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WILLIAM HARRIS INVESTORS INC
> MBRX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 12/31/2009 | METABASIS THERAPEUTICS INC | MBRX | 620,346 | 0 | 239,000 | -27,000 | $0.39 |
| 09/30/2009 | METABASIS THERAPEUTICS INC | MBRX | 620,346 | 0 | 266,000 | -81,000 | $0.43 |
| 06/30/2009 | METABASIS THERAPEUTICS INC | MBRX | 620,346 | 0 | 347,000 | -93,000 | $0.56 |
| 03/31/2009 | METABASIS THERAPEUTICS INC | MBRX | 620,346 | 0 | 440,000 | 241,000 | $0.71 |
| 12/31/2008 | METABASIS THERAPEUTICS INC | MBRX | 620,346 | 0 | 199,000 | -502,000 | $0.32 |
| 09/30/2008 | METABASIS THERAPEUTICS INC | MBRX | 620,346 | 620,346 | 701,000 | 701,000 | $1.13 |
| 06/30/2008 | METABASIS THERAPEUTICS INC | MBRX | 420,346 | 20,346 | 652,000 | -172,000 | $1.55 |
| 03/31/2008 | METABASIS THERAPEUTICS INC | MBRX | 400,000 | 0 | 824,000 | -372,000 | $2.06 |
| 12/31/2007 | METABASIS THERAPEUTICS INC | MBRX | 400,000 | 400,000 | 1,196,000 | 1,196,000 | $2.99 |
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