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WELLINGTON MANAGEMENT GROUP LLP
> MBRX
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 09/30/2009 | METABASIS THERAPEUTICS INC | MBRX | 3,803,464 | -171,800 | 1,669,000 | -558,000 | $0.44 |
| 06/30/2009 | METABASIS THERAPEUTICS INC | MBRX | 3,975,264 | -519,200 | 2,227,000 | -964,000 | $0.56 |
| 03/31/2009 | METABASIS THERAPEUTICS INC | MBRX | 4,494,464 | -56,200 | 3,191,000 | 1,735,000 | $0.71 |
| 12/31/2008 | METABASIS THERAPEUTICS INC | MBRX | 4,550,664 | -333,049 | 1,456,000 | -4,063,000 | $0.32 |
| 09/30/2008 | METABASIS THERAPEUTICS INC | MBRX | 4,883,713 | -6,238 | 5,519,000 | -2,061,000 | $1.13 |
| 06/30/2008 | METABASIS THERAPEUTICS INC | MBRX | 4,889,951 | 1,804,851 | 7,580,000 | 1,224,000 | $1.55 |
| 03/31/2008 | METABASIS THERAPEUTICS INC | MBRX | 3,085,100 | 3,085,100 | 6,356,000 | 6,356,000 | $2.06 |
| 12/31/2007 | METABASIS THERAPEUTICS INC | MBRX | 2,341,900 | 2,341,900 | 7,189,000 | 7,189,000 | $3.07 |
| 09/30/2007 | METABASIS THERAPEUTICS INC | MBRX | 2,347,500 | 2,347,500 | 6,854,000 | 6,854,000 | $2.92 |
| 06/30/2007 | METABASIS THERAPEUTICS INC | MBRX | 2,128,500 | 2,128,500 | 14,900,000 | 14,900,000 | $7.00 |
| 03/31/2007 | METABASIS THERAPEUTICS INC | MBRX | 1,827,800 | 1,827,800 | 13,435,000 | 13,435,000 | $7.35 |
| 12/31/2006 | METABASIS THERAPEUTICS INC | MBRX | 1,030,900 | 1,030,900 | 7,753,000 | 7,753,000 | $7.52 |
| 09/30/2006 | METABASIS THERAPEUTICS INC | MBRX | 984,900 | 984,900 | 5,536,000 | 5,536,000 | $5.62 |
| 06/30/2006 | METABASIS THERAPEUTICS INC | MBRX | 984,900 | 984,900 | 7,515,000 | 7,515,000 | $7.63 |
| 03/31/2006 | METABASIS THERAPEUTICS INC | MBRX | 984,900 | 984,900 | 8,953,000 | 8,953,000 | $9.09 |
| 12/31/2005 | METABASIS THERAPEUTICS INC | MBRX | 1,000,000 | 1,000,000 | 8,000,000 | 8,000,000 | $8.00 |
| 09/30/2005 | METABASIS THERAPEUTICS INC | MBRX | 1,000,000 | 1,000,000 | 5,830,000 | 5,830,000 | $5.83 |
| 06/30/2005 | METABASIS THERAPEUTICS INC | MBRX | 1,000,000 | 1,000,000 | 3,149,000 | 3,149,000 | $3.15 |
| 03/31/2005 | METABASIS THERAPEUTICS INC | MBRX | 1,000,000 | 1,000,000 | 3,489,000 | 3,489,000 | $3.49 |
| 12/31/2004 | METABASIS THERAPEUTICS INC | MBRX | 1,000,000 | 1,000,000 | 7,251,000 | 7,251,000 | $7.25 |
| 09/30/2004 | METABASIS THERAPEUTICS INC | MBRX | 1,000,000 | 1,000,000 | 5,819,000 | 5,819,000 | $5.82 |
| 06/30/2004 | METABASIS THERAPEUTICS INC | MBRX | 1,000,000 | 1,000,000 | 6,790,000 | 6,790,000 | $6.79 |
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