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Cubist Systematic Strategies, LLC
> AMGN
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | AMGEN INC | AMGN | 10,149 | 7,801 | 2,253,281,000 | 1,685,652,000 | $222,020.00 |
| 03/31/2023 | AMGEN INC | AMGN | 2,348 | -101,300 | 567,629,000 | -26,654,482,000 | $241,750.00 |
| 12/31/2022 | AMGEN INC | AMGN | 103,648 | 26,866 | 27,222,111,000 | 27,204,804,000 | $262,640.00 |
| 09/30/2022 | AMGEN INC | AMGN | 76,782 | -119,265 | 17,307,000 | -30,391,000 | $225.40 |
| 06/30/2022 | AMGEN INC | AMGN | 196,047 | 154,500 | 47,698,000 | 37,651,000 | $243.30 |
| 03/31/2022 | AMGEN INC | AMGN | 41,547 | 5,123 | 10,047,000 | 1,853,000 | $241.82 |
| 12/31/2021 | AMGEN INC | AMGN | 36,424 | 24,850 | 8,194,000 | 5,373,000 | $224.96 |
| 06/30/2021 | AMGEN INC | AMGN | 11,574 | -7,664 | 2,821,000 | -1,602,000 | $243.74 |
| 12/31/2020 | AMGEN INC | AMGN | 19,238 | 18,031 | 4,423,000 | 4,116,000 | $229.91 |
| 09/30/2020 | AMGEN INC | AMGN | 1,207 | -382 | 307,000 | -68,000 | $254.35 |
| 06/30/2020 | AMGEN INC | AMGN | 1,589 | -22,610 | 375,000 | -4,531,000 | $236.00 |
| 03/31/2020 | AMGEN INC | AMGN | 24,199 | 12,056 | 4,906,000 | 1,979,000 | $202.74 |
| 12/31/2019 | AMGEN INC | AMGN | 12,143 | -91,095 | 2,927,000 | -17,051,000 | $241.04 |
| 09/30/2019 | AMGEN INC | AMGN | 103,238 | 51,118 | 19,978,000 | 10,373,000 | $193.51 |
| 06/30/2019 | AMGEN INC | AMGN | 52,120 | 26,916 | 9,605,000 | 4,817,000 | $184.29 |
| 03/31/2019 | AMGEN INC | AMGN | 25,204 | 13,796 | 4,788,000 | 2,567,000 | $189.97 |
| 12/31/2018 | AMGEN INC | AMGN | 11,408 | -8,899 | 2,221,000 | -1,988,000 | $194.69 |
| 09/30/2018 | AMGEN INC | AMGN | 20,307 | 9,277 | 4,209,000 | 2,173,000 | $207.27 |
| 06/30/2018 | AMGEN INC | AMGN | 11,030 | -10,135 | 2,036,000 | -1,572,000 | $184.59 |
| 03/31/2018 | AMGEN INC | AMGN | 21,165 | 13,976 | 3,608,000 | 2,358,000 | $170.47 |
| 12/31/2017 | AMGEN INC | AMGN | 7,189 | 4,072 | 1,250,000 | 669,000 | $173.88 |
| 09/30/2017 | AMGEN INC | AMGN | 3,117 | 117 | 581,000 | 64,000 | $186.40 |
| 06/30/2017 | AMGEN INC | AMGN | 3,000 | -12,218 | 517,000 | -1,980,000 | $172.33 |
| 03/31/2017 | AMGEN INC | AMGN | 15,218 | 7,756 | 2,497,000 | 1,406,000 | $164.08 |
| 12/31/2016 | AMGEN INC | AMGN | 7,462 | -32,119 | 1,091,000 | -5,512,000 | $146.21 |
| 09/30/2016 | AMGEN INC | AMGN | 39,581 | 28,835 | 6,603,000 | 4,968,000 | $166.82 |
| 06/30/2016 | AMGEN INC | AMGN | 10,746 | 10,746 | 1,635,000 | 1,635,000 | $152.15 |
| 03/31/2016 | AMGEN INC | AMGN | 0 | -8,118 | 0 | -1,318,000 | |
| 12/31/2015 | AMGEN INC | AMGN | 8,118 | -2,989 | 1,318,000 | -218,000 | $162.36 |
| 09/30/2015 | AMGEN INC | AMGN | 11,107 | -23,732 | 1,536,000 | -3,812,000 | $138.29 |
| 06/30/2015 | AMGEN INC | AMGN | 34,839 | 34,839 | 5,348,000 | 5,348,000 | $153.51 |
| 03/31/2015 | AMGEN INC | AMGN | 32,322 | 1,925 | 5,167,000 | 325,000 | $159.86 |
| 12/31/2014 | AMGEN INC | AMGN | 30,397 | 28,385 | 4,842,000 | 4,559,000 | $159.29 |
| 09/30/2014 | AMGEN INC | AMGN | 2,012 | -8,754 | 283,000 | -991,000 | $140.66 |
| 06/30/2014 | AMGEN INC | AMGN | 10,766 | 10,766 | 1,274,000 | 1,274,000 | $118.34 |
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