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DIMENSIONAL FUND ADVISORS LP
> AGIO
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | AGIOS PHARMACEUTICALS, INC. | AGIO | 2,263,818 | 172,467 | 64,109,168,000 | 16,071,756,000 | $28,319.05 |
| 03/31/2023 | AGIOS PHARMACEUTICALS, INC. | AGIO | 2,091,351 | 438,272 | 48,037,412,000 | 47,990,995,000 | $22,969.56 |
| 12/31/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,653,079 | 174,690 | 46,417,000 | 4,606,000 | $28.08 |
| 09/30/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,478,389 | 135,232 | 41,811,000 | 12,033,000 | $28.28 |
| 06/30/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,343,157 | 332,541 | 29,778,000 | 358,000 | $22.17 |
| 03/31/2022 | AGIOS PHARMACEUTICALS, INC. | AGIO | 1,010,616 | 285,215 | 29,420,000 | 5,575,000 | $29.11 |
| 12/31/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | 725,401 | 184,903 | 23,845,000 | -1,099,000 | $32.87 |
| 09/30/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | 540,498 | 256,725 | 24,944,000 | 9,307,000 | $46.15 |
| 06/30/2021 | AGIOS PHARMACEUTICALS, INC. | AGIO | 283,773 | -6,988 | 15,637,000 | 3,037,000 | $55.10 |
| 12/31/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | 290,761 | -34,845 | 12,600,000 | 1,205,000 | $43.33 |
| 09/30/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | 325,606 | -14,920 | 11,395,000 | -6,816,000 | $35.00 |
| 06/30/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | 340,526 | -44,620 | 18,211,000 | 4,547,000 | $53.48 |
| 03/31/2020 | AGIOS PHARMACEUTICALS, INC. | AGIO | 385,146 | 49,471 | 13,664,000 | -2,365,000 | $35.48 |
| 12/31/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 335,675 | 78,655 | 16,029,000 | 7,698,000 | $47.75 |
| 09/30/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 257,020 | 82,860 | 8,331,000 | -356,000 | $32.41 |
| 06/30/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 174,160 | -4,727 | 8,687,000 | -3,375,000 | $49.88 |
| 03/31/2019 | AGIOS PHARMACEUTICALS, INC. | AGIO | 178,887 | -3,263 | 12,062,000 | 3,663,000 | $67.43 |
| 12/31/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 182,150 | 39,255 | 8,399,000 | -2,620,000 | $46.11 |
| 09/30/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 142,895 | 42,200 | 11,019,000 | 2,539,000 | $77.11 |
| 06/30/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 100,695 | 24,051 | 8,480,000 | 2,212,000 | $84.21 |
| 03/31/2018 | AGIOS PHARMACEUTICALS, INC. | AGIO | 76,644 | 76,644 | 6,268,000 | 6,268,000 | $81.78 |
| 03/31/2016 | AGIOS PHARMACEUTICALS, INC. | AGIO | 0 | -36,774 | 0 | -4,120,000 | |
| 12/31/2015 | AGIOS PHARMACEUTICALS, INC. | AGIO | 0 | -50,137 | 0 | -3,538,000 | |
| 09/30/2015 | AGIOS PHARMACEUTICALS, INC. | AGIO | 50,137 | 13,363 | 3,538,000 | -582,000 | $70.57 |
| 06/30/2015 | AGIOS PHARMACEUTICALS, INC. | AGIO | 53,514 | 16,740 | 5,944,000 | 1,824,000 | $111.07 |
| 03/31/2015 | AGIOS PHARMACEUTICALS, INC. | AGIO | 46,329 | 9,555 | 4,370,000 | 250,000 | $94.33 |
| 12/31/2014 | AGIOS PHARMACEUTICALS, INC. | AGIO | 36,774 | 36,774 | 4,120,000 | 4,120,000 | $112.04 |
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