News + Filings Holdings
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TWO SIGMA INVESTMENTS, LP
> VRTX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 388,883 | 297,628 | 136,851,817,000 | 108,100,104,000 | $351,910.00 |
| 03/31/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 91,255 | 62,133 | 28,751,713,000 | 20,341,862,000 | $315,070.00 |
| 12/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 29,122 | 29,122 | 8,409,851,000 | 8,409,851,000 | $288,779.99 |
| 06/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -33,644 | 0 | -8,780,000 | |
| 03/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 33,644 | 33,644 | 8,780,000 | 8,780,000 | $260.97 |
| 12/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -959,684 | 0 | -174,077,000 | |
| 09/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 959,684 | 959,684 | 174,077,000 | 174,077,000 | $181.39 |
| 09/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -102,102 | 0 | -29,641,000 | |
| 06/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 102,102 | -363,044 | 29,641,000 | -81,040,000 | $290.31 |
| 03/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 465,146 | -328,323 | 110,681,000 | -63,049,000 | $237.95 |
| 12/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 793,469 | 280,834 | 173,730,000 | 86,879,000 | $218.95 |
| 09/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 512,635 | 95,464 | 86,851,000 | 10,350,000 | $169.42 |
| 06/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 417,171 | -243,353 | 76,501,000 | -45,002,000 | $183.38 |
| 03/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 660,524 | 253,455 | 121,503,000 | 54,048,000 | $183.95 |
| 12/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 407,069 | -171,514 | 67,455,000 | -44,061,000 | $165.71 |
| 09/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 578,583 | 464,469 | 111,516,000 | 92,121,000 | $192.74 |
| 06/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 114,114 | 70,060 | 19,395,000 | 12,215,000 | $169.96 |
| 03/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 44,054 | -868,670 | 7,180,000 | -129,601,000 | $162.98 |
| 12/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 912,724 | 462,416 | 136,781,000 | 68,316,000 | $149.86 |
| 09/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 450,308 | 60,238 | 68,465,000 | 18,197,000 | $152.04 |
| 06/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 390,070 | -255,360 | 50,268,000 | -20,310,000 | $128.87 |
| 03/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 645,430 | -381,425 | 70,578,000 | -5,070,000 | $109.35 |
| 12/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 1,026,855 | 604,506 | 75,648,000 | 38,815,000 | $73.67 |
| 09/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 422,349 | 422,349 | 36,833,000 | 36,833,000 | $87.21 |
| 06/30/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -995,248 | 0 | -79,112,000 | |
| 03/31/2016 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 995,248 | 995,248 | 79,112,000 | 79,112,000 | $79.49 |
| 12/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 342,901 | 186,603 | 43,147,000 | 23,847,000 | $125.83 |
| 09/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 430,551 | 274,253 | 44,838,000 | 25,538,000 | $104.14 |
| 06/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 156,298 | 156,298 | 19,300,000 | 19,300,000 | $123.48 |
| 06/30/2013 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -7,444 | 0 | -409,000 | |
| 03/31/2013 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 7,444 | -25,191 | 409,000 | -960,000 | $54.94 |
| 12/31/2012 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 32,635 | -236,311 | 1,369,000 | -13,678,000 | $41.95 |
| 09/30/2012 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 268,946 | 249,055 | 15,047,000 | 13,935,000 | $55.95 |
| 06/30/2012 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 19,891 | 19,891 | 1,112,000 | 1,112,000 | $55.90 |
| 12/31/2010 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -243,513 | 0 | -8,418,000 | |
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