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BAKER BROS. ADVISORS LP
> PACB
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. | PACB | 1,127,782 | 0 | 14,999,501,000 | 5,774,244,000 | $13,300.00 |
| 12/31/2022 | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. | PACB | 1,127,782 | 0 | 9,225,257,000 | 9,218,710,000 | $8,180.00 |
| 09/30/2022 | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. | PACB | 1,127,782 | -4,317,181 | 6,547,000 | -17,520,000 | $5.81 |
| 06/30/2022 | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. | PACB | 5,444,963 | 0 | 24,067,000 | -25,482,000 | $4.42 |
| 03/31/2022 | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. | PACB | 5,444,963 | 0 | 49,549,000 | -61,855,000 | $9.10 |
| 12/31/2021 | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. | PACB | 5,444,963 | 0 | 111,404,000 | -27,715,000 | $20.46 |
| 09/30/2021 | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. | PACB | 5,444,963 | 2,242,991 | 139,119,000 | 27,146,000 | $25.55 |
| 06/30/2021 | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. | PACB | 3,201,972 | 0 | 111,973,000 | 5,315,000 | $34.97 |
| 03/31/2021 | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. | PACB | 3,201,972 | 0 | 106,658,000 | 23,599,000 | $33.31 |
| 12/31/2020 | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. | PACB | 3,201,972 | -48,028 | 83,059,000 | 50,981,000 | $25.94 |
| 09/30/2020 | PACIFIC BIOSCIENCES OF CALIFORNIA, INC. | PACB | 3,250,000 | 3,250,000 | 32,078,000 | 32,078,000 | $9.87 |
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