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MANUFACTURERS LIFE INSURANCE COMPANY, THE
> RXDX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | Prometheus Biosciences, Inc. | RXDX | 0 | -41,883 | 0 | -4,494,884,000 | |
| 03/31/2023 | Prometheus Biosciences, Inc. | RXDX | 41,883 | 29,959 | 4,494,884,000 | 4,494,547,000 | $107,320.01 |
| 12/31/2022 | Prometheus Biosciences, Inc. | RXDX | 32,327 | 16,120 | 3,555,049,000 | 2,605,289,000 | $109,971.51 |
| 09/30/2022 | Prometheus Biosciences, Inc. | RXDX | 16,207 | 4,283 | 949,760,000 | 949,423,000 | $58,601.84 |
| 06/30/2022 | Prometheus Biosciences, Inc. | RXDX | 11,924 | -119 | 336,615,000 | -118,129,000 | $28,230.04 |
| 03/31/2022 | Prometheus Biosciences, Inc. | RXDX | 12,043 | -2,748 | 454,744,000 | 454,159,000 | $37,760.03 |
| 12/31/2021 | Prometheus Biosciences, Inc. | RXDX | 14,791 | 14,791 | 585,000 | 585,000 | $39.55 |
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