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CAISSE DE DEPOT ET PLACEMENT DU QUEBEC
> VRTX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 870,076 | -143,147 | 306,188,454,000 | -13,047,717,000 | $351,910.01 |
| 03/31/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,013,223 | 103,202 | 319,236,171,000 | 56,440,301,000 | $315,070.00 |
| 12/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 910,021 | -175,199 | 262,795,870,000 | 262,481,655,000 | $288,780.01 |
| 09/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,085,220 | -193,874 | 314,215,000 | -46,221,000 | $289.54 |
| 06/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,279,094 | 104,486 | 360,436,000 | 53,899,000 | $281.79 |
| 03/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,174,608 | -53,900 | 306,537,000 | 36,757,000 | $260.97 |
| 12/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,228,508 | -266,708 | 269,780,000 | -1,437,000 | $219.60 |
| 09/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,495,216 | 1,438,039 | 271,217,000 | 259,688,000 | $181.39 |
| 06/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 57,177 | 55,401 | 11,529,000 | 11,109,000 | $201.64 |
| 12/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,776 | -1,229 | 420,000 | -398,000 | $236.49 |
| 09/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,005 | -600 | 818,000 | -229,000 | $272.21 |
| 06/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,605 | -38 | 1,047,000 | 180,000 | $290.43 |
| 03/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,643 | -4,762 | 867,000 | -973,000 | $237.99 |
| 12/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 8,405 | 5,760 | 1,840,000 | 1,392,000 | $218.92 |
| 09/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 2,645 | -660 | 448,000 | -158,000 | $169.38 |
| 06/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,305 | -2,000 | 606,000 | -370,000 | $183.36 |
| 03/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 5,305 | -400 | 976,000 | 31,000 | $183.98 |
| 12/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 5,705 | 500 | 945,000 | -58,000 | $165.64 |
| 09/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 5,205 | -200 | 1,003,000 | 84,000 | $192.70 |
| 06/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 5,405 | 100 | 919,000 | 54,000 | $170.03 |
| 03/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 5,305 | -94,600 | 865,000 | -14,107,000 | $163.05 |
| 12/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 99,905 | 92,000 | 14,972,000 | 13,765,000 | $149.86 |
| 09/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 7,905 | 100 | 1,207,000 | 204,000 | $152.69 |
| 06/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 7,805 | 200 | 1,003,000 | 170,000 | $128.51 |
| 03/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 7,605 | 300 | 833,000 | 296,000 | $109.53 |
| 12/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 7,305 | -1,200 | 537,000 | -205,000 | $73.51 |
| 09/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 8,505 | -500 | 742,000 | -33,000 | $87.24 |
| 06/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 9,005 | 2,000 | 775,000 | 218,000 | $86.06 |
| 03/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 7,005 | 7,005 | 557,000 | 557,000 | $79.51 |
| 12/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 104,500 | 96,300 | 13,149,000 | 12,494,000 | $125.83 |
| 09/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 108,100 | 99,900 | 11,258,000 | 10,603,000 | $104.14 |
| 06/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 107,100 | 98,900 | 13,225,000 | 12,570,000 | $123.48 |
| 03/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 106,800 | 98,600 | 12,599,000 | 11,944,000 | $117.97 |
| 12/31/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 116,700 | 108,500 | 13,864,000 | 13,209,000 | $118.80 |
| 09/30/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 125,900 | -23,900 | 14,140,000 | 2,782,000 | $112.31 |
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