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WELLS FARGO & COMPANY
> IONS
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | IONIS PHARMACEUTICALS INC | IONS | 612,891 | -13,259 | 25,146,917,000 | 2,768,309,000 | $41,030.00 |
| 03/31/2023 | IONIS PHARMACEUTICALS INC | IONS | 626,150 | -63,722 | 22,378,608,000 | 22,348,095,000 | $35,740.01 |
| 09/30/2022 | IONIS PHARMACEUTICALS INC | IONS | 689,872 | -34,123 | 30,513,000 | 3,711,000 | $44.23 |
| 06/30/2022 | IONIS PHARMACEUTICALS INC | IONS | 723,995 | -118,289 | 26,802,000 | -4,396,000 | $37.02 |
| 03/31/2022 | IONIS PHARMACEUTICALS INC | IONS | 842,284 | 31,318 | 31,198,000 | 6,520,000 | $37.04 |
| 12/31/2021 | IONIS PHARMACEUTICALS INC | IONS | 810,966 | -42,404 | 24,678,000 | -3,944,000 | $30.43 |
| 09/30/2021 | IONIS PHARMACEUTICALS INC | IONS | 853,370 | 11,939 | 28,622,000 | -4,942,000 | $33.54 |
| 06/30/2021 | IONIS PHARMACEUTICALS INC | IONS | 841,431 | -315,568 | 33,564,000 | -18,454,000 | $39.89 |
| 03/31/2021 | IONIS PHARMACEUTICALS INC | IONS | 1,156,999 | 6,281 | 52,018,000 | -13,043,000 | $44.96 |
| 12/31/2020 | IONIS PHARMACEUTICALS INC | IONS | 1,150,718 | 232,691 | 65,061,000 | 21,500,000 | $56.54 |
| 09/30/2020 | IONIS PHARMACEUTICALS INC | IONS | 918,027 | -49,422 | 43,561,000 | -13,481,000 | $47.45 |
| 06/30/2020 | IONIS PHARMACEUTICALS INC | IONS | 967,449 | 156 | 57,042,000 | 11,309,000 | $58.96 |
| 03/31/2020 | IONIS PHARMACEUTICALS INC | IONS | 967,293 | -60,411 | 45,733,000 | -16,350,000 | $47.28 |
| 12/31/2019 | IONIS PHARMACEUTICALS INC | IONS | 1,027,704 | -12,876 | 62,083,000 | -259,000 | $60.41 |
| 09/30/2019 | IONIS PHARMACEUTICALS INC | IONS | 1,040,580 | -35,724 | 62,342,000 | -6,832,000 | $59.91 |
| 06/30/2019 | IONIS PHARMACEUTICALS INC | IONS | 1,076,304 | 59,667 | 69,174,000 | -13,347,000 | $64.27 |
| 03/31/2019 | IONIS PHARMACEUTICALS INC | IONS | 1,016,637 | -121,671 | 82,521,000 | 20,984,000 | $81.17 |
| 12/31/2018 | IONIS PHARMACEUTICALS INC | IONS | 1,138,308 | -26,959 | 61,537,000 | 1,433,000 | $54.06 |
| 09/30/2018 | IONIS PHARMACEUTICALS INC | IONS | 1,165,267 | -43,436 | 60,104,000 | 9,738,000 | $51.58 |
| 06/30/2018 | IONIS PHARMACEUTICALS INC | IONS | 1,208,703 | 66,535 | 50,366,000 | 20,000 | $41.67 |
| 03/31/2018 | IONIS PHARMACEUTICALS INC | IONS | 1,142,168 | 38,839 | 50,346,000 | -5,151,000 | $44.08 |
| 12/31/2017 | IONIS PHARMACEUTICALS INC | IONS | 1,103,329 | -50,719 | 55,497,000 | -3,013,000 | $50.30 |
| 09/30/2017 | IONIS PHARMACEUTICALS INC | IONS | 1,154,048 | -23,672 | 58,510,000 | 11,166,000 | $50.70 |
| 03/31/2017 | IONIS PHARMACEUTICALS INC | IONS | 1,177,720 | -20,643 | 47,344,000 | -9,974,000 | $40.20 |
| 12/31/2016 | IONIS PHARMACEUTICALS INC | IONS | 1,198,363 | 350,451 | 57,318,000 | 26,251,000 | $47.83 |
| 09/30/2016 | IONIS PHARMACEUTICALS INC | IONS | 847,912 | 847,912 | 31,067,000 | 31,067,000 | $36.64 |
| 06/30/2016 | IONIS PHARMACEUTICALS INC | IONS | 870,787 | 284,860 | 20,281,000 | -16,005,000 | $23.29 |
| 03/31/2016 | IONIS PHARMACEUTICALS INC | IONS | 847,168 | 261,241 | 34,310,000 | -1,976,000 | $40.50 |
| 12/31/2015 | IONIS PHARMACEUTICALS INC | IONS | 585,927 | 585,927 | 36,286,000 | 36,286,000 | $61.93 |
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