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CITADEL ADVISORS LLC
> AGIO
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | AGIOS PHARMACEUTICALS, INC. | AGIO | 175,191 | -43,826 | 4,961,409,000 | -1,188,588,000 | $28,320.00 |
| 12/31/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | 219,017 | -30,635 | 6,149,997,000 | 6,142,937,000 | $28,080.00 |
| 09/30/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | 249,652 | -83,929 | 7,060,000 | -335,000 | $28.28 |
| 06/30/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | 333,581 | 301,818 | 7,395,000 | 6,470,000 | $22.17 |
| 03/31/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | 31,763 | 11,534 | 925,000 | 260,000 | $29.12 |
| 12/31/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | 20,229 | -78,253 | 665,000 | -3,880,000 | $32.87 |
| 09/30/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | 98,482 | 98,482 | 4,545,000 | 4,545,000 | $46.15 |
| 06/30/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | 0 | -179,873 | 0 | -9,289,000 | |
| 03/31/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | 179,873 | 159,051 | 9,289,000 | 8,387,000 | $51.64 |
| 12/31/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | 20,822 | -181,609 | 902,000 | -6,183,000 | $43.32 |
| 09/30/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | 202,431 | 99,032 | 7,085,000 | 1,555,000 | $35.00 |
| 06/30/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | 103,399 | -381,542 | 5,530,000 | -11,675,000 | $53.48 |
| 03/31/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | 484,941 | 240,568 | 17,205,000 | 5,537,000 | $35.48 |
| 12/31/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 244,373 | -111,529 | 11,668,000 | 136,000 | $47.75 |
| 09/30/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 355,902 | -275,156 | 11,532,000 | -19,945,000 | $32.40 |
| 06/30/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 631,058 | 206,570 | 31,477,000 | 2,849,000 | $49.88 |
| 03/31/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 424,488 | 143,253 | 28,628,000 | 15,659,000 | $67.44 |
| 12/31/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 281,235 | 114,345 | 12,969,000 | 99,000 | $46.11 |
| 09/30/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 166,890 | 163,389 | 12,870,000 | 12,575,000 | $77.12 |
| 06/30/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 3,501 | -14,854 | 295,000 | -1,206,000 | $84.26 |
| 03/31/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 18,355 | -73,115 | 1,501,000 | -3,728,000 | $81.78 |
| 12/31/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | 91,470 | 91,470 | 5,229,000 | 5,229,000 | $57.17 |
| 09/30/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | 0 | -155,353 | 0 | -7,993,000 | |
| 06/30/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | 155,353 | 155,353 | 7,993,000 | 7,993,000 | $51.45 |
| 03/31/2017 | AGIOS PHARMACEUTICALS, INC. | AGIO | 0 | -21,066 | 0 | -879,000 | |
| 12/31/2016 | AGIOS PHARMACEUTICALS, INC. | AGIO | 21,066 | -199,803 | 879,000 | -10,787,000 | $41.73 |
| 09/30/2016 | AGIOS PHARMACEUTICALS, INC. | AGIO | 220,869 | 220,869 | 11,666,000 | 11,666,000 | $52.82 |
| 03/31/2016 | AGIOS PHARMACEUTICALS, INC. | AGIO | 0 | -562 | 0 | -36,000 | |
| 12/31/2015 | AGIOS PHARMACEUTICALS, INC. | AGIO | 562 | 562 | 36,000 | 36,000 | $64.06 |
| 09/30/2015 | AGIOS PHARMACEUTICALS, INC. | AGIO | 0 | -38,374 | 0 | -4,265,000 | |
| 06/30/2015 | AGIOS PHARMACEUTICALS, INC. | AGIO | 38,374 | 25,603 | 4,265,000 | 3,061,000 | $111.14 |
| 03/31/2015 | AGIOS PHARMACEUTICALS, INC. | AGIO | 12,771 | -2,766 | 1,204,000 | -537,000 | $94.28 |
| 12/31/2014 | AGIOS PHARMACEUTICALS, INC. | AGIO | 15,537 | -126,915 | 1,741,000 | -6,998,000 | $112.06 |
| 09/30/2014 | AGIOS PHARMACEUTICALS, INC. | AGIO | 142,452 | -21,622 | 8,739,000 | 1,221,000 | $61.35 |
| 06/30/2014 | AGIOS PHARMACEUTICALS, INC. | AGIO | 164,074 | 164,074 | 7,518,000 | 7,518,000 | $45.82 |
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