL | Grant | Common Stock | 4.7k | $0.00 | $0 | | 04/25/2019 |
| 06/19/2018 | Karyopharm Therapeutics Inc. | KPTI | Grant | Nonstatutory Stock Option (right to buy) | 17k | $18.80 | $319.6k | | 06/19/2018 |
| 06/08/2018 | Protara Therapeutics, Inc. | PRTO | Grant | Stock Option (Right to Buy) | 12.7k | $2.50 | $31.8k | | 06/08/2018 |
| 05/30/2018 | TETRAPHASE PHARMACEUTICALS INC | TTPH | Grant | Stock option (right to buy) | 12.5k | $3.68 | $46k | | 05/30/2018 |
| 05/24/2018 | COLLEGIUM PHARMACEUTICAL, INC | COLL | Grant | Common Stock | 2.3k | $0.00 | $0 | | 05/24/2018 |
| 05/24/2018 | COLLEGIUM PHARMACEUTICAL, INC | COLL | Grant | Stock Option (Right to Purchase) | 4.5k | $24.95 | $112.4k | | 05/24/2018 |
| 11/14/2017 | Protara Therapeutics, Inc. | PRTO | Grant | Common Stock | 3.8k | $1.89 | $7.2k | | 11/10/2017 |
| 11/13/2017 | Protara Therapeutics, Inc. | PRTO | Grant | Common Stock | 25.7k | $1.92 | $49.3k | | 11/10/2017 |
| 11/10/2017 | Protara Therapeutics, Inc. | PRTO | Grant | Common Stock | 23.8k | $1.96 | $46.7k | | 11/10/2017 |
| 06/20/2017 | Protara Therapeutics, Inc. | PRTO | Grant | Stock Option (Right to Buy) | 6.7k | $1.30 | $8.7k | | 06/20/2017 |
| 06/15/2017 | Karyopharm Therapeutics Inc. | KPTI | Grant | Nonstatutory Stock Option (right to buy) | 17k | $9.18 | $156.1k | | 06/15/2017 |
| 05/31/2017 | TETRAPHASE PHARMACEUTICALS INC | TTPH | Grant | Stock option (right to buy) | 12.5k | $6.89 | $86.1k | | 05/31/2017 |
| 05/24/2017 | COLLEGIUM PHARMACEUTICAL, INC | COLL | Grant | Stock Option (Right to Purchase) | 19.9k | $9.33 | $185.2k | | 05/24/2017 |
| 06/16/2016 | Karyopharm Therapeutics Inc. | KPTI | Grant | Nonstatutory Stock Option (right to buy) | 10k | $8.06 | $80.6k | | 06/16/2016 |
| 06/09/2016 | Protara Therapeutics, Inc. | PRTO | Grant | Stock Option (Right to Buy) | 6.7k | $5.90 | $39.3k | | 06/09/2016 |
| 06/09/2016 | COLLEGIUM PHARMACEUTICAL, INC | COLL | Grant | Stock Option (Right to Purchase) | 8.7k | $16.49 | $143.5k | | 06/09/2016 |
| 06/08/2016 | TETRAPHASE PHARMACEUTICALS INC | TTPH | Grant | Stock option (right to buy) | 10k | $4.27 | $42.7k | | 06/08/2016 |
| 06/10/2015 | TETRAPHASE PHARMACEUTICALS INC | TTPH | Grant | Stock option (right to buy) | 10k | $42.26 | $422.6k | | 06/10/2015 |
| 06/02/2015 | Protara Therapeutics, Inc. | PRTO | Grant | Stock Option (Right to Buy) | 6.7k | $17.59 | $117.3k | | 06/02/2015 |
| 05/22/2015 | Karyopharm Therapeutics Inc. | KPTI | Grant | Nonstatutory Stock Option (right to buy) | 10k | $26.15 | $261.5k | | 05/22/2015 |
| 07/08/2014 | Karyopharm Therapeutics Inc. | KPTI | Grant | Nonstatutory Stock Option (right to buy) | 10k | $36.04 | $360.4k | | 07/08/2014 |
| 06/12/2014 | TETRAPHASE PHARMACEUTICALS INC | TTPH | Grant | Stock option (right to buy) | 10k | $11.26 | $112.6k | | 06/12/2014 |
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