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DRIEHAUS CAPITAL MANAGEMENT LLC
> XENE
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | Xenon Pharmaceuticals Inc. | XENE | 4,760,853 | 105,928 | 183,292,841,000 | 16,693,075,000 | $38,500.00 |
| 03/31/2023 | Xenon Pharmaceuticals Inc. | XENE | 4,654,925 | 150,905 | 166,599,766,000 | 166,437,171,000 | $35,790.00 |
| 09/30/2022 | Xenon Pharmaceuticals Inc. | XENE | 4,504,020 | 112,982 | 162,595,000 | 29,020,000 | $36.10 |
| 06/30/2022 | Xenon Pharmaceuticals Inc. | XENE | 4,391,038 | 1,090,611 | 133,575,000 | 32,681,000 | $30.42 |
| 03/31/2022 | Xenon Pharmaceuticals Inc. | XENE | 3,300,427 | 177,198 | 100,894,000 | 3,324,000 | $30.57 |
| 12/31/2021 | Xenon Pharmaceuticals Inc. | XENE | 3,123,229 | 1,611,686 | 97,569,674 | 74,473,674 | $31.24 |
| 09/30/2021 | Xenon Pharmaceuticals Inc. | XENE | 1,511,543 | 566,408 | 23,096,000 | 5,498,000 | $15.28 |
| 06/30/2021 | Xenon Pharmaceuticals Inc. | XENE | 945,135 | 173,725 | 17,598,000 | 3,790,000 | $18.62 |
| 03/31/2021 | Xenon Pharmaceuticals Inc. | XENE | 771,410 | 325,966 | 13,808,000 | 6,957,000 | $17.90 |
| 12/31/2020 | Xenon Pharmaceuticals Inc. | XENE | 445,444 | -5,863 | 6,851,000 | 1,855,000 | $15.38 |
| 09/30/2020 | Xenon Pharmaceuticals Inc. | XENE | 451,307 | -12,926 | 4,996,000 | -825,000 | $11.07 |
| 06/30/2020 | Xenon Pharmaceuticals Inc. | XENE | 464,233 | 1,901 | 5,821,000 | 578,000 | $12.54 |
| 03/31/2020 | Xenon Pharmaceuticals Inc. | XENE | 462,332 | 462,332 | 5,243,000 | 5,243,000 | $11.34 |
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