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NORTHERN TRUST CORP
> IONS
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2023 | IONIS PHARMACEUTICALS INC | IONS | 671,078 | 12,612 | 27,534,330,000 | 4,000,756,000 | $41,030.00 |
| 03/31/2023 | IONIS PHARMACEUTICALS INC | IONS | 658,466 | 34,826 | 23,533,574,000 | 23,505,991,000 | $35,740.00 |
| 09/30/2022 | IONIS PHARMACEUTICALS INC | IONS | 623,640 | -1,832 | 27,583,000 | 4,428,000 | $44.23 |
| 06/30/2022 | IONIS PHARMACEUTICALS INC | IONS | 625,472 | -23,062 | 23,155,000 | -865,000 | $37.02 |
| 03/31/2022 | IONIS PHARMACEUTICALS INC | IONS | 648,534 | -12,356 | 24,020,000 | 3,908,000 | $37.04 |
| 12/31/2021 | IONIS PHARMACEUTICALS INC | IONS | 660,890 | 5,469 | 20,112,000 | -1,872,000 | $30.43 |
| 09/30/2021 | IONIS PHARMACEUTICALS INC | IONS | 655,421 | -16,152 | 21,984,000 | -4,805,000 | $33.54 |
| 06/30/2021 | IONIS PHARMACEUTICALS INC | IONS | 671,573 | -153,601 | 26,789,000 | -19,867,000 | $39.89 |
| 12/31/2020 | IONIS PHARMACEUTICALS INC | IONS | 825,174 | -6,362 | 46,656,000 | 7,199,000 | $56.54 |
| 09/30/2020 | IONIS PHARMACEUTICALS INC | IONS | 831,536 | -3,957 | 39,457,000 | -44,000 | $47.45 |
| 03/31/2020 | IONIS PHARMACEUTICALS INC | IONS | 835,493 | 37,206 | 39,501,000 | -8,724,000 | $47.28 |
| 12/31/2019 | IONIS PHARMACEUTICALS INC | IONS | 798,287 | -971 | 48,225,000 | 342,000 | $60.41 |
| 09/30/2019 | IONIS PHARMACEUTICALS INC | IONS | 799,258 | -6,639 | 47,883,000 | -3,911,000 | $59.91 |
| 06/30/2019 | IONIS PHARMACEUTICALS INC | IONS | 805,897 | 153,326 | 51,794,000 | -1,175,000 | $64.27 |
| 03/31/2019 | IONIS PHARMACEUTICALS INC | IONS | 652,571 | 5,781 | 52,969,000 | 18,003,000 | $81.17 |
| 12/31/2018 | IONIS PHARMACEUTICALS INC | IONS | 646,790 | 6,578 | 34,966,000 | 1,943,000 | $54.06 |
| 09/30/2018 | IONIS PHARMACEUTICALS INC | IONS | 640,212 | 18,569 | 33,023,000 | 7,120,000 | $51.58 |
| 06/30/2018 | IONIS PHARMACEUTICALS INC | IONS | 621,643 | 21,286 | 25,903,000 | -561,000 | $41.67 |
| 03/31/2018 | IONIS PHARMACEUTICALS INC | IONS | 600,357 | 13,375 | 26,464,000 | -3,061,000 | $44.08 |
| 12/31/2017 | IONIS PHARMACEUTICALS INC | IONS | 586,982 | -4,396 | 29,525,000 | -458,000 | $50.30 |
| 09/30/2017 | IONIS PHARMACEUTICALS INC | IONS | 591,378 | -30,438 | 29,983,000 | -1,648,000 | $50.70 |
| 06/30/2017 | IONIS PHARMACEUTICALS INC | IONS | 621,816 | 44,750 | 31,631,000 | 8,433,000 | $50.87 |
| 03/31/2017 | IONIS PHARMACEUTICALS INC | IONS | 577,066 | 577,066 | 23,198,000 | 23,198,000 | $40.20 |
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