| In millions, except per share items | Dec-31-18 | Dec-31-17 | Dec-31-16 | Dec-31-15 | Dec-31-14 | Dec-31-13 | Dec-31-12 | Dec-31-11 |
| | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K | 10-K |
| Revenues: |
| Royalty revenues | | | | 53.9 | | | | |
| Product revenues | | | | 240.7 | 659.7 | 624.6 | | |
| Total revenues [+] | 6.1 | 44.8 | 143.2 | 294.5 | 659.7 | 624.6 | 558.6 | 484.7 |
| Royalties | | | | 53.9 | | | | |
| Products | | | | 240.7 | 659.7 | 624.6 | | |
| Revenue growth [+] | -86.3% | -68.7% | -51.4% | -55.4% | 5.6% | 11.8% | 15.2% | 10.8% |
| Product revenues | | | | -63.5% | 5.6% | | | |
| Cost of goods sold | 7.3 | 47.2 | 60.7 | 104.0 | 233.3 | 216.6 | 177.3 | 156.9 |
| Gross profit | -1.1 | -2.4 | 82.5 | 190.6 | 426.4 | 408.0 | 381.2 | 327.9 |
| Gross margin | -18.2% | -5.4% | 57.6% | 64.7% | 64.6% | 65.3% | 68.3% | 67.6% |
| Selling, general and administrative | 52.2 | 132.2 | 212.5 | 285.3 | 315.0 | 247.8 | 171.8 | 159.6 |
| Research and development | 133.0 | 138.4 | 92.1 | 90.4 | 139.5 | 138.3 | 126.4 | 110.2 |
| Equity in earnings | | | | | -1.7 | | | |
| Other operating expenses | | | | -5.0 | -25.7 | | | -18.0 |
| EBITDA [+] | -183.1 | -251.0 | -191.0 | -145.3 | 30.3 | 54.1 | 90.3 | 82.3 |
| EBITDA growth | -27.0% | 31.4% | 31.5% | -579.2% | -44.0% | -40.1% | 9.8% | 16.7% |
| EBITDA margin | -2983.8% | -560.5% | -133.4% | -49.3% | 4.6% | 8.7% | 16.2% | 17.0% |
| Depreciation | 3.2 | 17.5 | 13.5 | 24.8 | 2.2 | 18.4 | 2.9 | 3.6 |
| EBITA | -186.3 | -268.5 | -204.6 | -170.1 | 28.1 | 35.7 | 87.5 | 78.7 |
| EBITA margin | -3035.8% | -599.5% | -142.9% | -57.8% | 4.3% | 5.7% | 15.7% | 16.2% |
| Amortization of intangibles | | 4.5 | 17.5 | 10.0 | 32.2 | 13.8 | 4.4 | 2.6 |
| EBIT [+] | -186.3 | -273.0 | -222.1 | -180.1 | -4.1 | 21.9 | 83.1 | 76.1 |
| EBIT growth | -31.7% | 22.9% | 23.3% | 4313.8% | -118.6% | -73.7% | 9.2% | 18.1% |
| EBIT margin | -3035.8% | -609.5% | -155.1% | -61.2% | -0.6% | 3.5% | 14.9% | 15.7% |
| Non-recurring items [+] | 5.1 | 392.1 | | 5.0 | 25.7 | | | 18.0 |
| Asset impairment | 5.1 | 392.1 | | | | | | |
| Legal settlement | | | | 5.0 | 25.7 | | | 18.0 |
| Interest expense | 49.4 | 48.6 | 44.5 | 37.1 | 15.7 | 15.5 | 8.0 | |
| Interest expense | 49.4 | 48.6 | 44.5 | 37.1 | 15.7 | 15.5 | 8.0 | |
| Other income (expense), net [+] | -45.3 | 9.4 | 287.1 | 57.7 | 43.4 | 18.8 | 11.1 | 19.8 |
| Asset impairment charges | | | | | -7.5 | | | |
| Impairment of investments | | | | | -7.5 | | | |
| Gain (loss) on sale of assets | | | 288.3 | | | | | |
| Gain (loss) on investments | -51.9 | | | | | | | |
| Realized gain (loss) on investments | | | | 19.8 | | | | |
| Gain (loss) on debt retirement | | | -5.4 | | | | | |
| Extraordinary gain | | | | 22.6 | | | | |
| Other | 5.6 | 1.8 | 0.3 | 20.0 | 0.9 | 1.4 | 1.1 | 1.8 |
| Pre-tax income | -286.1 | -704.3 | 20.6 | -164.5 | -2.1 | 25.2 | 86.2 | 77.8 |
| Income taxes | -50.9 | -96.6 | 0.1 | -29.7 | -2.3 | 2.3 | -35.0 | -50.0 |
| Tax rate | 17.8% | 13.7% | 0.3% | 18.1% | 108.5% | 9.0% | | |
| Minority interest | | | -0.1 | 0.0 | -0.1 | -0.3 | 0.1 | |
| Earnings from continuing ops | -358.4 | -708.4 | -119.1 | -134.8 | 0.3 | 38.4 | 51.2 | 127.9 |
| Earnings from discontinued ops | | | | -218.0 | -32.5 | | | |
| Net income | -358.4 | -708.4 | -119.1 | -352.8 | -32.2 | 38.4 | 51.2 | 127.9 |
| Net margin | -5838.6% | -1581.6% | -83.2% | -119.8% | -4.9% | 6.1% | 9.2% | 26.4% |
| |
| Basic EPS [+] | ($4.87) | ($9.79) | ($1.70) | ($2.02) | $0.00 | $0.66 | $0.96 | $2.39 |
| Growth | -50.2% | 474.6% | -15.6% | -40881.3% | -99.3% | -30.8% | -60.0% | 20.7% |
| Diluted EPS [+] | ($4.87) | ($9.79) | ($1.63) | ($2.02) | $0.00 | $0.61 | $0.92 | $2.35 |
| Growth | -50.2% | 500.2% | -19.2% | -42269.7% | -99.2% | -33.7% | -60.7% | 19.5% |
| |
| Shares outstanding (basic) [+] | 73.6 | 72.4 | 69.9 | 66.8 | 64.5 | 58.1 | 53.5 | 53.5 |
| Growth | 1.7% | 3.5% | 4.6% | 3.6% | 11.0% | 8.5% | 0.1% | 1.2% |
| Shares outstanding (diluted) [+] | 73.6 | 72.4 | 73.0 | 66.8 | 66.7 | 62.7 | 55.3 | 54.4 |
| Growth | 1.7% | -0.9% | 9.3% | 0.2% | 6.4% | 13.2% | 1.7% | 2.3% |
| |
| EBIT is a non-GAAP figure that excludes all non-recurring expenses: restructuring costs, asset impairments, IPR&D writeoffs, and other unusual charges. |