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MARSHALL WACE, LLP
> VRTX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 179,800 | -230,221 | 63,273,418,000 | -55,132,449,000 | $351,910.00 |
| 12/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 410,021 | 136,169 | 118,405,867,000 | 118,326,576,000 | $288,780.01 |
| 09/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 273,852 | -117,300 | 79,291,000 | -30,932,000 | $289.54 |
| 06/30/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 391,152 | 391,152 | 110,223,000 | 110,223,000 | $281.79 |
| 03/31/2022 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -150,000 | 0 | -32,940,000 | |
| 12/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 150,000 | -406,678 | 32,940,000 | -68,035,000 | $219.60 |
| 09/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 556,678 | 5,719 | 100,975,000 | -10,115,000 | $181.39 |
| 06/30/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 550,959 | 364,231 | 111,090,000 | 70,963,000 | $201.63 |
| 03/31/2021 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 186,728 | -12,859 | 40,127,000 | -7,044,000 | $214.90 |
| 12/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 199,587 | 158,119 | 47,171,000 | 35,888,000 | $236.34 |
| 09/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 41,468 | 36,846 | 11,283,000 | 9,941,000 | $272.09 |
| 06/30/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 4,622 | 3,982 | 1,342,000 | 1,190,000 | $290.35 |
| 03/31/2020 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 640 | -36,885 | 152,000 | -8,064,000 | $237.50 |
| 12/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 37,525 | -36,033 | 8,216,000 | -4,246,000 | $218.95 |
| 09/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 73,558 | -18,727 | 12,462,000 | -4,462,000 | $169.42 |
| 06/30/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 92,285 | 30,053 | 16,924,000 | 5,477,000 | $183.39 |
| 03/31/2019 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 62,232 | 672 | 11,447,000 | 1,246,000 | $183.94 |
| 12/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 61,560 | -123,252 | 10,201,000 | -25,420,000 | $165.71 |
| 09/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 184,812 | -191,673 | 35,621,000 | -28,366,000 | $192.74 |
| 06/30/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 376,485 | 343,094 | 63,987,000 | 58,545,000 | $169.96 |
| 03/31/2018 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 33,391 | -77,273 | 5,442,000 | -11,142,000 | $162.98 |
| 12/31/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 110,664 | 89,097 | 16,584,000 | 13,306,000 | $149.86 |
| 09/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 21,567 | -27,265 | 3,278,000 | -3,021,000 | $151.99 |
| 06/30/2017 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 48,832 | 48,832 | 6,299,000 | 6,299,000 | $128.99 |
| 12/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -93,510 | 0 | -9,738,000 | |
| 09/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 93,510 | 93,510 | 9,738,000 | 9,738,000 | $104.14 |
| 06/30/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 24,785 | 24,785 | 3,060,000 | 3,060,000 | $123.46 |
| 03/31/2015 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 176,236 | 176,236 | 20,790,000 | 20,790,000 | $117.97 |
| 12/31/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 416,111 | 416,111 | 49,434,000 | 49,434,000 | $118.80 |
| 09/30/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -3,290 | 0 | -311,000 | |
| 06/30/2014 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 3,290 | 3,290 | 311,000 | 311,000 | $94.53 |
| 09/30/2008 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -816,772 | 0 | -27,337,000 | |
| 06/30/2008 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 816,772 | 816,772 | 27,337,000 | 27,337,000 | $33.47 |
| 09/30/2007 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 0 | -71,500 | 0 | -2,042,000 | |
| 06/29/2007 | VERTEX PHARMACEUTICALS INC / MA | VRTX | 71,500 | 71,500 | 2,042,000 | 2,042,000 | $28.56 |
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