Type	Name	Date
Underwriting agreement	Underwriting Agreement, by and among the Company and J.P. Morgan Securities LLC and Merrill Lynch, Pierce, Fenner & Smith Incorporated, as representatives of the several Underwriters	08/15/2013

Type	Name	Date
By-Laws	Amended and Restated Bylaws of The Medicines Company	01/06/2020

Type	Name	Date
Employment agreement	Amended and Restated Employment Agreement between The Medicines Company and Clive Meanwell	06/01/2016
Equity incentive plans	Amendment No. 3 to the 2013 Stock Incentive Plan	06/01/2016
Equity incentive plans	Amendment No. 2 to the 2013 Stock Incentive Plan	06/02/2015

Type	Name	Date
Merger agreement	Agreement and Plan of Merger, by and among The Medicines Company, Novartis AG and Medusa Merger Corporation	11/25/2019
Acquisition / asset purchase agreement	Purchase and Sale Agreement, by and among The Medicines Company, Chiesi Farmaceutici S.p.A. and Chiesi USA, Inc.*†	05/13/2016
Acquisition / asset purchase agreement	PURCHASE AND SALE AGREEMENT BY AND BETWEEN THE MEDICINES COMPANY, MALLINCKRODT HOSPITAL PRODUCTS, INC., MALLINCKRODT GROUP SARL, AND MALLINCKRODT PHARMACEUTICALS IRELAND LIMITED	02/03/2016